Review
Oncology
Xin Cheng, Kecheng Lou, Liang Ding, Xiaofeng Zou, Ruohui Huang, Gang Xu, Junrong Zou, Guoxi Zhang
Summary: This article summarizes the important role of Hippo-YAP in bladder cancer, including regulating the survival, progression, and chemotherapy resistance of cancer stem cells. It also explores the role of Hippo-YAP in regulating bladder cancer stem cells, as well as its clinical potential in the treatment of BC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Zhong-Ming Huang, Hai Wang, Zhi-Gang Ji
Summary: miR-217 expression was significantly higher in T24 and 5367 cell lines. Exosomal miR-217 mimic enhanced proliferation and migration, while inhibiting apoptosis of the cancer cells. Conversely, exosomal miR-217 inhibitor suppressed proliferation and migration but stimulated apoptosis. Additionally, miR-217 may act as an oncogene in bladder cancer cells through the Hippo-YAP signaling pathway.
INFLAMMATION RESEARCH
(2021)
Article
Cell Biology
Hualin Chen, Wenjie Yang, Yingjie Li, Zhigang Ji
Summary: PLAGL2 is overexpressed in bladder cancer tissues and is associated with decreased survival. Mechanistically, overexpressed PLAGL2 activates the RACGAP1/RhoA GTPase/YAP1 signaling pathway, promoting proliferation and metastasis of bladder cancer cells. Targeting the core nodes of this signaling pathway may have therapeutic potential for bladder cancer.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Yan Gu, Yanrong Chen, Lai Wei, Shuang Wu, Kaicheng Shen, Chengxiang Liu, Yan Dong, Yang Zhao, Yue Zhang, Chi Zhang, Wenling Zheng, Jiangyi He, Yunlong Wang, Yifei Li, Xiaoxin Zhao, Hongwei Wang, Jun Tan, Liting Wang, Qi Zhou, Ganfeng Xie, Houjie Liang, Juanjuan Ou
Summary: Loss of ABHD5 promotes the activation of c-Met via a non-canonical pathway, sustaining the stemness of colorectal cancer cells.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Xu Li, Shu Zhuo, Yong Suk Cho, Yuchen Liu, Yingzi Yang, Jian Zhu, Jin Jiang
Summary: Hippo signaling inhibits the oncogenic potential of YAP/TAZ-TEAD transcriptional complex, restricting tumor growth. In AR-positive prostate cancer, YAP acts as a tumor suppressor by counteracting TEAD-mediated AR signaling. YAP competes with AR for TEAD binding, disrupting AR-TEAD interaction and preventing TEAD from promoting AR signaling. Targeting the Hippo signaling pathway may provide a therapeutic opportunity to treat therapy resistant AR variants-driven prostate cancer.
Article
Cell Biology
Zijun Qian, Xiaoting Tian, Yayou Miao, Xin Xu, Xuehua Cheng, Mengyi Wu, Yongchun Yu
Summary: This study demonstrates that Bufalin can inhibit the proliferation of lung cancer cells in vivo/in vitro by suppressing the Hippo-YAP pathway. The findings show that Bufalin promotes the binding of LATS and YAP, leading to increased YAP phosphorylation. Phosphorylated YAP is unable to enter the nucleus and activate the expression of downstream proliferation-related genes, while the retained YAP in the cytoplasm undergoes degradation. This study verifies the key role of YAP in stimulating lung cancer proliferation and identifies Bufalin as a potential anticancer drug target.
CELLULAR SIGNALLING
(2023)
Review
Biochemistry & Molecular Biology
Filippos Koinis, Evangelia Chantzara, Michael Samarinas, Anastasia Xagara, Zisis Kratiras, Vasiliki Leontopoulou, Athanasios Kotsakis
Summary: This article summarizes the role of the Hippo pathway in prostate cancer and identifies knowledge gaps that need to be addressed for the development of YAP-targeted treatment strategies.
Review
Medicine, Research & Experimental
Wenhao Mao, Jia Mai, Hui Peng, Junhu Wan, Ting Sun
Summary: This review explores the oncogenic role and regulatory mechanism of YAP in PDAC, highlighting its potential as a therapeutic target in various human cancers.
Review
Oncology
Yibo Guo, Juan Luo, Hailin Zou, Chenxin Liu, Liang Deng, Peng Li
Summary: This article provides an overview of the core components and upstream regulators of Hippo-YAP/TAZ signaling in mammals, and systematically summarizes the identified transcription factors or partners responsible for the downstream transcriptional output of YAP/TAZ in various cancers.
Article
Biochemistry & Molecular Biology
Helen Wedegaertner, Wen-An Pan, Carlos C. Gonzalez, David J. Gonzalez, JoAnn Trejo
Summary: Adaptor proteins play a significant role in controlling cellular signaling. A recently discovered family of mammalian arrestins, called alpha-arrestins, have been found to function as tumor suppressors and regulate cellular signaling of GPCRs in cancer. However, the regulatory mechanisms of alpha-arrestin activation and function are not yet well understood.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Xiaoyan Li, Zhengming Wu, Jing He, Yiting Jin, Chengyu Chu, Yun Cao, Fei Gu, Hongying Wang, Chenjian Hou, Xiuping Liu, Qiang Zou
Summary: The incidence of thyroid cancer is increasing globally, with poor prognosis associated with distant metastases. OGT and YAP play critical roles in papillary thyroid cancer, suggesting potential for targeted therapies.
Correction
Biochemistry & Molecular Biology
Xiao Zheng, Lujun Chen, You Zhou, Qi Wang, Zhuojun Zheng, Bin Xu, Chen Wu, Qi Zhou, Wenwei Hu, Changping Wu, Jingting Jiang
Summary: The paper has published an amendment which can be accessed through the original article.
Article
Chemistry, Medicinal
Wenchao Lu, Mengyang Fan, Wenzhi Ji, Jason Tse, Inchul You, Scott B. Ficarro, Isidoro Tavares, Jianwei Che, Audrey Y. Kim, Xijun Zhu, Andrew Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Stephen M. Hinshaw, Behnam Nabet, Steven M. Corsello, Nicholas Kwiatkowski, Jarrod A. Marto, Tinghu Zhang, Nathanael S. Gray
Summary: TEAD proteins, along with their coactivators YAP and TAZ, are important regulators of gene expression in the Hippo pathway. Aberrant TEAD/YAP signaling has been implicated in various cancers. Recent research has identified TEADs as being palmitoylated, suggesting a new avenue for developing anticancer drugs targeting TEAD.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Medicine, General & Internal
Nan Zheng, Shan Liu, Huiting Zeng, Huajun Zhao, Lixu Jin
Summary: This study found that WZ10 can significantly inhibit the proliferation and invasion of ovarian cancer OVCAR3 cells by downregulating the activation of the Hippo-YAP pathway, and induce cell apoptosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Karen Aitken, Priyank Yadav, Martin Sidler, Thenuka Thanabalasingam, Tabina Ahmed, Prateek Aggarwal, Shing Tai Yip, Nefateri Jeffrey, Jia-Xin Jiang, Aliza Siebenaller, Chris Sotiropoulos, Ryan Huang, David Minh Quynh Le, Paul Delgado-Olguin, Darius Bagli
Summary: Rodents have the ability to regenerate their bladders and migrate bladder smooth muscle cells (BSMCs) after subtotal cystectomy (STC), which involves the key roles of YAP/WWTR1 and BDNF (Brain-derived neurotrophic factor) in development and regeneration. Experiments on regeneration and wound repair models were conducted to examine the expressions of YAP/WWTR1, BDNF, and CYR61, and live cell microscopy was used to observe cell movement and division in an ex vivo STC model. Inhibition of YAP/WWTR1 and BDNF signaling reduced scratch-induced migration of BSMCs and elevated expressions of BDNF and CYR61 were observed during STC and partial bladder outlet obstruction (PBO).
Article
Oncology
Shijie Li, Shiyang Lu, Xuefeng Liu, Xiaonan Chen
Summary: This study found that the serum albumin-to-alkaline phosphatase ratio (AAPR) is significantly associated with the prognosis of bladder cancer patients receiving radical cystectomy, providing insights for clinical decision-making and risk stratification. The AAPR-based nomograms showed good predictive accuracy for overall survival, cancer-specific survival, and recurrence-free survival.
FRONTIERS IN ONCOLOGY
(2021)
Article
Urology & Nephrology
Shijie Li, Xuefeng Liu, Xiaonan Chen
Summary: A prognostic nomogram was developed and validated to predict the prognosis of PBS patients, aiding clinicians in assessing risk factors and formulating optimal individualized treatment strategies. The nomogram outperformed the TNM staging system and could effectively distinguish patients with different survival risks.
Article
Oncology
Shijie Li, Xuefeng Liu, Xiaonan Chen
Summary: This study compared the clinical and pathological characteristics and outcomes of different subtypes of papillary renal cell carcinoma (PRCC) and found that type 2 PRCC had significantly poorer survival rates. Smoking history and pathological characteristics were independent factors for predicting the oncological outcomes of PRCC patients.
Article
Oncology
Yiqiao Zhao, Zijia Tao, Lei Li, Jianyi Zheng, Xiaonan Chen
Summary: In this study, we developed a prognostic model based on gene expression profiles to predict biochemical recurrence (BCR) in prostate cancer patients. The model showed strong predictive ability and could be a valuable tool for clinical use and further research in understanding the mechanisms underlying prostate cancer.
Review
Medicine, Research & Experimental
Mingyang Li, Zijia Tao, Yiqiao Zhao, Lei Li, Jianyi Zheng, Zeyu Li, Xiaonan Chen
Summary: In recent years, m(5)C RNA modification has been found to play a crucial role in regulating RNA metabolism and function, affecting cell proliferation, differentiation, apoptosis, and other biological processes. m(5)C modification is associated with the pathogenesis and progression of cancers, and abnormal expression of related genes can be used to predict patient prognosis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Genetics & Heredity
Lei Li, Zijia Tao, Yiqiao Zhao, Mingyang Li, Jianyi Zheng, Zeyu Li, Xiaonan Chen
Summary: This study investigated the relationship between N-6-methyladenosine and 5-methylcytosine regulators and clear cell renal cell carcinoma and identified five potential biomarkers for future research.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, General & Internal
Jianyi Zheng, Shijie Li, Yiqiao Zhao, Zijia Tao, Lei Li, Zeyu Li, Mingyang Li, Xiaonan Chen
Summary: This study successfully constructed and validated nomograms to predict overall survival (OS) and cancer-specific survival (CSS) for patients with chromophobe renal cell carcinoma (chRCC) after nephrectomy. The nomograms showed accurate discrimination and were proven to be better in accuracy and efficacy ability compared to the seventh tumor, node, and metastasis stage. These nomograms can assist clinical doctors in choosing individual treatment strategies for chRCC patients.
Article
Oncology
Shijie Li, Zeyu Li, Jianyi Zheng, Xiaonan Chen
Summary: This study aimed to investigate risk factors for intraoperative hemodynamic instability (HDI) and construct a clinical model for predicting intraoperative HDI for large pheochromocytomas and paragangliomas (PPGLs) patients. Independent risk factors were identified and a predictive model was constructed, which showed good predictive power in the training and validation cohorts. This model can help in individualized pre-treatment decision-making.
Review
Biochemistry & Molecular Biology
Mingyang Li, Lei Li, Jianyi Zheng, Zeyu Li, Shijie Li, Kefeng Wang, Xiaonan Chen
Summary: Renal cell carcinoma (RCC) is a common type of kidney cancer with unremarkable symptoms in early stages and low sensitivity to radiotherapy and chemotherapy. Liquid biopsy, an emerging non-invasive test, can measure patient biomarkers for diagnosis, prognostic assessment, treatment monitoring, and response evaluation. With rapid development and iteration of extraction and analysis technologies, liquid biopsy has become a low cost, high efficiency, and high accuracy clinical detection method. In this review, we comprehensively discuss the components, clinical applications, limitations, and future prospects of liquid biopsy in the past 5 years.
Article
Medicine, General & Internal
Zeyu Li, Lei Li, Jianyi Zheng, Mingyang Li, Siyu Wu, Kerong Xin, Rong Li, Song Bai, Xiaonan Chen
Summary: This study aimed to investigate the relationship between kidney stone history and human bone health. Results showed a negative correlation between lumbar bone mineral density and kidney stone history, and an interaction between serum 25-hydroxyvitamin D and lumbar BMD regarding kidney stone formation. Therefore, maintaining high lumbar BMD and serum 25-hydroxyvitamin D levels may help prevent the occurrence of kidney stones.
Review
Medicine, Research & Experimental
Siyu Wu, Rong Li, Yuanhong Jiang, Jiazheng Yu, Jianyi Zheng, Zeyu Li, Mingyang Li, Kerong Xin, Yang Wang, Zhenqun Xu, Shijie Li, Xiaonan Chen
Summary: Liquid biopsy is an accurate method for determining molecular profiles in urothelial carcinoma (UC). It has the potential to play a crucial role in early diagnosis, treatment monitoring, and prognosis prediction, thereby contributing to precision medicine in UC management.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Lei Li, Mingyang Li, Jianyi Zheng, Zeyu Li, Xiaonan Chen
Summary: This study reveals that NSUN5 is highly expressed in ccRCC and is associated with tumor immunity. The high-risk group responds poorly to immunosuppressive treatment and has lower stromal scores compared to the low-risk group. NSUN5 knockout reduces ccRCC cell proliferation and migration, while increasing apoptosis.
Review
Biochemistry & Molecular Biology
Shijie Li, Kerong Xin, Shen Pan, Yang Wang, Jianyi Zheng, Zeyu Li, Xuefeng Liu, Bitian Liu, Zhenqun Xu, Xiaonan Chen
Summary: Bladder cancer is a global clinical challenge characterized by late presentation, poor prognosis, and low survival rates. Traditional methods for diagnosis and monitoring, such as cystoscopy and tissue biopsy, have limitations and high costs. In recent years, liquid biopsies, specifically blood-based ones, have emerged as highly efficient methods for discovering biomarkers and monitoring tumor progression. Several liquid biopsy biomarkers have shown promising results in clinical applications, including early detection, residual disease detection, recurrence prediction, and therapy response.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Biotechnology & Applied Microbiology
Zijia Tao, Enchong Zhang, Lei Li, Jianyi Zheng, Yiqiao Zhao, Xiaonan Chen
Summary: The study successfully established a unified prognostic risk model, incorporating clinical stage and immune-related gene pairs, to effectively assess the overall survival of ccRCC patients. The model showed high accuracy in predicting survival outcomes across multiple validation cohorts, demonstrating better performance than individual IRGP signatures. Immune infiltration analysis revealed higher abundance of certain immune cells in ccRCC patients with poor prognosis.
Article
Oncology
Shijie Li, Yiqiao Zhao, Xiaonan Chen
Summary: This study identified dysregulated circRNAs in human bladder cancer and their potential association with cancer-related pathways. Construction of a circRNA-microRNA-mRNA network revealed additional roles of these circRNAs in promoting the malignant biological behavior of BC. The results suggest that hsa_circRNA_100876 may serve as a potential non-invasive biomarker for the early detection and screening of BC.