Downregulation of MYPT1 increases tumor resistance in ovarian cancer by targeting the Hippo pathway and increasing the stemness

A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling

(2019) Xiao Zheng et al.   Molecular Cancer

Activated Fibroblast Program Orchestrates Tumor Initiation and Progression; Molecular Mechanisms and the Associated Therapeutic Strategies

(2019) Go J. Yoshida et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

New markers for human ovarian cancer that link platinum resistance to the cancer stem cell phenotype and define new therapeutic combinations and diagnostic tools

(2019) Sandra Muñoz-Galván et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Regulation of the Hippo pathway in cancer biology

(2018) Sungho Moon et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

YAP/TAZ Activation as a Target for Treating Metastatic Cancer

(2018) Janine Warren et al.   Cancers

Tumor cell-secreted PLD increases tumor stemness by senescence-mediated communication with microenvironment

(2018) Sandra Muñoz-Galván et al.   ONCOGENE

MicroRNA-30d promotes angiogenesis and tumor growth via MYPT1/c-JUN/VEGFA pathway and predicts aggressive outcome in prostate cancer

(2017) Zhuo-yuan Lin et al.   Molecular Cancer

Platelets reduce anoikis and promote metastasis by activating YAP1 signaling

(2017) Monika Haemmerle et al.   Nature Communications

The impact of EpCAM expression on response to chemotherapy and clinical outcomes in patients with epithelial ovarian cancer

(2017) Shingo Tayama et al.   Oncotarget

Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability

(2017) Ana Maria G Dumitru et al.   eLife

Therapeutic strategies targeting cancer stem cells

(2015) Go J. Yoshida et al.   CANCER SCIENCE

Loss of the tumor suppressor spinophilin (PPP1R9B) increases the cancer stem cell population in breast tumors

(2015) I Ferrer et al.   ONCOGENE

Hippo Coactivator YAP1 Upregulates SOX9 and Endows Esophageal Cancer Cells with Stem-like Properties

(2014) S. Song et al.   CANCER RESEARCH

Cancer stem cells - important players in tumor therapy resistance

(2014) Selcuk Colak et al.   FEBS Journal

Myosin Phosphatase Target Subunit 1 (MYPT1) Regulates the Contraction and Relaxation of Vascular Smooth Muscle and Maintains Blood Pressure

(2014) Yan-Ning Qiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ovarian cancer

(2014) Gordon C Jayson et al.   LANCET

YAP Promotes Ovarian Cancer Cell Tumorigenesis and Is Indicative of a Poor Prognosis for Ovarian Cancer Patients

(2014) Yan Xia et al.   PLoS One

MYPT1 regulates contractility and microtubule acetylation to modulate integrin adhesions and matrix assembly

(2014) E. Emily Joo et al.   Nature Communications

Capturing the mammalian Hippo: Elucidating its role in cancer

(2013) Miki Nishio et al.   CANCER SCIENCE

Altered Contractile Phenotypes of Intestinal Smooth Muscle in Mice Deficient in Myosin Phosphatase Target Subunit 1

(2013) Wei–Qi He et al.   GASTROENTEROLOGY

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

Targeting cancer stem cells to suppress acquired chemotherapy resistance

(2013) S J Vidal et al.   ONCOGENE

Redox regulation in stem-like cancer cells by CD44 variant isoforms

(2013) O Nagano et al.   ONCOGENE

Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase

(2013) Isabel Serrano et al.   Nature Communications

LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression

(2012) Tatsuyuki Chiyoda et al.   JOURNAL OF CELL BIOLOGY

LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker

(2012) Dahu Chen et al.   NATURE MEDICINE

The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain

(2012) J. M. Lamar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The YAP and TAZ transcription co-activators: Key downstream effectors of the mammalian Hippo pathway

(2012) Wanjin Hong et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene

(2011) X Zhang et al.   ONCOGENE

E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components

(2011) N.-G. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ovarian cancer stem-like side-population cells are tumourigenic and chemoresistant

(2010) L Hu et al.   BRITISH JOURNAL OF CANCER

Hippo Pathway Effector Yap Is an Ovarian Cancer Oncogene

(2010) C. A. Hall et al.   CANCER RESEARCH

Hippo signaling: growth control and beyond

(2010) G. Halder et al.   DEVELOPMENT

The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version

(2010) B. Zhao et al.   GENES & DEVELOPMENT

Cancer Stem Cells and Aneuploid Populations within Developing Tumors Are the Major Determinants of Tumor Dormancy

(2009) A. P. Kusumbe et al.   CANCER RESEARCH

Rho-regulated Myosin phosphatase establishes the level of protrusive activity required for cell movements during zebrafish gastrulation

(2009) D. C. Weiser et al.   DEVELOPMENT

PC3 Human Prostate Carcinoma Cell Holoclones Contain Self-renewing Tumor-Initiating Cells

(2008) H. Li et al.   CANCER RESEARCH

Myosin Phosphatase-Targeting Subunit 1 Regulates Mitosis by Antagonizing Polo-like Kinase 1

(2008) Shigeko Yamashiro et al.   DEVELOPMENTAL CELL