标题
The Hippo Signaling Pathway in Drug Resistance in Cancer
作者
关键词
-
出版物
Cancers
Volume 13, Issue 2, Pages 318
出版商
MDPI AG
发表日期
2021-01-18
DOI
10.3390/cancers13020318
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- YAP1 is an independent prognostic marker in pancreatic cancer and associated with extracellular matrix remodeling
- (2020) Qimin Zhou et al. Journal of Translational Medicine
- Downregulation of MYPT1 increases tumor resistance in ovarian cancer by targeting the Hippo pathway and increasing the stemness
- (2020) Sandra Muñoz-Galván et al. Molecular Cancer
- Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties
- (2020) Tito Panciera et al. NATURE MATERIALS
- Screening for YAP Inhibitors Identifies Statins as Modulators of Fibrosis
- (2020) Daniela M. Santos et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Synergistic enhancement of efficacy of platinum drugs with verteporfin in ovarian cancer cells
- (2020) Venkata Ramesh Dasari et al. BMC CANCER
- YAP1/TAZ drives ependymoma-like tumour formation in mice
- (2020) Noreen Eder et al. Nature Communications
- Hippo-YAP1 Is a Prognosis Marker and Potentially Targetable Pathway in Advanced Gallbladder Cancer
- (2020) Patricia García et al. Cancers
- Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine
- (2020) Anwesha Dey et al. NATURE REVIEWS DRUG DISCOVERY
- TAZ-regulated expression of IL-8 is involved in chemoresistance of hepatocellular carcinoma cells
- (2020) Hao Zhang et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Concepts of extracellular matrix remodelling in tumour progression and metastasis
- (2020) Juliane Winkler et al. Nature Communications
- Cancer statistics, 2019
- (2019) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Drug-drug interactions in breast cancer patients treated with CDK4/6 inhibitors
- (2019) Stefano Fogli et al. CANCER TREATMENT REVIEWS
- Large tumor suppressor kinase 2 overexpression attenuates 5-FU-resistance in colorectal cancer via activating the JNK-MIEF1-mitochondrial division pathway
- (2019) Weilong Yao et al. Cancer Cell International
- Phosphorylation of Merlin by Aurora A kinase appears necessary for mitotic progression
- (2019) Vinay Mandati et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Loss of miR‑873 contributes to gemcitabine resistance in triple‑negative breast cancer via targeting ZEB1
- (2019) Gangyue Wang et al. Oncology Letters
- The Hippo Signaling Pathway in Development and Disease
- (2019) Yonggang Zheng et al. DEVELOPMENTAL CELL
- Therapeutic targeting of 3′,5′-cyclic nucleotide phosphodiesterases: inhibition and beyond
- (2019) George S. Baillie et al. NATURE REVIEWS DRUG DISCOVERY
- Reciprocal Crosstalk Between YAP1/Hippo Pathway and the p53 Family Proteins: Mechanisms and Outcomes in Cancer
- (2019) Nitin Raj et al. Frontiers in Cell and Developmental Biology
- YAP1 Mediates Resistance to MEK1/2 Inhibition in Neuroblastomas with Hyperactivated RAS Signaling
- (2019) Grace E. Coggins et al. CANCER RESEARCH
- Verteporfin- and sodium porfimer-mediated photodynamic therapy enhances pancreatic cancer cell death without activating stromal cells in the microenvironment
- (2019) Jingjing Lu et al. JOURNAL OF BIOMEDICAL OPTICS
- A view on drug resistance in cancer
- (2019) Neil Vasan et al. NATURE
- RASSF6 Is Downregulated In Human Bladder Cancers And Regulates Doxorubicin Sensitivity And Mitochondrial Membrane Potential Via The Hippo Signaling Pathway
- (2019) Shutao Tan et al. OncoTargets and Therapy
- Verteporfin-induced lysosomal compartment dysregulation potentiates the effect of sorafenib in hepatocellular carcinoma
- (2019) Jacopo Gavini et al. Cell Death & Disease
- Verteporfin-Loaded Lipid Nanoparticles Improve Ovarian Cancer Photodynamic Therapy In Vitro and In Vivo
- (2019) Michy et al. Cancers
- FDA- and EMA-Approved Tyrosine Kinase Inhibitors in Advanced EGFR-Mutated Non-Small Cell Lung Cancer: Safety, Tolerability, Plasma Concentration Monitoring, and Management
- (2019) Isabelle Solassol et al. Biomolecules
- AJUBA increases the cisplatin resistance through hippo pathway in cervical cancer
- (2018) Lihong Bi et al. GENE
- A global perspective on vasoactive agents in shock
- (2018) Djillali Annane et al. INTENSIVE CARE MEDICINE
- Verteporfin inhibits YAP-induced bladder cancer cell growth and invasion via Hippo signaling pathway
- (2018) Liang Dong et al. International Journal of Medical Sciences
- Classifying BRAF alterations in cancer: new rational therapeutic strategies for actionable mutations
- (2018) Matthew Dankner et al. ONCOGENE
- FDA Approval Summary: Dabrafenib and Trametinib for the Treatment of Metastatic Non‐Small Cell Lung Cancers HarboringBRAF V600EMutations
- (2018) Lauretta Odogwu et al. ONCOLOGIST
- Hippo Signaling: Key Emerging Pathway in Cellular and Whole-Body Metabolism
- (2018) Amin Ardestani et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Verteporfin enhances the sensitivity of LOVO/TAX cells to taxol via YAP inhibition
- (2018) Ganggang Shi et al. Experimental and Therapeutic Medicine
- miR-363 confers taxane resistance in ovarian cancer by targeting the Hippo pathway member, LATS2
- (2018) Zeinab Mohamed et al. Oncotarget
- A tightly controlled Src-YAP signaling axis determines therapeutic response to dasatinib in renal cell carcinoma
- (2018) Jingya Sun et al. Theranostics
- Activation mechanisms of the Hippo kinase signaling cascade
- (2018) Sung Jun Bae et al. BIOSCIENCE REPORTS
- Functional significance of Hippo/YAP signaling for drug resistance in colorectal cancer
- (2018) Ruolan Song et al. MOLECULAR CARCINOGENESIS
- Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4
- (2018) Francesca Zanconato et al. NATURE MEDICINE
- Inhibition of YAP reverses primary resistance to EGFR inhibitors in colorectal cancer cells
- (2018) Bi‑Sheng Liu et al. ONCOLOGY REPORTS
- Loss of the FAT1 Tumor Suppressor Promotes Resistance to CDK4/6 Inhibitors via the Hippo Pathway
- (2018) Zhiqiang Li et al. CANCER CELL
- Role of inhibitor of yes-associated protein 1 in triple-negative breast cancer with taxol-based chemoresistance
- (2018) Ying Li et al. CANCER SCIENCE
- Statin use and mortality among ovarian cancer patients: A population-based cohort study
- (2017) Freija Verdoodt et al. INTERNATIONAL JOURNAL OF CANCER
- Taxane-mediated radiosensitization derives from chromosomal missegregation on tripolar mitotic spindles orchestrated by AURKA and TPX2
- (2017) M Orth et al. ONCOGENE
- Hippo pathway mediates resistance to cytotoxic drugs
- (2017) Taranjit S. Gujral et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer
- (2017) Shi Jiao et al. Nature Communications
- YAP-Dependent AXL Overexpression Mediates Resistance to EGFR Inhibitors in NSCLC
- (2017) Elena Ghiso et al. NEOPLASIA
- Hippo pathway effector YAP inhibition restores the sensitivity of EGFR-TKI in lung adenocarcinoma having primary or acquired EGFR-TKI resistance
- (2016) Jeong Eun Lee et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Phosphodiesterase 5/protein kinase G signal governs stemness of prostate cancer stem cells through Hippo pathway
- (2016) Naihua Liu et al. CANCER LETTERS
- Overview of CDK9 as a target in cancer research
- (2016) Fatima Morales et al. CELL CYCLE
- Verteporfin can Reverse the Paclitaxel Resistance Induced by YAP Over-Expression in HCT-8/T Cells without Photoactivation through Inhibiting YAP Expression
- (2016) Wang Pan et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
- (2016) Piotr Ponikowski et al. EUROPEAN HEART JOURNAL
- The Natural cAMP Elevating Compound Forskolin in Cancer Therapy: Is It Time?
- (2016) Luigi Sapio et al. JOURNAL OF CELLULAR PHYSIOLOGY
- MEK inhibitors as a novel therapy for neuroblastoma: Their in vitro effects and predicting their efficacy
- (2016) Tomoko Tanaka et al. JOURNAL OF PEDIATRIC SURGERY
- Statin attenuates cell proliferative ability via TAZ (WWTR1) in hepatocellular carcinoma
- (2016) Takaaki Higashi et al. MEDICAL ONCOLOGY
- Antitumor activity of dobutamine on human osteosarcoma cells
- (2016) JUN YIN et al. Oncology Letters
- ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types
- (2016) Waltraut Lehmann et al. Nature Communications
- YAP promotes erlotinib resistance in human non-small cell lung cancer cells
- (2016) Ping-Chih Hsu et al. Oncotarget
- Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer
- (2015) Fa-Xing Yu et al. CELL
- Organ Size Control: Lessons from Drosophila
- (2015) Iswar K. Hariharan DEVELOPMENTAL CELL
- Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation
- (2015) M. H. Kim et al. EMBO JOURNAL
- The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression
- (2015) Chunbo He et al. EMBO Molecular Medicine
- Nuclear TAZ expression associates with the triple-negative phenotype in breast cancer
- (2015) J. Diaz-Martin et al. ENDOCRINE-RELATED CANCER
- Oncoprotein YAP Regulates the Spindle Checkpoint Activation in a Mitotic Phosphorylation-dependent Manner through Up-regulation of BubR1
- (2015) Shuping Yang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors
- (2015) Chun-Han Lin et al. MOLECULAR BIOLOGY OF THE CELL
- YAP Drives Growth by Controlling Transcriptional Pause Release from Dynamic Enhancers
- (2015) Giorgio G. Galli et al. MOLECULAR CELL
- YAP overexpression promotes the epithelial-mesenchymal transition and chemoresistance in pancreatic cancer cells
- (2015) YANLI YUAN et al. Molecular Medicine Reports
- Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth
- (2015) Francesca Zanconato et al. NATURE CELL BIOLOGY
- The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies
- (2015) Luping Lin et al. NATURE GENETICS
- Regulation of sensitivity of tumor cells to antitubulin drugs by Cdk1-TAZ signalling
- (2015) Yulei Zhao et al. Oncotarget
- Upregulation of miR-181c contributes to chemoresistance in pancreatic cancer by inactivating the Hippo signaling pathway
- (2015) Meiyuan Chen et al. Oncotarget
- Verteporfin-based photodynamic therapy overcomes gemcitabine insensitivity in a panel of pancreatic cancer cell lines
- (2015) Jonathan P. Celli et al. LASERS IN SURGERY AND MEDICINE
- Mutant Gq/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP
- (2014) Fa-Xing Yu et al. CANCER CELL
- A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer
- (2014) Shi Jiao et al. CANCER CELL
- VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex
- (2014) Wenjing Zhang et al. CELL RESEARCH
- Cisplatin in cancer therapy: Molecular mechanisms of action
- (2014) Shaloam Dasari et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- The clinically used photosensitizer Verteporfin (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation
- (2014) Katarzyna Brodowska et al. EXPERIMENTAL EYE RESEARCH
- The Hippo pathway in chemotherapeutic drug resistance
- (2014) Yulei Zhao et al. INTERNATIONAL JOURNAL OF CANCER
- Identification, Mechanism of Action, and Antitumor Activity of a Small Molecule Inhibitor of Hippo, TGF- , and Wnt Signaling Pathways
- (2014) D. Basu et al. MOLECULAR CANCER THERAPEUTICS
- Metabolic control of YAP and TAZ by the mevalonate pathway
- (2014) Giovanni Sorrentino et al. NATURE CELL BIOLOGY
- TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells
- (2014) M Bartucci et al. ONCOGENE
- YAP1 is a potential biomarker for cetuximab resistance in head and neck cancer
- (2014) Fredrik Jerhammar et al. ORAL ONCOLOGY
- Cytotoxicity of Paclitaxel in Breast Cancer Is due to Chromosome Missegregation on Multipolar Spindles
- (2014) L. M. Zasadil et al. Science Translational Medicine
- Inhibitory effects of dobutamine on human gastric adenocarcinoma
- (2014) Hui-Xia Zheng WORLD JOURNAL OF GASTROENTEROLOGY
- Yes-associated protein (YAP) increases chemosensitivity of hepatocellular carcinoma cells by modulation of p53
- (2013) Nan Bai et al. CANCER BIOLOGY & THERAPY
- Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2
- (2013) Feng Yin et al. CELL
- Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis
- (2013) Y. Touil et al. CLINICAL CANCER RESEARCH
- Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation
- (2013) F.-X. Yu et al. GENES & DEVELOPMENT
- The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment
- (2013) Randy Johnson et al. NATURE REVIEWS DRUG DISCOVERY
- Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility
- (2013) Z. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling
- (2012) Fa-Xing Yu et al. CELL
- β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis
- (2012) Joseph Rosenbluh et al. CELL
- TAZ induces growth factor-independent proliferation through activation of EGFR ligand amphiregulin
- (2012) Nuo Yang et al. CELL CYCLE
- Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP
- (2012) Y. Liu-Chittenden et al. GENES & DEVELOPMENT
- Exploration of a new drug that targets YAP
- (2012) M. Fujii JOURNAL OF BIOCHEMISTRY
- KIBRA Regulates Aurora Kinase Activity and Is Required for Precise Chromosome Alignment During Mitosis
- (2012) Lin Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Statin Use and Reduced Cancer-Related Mortality
- (2012) Sune F. Nielsen et al. NEW ENGLAND JOURNAL OF MEDICINE
- YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14
- (2012) J-M Huang et al. ONCOGENE
- Overexpression of Yes-associated protein confers doxorubicin resistance in hepatocellullar carcinoma
- (2012) XINYING HUO et al. ONCOLOGY REPORTS
- Taxol Resistance in Breast Cancer Cells Is Mediated by the Hippo Pathway Component TAZ and Its Downstream Transcriptional Targets Cyr61 and CTGF
- (2011) D. Lai et al. CANCER RESEARCH
- The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells
- (2011) Michelangelo Cordenonsi et al. CELL
- A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription
- (2011) Y. Bao et al. JOURNAL OF BIOCHEMISTRY
- KIBRA Protein Phosphorylation Is Regulated by Mitotic Kinase Aurora and Protein Phosphatase 1
- (2011) Ling Xiao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hedgehog signal inhibitor forskolin suppresses cell proliferation and tumor growth of human rhabdomyosarcoma xenograft
- (2011) Hiroaki Yamanaka et al. JOURNAL OF PEDIATRIC SURGERY
- The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal
- (2011) Bin Zhao et al. NATURE CELL BIOLOGY
- Regulation of mitosis and taxane response by Daxx and Rassf1
- (2011) S Giovinazzi et al. ONCOGENE
- Human homolog of Drosophila expanded, hEx, functions as a putative tumor suppressor in human cancer cell lines independently of the Hippo pathway
- (2011) S Visser-Grieve et al. ONCOGENE
- The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene
- (2011) X Zhang et al. ONCOGENE
- Identification of a Disease-Defining Gene Fusion in Epithelioid Hemangioendothelioma
- (2011) M. R. Tanas et al. Science Translational Medicine
- Targeting tissue factor on tumour cells and angiogenic vascular endothelial cells by factor VII-targeted verteporfin photodynamic therapy for breast cancer in vitro and in vivoin mice
- (2010) Zhiwei Hu et al. BMC CANCER
- Ajuba LIM Proteins Are Negative Regulators of the Hippo Signaling Pathway
- (2010) Meghna Das Thakur et al. CURRENT BIOLOGY
- A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP
- (2010) B. Zhao et al. GENES & DEVELOPMENT
- The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCPE3 Ligase
- (2010) Chen-Ying Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hippo signaling at a glance
- (2010) Bin Zhao et al. JOURNAL OF CELL SCIENCE
- YAP dysregulation by phosphorylation or ΔNp63-mediated gene repression promotes proliferation, survival and migration in head and neck cancer subsets
- (2010) R Ehsanian et al. ONCOGENE
- Doxorubicin pathways
- (2010) Caroline F. Thorn et al. Pharmacogenetics and Genomics
- Connective Tissue Growth Factor Confers Drug Resistance in Breast Cancer through Concomitant Up-regulation of Bcl-xL and cIAP1
- (2009) M.-Y. Wang et al. CANCER RESEARCH
- Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms
- (2009) Fangfang Ren et al. DEVELOPMENTAL BIOLOGY
- The FERM-Domain Protein Expanded Regulates Hippo Pathway Activity via Direct Interactions with the Transcriptional Activator Yorkie
- (2009) Caroline Badouel et al. DEVELOPMENTAL CELL
- Identification of LATS transcriptional targets in HeLa cells using whole human genome oligonucleotide microarray
- (2009) Stacy Visser et al. GENE
- In vivo analysis of Yorkie phosphorylation sites
- (2009) H Oh et al. ONCOGENE
- Merlin Is a Potent Inhibitor of Glioma Growth
- (2008) Y.-K. I. Lau et al. CANCER RESEARCH
- Down-regulation of Mammalian Sterile 20-Like Kinase 1 by Heat Shock Protein 70 Mediates Cisplatin Resistance in Prostate Cancer Cells
- (2008) A. Ren et al. CANCER RESEARCH
- Microtubule dynamics as a target in oncology
- (2008) April L. Risinger et al. CANCER TREATMENT REVIEWS
- Yes-associated protein (YAP) functions as a tumor suppressor in breast
- (2008) M Yuan et al. CELL DEATH AND DIFFERENTIATION
- In vivo regulation of Yorkie phosphorylation and localization
- (2008) H. Oh et al. DEVELOPMENT
- The TEAD/TEF Family Protein Scalloped Mediates Transcriptional Output of the Hippo Growth-Regulatory Pathway
- (2008) Shian Wu et al. DEVELOPMENTAL CELL
- TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway
- (2008) Q.-Y. Lei et al. MOLECULAR AND CELLULAR BIOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started