Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors

Molecular deconstruction, detection, and computational prediction of microenvironment-modulated cellular responses to cancer therapeutics

(2014) Mark A. LaBarge et al.   ADVANCED DRUG DELIVERY REVIEWS

Sorafenib resistance and JNK signaling in carcinoma during extracellular matrix stiffening

(2014) Thuy V. Nguyen et al.   BIOMATERIALS

Force Engages Vinculin and Promotes Tumor Progression by Enhancing PI3K Activation of Phosphatidylinositol (3,4,5)-Triphosphate

(2014) Matthew G. Rubashkin et al.   CANCER RESEARCH

TGF  and Amphiregulin Paracrine Network Promotes Resistance to EGFR Blockade in Colorectal Cancer Cells

(2014) S. Hobor et al.   CLINICAL CANCER RESEARCH

The role of Rho GTPase in cell stiffness and cisplatin resistance in ovarian cancer cells

(2014) Shivani Sharma et al.   Integrative Biology

The cancer glycocalyx mechanically primes integrin-mediated growth and survival

(2014) Matthew J. Paszek et al.   NATURE

Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression

(2014) Janna K Mouw et al.   NATURE MEDICINE

Age-Related Dysfunction in Mechanotransduction Impairs Differentiation of Human Mammary Epithelial Progenitors

(2014) Fanny A. Pelissier et al.   Cell Reports

Multiwell stiffness assay for the study of cell responsiveness to cytotoxic drugs

(2013) Silviya Zustiak et al.   BIOTECHNOLOGY AND BIOENGINEERING

Updates on the treatment of human epidermal growth factor receptor type 2-positive breast cancer

(2013) Miriam Kim et al.   CURRENT OPINION IN OBSTETRICS & GYNECOLOGY

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

(2012) Y. Liu-Chittenden et al.   GENES & DEVELOPMENT

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

(2012) Brendon M. Baker et al.   JOURNAL OF CELL SCIENCE

MET Activation Mediates Resistance to Lapatinib Inhibition of HER2-Amplified Gastric Cancer Cells

(2012) C.-T. Chen et al.   MOLECULAR CANCER THERAPEUTICS

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Effect of Substrate Stiffness on Early Mouse Embryo Development

(2012) Kevin S. Kolahi et al.   PLoS One

The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain

(2012) J. M. Lamar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of Yes-associated protein (YAP) expression is associated with estrogen and progesterone receptors negativity in invasive breast carcinomas

(2011) Rozina Tufail et al.   BREAST CANCER RESEARCH AND TREATMENT

Amphiregulin Exosomes Increase Cancer Cell Invasion

(2011) James N. Higginbotham et al.   CURRENT BIOLOGY

Yes-associated protein promotes tumour development in luminal epithelial derived breast cancer

(2011) Xiaodan Wang et al.   EUROPEAN JOURNAL OF CANCER

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinase

(2011) J. T. Garrett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amphiregulin regulates the activation of ERK and Akt through epidermal growth factor receptor and HER3 signals involved in the progression of pancreatic cancer

(2010) Fusanori Yotsumoto et al.   CANCER SCIENCE

Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells

(2010) Jörg Schrader et al.   HEPATOLOGY

HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment

(2009) Britta Weigelt et al.   BREAST CANCER RESEARCH AND TREATMENT

Novel Mechanism of Lapatinib Resistance in HER2-Positive Breast Tumor Cells: Activation of AXL

(2009) L. Liu et al.   CANCER RESEARCH

The elastic modulus of Matrigel™ as determined by atomic force microscopy

(2009) Shauheen S. Soofi et al.   JOURNAL OF STRUCTURAL BIOLOGY

YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway

(2009) Jianmin Zhang et al.   NATURE CELL BIOLOGY

Yes-associated protein (YAP) functions as a tumor suppressor in breast

(2008) M Yuan et al.   CELL DEATH AND DIFFERENTIATION

Lapatinib: A dual inhibitor of human epidermal growth factor receptor tyrosine kinases

(2008) P MEDINA et al.   CLINICAL THERAPEUTICS