Screening for YAP Inhibitors Identifies Statins as Modulators of Fibrosis

Lovastatin attenuates angiotensin II induced cardiovascular fibrosis through the suppression of YAP/TAZ signaling

(2019) Pei Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Defining the Activated Fibroblast Population in Lung Fibrosis Using Single Cell Sequencing

(2019) Rebecca Peyser et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Lipophilic statins inhibit YAP nuclear localization, co-activator activity and colony formation in pancreatic cancer cells and prevent the initial stages of pancreatic ductal adenocarcinoma in KrasG12D mice

(2019) Fang Hao et al.   PLoS One

Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis

(2019) Andrew J. Haak et al.   Science Translational Medicine

Melatonin Protects against Lung Fibrosis by Regulating the Hippo/YAP Pathway

(2018) Xiaoguang Zhao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Imaging flow cytometry: A method for examining dynamic native FOXO1 localization in human lymphocytes

(2018) Molly K. Hritzo et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Therapeutic Targeting of TAZ and YAP by Dimethyl Fumarate in Systemic Sclerosis Fibrosis

(2018) Tetsuo Toyama et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

YAP/TAZ upstream signals and downstream responses

(2018) Antonio Totaro et al.   NATURE CELL BIOLOGY

Statin Therapy and Outcomes in Trials of Nintedanib in Idiopathic Pulmonary Fibrosis

(2018) Michael Kreuter et al.   RESPIRATION

Yap/Taz mediate mTORC2-stimulated fibroblast activation and kidney fibrosis

(2018) Yuan Gui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Antifibrotic Activity of Prostacyclin Receptor Agonism is Mediated through Inhibition of YAP/TAZ

(2018) Katarina Zmajkovicova et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Inhibition of YAP signaling contributes to senescence of hepatic stellate cells induced by tetramethylpyrazine

(2017) Huanhuan Jin et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Mutual dependence of the MRTF–SRF and YAP–TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics

(2017) Charles T. Foster et al.   GENES & DEVELOPMENT

Yap/Taz Deletion in Gli+Cell-Derived Myofibroblasts Attenuates Fibrosis

(2017) Ming Liang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Genetic tools for identifying and manipulating fibroblasts in the mouse

(2016) Jessica M. Swonger et al.   DIFFERENTIATION

Mechanisms of Hippo pathway regulation

(2016) Zhipeng Meng et al.   GENES & DEVELOPMENT

YAP/TAZ Are Mechanoregulators of TGF- -Smad Signaling and Renal Fibrogenesis

(2016) S. G. Szeto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Effect of statins on disease-related outcomes in patients with idiopathic pulmonary fibrosis

(2016) Michael Kreuter et al.   THORAX

Pleiotropic effects of statins in the diseases of the liver

(2016) Martin Janicko et al.   WORLD JOURNAL OF GASTROENTEROLOGY

TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology

(2016) Masato Morikawa et al.   Cold Spring Harbor Perspectives in Biology

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

(2015) Fei Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Hippo pathway effector YAP controls mouse hepatic stellate cell activation

(2015) Inge Mannaerts et al.   JOURNAL OF HEPATOLOGY

Statin use is associated with a reduced risk of fibrosis progression in chronic hepatitis C

(2015) Tracey G. Simon et al.   JOURNAL OF HEPATOLOGY

Statin Use Is Associated with Reduced Mortality in Patients with Interstitial Lung Disease

(2015) Signe Vedel-Krogh et al.   PLoS One

Small molecules inhibiting the nuclear localization of YAP/TAZ for chemotherapeutics and chemosensitizers against breast cancers

(2015) Yusuke Oku et al.   FEBS Open Bio

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

(2014) Talmadge E. King et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis

(2014) Luca Richeldi et al.   NEW ENGLAND JOURNAL OF MEDICINE

The pharmacology of statins

(2014) Cesare R. Sirtori   PHARMACOLOGICAL RESEARCH

The Biology of YAP/TAZ: Hippo Signaling and Beyond

(2014) Stefano Piccolo et al.   PHYSIOLOGICAL REVIEWS

Fibroblasts in fibrosis: novel roles and mediators

(2014) Ryan T. Kendall et al.   Frontiers in Pharmacology

Role of Lung Pericytes and Resident Fibroblasts in the Pathogenesis of Pulmonary Fibrosis

(2013) Chi Hung et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

Lovastatin-induced decrease of intracellular cholesterol level attenuates fibroblast-to-myofibroblast transition in bronchial fibroblasts derived from asthmatic patients

(2013) Marta Michalik et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Atorvastatin Attenuates Bleomycin-Induced Pulmonary Fibrosis via Suppressing iNOS Expression and the CTGF (CCN2)/ERK Signaling Pathway

(2013) Bo Zhu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibitory effects of pitavastatin on fibrogenic mediator production by human lung fibroblasts

(2013) Hiroaki Oka et al.   LIFE SCIENCES

Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility

(2013) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Statins and the risk of interstitial lung disease: a cohort study

(2013) Nathalie Saad et al.   THORAX

Recent Developments in Myofibroblast Biology

(2012) Boris Hinz et al.   AMERICAN JOURNAL OF PATHOLOGY

Statins and Pulmonary Fibrosis

(2012) Jin-Fu Xu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Acellular Normal and Fibrotic Human Lung Matrices as a Culture System forIn VitroInvestigation

(2012) Adam J. Booth et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Modulation of the Rho/ROCK Pathway in Heart and Lung after Thorax Irradiation Reveals Targets to Improve Normal Tissue Toxicity

(2012) Virginie Monceau et al.   CURRENT DRUG TARGETS

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

(2012) Y. Liu-Chittenden et al.   GENES & DEVELOPMENT

Quantifying nuclear p65 as a parameter for NF-κB activation: Correlation between ImageStream cytometry, microscopy, and Western blot

(2011) Orla Maguire et al.   CYTOMETRY PART A

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Effect of pravastatin on bleomycin-induced acute lung injury and pulmonary fibrosis

(2010) Jin Woo Kim et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP

(2010) B. Zhao et al.   GENES & DEVELOPMENT

Statins and Interstitial Lung Disease

(2008) Antonio B. Fernández et al.   CHEST

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

Rho Family GTPase Modification and Dependence on CAAXMotif-signaled Posttranslational Modification

(2008) Patrick J. Roberts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The bleomycin animal model: A useful tool to investigate treatment options for idiopathic pulmonary fibrosis?

(2007) Antje Moeller et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY