Function and regulation of SUMO proteases

Heat shock induces a massive but differential inactivation of SUMO-specific proteases

(2012) Manuel P. Pinto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

DeSUMOylating isopeptidase: a second class of SUMO protease

(2012) Eun Ju Shin et al.   EMBO REPORTS

Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions

(2012) Sarah Schulz et al.   EMBO REPORTS

SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage

(2012) Y. Yin et al.   GENES & DEVELOPMENT

RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair

(2012) Y. Galanty et al.   GENES & DEVELOPMENT

Small Ubiquitin-like Modifier (SUMO) Modification of E1 Cys Domain Inhibits E1 Cys Domain Enzymatic Activity

(2012) Khue Truong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA damage–inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger

(2012) Jannie Rendtlew Danielsen et al.   JOURNAL OF CELL BIOLOGY

The Small Ubiquitin-like Modifier-Deconjugating Enzyme Sentrin-Specific Peptidase 1 Switches IFN Regulatory Factor 8 from a Repressor to an Activator during Macrophage Activation

(2012) T.-H. Chang et al.   JOURNAL OF IMMUNOLOGY

Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis

(2012) Anna Plechanovová et al.   NATURE

Sumo-dependent substrate targeting of the SUMO protease Ulp1

(2011) Zachary C Elmore et al.   BMC BIOLOGY

Degringolade, a SUMO-targeted ubiquitin ligase, inhibits Hairy/Groucho-mediated repression

(2011) Mona Abed et al.   EMBO JOURNAL

The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex

(2011) Elisabeth Finkbeiner et al.   EMBO JOURNAL

Purification and identification of endogenous polySUMO conjugates

(2011) Roland Bruderer et al.   EMBO REPORTS

SUMOylation of Blimp-1 promotes its proteasomal degradation

(2011) Livnat Shimshon et al.   FEBS LETTERS

SUMOylation and SUMO-interacting Motif (SIM) of Metastasis Tumor Antigen 1 (MTA1) Synergistically Regulate Its Transcriptional Repressor Function

(2011) Lin Cong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Swapping Small Ubiquitin-like Modifier (SUMO) Isoform Specificity of SUMO Proteases SENP6 and SENP7

(2011) Kamela O. Alegre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into High Affinity Small Ubiquitin-like Modifier (SUMO) Recognition by SUMO-interacting Motifs (SIMs) Revealed by a Combination of NMR and Peptide Array Analysis

(2011) Andrew T. Namanja et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Desumoylation of the Endoplasmic Reticulum Membrane VAP Family Protein Scs2 by Ulp1 and SUMO Regulation of the Inositol Synthesis Pathway

(2011) R. Felberbaum et al.   MOLECULAR AND CELLULAR BIOLOGY

Reversible SUMOylation of TBL1-TBLR1 Regulates β-Catenin-Mediated Wnt Signaling

(2011) Hyo-Kyoung Choi et al.   MOLECULAR CELL

NF-κB Induction of the SUMO Protease SENP2: A Negative Feedback Loop to Attenuate Cell Survival Response to Genotoxic Stress

(2011) Moon Hee Lee et al.   MOLECULAR CELL

Mechanism of ubiquitylation by dimeric RING ligase RNF4

(2011) Anna Plechanovová et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Analysis of Papain-Like NlpC/P60 Superfamily Enzymes with a Circularly Permuted Topology Reveals Potential Lipid Binding Sites

(2011) Qingping Xu et al.   PLoS One

The SUMO Isopeptidase Ulp2p Is Required to Prevent Recombination-Induced Chromosome Segregation Lethality following DNA Replication Stress

(2011) Ming-Ta Lee et al.   PLoS Genetics

SENP1 participates in the dynamic regulation of Elk-1 SUMOylation

(2010) James Witty et al.   BIOCHEMICAL JOURNAL

Distribution and paralogue specificity of mammalian deSUMOylating enzymes

(2010) Nagamalleswari Kolli et al.   BIOCHEMICAL JOURNAL

SUMOylation can regulate the activity of ETS-like transcription factor 4

(2010) Sanna Kaikkonen et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Arf-induced turnover of the nucleolar nucleophosmin-associated SUMO-2/3 protease Senp3

(2010) Mei-Ling Kuo et al.   CELL CYCLE

The yeast SUMO isopeptidase Smt4/Ulp2 and the Polo Kinase Cdc5 act in an opposing fashion to regulate sumoylation in mitosis and cohesion at centromeres

(2010) Melissa L. Baldwin et al.   CELL CYCLE

Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90

(2010) Shan Yan et al.   EMBO JOURNAL

SUMO modification regulates the transcriptional activity of MAML1

(2010) Mikael J. Lindberg et al.   FASEB JOURNAL

Genetic Evidence That Polysumoylation Bypasses the Need for a SUMO-Targeted Ub Ligase

(2010) J. R. Mullen et al.   GENETICS

Induction of SENP1 in Endothelial Cells Contributes to Hypoxia-driven VEGF Expression and Angiogenesis

(2010) Ying Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional Repression by Sumoylation of Epstein-Barr Virus BZLF1 Protein Correlates with Association of Histone Deacetylase

(2010) Takayuki Murata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SUMO protease SENP6 is essential for inner kinetochore assembly

(2010) Debaditya Mukhopadhyay et al.   JOURNAL OF CELL BIOLOGY

Wss1 Is a SUMO-Dependent Isopeptidase That Interacts Genetically with the Slx5-Slx8 SUMO-Targeted Ubiquitin Ligase

(2010) J. R. Mullen et al.   MOLECULAR AND CELLULAR BIOLOGY

A Novel Mechanism for SUMO System Control: Regulated Ulp1 Nucleolar Sequestration

(2010) Y. Sydorskyy et al.   MOLECULAR AND CELLULAR BIOLOGY

The SUMO protease SENP6 is a direct regulator of PML nuclear bodies

(2010) Neil Hattersley et al.   MOLECULAR BIOLOGY OF THE CELL

Site-Specific Identification of SUMO-2 Targets in Cells Reveals an Inverted SUMOylation Motif and a Hydrophobic Cluster SUMOylation Motif

(2010) Ivan Matic et al.   MOLECULAR CELL

SUMO-Specific Protease 2 Is Essential for Suppression of Polycomb Group Protein-Mediated Gene Silencing during Embryonic Development

(2010) Xunlei Kang et al.   MOLECULAR CELL

Regulation of DNA Repair through DeSUMOylation and SUMOylation of Replication Protein A Complex

(2010) Hong Dou et al.   MOLECULAR CELL

The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

(2010) Jaclyn R. Gareau et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Proteomic analyses identify a diverse array of nuclear processes affected by small ubiquitin-like modifier conjugation in Arabidopsis

(2010) M. J. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteome-wide screens for small ubiquitin-like modifier (SUMO) substrates identify Arabidopsis proteins implicated in diverse biological processes

(2010) N. Elrouby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SUMO modification regulates the transcriptional activity of FLASH

(2009) Anne Hege Alm-Kristiansen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation

(2009) Chao Huang et al.   EMBO JOURNAL

Translocation of SenP5 from the Nucleoli to the Mitochondria Modulates DRP1-dependent Fission during Mitosis

(2009) Rodolfo Zunino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quality Control of a Transcriptional Regulator by SUMO-Targeted Degradation

(2009) Z. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Essential Role of Nuclear Localization for Yeast Ulp2 SUMO Protease Function

(2009) Mary B. Kroetz et al.   MOLECULAR BIOLOGY OF THE CELL

Protection from Isopeptidase-Mediated Deconjugation Regulates Paralog-Selective Sumoylation of RanGAP1

(2009) Shanshan Zhu et al.   MOLECULAR CELL

Principles of ubiquitin and SUMO modifications in DNA repair

(2009) Steven Bergink et al.   NATURE

Origin and function of ubiquitin-like proteins

(2009) Mark Hochstrasser   NATURE

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

System-Wide Changes to SUMO Modifications in Response to Heat Shock

(2009) F. Golebiowski et al.   Science Signaling

SUMOylation of RORα potentiates transcriptional activation function

(2008) Eun Ju Hwang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis

(2008) X Li et al.   CELL DEATH AND DIFFERENTIATION

Regulation of Mitotic Spindle Asymmetry by SUMO and the Spindle-Assembly Checkpoint in Yeast

(2008) Christian Leisner et al.   CURRENT BIOLOGY

The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing

(2008) Markus Haindl et al.   EMBO REPORTS

Activation of the Slx5–Slx8 Ubiquitin Ligase by Poly-small Ubiquitin-like Modifier Conjugates

(2008) Janet R. Mullen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the Human SENP7 Catalytic Domain and Poly-SUMO Deconjugation Activities for SENP6 and SENP7

(2008) Christopher D. Lima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases

(2008) Chawon Yun et al.   JOURNAL OF CELL BIOLOGY

Molecular basis of the redox regulation of SUMO proteases: a protective mechanism of intermolecular disulfide linkage against irreversible sulfhydryl oxidation

(2007) Zheng Xu et al.   FASEB JOURNAL