Current Nanoparticle-Based Technologies for Osteoarthritis Therapy

p47phox siRNA-Loaded PLGA Nanoparticles Suppress ROS/Oxidative Stress-Induced Chondrocyte Damage in Osteoarthritis

(2020) Hyo Jung Shin et al.   Polymers

Exosomal miR-9-5p secreted by bone marrow–derived mesenchymal stem cells alleviates osteoarthritis by inhibiting syndecan-1

(2020) Zhe Jin et al.   CELL AND TISSUE RESEARCH

p66shc siRNA Nanoparticles Ameliorate Chondrocytic Mitochondrial Dysfunction in Osteoarthritis

(2020) Hyo Jung Shin et al.   International Journal of Nanomedicine

Steady Augmentation of Anti-Osteoarthritic Actions of Rapamycin by Liposome-Encapsulation in Collaboration with Low-Intensity Pulsed Ultrasound

(2020) Chung-Hwan Chen et al.   International Journal of Nanomedicine

Role of MicroRNA, LncRNA, and Exosomes in the Progression of Osteoarthritis: A Review of Recent Literature

(2020) Fang Xie et al.   Orthopaedic Surgery

Chondrocyte-Targeted MicroRNA Delivery by Engineered Exosomes toward a Cell-Free Osteoarthritis Therapy

(2020) Yujie Liang et al.   ACS Applied Materials & Interfaces

Intraarticular injection of liposomal adenosine reduces cartilage damage in established murine and rat models of osteoarthritis

(2020) Carmen Corciulo et al.   Scientific Reports

Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis

(2020) Lei He et al.   Stem Cell Research & Therapy

The Application of MSCs-Derived Extracellular Vesicles in Bone Disorders: Novel Cell-Free Therapeutic Strategy

(2020) Shuyu Liu et al.   Frontiers in Cell and Developmental Biology

Nanotechnology and Osteoarthritis. Part 1: Clinical Landscape and Opportunities for Advanced Diagnostics

(2020) Taylor B. Lawson et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Hyaluronic Acid Loaded with Cerium Oxide Nanoparticles as Antioxidant in Hydrogen Peroxide Induced Chondrocytes Injury: An In Vitro Osteoarthritis Model

(2020) Yi-Wen Lin et al.   MOLECULES

MMP-13 enzyme and pH responsive theranostic nanoplatform for osteoarthritis

(2020) Qiumei Lan et al.   JOURNAL OF NANOBIOTECHNOLOGY

Pro-resolving lipid mediator ameliorates obesity induced osteoarthritis by regulating synovial macrophage polarisation

(2019) Antonia Rujia Sun et al.   Scientific Reports

Liposome-encapsulated fish oil protein-tagged gold nanoparticles for intra-articular therapy in osteoarthritis

(2019) Amrita Sarkar et al.   Nanomedicine

Cell Therapy for Knee Osteoarthritis: Mesenchymal Stromal Cells

(2019) Christopher Kim et al.   GERONTOLOGY

Drug nanocrystals: Fabrication methods and promising therapeutic applications

(2019) Imran Shair Mohammad et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis

(2019) Jiangyi Wu et al.   BIOMATERIALS

The Therapeutic Potential and Role of miRNA, lncRNA, and circRNA in Osteoarthritis

(2019) Yuangang Wu et al.   CURRENT GENE THERAPY

Adenosine-Functionalized Biodegradable PLA-b-PEG Nanoparticles Ameliorate Osteoarthritis in Rats

(2019) Xiuling Liu et al.   Scientific Reports

The Mitochondria–Endoplasmic Reticulum Contacts and Their Critical Role in Aging and Age-Associated Diseases

(2019) Ornella Moltedo et al.   Frontiers in Cell and Developmental Biology

Dendrimers in the context of nanomedicine

(2019) Ana Paula Dias et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Secretome and Extracellular Vesicles as New Biological Therapies for Knee Osteoarthritis: A Systematic Review

(2019) Daniele D’Arrigo et al.   Journal of Clinical Medicine

Manganese dioxide nanoparticles protect cartilage from inflammation-induced oxidative stress

(2019) Shreedevi Kumar et al.   BIOMATERIALS

Acid-activatable polymeric curcumin nanoparticles as therapeutic agents for osteoarthritis

(2019) Changsun Kang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

(2019) Zhaogang Yang et al.   Nature Biomedical Engineering

Macrophage depletion using clodronate liposomes decreases tumorigenesis and alters gut microbiota in the AOM/DSS mouse model of colon cancer

(2018) Jackie E. Bader et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Chondroprotective Effects of Hyaluronic Acid-Chitosan Nanoparticles Containing Plasmid DNA Encoding Cytokine Response Modifier A in a Rat Knee Osteoarthritis Model

(2018) Pang-hu Zhou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Intra-articular injection of kartogenin-conjugated polyurethane nanoparticles attenuates the progression of osteoarthritis

(2018) Wenshuai Fan et al.   DRUG DELIVERY

Poly (amidoamine) (PAMAM) dendrimer mediated delivery of drug and pDNA/siRNA for cancer therapy

(2018) Jun Li et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Nanocrystal-Polymer Particles: Extended Delivery Carriers for Osteoarthritis Treatment

(2018) Pierre Maudens et al.   Small

Three-Dimensional Spheroid Culture Increases Exosome Secretion from Mesenchymal Stem Cells

(2018) Mijin Kim et al.   Tissue Engineering and Regenerative Medicine

Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations

(2018) Jaison Jeevanandam et al.   Beilstein Journal of Nanotechnology

Nano-gold displayed anti-inflammatory property via NF-kB pathways by suppressing COX-2 activity

(2018) Mahmood Ahmad Khan et al.   Artificial Cells Nanomedicine and Biotechnology

Three-Dimensional Spheroid Culture Increases Exosome Secretion from Mesenchymal Stem Cells

(2018) Mijin Kim et al.   Tissue Engineering and Regenerative Medicine

Intra-articular biomaterials-assisted delivery to treat temporomandibular joint disorders

(2018) Khandmaa Dashnyam et al.   Journal of Tissue Engineering

A hyaluronic acid binding peptide-polymer system for treating osteoarthritis

(2018) Heather J. Faust et al.   BIOMATERIALS

Therapeutic potential of hyaluronic acid/chitosan nanoparticles for the delivery of curcuminoid in knee osteoarthritis and an in�vitro evaluation in chondrocytes

(2018) Jian Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Cardiovascular Risk of Nonsteroidal Anti-inflammatory Drugs and Classical and Selective Cyclooxygenase-2 Inhibitors: A Meta-analysis of Observational Studies

(2018) Luis Hermenegildo Martín Arias et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Chitosan-based nanoparticles as drug delivery systems: a review on two decades of research

(2018) Sweet Naskar et al.   JOURNAL OF DRUG TARGETING

Intra-articular Mesenchymal Stem Cells in Osteoarthritis of the Knee: A Systematic Review of Clinical Outcomes and Evidence of Cartilage Repair

(2018) Chul-Won Ha et al.   ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY

Exosomal KLF3-AS1 from hMSCs promoted cartilage repair and chondrocyte proliferation in osteoarthritis

(2018) Yubao Liu et al.   BIOCHEMICAL JOURNAL

MSC-derived exosomes promote proliferation and inhibit apoptosis of chondrocytes via lncRNA-KLF3-AS1/miR-206/GIT1 axis in osteoarthritis

(2018) Yubao Liu et al.   CELL CYCLE

TGF-β1 promoted chondrocyte proliferation by regulating Sp1 through MSC-exosomes derived miR-135b

(2018) Rui Wang et al.   CELL CYCLE

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Cartilage-penetrating nanocarriers improve delivery and efficacy of growth factor treatment of osteoarthritis

(2018) Brett C. Geiger et al.   Science Translational Medicine

Hydrostatic Pressure Regulates MicroRNA Expression Levels in Osteoarthritic Chondrocyte Cultures via the Wnt/β-Catenin Pathway

(2017) Sara Cheleschi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A novel chondroitin sulfate decorated nano platinum for the treatment of osteoarthritis

(2017) Xue-feng Yin et al.   Materials Science & Engineering C-Materials for Biological Applications

Protective effects of psoralidin on IL‑1β‑induced chondrocyte apoptosis

(2017) Zhitao Rao et al.   Molecular Medicine Reports

Poly-beta-amino-esters nano-vehicles based drug delivery system for cartilage

(2017) Stefano Perni et al.   Nanomedicine-Nanotechnology Biology and Medicine

Polyethylene glycol modified PAMAM dendrimer delivery of kartogenin to induce chondrogenic differentiation of mesenchymal stem cells

(2017) Qing Hu et al.   Nanomedicine-Nanotechnology Biology and Medicine

Hyaluronic Acid Hydrogel Functionalized with Self-Assembled Micelles of Amphiphilic PEGylated Kartogenin for the Treatment of Osteoarthritis

(2017) Mi-Lan Kang et al.   TISSUE ENGINEERING PART A

Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression

(2017) Carmen Corciulo et al.   Nature Communications

Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis

(2017) Stella Cosenza et al.   Scientific Reports

Comparison of exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells and synovial membrane-derived mesenchymal stem cells for the treatment of osteoarthritis

(2017) Yu Zhu et al.   Stem Cell Research & Therapy

Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix

(2017) Yafei Wang et al.   Stem Cell Research & Therapy

Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model

(2017) Shi-Cong Tao et al.   Theranostics

Role of mesenchymal stem cells in osteoarthritis treatment

(2017) Ling Kong et al.   Journal of Orthopaedic Translation

Obesity-associated metabolic syndrome spontaneously induces infiltration of pro-inflammatory macrophage in synovium and promotes osteoarthritis

(2017) Antonia RuJia Sun et al.   PLoS One

Self-Assembly of Multi-nanozymes to Mimic an Intracellular Antioxidant Defense System

(2016) Yanyan Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

Recent advances in polymeric micelles for anti-cancer drug delivery

(2016) Swati Biswas et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

MicroRNA-34a affects chondrocyte apoptosis and proliferation by targeting the SIRT1/p53 signaling pathway during the pathogenesis of osteoarthritis

(2016) SHIJU YAN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Effect of particle size on the biodistribution of nano- and microparticles following intra-articular injection in mice

(2016) Julie Pradal et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Current applications of nanoparticles in infectious diseases

(2016) Hinojal Zazo et al.   JOURNAL OF CONTROLLED RELEASE

MicroRNA-9 regulates the development of knee osteoarthritis through the NF-kappaB1 pathway in chondrocytes

(2016) Ronghe Gu et al.   MEDICINE

Nanodrugs to target articular cartilage: An emerging platform for osteoarthritis therapy

(2016) Massimo Bottini et al.   Nanomedicine-Nanotechnology Biology and Medicine

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

(2016) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Platinum nanozymes recover cellular ROS homeostasis in an oxidative stress-mediated disease model

(2016) Mauro Moglianetti et al.   Nanoscale

Antioxidant cerium oxide nanoparticle hydrogels for cellular encapsulation

(2015) Jessica D. Weaver et al.   Acta Biomaterialia

Influence of dendritic polyglycerol sulfates on knee osteoarthritis: an experimental study in the rat osteoarthritis model

(2015) Tobias Schneider et al.   BMC MUSCULOSKELETAL DISORDERS

Effects of dendritic polyglycerol sulfate on articular chondrocytes

(2015) Tobias Schneider et al.   INFLAMMATION RESEARCH

In vivo anti-apoptosis activity of novel berberine-loaded chitosan nanoparticles effectively ameliorates osteoarthritis

(2015) Yan Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Controlled Release of an Anti-inflammatory Drug Using an Ultrasensitive ROS-Responsive Gas-Generating Carrier for Localized Inflammation Inhibition

(2015) Ming-Fan Chung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Osteoarthritis

(2015) S Glyn-Jones et al.   LANCET

Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications

(2015) Randy Cheung et al.   Marine Drugs

Effects of insulin-like growth factor-1 and dexamethasone on cytokine-challenged cartilage: relevance to post-traumatic osteoarthritis

(2015) Y. Li et al.   OSTEOARTHRITIS AND CARTILAGE

Bioinspired reduced graphene oxide nanosheets using Terminalia chebula seeds extract

(2015) Sireesh Babu Maddinedi et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Applications of polymer micelles for imaging and drug delivery

(2015) Sara Movassaghian et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

mTOR: A Potential Therapeutic Target in Osteoarthritis?

(2015) Bandna Pal et al.   Drugs in research & development

MiR-210 inhibits NF-κB signaling pathway by targeting DR6 in osteoarthritis

(2015) Dawei Zhang et al.   Scientific Reports

Particle-based technologies for osteoarthritis detection and therapy

(2015) Taylor E. Kavanaugh et al.   Drug Delivery and Translational Research

Polymer therapeutics: Top 10 selling pharmaceuticals — What next?

(2014) Ruth Duncan   JOURNAL OF CONTROLLED RELEASE

How best to preserve and reveal the structural intricacies of cartilaginous tissue

(2014) Ernst B. Hunziker et al.   MATRIX BIOLOGY

Enhanced lubrication on tissue and biomaterial surfaces through peptide-mediated binding of hyaluronic acid

(2014) Anirudha Singh et al.   NATURE MATERIALS

Emerging regulators of the inflammatory process in osteoarthritis

(2014) Ru Liu-Bryan et al.   Nature Reviews Rheumatology

Mouse models of osteoarthritis: modelling risk factors and assessing outcomes

(2014) Hang Fang et al.   Nature Reviews Rheumatology

Beneficial Effects of Cerium Oxide Nanoparticles in Development of Chondrocyte-Seeded Hydrogel Constructs and Cellular Response to Interleukin Insults

(2014) Sathish Ponnurangam et al.   TISSUE ENGINEERING PART A

Dendrimers: synthesis, applications, and properties

(2014) Elham Abbasi et al.   Nanoscale Research Letters

Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors

(2013) Su Chul Jang et al.   ACS Nano

Nanotechnology in the targeted drug delivery for bone diseases and bone regeneration

(2013) Gu et al.   International Journal of Nanomedicine

Titanium-doped cerium oxide nanoparticles protect cells from hydrogen peroxide-induced apoptosis

(2013) Andrea Clark et al.   JOURNAL OF NANOPARTICLE RESEARCH

Progress in intra-articular therapy

(2013) Christopher H. Evans et al.   Nature Reviews Rheumatology

Preventing UV induced cell damage by scavenging reactive oxygen species with enzyme-mimic Au–Pt nanocomposites

(2013) Bin Xiong et al.   TALANTA

MMP13 is a critical target gene during the progression of osteoarthritis

(2013) Meina Wang et al.   ARTHRITIS RESEARCH & THERAPY

Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes

(2013) Takeshi Katsuda et al.   Scientific Reports

Homeostatic Mechanisms in Articular Cartilage and Role of Inflammation in Osteoarthritis

(2013) Xavier Houard et al.   Current Rheumatology Reports

The Impact of Osteoarthritis in the United States

(2012) Louise Murphy et al.   AMERICAN JOURNAL OF NURSING

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Emerging Frontiers in cartilage and chondrocyte biology

(2012) Amanda J. Fosang et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

A review of current nanoparticle and targeting moieties for the delivery of cancer therapeutics

(2012) Stephanie D. Steichen et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Controlled synergistic delivery of paclitaxel and heat from poly(β-amino ester)/iron oxide-based hydrogel nanocomposites

(2012) Samantha A. Meenach et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Exosome-mediated delivery of siRNA in vitro and in vivo

(2012) Samir El-Andaloussi et al.   Nature Protocols

A Stem Cell-Based Approach to Cartilage Repair

(2012) K. Johnson et al.   SCIENCE

Advances in top–down and bottom–up surface nanofabrication: Techniques, applications & future prospects

(2011) Abhijit Biswas et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Osteoarthritis: an update with relevance for clinical practice

(2011) Johannes WJ Bijlsma et al.   LANCET

The Basic Science of Human Knee Menisci

(2011) Alice J. S. Fox et al.   Sports Health-A Multidisciplinary Approach

Oxidative stress-dependent p66Shc phosphorylation in skin fibroblasts of children with mitochondrial disorders

(2010) Magdalena Lebiedzinska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

In vivo tumor diagnosis and photodynamic therapy via tumoral pH-responsive polymeric micelles

(2010) Heebeom Koo et al.   CHEMICAL COMMUNICATIONS

NF-κB Signaling: Multiple Angles to Target OA

(2010) Kenneth B. Marcu et al.   CURRENT DRUG TARGETS

Rotenone prevents impact-induced chondrocyte death

(2010) Wendy Goodwin et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release

(2010) Chris Oerlemans et al.   PHARMACEUTICAL RESEARCH

Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue

(2009) Christine J Weydert et al.   Nature Protocols

Mitochondrial DNA damage is involved in apoptosis caused by pro-inflammatory cytokines in human OA chondrocytes

(2009) J. Kim et al.   OSTEOARTHRITIS AND CARTILAGE

Clinical Pharmacokinetic and Pharmacodynamic Profile of Etoricoxib

(2008) Jody K Takemoto et al.   CLINICAL PHARMACOKINETICS

Biodegradable Polyurethanes: Synthesis and Applications in Regenerative Medicine

(2008) Scott A. Guelcher   TISSUE ENGINEERING PART B-REVIEWS

Differential effects of tumor necrosis factor-α and interleukin-1β on cell death in human articular chondrocytes

(2007) B. Caramés et al.   OSTEOARTHRITIS AND CARTILAGE