Obesity-associated metabolic syndrome spontaneously induces infiltration of pro-inflammatory macrophage in synovium and promotes osteoarthritis

Saturated fatty acids induce development of both metabolic syndrome and osteoarthritis in rats

(2017) Sunderajhan Sekar et al.   Scientific Reports

Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

(2016) William H. Robinson et al.   Nature Reviews Rheumatology

High LDL levels lead to increased synovial inflammation and accelerated ectopic bone formation during experimental osteoarthritis

(2016) W. de Munter et al.   OSTEOARTHRITIS AND CARTILAGE

Cartilage inflammation and degeneration is enhanced by pro-inflammatory (M1) macrophages in vitro , but not inhibited directly by anti-inflammatory (M2) macrophages

(2016) L. Utomo et al.   OSTEOARTHRITIS AND CARTILAGE

Molecular and cellular mechanisms linking inflammation to insulin resistance and β-cell dysfunction

(2016) Hadi Khodabandehloo et al.   Translational Research

Insulin and vanadium protect against osteoarthritis development secondary to diabetes mellitus in rats

(2016) Abbas O. El Karib et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Suppressive Effects of Insulin on Tumor Necrosis Factor-Dependent Early Osteoarthritic Changes Associated With Obesity and Type 2 Diabetes Mellitus

(2016) Daisuke Hamada et al.   Arthritis & Rheumatology

Macrophage activation and its role in repair and pathology after spinal cord injury

(2015) John C. Gensel et al.   BRAIN RESEARCH

Response to diet-induced obesity produces time-dependent induction and progression of metabolic osteoarthritis in rat knees

(2015) Kelsey H. Collins et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Characterization of diabetic osteoarthritic cartilage and role of high glucose environment on chondrocyte activation: toward pathophysiological delineation of diabetes mellitus-related osteoarthritis

(2015) M.-C. Laiguillon et al.   OSTEOARTHRITIS AND CARTILAGE

Relationship between inflammation, the gut microbiota, and metabolic osteoarthritis development: studies in a rat model

(2015) K.H. Collins et al.   OSTEOARTHRITIS AND CARTILAGE

Using diet-induced obesity to understand a metabolic subtype of osteoarthritis in rats

(2015) K.H. Collins et al.   OSTEOARTHRITIS AND CARTILAGE

Impact of obesity on disability, function, and physical activity: data from the Osteoarthritis Initiative

(2015) JA Batsis et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Reactivity of rat bone marrow-derived macrophages to neurotransmitter stimulation in the context of collagen II-induced arthritis

(2015) Dominique Muschter et al.   ARTHRITIS RESEARCH & THERAPY

High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation

(2015) Jamie E. Rayahin et al.   ACS Biomaterials-Science & Engineering

High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation

(2015) Jamie E. Rayahin et al.   ACS Biomaterials Science & Engineering

High-fat diet-induced obesity Rat model: a comparison between Wistar and Sprague-Dawley Rat

(2015) Cláudia Marques et al.   Adipocyte

Dietary fatty acid content regulates wound repair and the pathogenesis of osteoarthritis following joint injury

(2014) Chia-Lung Wu et al.   ANNALS OF THE RHEUMATIC DISEASES

Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation

(2014) Shinya U. Amano et al.   Cell Metabolism

Women with Osteoarthritis have Elevated Synovial Fluid Levels of Insulin-Like Growth Factor (IGF)-1 and IGF-Binding Protein-3

(2014) Shirin Hooshmand et al.   JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY

Osteoarthritis, obesity and weight loss: evidence, hypotheses and horizons - a scoping review

(2014) H. Bliddal et al.   Obesity Reviews

Treatment efficacy of adipose-derived stem cells in experimental osteoarthritis is driven by high synovial activation and reflected by S100A8/A9 serum levels

(2014) R.F. Schelbergen et al.   OSTEOARTHRITIS AND CARTILAGE

Role of dentin matrix protein 1 in cartilage redifferentiation and osteoarthritis

(2014) Indira Prasadam et al.   RHEUMATOLOGY

An optimized Protocol for Human M2 Macrophages using M-CSF and IL-4/IL-10/TGF-βYields a Dominant Immunosuppressive Phenotype

(2014) S. Mia et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Functions of Arginase Isoforms in Macrophage Inflammatory Responses: Impact on Cardiovascular Diseases and Metabolic Disorders

(2014) Zhihong Yang et al.   Frontiers in Immunology

From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation

(2014) Paola Italiani et al.   Frontiers in Immunology

Phenotypic Transitions of Macrophages Orchestrate Tissue Repair

(2013) Margaret L. Novak et al.   AMERICAN JOURNAL OF PATHOLOGY

Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance

(2013) Byung-Cheol Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Blocking Interleukin-1  Induces a Healing-Associated Wound Macrophage Phenotype and Improves Healing in Type 2 Diabetes

(2013) R. E. Mirza et al.   DIABETES

Retinoic acid promotes the development of Arg1-expressing dendritic cells for the regulation of T-cell differentiation

(2013) Jinsam Chang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Impact of extracellular matrix derived from osteoarthritis subchondral bone osteoblasts on osteocytes: role of integrinβ1 and focal adhesion kinase signaling cues

(2013) Indira Prasadam et al.   ARTHRITIS RESEARCH & THERAPY

Effects of an aqueous extract of Eucommia on articular cartilage in a rat model of osteoarthritis of the knee

(2013) HAI LU et al.   Experimental and Therapeutic Medicine

Hormonal modulation of connective tissue homeostasis and sex differences in risk for osteoarthritis of the knee

(2013) Barbara D Boyan et al.   Biology of Sex Differences

Metabolic inflammation: Connecting obesity and insulin resistance

(2012) Nassim Dali-Youcef et al.   ANNALS OF MEDICINE

Exercise training attenuates hepatic inflammation, fibrosis and macrophage infiltration during diet induced-obesity in mice

(2012) Noriaki Kawanishi et al.   BRAIN BEHAVIOR AND IMMUNITY

Osteoarthritis synovial fluid activates pro-inflammatory cytokines in primary human chondrocytes

(2012) Paula Hoff et al.   INTERNATIONAL ORTHOPAEDICS

Aggravation of ADAMTS and Matrix Metalloproteinase Production and Role of ERK1/2 Pathway in the Interaction of Osteoarthritic Subchondral Bone Osteoblasts and Articular Cartilage Chondrocytes -- Possible Pathogenic Role in Osteoarthritis

(2012) I. PRASADAM et al.   JOURNAL OF RHEUMATOLOGY

Metabolic syndrome meets osteoarthritis

(2012) Qi Zhuo et al.   Nature Reviews Rheumatology

Serum adipokines in osteoarthritis; comparison with controls and relationship with local parameters of synovial inflammation and cartilage damage

(2012) T.N. de Boer et al.   OSTEOARTHRITIS AND CARTILAGE

Interleukin-6 is elevated in synovial fluid of patients with focal cartilage defects and stimulates cartilage matrix production in an in vitro regeneration model

(2012) Anika I Tsuchida et al.   ARTHRITIS RESEARCH & THERAPY

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Quantitative magnetic resonance imaging evidence of synovial proliferation is associated with radiographic severity of knee osteoarthritis

(2011) Svetlana Krasnokutsky et al.   ARTHRITIS AND RHEUMATISM

Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: Effects of short-term exercise

(2011) Timothy M. Griffin et al.   ARTHRITIS AND RHEUMATISM

Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis

(2011) Peter L. E. M. van Lent et al.   ARTHRITIS AND RHEUMATISM

A comparative study of serum and synovial fluid lipoprotein levels in patients with various arthritides

(2011) F. Oliviero et al.   CLINICA CHIMICA ACTA

Increased Macrophage Migration Into Adipose Tissue in Obese Mice

(2011) D. Y. Oh et al.   DIABETES

ERK-1/2 and p38 in the regulation of hypertrophic changes of normal articular cartilage chondrocytes induced by osteoarthritic subchondral osteoblasts

(2010) Indira Prasadam et al.   ARTHRITIS AND RHEUMATISM

Obesity and Inflammation – Targets for OA Therapy

(2010) F. Iannone et al.   CURRENT DRUG TARGETS

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

(2010) Jérémie Sellam et al.   Nature Reviews Rheumatology

Circulating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults

(2010) O. Stannus et al.   OSTEOARTHRITIS AND CARTILAGE

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE

Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice

(2010) Timothy M Griffin et al.   ARTHRITIS RESEARCH & THERAPY

Flow cytometric characterization of freshly isolated and culture expanded human synovial cell populations in patients with chronic arthritis

(2010) Kristel B Van Landuyt et al.   ARTHRITIS RESEARCH & THERAPY

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound?

(2008) Carla R Scanzello et al.   CURRENT OPINION IN RHEUMATOLOGY

Novel synovial fluid recovery method allows for quantification of a marker of arthritis in mice

(2008) D.R. Seifer et al.   OSTEOARTHRITIS AND CARTILAGE