Animal Models of Metabolic Disorders in the Study of Neurodegenerative Diseases: An Overview

Lifestyle Modifications and Nutritional Interventions in Aging-Associated Cognitive Decline and Alzheimer’s Disease

(2020) Gurjit Kaur Bhatti et al.   Frontiers in Aging Neuroscience

Exercise and Curcumin in Combination Improves Cognitive Function and Attenuates ER Stress in Diabetic Rats

(2020) Jin Ah Cho et al.   Nutrients

Brain Metabolism Alterations in Type 2 Diabetes: What Did We Learn From Diet-Induced Diabetes Models?

(2020) Alba M. Garcia-Serrano et al.   Frontiers in Neuroscience

High fat diet worsens Alzheimer’s disease-related behavioral abnormalities and neuropathology in APP/PS1 mice, but not by synergistically decreasing cerebral blood flow

(2020) Oliver Bracko et al.   Scientific Reports

High Cholesterol Diet Exacerbates Blood-Brain Barrier Disruption in LDLr–/– Mice: Impact on Cognitive Function

(2020) Jade de Oliveira et al.   JOURNAL OF ALZHEIMERS DISEASE

High fat diet-induced obesity causes a reduction in brain tyrosine hydroxylase levels and non-motor features in rats through metabolic dysfunction, neuroinflammation and oxidative stress

(2020) Aline Bittencourt et al.   NUTRITIONAL NEUROSCIENCE

Neurochemical Modifications in the Hippocampus, Cortex and Hypothalamus of Mice Exposed to Long-Term High-Fat Diet

(2019) Blanca Lizarbe et al.   Frontiers in Neuroscience

Impact of Caffeine Consumption on Type 2 Diabetes-Induced Spatial Memory Impairment and Neurochemical Alterations in the Hippocampus

(2019) João M. N. Duarte et al.   Frontiers in Neuroscience

Parkinson's Disease and the Environment

(2019) Nicole Ball et al.   Frontiers in Neurology

Associations between obesity and cognitive impairment in the Chinese elderly: an observational study

(2019) Qingtao Hou et al.   Clinical Interventions in Aging

Insulin deficiency and intranasal insulin alter brain mitochondrial function: a potential factor for dementia in diabetes

(2019) Gregory N. Ruegsegger et al.   FASEB JOURNAL

Short-term high-fat diet modulates several inflammatory, ER stress, and apoptosis markers in the hippocampus of young mice

(2019) Susana Castelo Branco Ramos Nakandakari et al.   BRAIN BEHAVIOR AND IMMUNITY

Glycogen metabolism is impaired in the brain of male type 2 diabetic Goto‐Kakizaki rats

(2019) Ana Francisca Soares et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Association between Dietary Cholesterol and Their Food Sources and Risk for Hypercholesterolemia: The 2012–2016 Korea National Health and Nutrition Examination Survey

(2019) Dongjoo Cha et al.   Nutrients

Dysregulated Lipid Metabolism and Its Role in α-Synucleinopathy in Parkinson’s Disease

(2019) Irina Alecu et al.   Frontiers in Neuroscience

Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics

(2019) Sneham Tiwari et al.   International Journal of Nanomedicine

Radiologic evidence that hypothalamic gliosis is improved after bariatric surgery in obese women with type 2 diabetes

(2019) Simone van de Sande-Lee et al.   INTERNATIONAL JOURNAL OF OBESITY

Associations between cerebrovascular risk factors and parkinson disease

(2019) Benjamin R. Kummer et al.   ANNALS OF NEUROLOGY

Re-thinking the Etiological Framework of Neurodegeneration

(2019) Ximena Castillo et al.   Frontiers in Neuroscience

Neuroinflammation as a Common Feature of Neurodegenerative Disorders

(2019) Leonardo Guzman-Martinez et al.   Frontiers in Pharmacology

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

High Fat Diet Suppresses Peroxisome Proliferator-Activated Receptors and Reduces Dopaminergic Neurons in the Substantia Nigra

(2019) Yu-Chia Kao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

LDL Receptor Deficiency Does not Alter Brain Amyloid-β Levels but Causes an Exacerbation of Apoptosis

(2019) Jade de Oliveira et al.   JOURNAL OF ALZHEIMERS DISEASE

Intrastriatal injection of preformed alpha-synuclein fibrils alters central and peripheral immune cell profiles in non-transgenic mice

(2019) Rachael H. Earls et al.   Journal of Neuroinflammation

Impaired adult hippocampal neurogenesis in a mouse model of familial hypercholesterolemia: A role for the LDL receptor and cholesterol metabolism in adult neural precursor cells

(2019) Daiane F. Engel et al.   Molecular Metabolism

Sustained high-fat diet modulates inflammation, insulin signalling and cognition in mice and a modified xenin peptide ameliorates neuropathology in a chronic high-fat model

(2018) Paul Denver et al.   DIABETES OBESITY & METABOLISM

Targeting Insulin for Alzheimer’s Disease: Mechanisms, Status and Potential Directions

(2018) Jung Hyun Lee et al.   JOURNAL OF ALZHEIMERS DISEASE

Revisiting the Paraquat-Induced Sporadic Parkinson’s Disease-Like Model

(2018) Sussy Bastías-Candia et al.   MOLECULAR NEUROBIOLOGY

Association between diabetes and subsequent Parkinson disease

(2018) Eduardo De Pablo-Fernandez et al.   NEUROLOGY

Dapsone protects brain microvascular integrity from high-fat diet induced LDL oxidation

(2018) Rui Zhan et al.   Cell Death & Disease

Cellular and Molecular Basis of Neurodegeneration in Parkinson Disease

(2018) Xian-Si Zeng et al.   Frontiers in Aging Neuroscience

Pro- and Anti-inflammatory Effects of High Cholesterol Diet on Aged Brain

(2018) Yali Chen et al.   Aging and Disease

Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables

(2018) Emma Ahlqvist et al.   Lancet Diabetes & Endocrinology

High-fat diet protects the blood-brain barrier in an Alzheimer's disease mouse model

(2018) Shirin Elhaik Goldman et al.   AGING CELL

Folic Acid Plus α-Tocopherol Mitigates Amyloid-β-Induced Neurotoxicity through Modulation of Mitochondrial Complexes Activity

(2018) Cláudia P. Figueiredo et al.   JOURNAL OF ALZHEIMERS DISEASE

Age-Related Cognitive Decline in Hypercholesterolemic LDL Receptor Knockout Mice (LDLr−/−): Evidence of Antioxidant Imbalance and Increased Acetylcholinesterase Activity in the Prefrontal Cortex

(2018) Eduardo Luiz Gasnhar Moreira et al.   JOURNAL OF ALZHEIMERS DISEASE

Intrahippocampal Administration of Amyloid-β1-42 Oligomers Acutely Impairs Spatial Working Memory, Insulin Signaling, and Hippocampal Metabolism

(2018) Jiah Pearson-Leary et al.   JOURNAL OF ALZHEIMERS DISEASE

Increased Susceptibility to Amyloid-β-Induced Neurotoxicity in Mice Lacking the Low-Density Lipoprotein Receptor

(2018) Jade de Oliveira et al.   JOURNAL OF ALZHEIMERS DISEASE

Rapid and reversible impairment of episodic memory by a high-fat diet in mice

(2018) Fiona H. McLean et al.   Scientific Reports

Metabolic syndrome and risk of Parkinson disease: A nationwide cohort study

(2018) Ga Eun Nam et al.   PLOS MEDICINE

Temporal and regional progression of Alzheimer’s disease-like pathology in 3xTg-AD mice

(2018) Ramona Belfiore et al.   AGING CELL

All (animal) models (of neurodegeneration) are wrong. Are they also useful?

(2018) Richard M. Ransohoff   JOURNAL OF EXPERIMENTAL MEDICINE

Invited Review: APOE at the interface of inflammation, neurodegeneration and pathological protein spread in Alzheimer's disease

(2018) M. Tzioras et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

(2018) Richard Gordon et al.   Science Translational Medicine

The Early Events That Initiate β-Amyloid Aggregation in Alzheimer’s Disease

(2018) Xingyu Zhang et al.   Frontiers in Aging Neuroscience

The Search for Environmental Causes of Parkinson’s Disease: Moving Forward

(2018) Honglei Chen et al.   Journal of Parkinsons Disease

Parkinsonism in Inherited Metabolic Disorders: Key Considerations and Major Features

(2018) Nattakarn Limphaibool et al.   Frontiers in Neurology

Occupational pesticide use and Parkinson's disease in the Parkinson Environment Gene (PEG) study

(2017) Shilpa Narayan et al.   ENVIRONMENT INTERNATIONAL

Pesticide use in agriculture and Parkinson’s disease in the AGRICAN cohort study

(2017) Camille Pouchieu et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Association Between Midlife Vascular Risk Factors and Estimated Brain Amyloid Deposition

(2017) Rebecca F. Gottesman et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Changes in Synaptic Plasticity and Glutamate Receptors in Type 2 Diabetic KK-Ay Mice

(2017) Huajing Yin et al.   JOURNAL OF ALZHEIMERS DISEASE

Long-term exposition to a high fat diet favors the appearance of β-amyloid depositions in the brain of C57BL/6J mice. A potential model of sporadic Alzheimer’s disease

(2017) Oriol Busquets et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Elderly apolipoprotein E‑/‑ mice with advanced atherosclerotic lesions in the aorta do not develop Alzheimer's disease-like pathologies

(2017) Reut Shnerb Ganor et al.   Molecular Medicine Reports

Studies for Improving a Rat Model of Alzheimer’s Disease: Icv Administration of Well-Characterized β-Amyloid 1-42 Oligomers Induce Dysfunction in Spatial Memory

(2017) Ágnes Kasza et al.   MOLECULES

Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

(2017) J.A. Obeso et al.   MOVEMENT DISORDERS

High-fat diet and aging interact to produce neuroinflammation and impair hippocampal- and amygdalar-dependent memory

(2017) Sarah J. Spencer et al.   NEUROBIOLOGY OF AGING

The blood-brain barrier in Alzheimer's disease

(2017) Elena Zenaro et al.   NEUROBIOLOGY OF DISEASE

Hypercholesterolemia causes psychomotor abnormalities in mice and alterations in cortico-striatal biogenic amine neurotransmitters: Relevance to Parkinson's disease

(2017) Rajib Paul et al.   NEUROCHEMISTRY INTERNATIONAL

GLUT4 Mobilization Supports Energetic Demands of Active Synapses

(2017) Ghazaleh Ashrafi et al.   NEURON

Alterations of Brain Energy Metabolism in Type 2 Diabetic Goto-Kakizaki Rats Measured In Vivo by 13C Magnetic Resonance Spectroscopy

(2017) Freya-Merret Girault et al.   NEUROTOXICITY RESEARCH

The impact of obesity on brain iron levels and α-synuclein expression is regionally dependent

(2017) Jian Han et al.   NUTRITIONAL NEUROSCIENCE

Obesity as a risk factor for Alzheimer's disease: weighing the evidence

(2017) S. Alford et al.   Obesity Reviews

Alzheimer’s disease: as it was in the beginning

(2017) Stanislav Kozlov et al.   REVIEWS IN THE NEUROSCIENCES

Editor’s Highlight: Nlrp3 Is Required for Inflammatory Changes and Nigral Cell Loss Resulting From Chronic Intragastric Rotenone Exposure in Mice

(2017) Eileen M. Martinez et al.   TOXICOLOGICAL SCIENCES

Pathology of Neurodegenerative Diseases

(2017) Brittany N. Dugger et al.   Cold Spring Harbor Perspectives in Biology

Global loss of acetylcholinesterase activity with mitochondrial complexes inhibition and inflammation in brain of hypercholesterolemic mice

(2017) Rajib Paul et al.   Scientific Reports

Targeted inhibition of RAGE in substantia nigra of rats blocks 6-OHDA–induced dopaminergic denervation

(2017) Juciano Gasparotto et al.   Scientific Reports

Insulin Resistance as a Link between Amyloid-Beta and Tau Pathologies in Alzheimer’s Disease

(2017) Roger J. Mullins et al.   Frontiers in Aging Neuroscience

The MPTP Story

(2017) J. William Langston   Journal of Parkinsons Disease

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

A High-fat Diet Induces a Loss of Midbrain Dopaminergic Neuronal Function That Underlies Motor Abnormalities

(2017) Yunseon Jang et al.   Experimental Neurobiology

Mitochondrial Alterations, Oxidative Stress and Neuroinflammation in Alzheimer's Disease

(2017) M. Verri et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Reductions in Amyloid-β-Derived Neuroinflammation, with Minocycline, Restore Cognition but do not Significantly Affect Tau Hyperphosphorylation

(2017) Anna Parachikova et al.   JOURNAL OF ALZHEIMERS DISEASE

Cholesterol contributes to dopamine-neuronal loss in MPTP mouse model of Parkinson’s disease: Involvement of mitochondrial dysfunctions and oxidative stress

(2017) Rajib Paul et al.   PLoS One

The Genetic Spectrum of Familial Hypercholesterolemia (FH) in the Iranian Population

(2017) R. H. Fairoozy et al.   Scientific Reports

Alzheimer’s disease: experimental models and reality

(2016) Eleanor Drummond et al.   ACTA NEUROPATHOLOGICA

AMPK in Neurodegenerative Diseases: Implications and Therapeutic Perspectives

(2016) Claudia Marinangeli et al.   CURRENT DRUG TARGETS

Insulin Resistance and Neurodegeneration: Progress Towards the Development of New Therapeutics for Alzheimer’s Disease

(2016) Suzanne M. de la Monte   DRUGS

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Neuropsychological performance of young familial hypercholesterolemia patients

(2016) Mar Ariza et al.   European Journal of Internal Medicine

Early life adversities or high fat diet intake reduce cognitive function and alter BDNF signaling in adult rats: Interplay of these factors changes these effects

(2016) Danusa Mar Arcego et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Monitoring Blood-Brain Barrier Integrity Following Amyloid-β Immunotherapy Using Gadolinium-Enhanced MRI in a PDAPP Mouse Model

(2016) Ines Blockx et al.   JOURNAL OF ALZHEIMERS DISEASE

Changes in insulin and insulin signaling in Alzheimer’s disease: cause or consequence?

(2016) Molly Stanley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Middle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology

(2016) E. Candeias et al.   MOLECULAR NEUROBIOLOGY

Effects of caloric restriction on O-GlcNAcylation, Ca 2+ signaling, and learning impairment in the hippocampus of ob/ob mice

(2016) Byeong Tak Jeon et al.   NEUROBIOLOGY OF AGING

Antidiabetic drugs restore abnormal transport of amyloid-β across the blood–brain barrier and memory impairment in db / db mice

(2016) Fang Chen et al.   NEUROPHARMACOLOGY

Metabonomic profiles delineate potential role of glutamate-glutamine cycle in db/db mice with diabetes-associated cognitive decline

(2016) Yongquan Zheng et al.   Molecular Brain

A High-Fat Diet Causes Impairment in Hippocampal Memory and Sex-Dependent Alterations in Peripheral Metabolism

(2016) Erica L. Underwood et al.   NEURAL PLASTICITY

Pathophysiology of Motor Dysfunction in Parkinson’s Disease as the Rationale for Drug Treatment and Rehabilitation

(2016) Francesca Magrinelli et al.   Parkinsons Disease

Intracerebroventricular Injection of Amyloid-β Peptides in Normal Mice to Acutely Induce Alzheimer-like Cognitive Deficits

(2016) Hye Yun Kim et al.   Jove-Journal of Visualized Experiments

Defining severe familial hypercholesterolaemia and the implications for clinical management: a consensus statement from the International Atherosclerosis Society Severe Familial Hypercholesterolemia Panel

(2016) Raul D Santos et al.   Lancet Diabetes & Endocrinology

The rotenone-induced rat model of Parkinson's disease: Behavioral and electrophysiological findings

(2015) Christof von Wrangel et al.   BEHAVIOURAL BRAIN RESEARCH

Efficacy of Donepezil for Cognitive Impairments in Familial Hypercholesterolemia: Preclinical Proof of Concept

(2015) Jadna Bogado Lopes et al.   CNS Neuroscience & Therapeutics

Rodent models for Alzheimer’s disease drug discovery

(2015) Daniela Puzzo et al.   Expert Opinion on Drug Discovery

Age-dependent impairment of glucose tolerance in the 3xTg-AD mouse model of Alzheimer’s disease

(2015) Milene Vandal et al.   FASEB JOURNAL

Melatonin is protective against 6-hydroxydopamine-induced oxidative stress in a hemiparkinsonian rat model

(2015) O. Ozsoy et al.   FREE RADICAL RESEARCH

Insulin and Insulin-like Growth Factor 1 (IGF-1) Modulate Cytoplasmic Glucose and Glycogen Levels but Not Glucose Transport across the Membrane in Astrocytes

(2015) Marko Muhič et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid   Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases

(2015) M. Brkic et al.   JOURNAL OF NEUROSCIENCE

APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice

(2015) De-shan Liu et al.   Molecular Neurodegeneration

Midlife adiposity predicts earlier onset of Alzheimer’s dementia, neuropathology and presymptomatic cerebral amyloid accumulation

(2015) Y-F Chuang et al.   MOLECULAR PSYCHIATRY

Shared Neuropathological Characteristics of Obesity, Type 2 Diabetes and Alzheimer’s Disease: Impacts on Cognitive Decline

(2015) Jennifer Walker et al.   Nutrients

Metabolic Alterations Associated to Brain Dysfunction in Diabetes

(2015) João M N. Duarte   Aging and Disease

Neuroinflammation in Parkinson’s disease and its potential as therapeutic target

(2015) Qinqin Wang et al.   Translational Neurodegeneration

The paradox of neuronal insulin action and resistance in the development of aging-associated diseases

(2014) Sophie M. Steculorum et al.   Alzheimers & Dementia

Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition

(2014) Gustavo A Rodriguez et al.   Journal of Neuroinflammation

Individual and joint prevalence of three nonmotor symptoms of PD in the US general population

(2014) Honglei Chen et al.   MOVEMENT DISORDERS

High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice

(2014) Steven E. Arnold et al.   NEUROBIOLOGY OF DISEASE

Altered cerebral vascular volumes and solute transport at the blood–brain barriers of two transgenic mouse models of Alzheimer's disease

(2014) Tuan Minh Do et al.   NEUROPHARMACOLOGY

Clinical Genetics of Alzheimer’s Disease

(2014) Zhangyu Zou et al.   Biomed Research International

Obesity and cognitive decline: role of inflammation and vascular changes

(2014) Jason C. D. Nguyen et al.   Frontiers in Neuroscience

Type 2 Diabetes as a Risk Factor for Alzheimer's Disease: The Confounders, Interactions, and Neuropathology Associated With This Relationship

(2013) N. T. Vagelatos et al.   EPIDEMIOLOGIC REVIEWS

Hypercholesterolemia induces short-term spatial memory impairments in mice: up-regulation of acetylcholinesterase activity as an early and causal event?

(2013) Eduardo Luiz Gasnhar Moreira et al.   JOURNAL OF NEURAL TRANSMISSION

Memantine Rescues Transient Cognitive Impairment Caused by High-Molecular-Weight A  Oligomers But Not the Persistent Impairment Induced by Low-Molecular-Weight Oligomers

(2013) C. P. Figueiredo et al.   JOURNAL OF NEUROSCIENCE

The genetics of Parkinson's disease: Progress and therapeutic implications

(2013) Andrew B. Singleton et al.   MOVEMENT DISORDERS

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Behavioral Characterization of A53T Mice Reveals Early and Late Stage Deficits Related to Parkinson’s Disease

(2013) Katrina L. Paumier et al.   PLoS One

Nutrition as a link between obesity and cardiovascular disease: how can we stop the obesity epidemic?

(2013) Marleen A. van Baak   THROMBOSIS AND HAEMOSTASIS

A Guide to Neurotoxic Animal Models of Parkinson's Disease

(2013) K. Tieu   Cold Spring Harbor Perspectives in Medicine

Genetics of Parkinson's Disease

(2013) C. Klein et al.   Cold Spring Harbor Perspectives in Medicine

Animal Models of Alzheimer Disease

(2013) F. M. LaFerla et al.   Cold Spring Harbor Perspectives in Medicine

Hyperinsulinemia in rats causes impairment of spatial memory and learning with defects in hippocampal synaptic plasticity by involvement of postsynaptic mechanisms

(2013) Amer Kamal et al.   EXPERIMENTAL BRAIN RESEARCH

Involvement of cholinergic mechanisms in the behavioral effects of dietary fat consumption

(2012) Irene Morganstern et al.   BRAIN RESEARCH

The use of animal models in diabetes research

(2012) Aileen JF King   BRITISH JOURNAL OF PHARMACOLOGY

Transgenic Mouse Models of Alzheimer Disease: Developing a Better Model as a Tool for Therapeutic Interventions

(2012) Masashi Kitazawa et al.   CURRENT PHARMACEUTICAL DESIGN

APOE4-specific Changes in Aβ Accumulation in a New Transgenic Mouse Model of Alzheimer Disease

(2012) Katherine L. Youmans et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of acute and chronic hyperglycemia on the neurochemical profiles in the rat brain with streptozotocin-induced diabetes detected using in vivo1H MR spectroscopy at 9.4 T

(2012) Wen-Tung Wang et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid-β oligomers link depressive-like behavior and cognitive deficits in mice

(2012) J H Ledo et al.   MOLECULAR PSYCHIATRY

Aging-Related Changes in Blood-Brain Barrier Integrity and the Effect of Dietary Fat

(2012) R. Takechi et al.   Neurodegenerative Diseases

Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease

(2012) Louise M. Collins et al.   NEUROPHARMACOLOGY

Caffeine Consumption Prevents Diabetes-Induced Memory Impairment and Synaptotoxicity in the Hippocampus of NONcZNO10/LTJ Mice

(2012) João M. N. Duarte et al.   PLoS One

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Assessing the contribution of inflammation in models of Alzheimer's disease: Figure 1

(2011) Hannah Johnston et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease

(2011) Susan Duty et al.   BRITISH JOURNAL OF PHARMACOLOGY

Probucol, a lipid-lowering drug, prevents cognitive and hippocampal synaptic impairments induced by amyloid β peptide in mice

(2011) Danúbia B. Santos et al.   EXPERIMENTAL NEUROLOGY

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

LXR agonist increases apoE secretion from HepG2 spheroid, together with an increased production of VLDL and apoE-rich large HDL

(2011) Makoto Kurano et al.   Lipids in Health and Disease

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

(2011) Sergio T. Ferreira et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Positive correlation between elevated plasma cholesterol levels and cognitive impairments in LDL receptor knockout mice: relevance of cortico-cerebral mitochondrial dysfunction and oxidative stress

(2011) J. de Oliveira et al.   NEUROSCIENCE

Serum Cholesterol and the Progression of Parkinson's Disease: Results from DATATOP

(2011) Xuemei Huang et al.   PLoS One

Higher Incidence of Mild Cognitive Impairment in Familial Hypercholesterolemia

(2010) Daniel Zambón et al.   AMERICAN JOURNAL OF MEDICINE

The cholinergic system in aging and neuronal degeneration

(2010) Reinhard Schliebs et al.   BEHAVIOURAL BRAIN RESEARCH

Atorvastatin prevents hippocampal cell death, neuroinflammation and oxidative stress following amyloid-β1–40 administration in mice: Evidence for dissociation between cognitive deficits and neuronal damage

(2010) Tetsadê C.B. Piermartiri et al.   EXPERIMENTAL NEUROLOGY

Review Article: Genetics of Alzheimer Disease

(2010) Lynn M. Bekris et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Hypercholesterolemia in rats impairs the cholinergic system and leads to memory deficits

(2010) Celine Ullrich et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Genetic Animal Models of Parkinson's Disease

(2010) Ted M. Dawson et al.   NEURON

Time-course of nigrostriatal neurodegeneration and neuroinflammation in the 6-hydroxydopamine-induced axonal and terminal lesion models of Parkinson's disease in the rat

(2010) S. Walsh et al.   NEUROSCIENCE

Oxidative stress impairs learning and memory in apoE knockout mice

(2010) Marianne Evola et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

APOE and cholesterol homeostasis in Alzheimer's disease

(2010) Valérie Leduc et al.   TRENDS IN MOLECULAR MEDICINE

Review: Obesity and Alzheimer’s Disease: A Link Between Body Weight and Cognitive Function in Old Age

(2009) Ebrahim K. Naderali et al.   American Journal of Alzheimers Disease and Other Dementias

Midlife and Late-Life Obesity and the Risk of Dementia

(2009) Annette L. Fitzpatrick et al.   ARCHIVES OF NEUROLOGY

Midlife Serum Cholesterol and Increased Risk of Alzheimer’s and Vascular Dementia Three Decades Later

(2009) Alina Solomon et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Decreased inflammation and augmented expression of trophic factors correlate with MOG-induced neuroprotection of the injured nigrostriatal system in the murine MPTP model of Parkinson's disease

(2009) I. Kurkowska-Jastrzębska et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Overweight in midlife and risk of dementia: a 40-year follow-up study

(2009) L B Hassing et al.   INTERNATIONAL JOURNAL OF OBESITY

Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats

(2009) João M. N. Duarte et al.   JOURNAL OF NEUROCHEMISTRY

A highly reproducible rotenone model of Parkinson's disease

(2009) Jason R. Cannon et al.   NEUROBIOLOGY OF DISEASE

Failures to reconsolidate memory in a mouse model of Alzheimer’s disease

(2009) Masuo Ohno   NEUROBIOLOGY OF LEARNING AND MEMORY

Behavior, neurotransmitters and inflammation in three regimens of the MPTP mouse model of Parkinson's disease

(2009) Dirk W. Luchtman et al.   PHYSIOLOGY & BEHAVIOR

Plasma Lipid Levels in the Elderly Are Not Associated with the Risk of Mild Cognitive Impairment

(2008) Christiane Reitz et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Role of reactive oxygen species in the neurotoxicity of environmental agents implicated in Parkinson's disease

(2008) Derek A. Drechsel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Caffeine protects against MPTP-induced blood-brain barrier dysfunction in mouse striatum

(2008) Xuesong Chen et al.   JOURNAL OF NEUROCHEMISTRY

Central obesity and increased risk of dementia more than three decades later

(2008) R. A. Whitmer et al.   NEUROLOGY

Total cholesterol and the risk of Parkinson disease

(2008) G. Hu et al.   NEUROLOGY

Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis

(2008) M. A. Beydoun et al.   Obesity Reviews

Parkinson's disease and pesticides: a toxicological perspective

(2008) J HATCHER et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Genetic findings in Parkinson’s disease and translation into treatment: a leading role for mitochondria?

(2007) V. Bogaerts et al.   GENES BRAIN AND BEHAVIOR