The Early Events That Initiate β-Amyloid Aggregation in Alzheimer’s Disease
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The Early Events That Initiate β-Amyloid Aggregation in Alzheimer’s Disease
Authors
Keywords
-
Journal
Frontiers in Aging Neuroscience
Volume 10, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2018-11-13
DOI
10.3389/fnagi.2018.00359
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Aging and Alzheimer’s disease: Comparison and associations from molecular to system level
- (2018) Xian Xia et al. AGING CELL
- TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function
- (2018) Yingjun Zhao et al. NEURON
- Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer’s Disease Models
- (2018) C.Y. Daniel Lee et al. NEURON
- Traumatic Brain Injury and Alzheimer's Disease: The Cerebrovascular Link
- (2018) Jaime Ramos-Cejudo et al. EBioMedicine
- Alzheimer's Disease and Diabetes: An Integrative View of the Role of Mitochondria, Oxidative Stress, and Insulin
- (2018) Paula I. Moreira JOURNAL OF ALZHEIMERS DISEASE
- Bridging Integrator 1 (BIN1) Protein Expression Increases in the Alzheimer's Disease Brain and Correlates with Neurofibrillary Tangle Pathology
- (2018) Christopher J. Holler et al. JOURNAL OF ALZHEIMERS DISEASE
- Can a Bacterial Endotoxin be a Key Factor in the Kinetics of Amyloid Fibril Formation?
- (2018) Annalia Asti et al. JOURNAL OF ALZHEIMERS DISEASE
- Microglia in neurodegeneration
- (2018) Suzanne Hickman et al. NATURE NEUROSCIENCE
- A new era for understanding amyloid structures and disease
- (2018) Matthew G. Iadanza et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- S100A9-Driven Amyloid-Neuroinflammatory Cascade in Traumatic Brain Injury as a Precursor State for Alzheimer’s Disease
- (2018) Chao Wang et al. Scientific Reports
- Microglia in Alzheimer’s disease
- (2017) Heela Sarlus et al. JOURNAL OF CLINICAL INVESTIGATION
- Molecular Origins of the Compatibility between Glycosaminoglycans and Aβ40 Amyloid Fibrils
- (2017) Katie L. Stewart et al. JOURNAL OF MOLECULAR BIOLOGY
- Traumatic Brain Injury Alters the Metabolism and Facilitates Alzheimer’s Disease in a Murine Model
- (2017) Dandan Lou et al. MOLECULAR NEUROBIOLOGY
- Molecular interaction between type 2 diabetes and Alzheimer’s disease through cross-seeding of protein misfolding
- (2017) I Moreno-Gonzalez et al. MOLECULAR PSYCHIATRY
- Stop Alzheimer’s before it starts
- (2017) Eric McDade et al. NATURE
- Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease
- (2017) Carmen Venegas et al. NATURE
- Islet amyloid polypeptide: Another key molecule in Alzheimer’s pathogenesis?
- (2017) Yun Zhang et al. PROGRESS IN NEUROBIOLOGY
- Inflammaging and ‘Garb-aging’
- (2017) Claudio Franceschi et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Targeting Apolipoprotein E/Amyloid β Binding by Peptoid CPO_Aβ17-21 P Ameliorates Alzheimer’s Disease Related Pathology and Cognitive Decline
- (2017) Shan Liu et al. Scientific Reports
- Blood biomarkers indicate mild neuroaxonal injury and increased amyloidβproduction after transient hypoxia during breath-hold diving
- (2016) Magnus Gren et al. BRAIN INJURY
- Monomer Dynamics of Alzheimer Peptides and Kinetic Control of Early Aggregation in Alzheimer's Disease
- (2016) Srabasti Acharya et al. CHEMPHYSCHEM
- Bin1 and CD2AP polarise the endocytic generation of beta‐amyloid
- (2016) Florent Ubelmann et al. EMBO REPORTS
- BIN1 regulates BACE1 intracellular trafficking and amyloid-β production
- (2016) Toji Miyagawa et al. HUMAN MOLECULAR GENETICS
- TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
- (2016) Yaming Wang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- TREM2 variants: new keys to decipher Alzheimer disease pathogenesis
- (2016) Marco Colonna et al. NATURE REVIEWS NEUROSCIENCE
- TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy
- (2016) Peng Yuan et al. NEURON
- TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia
- (2016) Felix L. Yeh et al. NEURON
- Diabetes and Alzheimer’s disease crosstalk
- (2016) David Baglietto-Vargas et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Alzheimer, mitochondria and gender
- (2016) Amandine Grimm et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease
- (2016) Francesca Pistollato et al. NUTRITION REVIEWS
- Complement and microglia mediate early synapse loss in Alzheimer mouse models
- (2016) S. Hong et al. SCIENCE
- Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease
- (2016) Deepak Kumar Vijaya Kumar et al. Science Translational Medicine
- Loss of Bin1 Promotes the Propagation of Tau Pathology
- (2016) Sara Calafate et al. Cell Reports
- Association of Traumatic Brain Injury With Late-Life Neurodegenerative Conditions and Neuropathologic Findings
- (2016) Paul K. Crane et al. JAMA Neurology
- Cross-Seeding Interaction between β-Amyloid and Human Islet Amyloid Polypeptide
- (2015) Rundong Hu et al. ACS Chemical Neuroscience
- Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis
- (2015) Celeste M. Karch et al. BIOLOGICAL PSYCHIATRY
- TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
- (2015) Yaming Wang et al. CELL
- Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)
- (2015) Yuka Atagi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo
- (2015) Shannon L. Macauley et al. JOURNAL OF CLINICAL INVESTIGATION
- TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models
- (2015) Taylor R. Jay et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Three dimensions of the amyloid hypothesis: time, space and 'wingmen'
- (2015) Erik S Musiek et al. NATURE NEUROSCIENCE
- Oxidative stress and lipid peroxidation are upstream of amyloid pathology
- (2015) Muriel Arimon et al. NEUROBIOLOGY OF DISEASE
- Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques
- (2015) Carlo Condello et al. Nature Communications
- Historic evidence to support a causal relationship between spirochetal infections and Alzheimer’s disease
- (2015) Judith Miklossy Frontiers in Aging Neuroscience
- Exogenous amyloidogenic proteins function as seeds in amyloid β-protein aggregation
- (2014) Kenjiro Ono et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Geroscience: Linking Aging to Chronic Disease
- (2014) Brian K. Kennedy et al. CELL
- Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes
- (2014) Alvin Lu et al. CELL
- Etiology and Pathogenesis of Late-Onset Alzheimer’s Disease
- (2014) Brian J. Balin et al. CURRENT ALLERGY AND ASTHMA REPORTS
- REST and stress resistance in ageing and Alzheimer’s disease
- (2014) Tao Lu et al. NATURE
- Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases
- (2014) Jing L Guo et al. NATURE MEDICINE
- Proteostasis impairment in protein-misfolding and -aggregation diseases
- (2014) Mark S. Hipp et al. TRENDS IN CELL BIOLOGY
- Herpes simplex virus type 1 and Alzheimer’s disease: increasing evidence for a major role of the virus
- (2014) Ruth F. Itzhaki Frontiers in Aging Neuroscience
- Type 2 diabetes as a risk factor for cognitive impairment: current insights
- (2014) Hiroyuki Umegaki Clinical Interventions in Aging
- Clinical epidemiology of Alzheimer’s disease: assessing sex and gender differences
- (2014) Michelle Mielke et al. Clinical Epidemiology
- The role of pro-inflammatory S100A9 in Alzheimer’s disease amyloid-neuroinflammatory cascade
- (2013) Chao Wang et al. ACTA NEUROPATHOLOGICA
- Amylin deposition in the brain: A second amyloid in Alzheimer disease?
- (2013) Kaleena Jackson et al. ANNALS OF NEUROLOGY
- Subgroups of Alzheimer's Disease Associated with Diabetes Mellitus Based on Brain Imaging
- (2013) Raita Fukazawa et al. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
- Insulin, cognition, and dementia
- (2013) Brenna Cholerton et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Signature Amyloid β Profiles Are Produced by Different γ-Secretase Complexes
- (2013) Hermien Acx et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology
- (2013) J Chapuis et al. MOLECULAR PSYCHIATRY
- Self-propagation of pathogenic protein aggregates in neurodegenerative diseases
- (2013) Mathias Jucker et al. NATURE
- The role of autophagy in neurodegenerative disease
- (2013) Ralph A Nixon NATURE MEDICINE
- Impaired glycemia increases disease progression in mild cognitive impairment
- (2013) Jill K. Morris et al. NEUROBIOLOGY OF AGING
- Higher glucose levels associated with lower memory and reduced hippocampal microstructure
- (2013) L. Kerti et al. NEUROLOGY
- Microglia as Dynamic and Essential Components of the Amyloid Hypothesis
- (2013) Sam Gandy et al. NEURON
- Glucose Levels and Risk of Dementia
- (2013) Paul K. Crane et al. NEW ENGLAND JOURNAL OF MEDICINE
- High Glucose Promotes Aβ Production by Inhibiting APP Degradation
- (2013) Yi Yang et al. PLoS One
- Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease
- (2013) Meng-Shan Tan et al. TRENDS IN MOLECULAR MEDICINE
- Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease
- (2013) D. M. Holtzman et al. Cold Spring Harbor Perspectives in Medicine
- Disease to Dirt: The Biology of Microbial Amyloids
- (2013) David A. Hufnagel et al. PLoS Pathogens
- Amylin Uncovered: A Review on the Polypeptide Responsible for Type II Diabetes
- (2013) Karen Pillay et al. Biomed Research International
- Dysfunction of the mTOR pathway is a risk factor for Alzheimer’s disease
- (2013) Sharon C Yates et al. Acta Neuropathologica Communications
- Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer’s disease
- (2012) Lara Wahlster et al. ACTA NEUROPATHOLOGICA
- Oxidative lipid modification of nicastrin enhances amyloidogenic γ-secretase activity in Alzheimer’s disease
- (2012) A-Ryeong Gwon et al. AGING CELL
- Accumulation of autophagosomes contributes to enhanced amyloidogenic APP processing under insulin-resistant conditions
- (2012) Sung Min Son et al. Autophagy
- Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease
- (2012) Francesc X. Guix et al. EMBO Molecular Medicine
- Insulin Has Multiple Antiamyloidogenic Effects on Human Neuronal Cells
- (2012) Giuseppe Pandini et al. ENDOCRINOLOGY
- Astrocytes: Conductors of the Alzheimer disease neuroinflammatory symphony
- (2012) Rodrigo Medeiros et al. EXPERIMENTAL NEUROLOGY
- Microbial Amyloids Induce Interleukin 17A (IL-17A) and IL-22 Responses via Toll-Like Receptor 2 Activation in the Intestinal Mucosa
- (2012) Jessalyn H. Nishimori et al. INFECTION AND IMMUNITY
- An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers
- (2012) Theresa R. Bomfim et al. JOURNAL OF CLINICAL INVESTIGATION
- Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice
- (2012) Dimitrije Krstic et al. Journal of Neuroinflammation
- Targeting Astrocytes Ameliorates Neurologic Changes in a Mouse Model of Alzheimer's Disease
- (2012) J. L. Furman et al. JOURNAL OF NEUROSCIENCE
- Genetic insights in Alzheimer's disease
- (2012) Karolien Bettens et al. LANCET NEUROLOGY
- Infectious Agents and Neurodegeneration
- (2012) Giovanna De Chiara et al. MOLECULAR NEUROBIOLOGY
- Brain Ischemia Activates β- and γ-Secretase Cleavage of Amyloid Precursor Protein: Significance in Sporadic Alzheimer’s Disease
- (2012) Ryszard Pluta et al. MOLECULAR NEUROBIOLOGY
- A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline
- (2012) Thorlakur Jonsson et al. NATURE
- NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
- (2012) Michael T. Heneka et al. NATURE
- The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
- (2012) Iryna Benilova et al. NATURE NEUROSCIENCE
- Deciphering the mechanism underlying late-onset Alzheimer disease
- (2012) Dimitrije Krstic et al. Nature Reviews Neurology
- Neuroinflammatory phenotype in early Alzheimer's disease
- (2012) Tiffany L. Sudduth et al. NEUROBIOLOGY OF AGING
- Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease
- (2012) Randall J. Bateman et al. NEW ENGLAND JOURNAL OF MEDICINE
- TREM2 Variants in Alzheimer's Disease
- (2012) Rita Guerreiro et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mechanisms Underlying Insulin Deficiency-Induced Acceleration of β-Amyloidosis in a Mouse Model of Alzheimer's Disease
- (2012) Latha Devi et al. PLoS One
- Insulin-resistant brain state: The culprit in sporadic Alzheimer's disease?
- (2011) Sónia C. Correia et al. AGEING RESEARCH REVIEWS
- Cross-Amyloid Interaction of Aβ and IAPP at Lipid Membranes
- (2011) Janine Seeliger et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP
- (2011) Sascha W Weyer et al. EMBO JOURNAL
- Specific lipid recognition is a general feature of CD300 and TREM molecules
- (2011) John P. Cannon et al. IMMUNOGENETICS
- Structure-dependent Impairment of Intracellular Apolipoprotein E4 Trafficking and Its Detrimental Effects Are Rescued by Small-molecule Structure Correctors
- (2011) Jens Brodbeck et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Obesity is associated with hypothalamic injury in rodents and humans
- (2011) Joshua P. Thaler et al. JOURNAL OF CLINICAL INVESTIGATION
- The Many Faces of Tau
- (2011) Meaghan Morris et al. NEURON
- C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid- (A ) and acts in concert with A to elicit neuronal and behavioral deficits in mice
- (2011) N. Bien-Ly et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
- (2011) R. C. Paolicelli et al. SCIENCE
- Aging as an Event of Proteostasis Collapse
- (2011) R. C. Taylor et al. Cold Spring Harbor Perspectives in Biology
- Identification of Hot Regions of the Aβ-IAPP Interaction Interface as High-Affinity Binding Sites in both Cross- and Self-Association
- (2010) Erika Andreetto et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Toll-like receptors 1 and 2 cooperatively mediate immune responses to curli, a common amyloid from enterobacterial biofilms
- (2010) Çagla Tükel et al. CELLULAR MICROBIOLOGY
- Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease
- (2010) Markel Olabarria et al. GLIA
- Microglia Activation and Anti-inflammatory Regulation in Alzheimer’s Disease
- (2010) Lih-Fen Lue et al. MOLECULAR NEUROBIOLOGY
- A human gut microbial gene catalogue established by metagenomic sequencing
- (2010) Junjie Qin et al. NATURE
- Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
- (2010) Jorge J Palop et al. NATURE NEUROSCIENCE
- How does diabetes accelerate Alzheimer disease pathology?
- (2010) Catrina Sims-Robinson et al. Nature Reviews Neurology
- Traumatic brain injury and amyloid-β pathology: a link to Alzheimer's disease?
- (2010) Victoria E. Johnson et al. NATURE REVIEWS NEUROSCIENCE
- The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide
- (2010) Stephanie J. Soscia et al. PLoS One
- Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and A deposition in an Alzheimer mouse model with diabetes
- (2010) S. Takeda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Aβ-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease
- (2010) Yadong Huang TRENDS IN MOLECULAR MEDICINE
- Cross Currents in Protein Misfolding Disorders: Interactions and Therapy
- (2009) Rodrigo Morales et al. CNS & Neurological Disorders-Drug Targets
- Type 1 diabetes exaggerates features of Alzheimer's disease in APP transgenic mice
- (2009) Corinne G. Jolivalt et al. EXPERIMENTAL NEUROLOGY
- ApoE4 Decreases Spine Density and Dendritic Complexity in Cortical Neurons In Vivo
- (2009) S. B. Dumanis et al. JOURNAL OF NEUROSCIENCE
- Oxidative stress up-regulates presenilin 1 in lipid rafts in neuronal cells
- (2009) Akiko Oda et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus
- (2009) Tony Valente et al. NEUROBIOLOGY OF DISEASE
- The Role of Apolipoprotein E in Alzheimer's Disease
- (2009) Jungsu Kim et al. NEURON
- Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers
- (2009) Fernanda G. De Felice et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dietary fats, cerebrovasculature integrity and Alzheimer’s disease risk
- (2009) R. Takechi et al. PROGRESS IN LIPID RESEARCH
- A Lack of Amyloid β Plaques Despite Persistent Accumulation of Amyloid β in Axons of Long-Term Survivors of Traumatic Brain Injury
- (2008) Xiao-Han Chen et al. BRAIN PATHOLOGY
- The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1α
- (2008) Michela Guglielmotto et al. JOURNAL OF NEUROCHEMISTRY
- Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling
- (2008) Aileen M. Moloney et al. NEUROBIOLOGY OF AGING
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now