Shared Neuropathological Characteristics of Obesity, Type 2 Diabetes and Alzheimer’s Disease: Impacts on Cognitive Decline

Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults

(2017) Mark A. Reger et al.   JOURNAL OF ALZHEIMERS DISEASE

Vitamin C Deficiency in the Brain Impairs Cognition, Increases Amyloid Accumulation and Deposition, and Oxidative Stress in APP/PSEN1 and Normally Aging Mice

(2015) Shilpy Dixit et al.   ACS Chemical Neuroscience

Differential proteomic and behavioral effects of long-term voluntary exercise in wild-type and APP-overexpressing transgenics

(2015) Shailaja Kishan Rao et al.   NEUROBIOLOGY OF DISEASE

Examining the relationship between obesity and cognitive function: A systematic literature review

(2015) Christina Prickett et al.   Obesity Research & Clinical Practice

Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer’s disease

(2015) Fernanda G. De Felice et al.   Frontiers in Aging Neuroscience

The incretin hormones glucagonlike peptide 1 and glucose-dependent insulinotropic polypeptide are neuroprotective in mouse models of Alzheimer's disease

(2014) Christian Hölscher   Alzheimers & Dementia

Assessing Premorbid Cognitive Ability in Adults With Type 2 Diabetes Mellitus—a Review With Implications for Future Intervention Studies

(2014) Rachel Heloise Xiwen Wong et al.   Current Diabetes Reports

Possible Role of Vascular Risk Factors in Alzheimer's Disease and Vascular Dementia

(2014) Mehrul Hasnain et al.   CURRENT PHARMACEUTICAL DESIGN

Brain Changes Underlying Cognitive Dysfunction in Diabetes: What Can We Learn From MRI?

(2014) G. J. Biessels et al.   DIABETES

Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice

(2014) Yanxing Chen et al.   EXPERIMENTAL NEUROLOGY

Caloric restriction can improve learning ability in C57/BL mice via regulation of the insulin-PI3K/Akt signaling pathway

(2014) Lina Ma et al.   NEUROLOGICAL SCIENCES

Lixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's disease

(2014) Paula L. McClean et al.   NEUROPHARMACOLOGY

A Functional Polymorphism in the Promoter Region of MicroRNA-146a Is Associated with the Risk of Alzheimer Disease and the Rate of Cognitive Decline in Patients

(2014) Lili Cui et al.   PLoS One

High-Fat-Diet-Induced Weight Gain Ameliorates Bone Loss without Exacerbating AβPP Processing and Cognition in Female APP/PS1 Mice

(2014) Yunhua Peng et al.   Frontiers in Cellular Neuroscience

Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia

(2014) Dana M Niedowicz et al.   Acta Neuropathologica Communications

Short-term weight loss attenuates local tissue inflammation and improves insulin sensitivity without affecting adipose inflammation in obese mice

(2013) Dae Young Jung et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Immature mice are more susceptible to the detrimental effects of high fat diet on cancellous bone in the distal femur

(2013) Jason A. Inzana et al.   BONE

Obesity induced by a high-fat diet is associated with increased immune cell entry into the central nervous system

(2013) Laura B. Buckman et al.   BRAIN BEHAVIOR AND IMMUNITY

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

(2013) Mychael V. Lourenco et al.   Cell Metabolism

Vascular Oxidative Stress and Mitochondrial Failure in the Pathobiology of Alzheimer’s Disease: A New Approach to Therapy

(2013) Marta Sochocka et al.   CNS & Neurological Disorders-Drug Targets

Disruption of the Cerebral White Matter Network Is Related to Slowing of Information Processing Speed in Patients With Type 2 Diabetes

(2013) Y. D. Reijmer et al.   DIABETES

Type 2 Diabetes as a Risk Factor for Alzheimer's Disease: The Confounders, Interactions, and Neuropathology Associated With This Relationship

(2013) N. T. Vagelatos et al.   EPIDEMIOLOGIC REVIEWS

Short-term environmental enrichment, in the absence of exercise, improves memory, and increases NGF concentration, early neuronal survival, and synaptogenesis in the dentate gyrus in a time-dependent manner

(2013) Amy M. Birch et al.   HIPPOCAMPUS

Mechanisms and effects of curcumin on spatial learning and memory improvement in APPswe/PS1dE9 mice

(2013) Pengwen Wang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Increased blood–brain barrier vulnerability to systemic inflammation in an Alzheimer disease mouse model

(2013) Shuko Takeda et al.   NEUROBIOLOGY OF AGING

Oxidative Stress and the Pathogenesis of Alzheimer's Disease

(2013) Yan Zhao et al.   Oxidative Medicine and Cellular Longevity

Sex differences in adipose tissue

(2013) Esther Fuente-Martín et al.   Adipocyte

The effect of ageing on neurogenesis and oxidative stress in the APPswe/PS1deltaE9 mouse model of Alzheimer's disease

(2012) Alison Hamilton et al.   BRAIN RESEARCH

Multiple Defects in Energy Metabolism in Alzheimers Disease

(2012) I. L. Ferreira et al.   CURRENT DRUG TARGETS

Amyloid-  Induces Hepatic Insulin Resistance by Activating JAK2/STAT3/SOCS-1 Signaling Pathway

(2012) Y. Zhang et al.   DIABETES

Amyloid-  Induces Hepatic Insulin Resistance In Vivo via JAK2

(2012) Y. Zhang et al.   DIABETES

Impaired Insulin Sensitivity as Indexed by the HOMA Score Is Associated With Deficits in Verbal Fluency and Temporal Lobe Gray Matter Volume in the Elderly

(2012) C. Benedict et al.   DIABETES CARE

Obesity and Cognitive Aging

(2012) A. K. Dahl et al.   EPIDEMIOLOGIC REVIEWS

Exercise Is More Effective than Diet Control in Preventing High Fat Diet-induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice

(2012) Masato Maesako et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatocyte-specific Deletion of Janus Kinase 2 (JAK2) Protects against Diet-induced Steatohepatitis and Glucose Intolerance

(2012) Sally Yu Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Regional astrogliosis in the mouse hypothalamus in response to obesity

(2012) Laura B. Buckman et al.   JOURNAL OF COMPARATIVE NEUROLOGY

TNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation

(2012) Karim Belarbi et al.   Journal of Neuroinflammation

Tumor necrosis factor-α synthesis inhibitor 3,6′-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer’s disease

(2012) David Tweedie et al.   Journal of Neuroinflammation

A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease

(2012) Yoshihiro Kashiwaya et al.   NEUROBIOLOGY OF AGING

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

IRS-2 Deficiency Impairs NMDA Receptor-Dependent Long-term Potentiation

(2011) Eduardo D. Martín et al.   CEREBRAL CORTEX

Inflammatory signaling in Alzheimer disease and depression

(2011) R. BARBER   CLEVELAND CLINIC JOURNAL OF MEDICINE

Susceptibility to diet-induced obesity and glucose intolerance in the APP SWE/PSEN1 A246E mouse model of Alzheimer’s disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein

(2011) N. Mody et al.   DIABETOLOGIA

Sex differences during the course of diet-induced obesity in mice: adipose tissue expandability and glycemic control

(2011) D Medrikova et al.   INTERNATIONAL JOURNAL OF OBESITY

Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice

(2011) Masato Maesako et al.   NEUROBIOLOGY OF AGING

Dietary Antioxidants and Long-term Risk of Dementia

(2010) Elizabeth E. Devore et al.   ARCHIVES OF NEUROLOGY

Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis

(2010) Takahisa Nakamura et al.   CELL

Accelerated cognitive decline in patients with type 2 diabetes: MRI correlates and risk factors

(2010) Yael D. Reijmer et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Enduring consequences of maternal obesity for brain inflammation and behavior of offspring

(2010) Staci D. Bilbo et al.   FASEB JOURNAL

A microarray analysis of sexual dimorphism of adipose tissues in high-fat-diet-induced obese mice

(2010) K L Grove et al.   INTERNATIONAL JOURNAL OF OBESITY

Oxidative insults to neurons and synapse are prevented by aged garlic extract and S-allyl-l-cysteine treatment in the neuronal culture and APP-Tg mouse model

(2010) Balmiki Ray et al.   JOURNAL OF NEUROCHEMISTRY

Vascular Cognitive Disorder. A Biological and Clinical Overview

(2010) Leontino Battistin et al.   NEUROCHEMICAL RESEARCH

Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and A  deposition in an Alzheimer mouse model with diabetes

(2010) S. Takeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Different Patterns of Cerebral Injury in Dementia With or Without Diabetes

(2009) Joshua A. Sonnen   ARCHIVES OF NEUROLOGY

Modifiers of cognitive function and brain structure in middle-aged and elderly individuals with type 2 diabetes mellitus

(2009) Hannah Bruehl et al.   BRAIN RESEARCH

Cognitive impairment in nondiabetic middle-aged and older adults is associated with insulin resistance

(2009) H. Bruehl et al.   JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

(2009) Ethan J. Anderson et al.   JOURNAL OF CLINICAL INVESTIGATION

Cognitive impairment following high fat diet consumption is associated with brain inflammation

(2009) Paul J. Pistell et al.   JOURNAL OF NEUROIMMUNOLOGY

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

(2009) M. Milanski et al.   JOURNAL OF NEUROSCIENCE

Systemic inflammation and disease progression in Alzheimer disease

(2009) C. Holmes et al.   NEUROLOGY

Caloric restriction attenuates amyloid deposition in middle-aged dtg APP/PS1 mice

(2009) Peter R. Mouton et al.   NEUROSCIENCE LETTERS

Antioxidants and cognitive training interact to affect oxidative stress and memory in APP/PSEN1 mice

(2009) F.E. Harrison et al.   NUTRITIONAL NEUROSCIENCE

Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis

(2008) M. A. Beydoun et al.   Obesity Reviews

The brain expression of genes involved in inflammatory response, the ribosome and learning and memory is altered by centrally injected lipopolysaccharide in mice

(2008) R H Bonow et al.   PHARMACOGENOMICS JOURNAL

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL