Inflammatory links between obesity and metabolic disease

The Effects of Salsalate on Glycemic Control in Patients With Type 2 Diabetes

(2013) Allison B. Goldfine   ANNALS OF INTERNAL MEDICINE

Alternative Macrophage Activation and Metabolism

(2011) Justin I. Odegaard et al.   Annual Review of Pathology-Mechanisms of Disease

Adiponectin Enhances Insulin Sensitivity by Increasing Hepatic IRS-2 Expression via a Macrophage-Derived IL-6-Dependent Pathway

(2011) Motoharu Awazawa et al.   Cell Metabolism

NF-κB, Inflammation, and Metabolic Disease

(2011) Rebecca G. Baker et al.   Cell Metabolism

Maternal High-Fat Diet Disturbs Uteroplacental Hemodynamics and Increases the Frequency of Stillbirth in a Nonhuman Primate Model of Excess Nutrition

(2011) Antonio E. Frias et al.   ENDOCRINOLOGY

Inflammation of the Hypothalamus Leads to Defective Pancreatic Islet Function

(2011) Vivian C. Calegari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

(2011) William L. Holland et al.   JOURNAL OF CLINICAL INVESTIGATION

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress

(2011) S. Purkayastha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

(2011) D. Wu et al.   SCIENCE

NF-κB activity in muscle from obese and type 2 diabetic subjects under basal and exercise-stimulated conditions

(2010) Puntip Tantiwong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation

(2010) Michael Spencer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Toll-like receptor 4 modulates skeletal muscle substrate metabolism

(2010) Madlyn I. Frisard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Adipose proinflammatory cytokine expression through sympathetic system is associated with hyperglycemia and insulin resistance in a rat ischemic stroke model

(2010) Ya-Yu Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis

(2010) Takahisa Nakamura et al.   CELL

Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals

(2010) Benjamin R. Carone et al.   CELL

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

The Role of Endoplasmic Reticulum Stress in the Progression of Atherosclerosis

(2010) Ira Tabas   CIRCULATION RESEARCH

Sphingolipids and insulin resistance: the five Ws

(2010) Scott A Summers   CURRENT OPINION IN LIPIDOLOGY

Dynamic, M2-Like Remodeling Phenotypes of CD11c+ Adipose Tissue Macrophages During High-Fat Diet-Induced Obesity in Mice

(2010) M. E. Shaul et al.   DIABETES

Cellularity and Adipogenic Profile of the Abdominal Subcutaneous Adipose Tissue From Obese Adolescents: Association With Insulin Resistance and Hepatic Steatosis

(2010) R. Kursawe et al.   DIABETES

C-C Chemokine Receptor 2 (CCR2) Regulates the Hepatic Recruitment of Myeloid Cells That Promote Obesity-Induced Hepatic Steatosis

(2010) A. E. Obstfeld et al.   DIABETES

A Recurring Problem With the Analysis of Energy Expenditure in Genetic Models Expressing Lean and Obese Phenotypes

(2010) A. A. Butler et al.   DIABETES

A Systems Biology Approach Identifies Inflammatory Abnormalities Between Mouse Strains Prior to Development of Metabolic Disease

(2010) M. A. Mori et al.   DIABETES

Minireview: Inflammation and Obesity Pathogenesis: The Hypothalamus Heats Up

(2010) Joshua P. Thaler et al.   ENDOCRINOLOGY

JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction

(2010) Giovanni Solinas et al.   FASEB JOURNAL

Newly identified adipose tissue macrophage populations in obesity with distinct chemokine and chemokine receptor expression

(2010) M Zeyda et al.   INTERNATIONAL JOURNAL OF OBESITY

TNF-α Antagonism with Etanercept Decreases Glucose and Increases the Proportion of High Molecular Weight Adiponectin in Obese Subjects with Features of the Metabolic Syndrome

(2010) Takara L. Stanley et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue

(2010) Aliki Kosteli et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammatory Role of Toll-Like Receptors in Human and Murine Adipose Tissue

(2010) Odile Poulain-Godefroy et al.   MEDIATORS OF INFLAMMATION

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

(2010) Sheau-Fang Ng et al.   NATURE

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

(2010) William L Holland et al.   NATURE MEDICINE

Pregravid Obesity Associates With Increased Maternal Endotoxemia and Metabolic Inflammation

(2010) Subhabrata Basu et al.   Obesity

Early-life determinants of overweight and obesity: a review of systematic reviews

(2010) L. Monasta et al.   Obesity Reviews

Multiple Markers of Inflammation and Weight Status: Cross-sectional Analyses Throughout Childhood

(2010) A. C. Skinner et al.   PEDIATRICS

The Relationship of Omental and Subcutaneous Adipocyte Size to Metabolic Disease in Severe Obesity

(2010) Jean O'Connell et al.   PLoS One

Myeloid Differentiation Factor 88 (MyD88)-Deficiency Increases Risk of Diabetes in Mice

(2010) Toru Hosoi et al.   PLoS One

Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism

(2010) B. F. Belgardt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5

(2010) M. Vijay-Kumar et al.   SCIENCE

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

Cytokine production by islets in health and diabetes: cellular origin, regulation and function

(2010) Marc Y. Donath et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitivity through IKKβ and ER Stress Inhibition

(2010) Eduardo R. Ropelle et al.   PLOS BIOLOGY

Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action

(2009) Vijayalakshmi Varma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Natural Killer T Cells Are Involved in Adipose Tissues Inflammation and Glucose Intolerance in Diet-Induced Obese Mice

(2009) Kazue Ohmura et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension

(2009) Y.-M. Kang et al.   CARDIOVASCULAR RESEARCH

The Protein Kinase IKKɛ Regulates Energy Balance in Obese Mice

(2009) Shian-Huey Chiang et al.   CELL

MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity

(2009) André Kleinridders et al.   Cell Metabolism

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

(2009) Lale Ozcan et al.   Cell Metabolism

Hematopoietic Cell-Specific Deletion of Toll-like Receptor 4 Ameliorates Hepatic and Adipose Tissue Insulin Resistance in High-Fat-Fed Mice

(2009) Maziyar Saberi et al.   Cell Metabolism

Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome

(2009) Michael B Fessler et al.   CURRENT OPINION IN LIPIDOLOGY

Accelerated Postnatal Growth Increases Lipogenic Gene Expression and Adipocyte Size in Low-Birth Weight Mice

(2009) E. Isganaitis et al.   DIABETES

Interleukin-10 Prevents Diet-Induced Insulin Resistance by Attenuating Macrophage and Cytokine Response in Skeletal Muscle

(2009) E.-G. Hong et al.   DIABETES

Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance

(2009) W. Huang et al.   DIABETES

Weight at Birth and All-Cause Mortality in Adulthood

(2009) Jennifer L. Baker et al.   EPIDEMIOLOGY

Tlr2 is critical for diet-induced metabolic syndrome in a murine model

(2009) Ryan W. Himes et al.   FASEB JOURNAL

Hypothalamic inflammation and energy homeostasis: Resolving the paradox

(2009) Joshua P. Thaler et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-γ in inflammation in human adipose tissue

(2009) R W O'Rourke et al.   INTERNATIONAL JOURNAL OF OBESITY

Human Adipose Tissue Macrophages: M1 and M2 Cell Surface Markers in Subcutaneous and Omental Depots and after Weight Loss

(2009) Judith Aron-Wisnewsky et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Palmitic acid mediates hypothalamic insulin resistance by altering PKC-θ subcellular localization in rodents

(2009) Stephen C. Benoit et al.   JOURNAL OF CLINICAL INVESTIGATION

Kupffer cells in non-alcoholic fatty liver disease: The emerging view

(2009) György Baffy   JOURNAL OF HEPATOLOGY

Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells

(2009) Kazuyo Moro et al.   NATURE

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice

(2009) Jian Liu et al.   NATURE MEDICINE

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Normalization of obesity-associated insulin resistance through immunotherapy

(2009) Shawn Winer et al.   NATURE MEDICINE

Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity

(2009) E. Fabbrini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation and Pregnancy

(2009) John R. Challis et al.   Reproductive Sciences

NOD-Like Receptors: Role in Innate Immunity and Inflammatory Disease

(2008) Grace Chen et al.   Annual Review of Pathology-Mechanisms of Disease

Macrophages, cytokines and β-cell death in Type 2 diabetes: Figure 1

(2008) Jan A. Ehses et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Adipocyte-Derived Th2 Cytokines and Myeloid PPARδ Regulate Macrophage Polarization and Insulin Sensitivity

(2008) Kihwa Kang et al.   Cell Metabolism

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

(2008) Justin I. Odegaard et al.   Cell Metabolism

Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

(2008) David Patsouris et al.   Cell Metabolism

Use of Salsalate to Target Inflammation in the Treatment of Insulin Resistance and Type 2 Diabetes

(2008) Allison B. Goldfine et al.   CTS-Clinical and Translational Science

Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

(2008) C. N. Lumeng et al.   DIABETES

Variations in DNA elucidate molecular networks that cause disease

(2008) Yanqing Chen et al.   NATURE

Genetics of gene expression and its effect on disease

(2008) Valur Emilsson et al.   NATURE

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Predominant Role for Parenchymal c-Jun Amino Terminal Kinase (JNK) in the Regulation of Systemic Insulin Sensitivity

(2008) Sara N. Vallerie et al.   PLoS One

Uncovering a Macrophage Transcriptional Program by Integrating Evidence from Motif Scanning and Expression Dynamics

(2008) Stephen A. Ramsey et al.   PLoS Computational Biology