Inflamm-Aging and Brain Insulin Resistance: New Insights and Role of Life-style Strategies on Cognitive and Social Determinants in Aging and Neurodegeneration

Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging

(2020) Shuai Ma et al.   CELL

Anti-Aging Effects of Calorie Restriction (CR) and CR Mimetics Based on the Senoinflammation Concept

(2020) Dae Hyun Kim et al.   Nutrients

Impact of HMGB1, RAGE, and TLR4 in Alzheimer’s Disease (AD): From Risk Factors to Therapeutic Targeting

(2020) Yam Nath Paudel et al.   Cells

Anti-Inflammatory Strategies Targeting Metaflammation in Type 2 Diabetes

(2020) Alina Kuryłowicz et al.   MOLECULES

Brain insulin sensitivity is linked to adiposity and body fat distribution

(2020) Stephanie Kullmann et al.   Nature Communications

The combined effects of microglia activation and brain glucose hypometabolism in early-onset Alzheimer’s disease

(2020) Giacomo Tondo et al.   Alzheimers Research & Therapy

Nicotinamide riboside supplementation corrects deficits in oxytocin, sociability and anxiety of CD157 mutants in a mouse model of autism spectrum disorder

(2020) Maria Gerasimenko et al.   Scientific Reports

Oxytocin Ameliorates Impaired Behaviors of High Fat Diet-Induced Obese Mice

(2020) Ryotaro Hayashi et al.   Frontiers in Endocrinology

The geroscience agenda: Toxic stress, hormetic stress, and the rate of aging

(2020) Elissa S. Epel   AGEING RESEARCH REVIEWS

Effects of caloric restriction on human physiological, psychological, and behavioral outcomes: highlights from CALERIE phase 2

(2020) James L Dorling et al.   NUTRITION REVIEWS

Astroglial asthenia and loss of function, rather than reactivity, contribute to the ageing of the brain

(2020) Alexei Verkhratsky et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Homeostatic model assessment of adiponectin (HOMA-Adiponectin) as a surrogate measure of insulin resistance in adolescents: Comparison with the hyperglycaemic clamp and homeostatic model assessment of insulin resistance

(2019) Cleliani de Cassia da Silva et al.   PLoS One

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

NAD+ metabolism as a target for metabolic health: have we found the silver bullet?

(2019) Niels J. Connell et al.   DIABETOLOGIA

Long‐term caloric restriction ameliorates deleterious effects of aging on white and brown adipose tissue plasticity

(2019) Patricia Corrales et al.   AGING CELL

Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease

(2019) Tomoko Wakabayashi et al.   Molecular Neurodegeneration

Insulin Signaling Impairment in the Brain as a Risk Factor in Alzheimer’s Disease

(2019) Christian Hölscher   Frontiers in Aging Neuroscience

S100 Proteins in Alzheimer’s Disease

(2019) Joana S. Cristóvão et al.   Frontiers in Neuroscience

Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics

(2019) Sneham Tiwari et al.   International Journal of Nanomedicine

Association of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging

(2019) Dimitrios Kapogiannis et al.   JAMA Neurology

Diet-induced hypothalamic dysfunction and metabolic disease, and the therapeutic potential of polyphenols

(2019) Ebrahim Samodien et al.   Molecular Metabolism

Microglia in Alzheimer Disease: Well-Known Targets and New Opportunities

(2019) Anne-Laure Hemonnot et al.   Frontiers in Aging Neuroscience

Brain Insulin Resistance and Hippocampal Plasticity: Mechanisms and Biomarkers of Cognitive Decline

(2019) Matteo Spinelli et al.   Frontiers in Neuroscience

A journey from microenvironment to macroenvironment: the role of metaflammation and epigenetic changes in cardiorenal disease

(2019) Mehmet Kanbay et al.   Clinical Kidney Journal

The Role of Brain Glycogen in Supporting Physiological Function

(2019) Laura R. Rich et al.   Frontiers in Neuroscience

The impact of depression and anxiety treatment on biological aging and metabolic stress: study protocol of the Mood treatment with antidepressants or running (MOTAR) study

(2019) Bianca A. Lever-van Milligen et al.   BMC Psychiatry

Inflammasome-mediated innate immunity in Alzheimer’s disease

(2019) Carmen Venegas et al.   FASEB JOURNAL

CD38, CD157, and RAGE as Molecular Determinants for Social Behavior

(2019) Haruhiro Higashida et al.   Cells

A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD + Decline

(2018) Mariana G. Tarragó et al.   Cell Metabolism

Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging

(2018) Leanne M. Redman et al.   Cell Metabolism

Mitochondrial DNA DAMPs Induce Inflammation and Insulin Resistance

(2018) LARYSA YUZEFOVYCH et al.   DIABETES

Sirtuins as Mediator of the Anti-Ageing Effects of Calorie Restriction in Skeletal and Cardiac Muscle

(2018) Alberto Zullo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Homocysteine and Dementia: An International Consensus Statement

(2018) A. David Smith et al.   JOURNAL OF ALZHEIMERS DISEASE

The Role of Immunosenescence in Neurodegenerative Diseases

(2018) Erica Costantini et al.   MEDIATORS OF INFLAMMATION

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

(2018) Yingjun Zhao et al.   NEURON

NAD+supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

(2018) Yujun Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's Disease and Type 2 Diabetes: A Critical Assessment of the Shared Pathological Traits

(2018) Shreyasi Chatterjee et al.   Frontiers in Neuroscience

Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines

(2018) Irene Maeve Rea et al.   Frontiers in Immunology

Adipocyte-derived Lysophosphatidylcholine Activates Adipocyte and Adipose Tissue Macrophage Nod-Like Receptor Protein 3 Inflammasomes Mediating Homocysteine-Induced Insulin Resistance

(2018) Song-Yang Zhang et al.   EBioMedicine

Mechanisms of the anti-aging and prolongevity effects of caloric restriction: evidence from studies of genetically modified animals

(2018) Shunsuke Hoshino et al.   Aging-US

Heat Shock Proteins in Alzheimer’s Disease: Role and Targeting

(2018) Claudia Campanella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sterile Inflammatory Role of High Mobility Group Box 1 Protein: Biological Functions and Involvement in Disease

(2018) Sera Gonelevue et al.   JOURNAL OF VASCULAR RESEARCH

Inflammasome signalling in brain function and neurodegenerative disease

(2018) Michael T. Heneka et al.   NATURE REVIEWS NEUROSCIENCE

IL-1β, IL-6, TNF- α and CRP in Elderly Patients with Depression or Alzheimer’s disease: Systematic Review and Meta-Analysis

(2018) Ada Ng et al.   Scientific Reports

Insulin Resistance in Alzheimer's Disease

(2018) Laís S. S. Ferreira et al.   Frontiers in Neuroscience

Exosomal biomarkers of brain insulin resistance associated with regional atrophy in Alzheimer's disease

(2017) Roger J. Mullins et al.   HUMAN BRAIN MAPPING

Fats for thoughts: An update on brain fatty acid metabolism

(2017) Adele Romano et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Inflammatory mechanisms linking obesity and metabolic disease

(2017) Alan R. Saltiel et al.   JOURNAL OF CLINICAL INVESTIGATION

Telomeres, Nutrition, and Longevity: Can We Really Navigate Our Aging?

(2017) Nikolina Škrobot Vidaček et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Current role of the NLRP3 inflammasome on obesity and insulin resistance: A systematic review

(2017) Jakeline Rheinheimer et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

NAD and the aging process: Role in life, death and everything in between

(2017) Claudia C.S. Chini et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers

(2017) Jason Pitt et al.   MOLECULAR BIOLOGY OF THE CELL

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

Insulin expression in cultured astrocytes and the decrease by amyloid β

(2017) Katsura Takano et al.   NEUROCHEMISTRY INTERNATIONAL

Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes

(2017) Na Zhao et al.   NEURON

Elucidating the Role of TREM2 in Alzheimer’s Disease

(2017) Jason D. Ulrich et al.   NEURON

Insulin and brain aging

(2017) Agnieszka Baranowska-Bik et al.   Przeglad Menopauzalny

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

(2017) Jesse S. Kerr et al.   TRENDS IN NEUROSCIENCES

Functional Foods and Lifestyle Approaches for Diabetes Prevention and Management

(2017) Ahmad Alkhatib et al.   Nutrients

PKR involvement in Alzheimer’s disease

(2017) Jacques Hugon et al.   Alzheimers Research & Therapy

The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer’s pathology

(2017) Sarah Westwood et al.   Alzheimers Research & Therapy

Insulin Resistance and Alzheimer’s Disease: Bioenergetic Linkages

(2017) Bryan J. Neth et al.   Frontiers in Aging Neuroscience

Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy

(2017) Kevin A. Clayton et al.   Frontiers in Neuroscience

Aging and Caloric Restriction Research: A Biological Perspective With Translational Potential

(2017) Priya Balasubramanian et al.   EBioMedicine

Caloric restriction preserves memory and reduces anxiety of aging mice with early enhancement of neurovascular functions

(2016) Ishita Parikh et al.   Aging-US

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

(2016) Valeria Calsolaro et al.   Alzheimers & Dementia

The role of insulin in the vascular contributions to age-related dementia

(2016) Timothy M. Hughes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Metaflammasome components in the human brain: a role in dementia with Alzheimer's pathology?

(2016) Mariko Taga et al.   BRAIN PATHOLOGY

Caloric Restriction Leads to Browning of White Adipose Tissue through Type 2 Immune Signaling

(2016) Salvatore Fabbiano et al.   Cell Metabolism

Diabetes and Cognitive Impairment

(2016) Lindsay A. Zilliox et al.   Current Diabetes Reports

Energy metabolism and inflammation in brain aging and Alzheimer’s disease

(2016) Fei Yin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Danger-associated molecular patterns in Alzheimer’s disease

(2016) Carmen Venegas et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment

(2016) Meric Erikci Ertunc et al.   JOURNAL OF LIPID RESEARCH

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

(2016) H. Zhang et al.   SCIENCE

Dietary phytochemicals and neuro-inflammaging: from mechanistic insights to translational challenges

(2016) Sergio Davinelli et al.   Immunity & Ageing

c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer’s Disease

(2016) Ramon Yarza et al.   Frontiers in Pharmacology

Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance

(2016) S. Nishimoto et al.   Science Advances

The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy

(2016) Urmi Sengupta et al.   EBioMedicine

Damage-associated molecular patterns and their pathological relevance in diabetes mellitus

(2015) Jung Jae Shin et al.   AGEING RESEARCH REVIEWS

Impact of diabetes on cognitive function and brain structure

(2015) Amir Moheet et al.   Annals of the New York Academy of Sciences

Caloric restriction improves diabetes-induced cognitive deficits by attenuating neurogranin-associated calcium signaling in high-fat diet-fed mice

(2015) Hwajin Kim et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Increased expression of IL-18 in the serum and islets of type 1 diabetics

(2015) Robert Z. Harms et al.   MOLECULAR IMMUNOLOGY

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Genetic Ablation of CD38 Protects against Western Diet-Induced Exercise Intolerance and Metabolic Inflexibility

(2015) Shian-Huey Chiang et al.   PLoS One

Mechanisms Linking Inflammation to Insulin Resistance

(2015) Li Chen et al.   International Journal of Endocrinology

A journey into a Mediterranean diet and type 2 diabetes: a systematic review with meta-analyses

(2015) Katherine Esposito et al.   BMJ Open

Immune aging, dysmetabolism, and inflammation in neurological diseases

(2015) Michela Deleidi et al.   Frontiers in Neuroscience

H2S- and NO-Signaling Pathways in Alzheimer's Amyloid Vasculopathy: Synergism or Antagonism?

(2015) Alla B. Salmina et al.   Frontiers in Physiology

Insulin, Aging, and the Brain: Mechanisms and Implications

(2015) Abimbola A. Akintola et al.   Frontiers in Endocrinology

The nature, significance, and glucagon-like peptide-1 analog treatment of brain insulin resistance in Alzheimer's disease

(2014) Konrad Talbot et al.   Alzheimers & Dementia

Islet Amyloid Polypeptide (IAPP): A Second Amyloid in Alzheimer's Disease

(2014) Janelle Fawver et al.   Current Alzheimer Research

Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

(2014) F. G. De Felice et al.   DIABETES

Cortical hypermetabolism in MCI subjects: a compensatory mechanism?

(2014) A. Ashraf et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Nutrient patterns and brain biomarkers of Alzheimer’s disease in cognitively normal individuals

(2014) V. Berti et al.   Journal of Nutrition Health & Aging

High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice

(2014) Steven E. Arnold et al.   NEUROBIOLOGY OF DISEASE

Higher glucose levels associated with lower memory and reduced hippocampal microstructure

(2014)   NEUROLOGY

Glial Asthenia and Functional Paralysis

(2014) Alexei Verkhratsky et al.   NEUROSCIENTIST

Insulin Receptor Signaling in Normal and Insulin-Resistant States

(2014) J. Boucher et al.   Cold Spring Harbor Perspectives in Biology

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

(2013) Mychael V. Lourenco et al.   Cell Metabolism

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

(2013) Bing Gong et al.   NEUROBIOLOGY OF AGING

Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production

(2012) Arya E. Mehran et al.   Cell Metabolism

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Calorie Restriction with a High-Fat Diet Effectively Attenuated Inflammatory Response and Oxidative Stress-Related Markers in Obese Tissues of the High Diet Fed Rats

(2012) Seungae Park et al.   MEDIATORS OF INFLAMMATION

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Insulin resistance and AD—extending the translational path

(2012) Suzanne Craft   Nature Reviews Neurology

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

Metabolic Syndrome: Is Nlrp3 Inflammasome a Trigger or a Target of Insulin Resistance?

(2011) Marcelo A. Mori et al.   CIRCULATION RESEARCH

Low-Grade Hypothalamic Inflammation Leads to Defective Thermogenesis, Insulin Resistance, and Impaired Insulin Secretion

(2011) Ana Paula Arruda et al.   ENDOCRINOLOGY

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

(2011) Ying Liu et al.   JOURNAL OF PATHOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease

(2010) Lisa Mosconi et al.   Annals of the New York Academy of Sciences

Caloric Restriction in Humans: Impact on Physiological, Psychological, and Behavioral Outcomes

(2010) Leanne M. Redman et al.   ANTIOXIDANTS & REDOX SIGNALING

Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis

(2010) Takahisa Nakamura et al.   CELL

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

(2010) Rinke Stienstra et al.   Cell Metabolism

SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity

(2009) Takeshi Yoshizaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Amyloid Deposition and Inflammation in APPswe/PS1dE9 Mouse Model of Alzheimers Disease

(2009) Lingfei Ruan et al.   Current Alzheimer Research

FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer’s disease

(2009) Lisa Mosconi et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

(2009) M. Milanski et al.   JOURNAL OF NEUROSCIENCE

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Insulin Resistance and Alzheimers Disease: Molecular Links & Clinical Implications

(2008) Karen Neumann et al.   Current Alzheimer Research

FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice

(2008) Adama Kamagate et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammaging as a prodrome to Alzheimer's disease

(2008) Brian Giunta et al.   Journal of Neuroinflammation