Brain Insulin Resistance and Hippocampal Plasticity: Mechanisms and Biomarkers of Cognitive Decline

Impact of Caffeine Consumption on Type 2 Diabetes-Induced Spatial Memory Impairment and Neurochemical Alterations in the Hippocampus

(2019) João M. N. Duarte et al.   Frontiers in Neuroscience

Outcomes and clinical implications of intranasal insulin administration to the central nervous system

(2019) João C.P. Santiago et al.   EXPERIMENTAL NEUROLOGY

The Medial Septum Is Insulin Resistant in the AD Presymptomatic Phase: Rescue by Nerve Growth Factor-Driven IRS1 Activation

(2018) Valentina Sposato et al.   MOLECULAR NEUROBIOLOGY

Intranasal insulin in Alzheimer's disease: Food for thought

(2018) Colin D. Chapman et al.   NEUROPHARMACOLOGY

Pro- and Anti-inflammatory Effects of High Cholesterol Diet on Aged Brain

(2018) Yali Chen et al.   Aging and Disease

Obesity, Cognitive Functioning and Dementia: Back to the Future

(2018) Merrill F. Elias et al.   JOURNAL OF ALZHEIMERS DISEASE

Cognitive Function and Decline in Obesity

(2018) Kelly Stanek Sellbom et al.   JOURNAL OF ALZHEIMERS DISEASE

Type 2 diabetes mellitus, brain atrophy and cognitive decline in older people: a longitudinal study

(2018) Michele L. Callisaya et al.   DIABETOLOGIA

High fat diet increases cognitive decline and neuroinflammation in a model of orexin loss

(2018) C.M. Duffy et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Exosomal biomarkers of brain insulin resistance associated with regional atrophy in Alzheimer's disease

(2017) Roger J. Mullins et al.   HUMAN BRAIN MAPPING

Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer’s Disease Biomarkers: A Pilot Clinical Trial

(2017) Suzanne Craft et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers

(2017) Jason Pitt et al.   MOLECULAR BIOLOGY OF THE CELL

Alterations of Brain Energy Metabolism in Type 2 Diabetic Goto-Kakizaki Rats Measured In Vivo by 13C Magnetic Resonance Spectroscopy

(2017) Freya-Merret Girault et al.   NEUROTOXICITY RESEARCH

Insulin-Like Growth Factor (IGF) Binding Protein-2, Independently of IGF-1, Induces GLUT-4 Translocation and Glucose Uptake in 3T3-L1 Adipocytes

(2017) Biruhalem Assefa et al.   Oxidative Medicine and Cellular Longevity

Loss of Leptin-Induced Modulation of Hippocampal Synaptic Trasmission and Signal Transduction in High-Fat Diet-Fed Mice

(2017) Marco Mainardi et al.   Frontiers in Cellular Neuroscience

Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a

(2017) Matteo Spinelli et al.   Nature Communications

Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults

(2017) Mark A. Reger et al.   JOURNAL OF ALZHEIMERS DISEASE

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

Dementia onset, incidence and risk in type 2 diabetes: a matched cohort study with the Fremantle Diabetes Study Phase I

(2016) Wendy A. Davis et al.   DIABETOLOGIA

Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer’s disease

(2016) Edward J. Goetzl et al.   FASEB JOURNAL

Animal models of metabolic syndrome: a review

(2016) Sok Kuan Wong et al.   Nutrition & Metabolism

Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans

(2016) Stephanie Kullmann et al.   PHYSIOLOGICAL REVIEWS

A CREB-Sirt1-Hes1 Circuitry Mediates Neural Stem Cell Response to Glucose Availability

(2016) Salvatore Fusco et al.   Cell Reports

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

(2015) Massimo S. Fiandaca et al.   Alzheimers & Dementia

Impact of diabetes on cognitive function and brain structure

(2015) Amir Moheet et al.   Annals of the New York Academy of Sciences

Hippocampal Insulin Resistance Impairs Spatial Learning and Synaptic Plasticity

(2015) Claudia A. Grillo et al.   DIABETES

Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia

(2015) Saion Chatterjee et al.   DIABETES CARE

Clinically Relevant Cognitive Impairment in Middle-Aged Adults With Childhood-Onset Type 1 Diabetes

(2015) Karen A. Nunley et al.   DIABETES CARE

Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer’s disease

(2015) Dimitrios Kapogiannis et al.   FASEB JOURNAL

Reduced Uptake of 18F-FDG and 15O-H2O in Alzheimer'S Disease-Related Regions after Glucose Loading

(2015) Kenji Ishibashi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD

(2015) Antonella Tramutola et al.   JOURNAL OF NEUROCHEMISTRY

Type 2 diabetes mellitus and biomarkers of neurodegeneration

(2015) Chris Moran et al.   NEUROLOGY

The hippocampus in aging and disease: From plasticity to vulnerability

(2015) T. Bartsch et al.   NEUROSCIENCE

Insulin resistance in brain alters dopamine turnover and causes behavioral disorders

(2015) Andre Kleinridders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of Hippocampal Neural Plasticity by Glucose-Related Signaling

(2015) Marco Mainardi et al.   NEURAL PLASTICITY

Aberrant insulin signaling in Alzheimer's disease: current knowledge

(2015) Gaurav Bedse et al.   Frontiers in Neuroscience

Insulin can induce the expression of a memory-related synaptic protein through facilitating AMPA receptor endocytosis in rat cortical neurons

(2014) Tsan-Ju Chen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

SIRT1 suppresses self-renewal of adult hippocampal neural stem cells

(2014) C.-y. Ma et al.   DEVELOPMENT

Adult neurogenesis: mechanisms and functional significance

(2014) S. M. G. Braun et al.   DEVELOPMENT

Repurposing Diabetes Drugs for Brain Insulin Resistance in Alzheimer Disease

(2014) M. Yarchoan et al.   DIABETES

Association Between Polymorphisms of the Insulin-Degrading Enzyme Gene and Late-Onset Alzheimer Disease

(2014) Shitao Wang et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Insulin induces phosphorylation of the AMPA receptor subunit GluR1, reversed by ZIP, and over-expression of Protein Kinase M zeta, reversed by amyloid beta

(2014) Linda Adzovic et al.   JOURNAL OF NEUROCHEMISTRY

Early detection of Alzheimer's disease using PiB and FDG PET

(2014) Ann D. Cohen et al.   NEUROBIOLOGY OF DISEASE

High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice

(2014) Steven E. Arnold et al.   NEUROBIOLOGY OF DISEASE

Chronic Functional Bowel Syndrome Enhances Gut-Brain Axis Dysfunction, Neuroinflammation, Cognitive Impairment, and Vulnerability to Dementia

(2014) Mak Adam Daulatzai   NEUROCHEMICAL RESEARCH

Blood-brain barrier disruption: mechanistic links between Western diet consumption and dementia

(2014) Ted M. Hsu et al.   Frontiers in Aging Neuroscience

Evidence for altered transport of insulin across the blood–brain barrier in insulin-resistant humans

(2013) Martin Heni et al.   ACTA DIABETOLOGICA

Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi

(2013) Lai-Ling Du et al.   AGE

Calorie restriction alleviates the age-related decrease in neural progenitor cell division in the aging brain

(2013) June-Hee Park et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Insulin, cognition, and dementia

(2013) Brenna Cholerton et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

SIRT1 regulates the neurogenic potential of neural precursors in the adult subventricular zone and hippocampus

(2013) Sumiti Saharan et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Higher glucose levels associated with lower memory and reduced hippocampal microstructure

(2013) L. Kerti et al.   NEUROLOGY

Glucose Levels and Risk of Dementia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

The therapeutic potential of endogenous hippocampal stem cells for the treatment of neurological disorders

(2013) Chanel J. Taylor et al.   Frontiers in Cellular Neuroscience

Diabetes mellitus and risk of dementia: A meta-analysis of prospective observational studies

(2013) Kapil Gudala et al.   Journal of Diabetes Investigation

Hyperinsulinemia in rats causes impairment of spatial memory and learning with defects in hippocampal synaptic plasticity by involvement of postsynaptic mechanisms

(2013) Amer Kamal et al.   EXPERIMENTAL BRAIN RESEARCH

Systematic review of the body of evidence for the use of biomarkers in the diagnosis of dementia

(2012) Anna H. Noel-Storr et al.   Alzheimers & Dementia

Fueling and Imaging Brain Activation

(2012) Gerald A Dienel   ASN Neuro

Ghrelin Signaling in the Ventral Hippocampus Stimulates Learned and Motivational Aspects of Feeding via PI3K-Akt Signaling

(2012) Scott E. Kanoski et al.   BIOLOGICAL PSYCHIATRY

Sirt1: Def-eating senescence?

(2012) Salvatore Fusco et al.   CELL CYCLE

Brain response to calorie restriction

(2012) Salvatore Fusco et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Neuronal autophagy and neurodegenerative diseases

(2012) Jin H. Son et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Juvenile, but not adult exposure to high-fat diet impairs relational memory and hippocampal neurogenesis in mice

(2012) Chloe Boitard et al.   HIPPOCAMPUS

Updated Energy Budgets for Neural Computation in the Neocortex and Cerebellum

(2012) Clare Howarth et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

The many faces of insulin-like peptide signalling in the brain

(2012) Ana M. Fernandez et al.   NATURE REVIEWS NEUROSCIENCE

Insulin Receptor β-Subunit Haploinsufficiency Impairs Hippocampal Late-Phase LTP and Recognition Memory

(2012) Robert Nisticò et al.   NEUROMOLECULAR MEDICINE

Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice

(2011) Mario Merlini et al.   ACTA NEUROPATHOLOGICA

The association between systemic inflammation and cognitive performance in the elderly: the Sydney Memory and Ageing Study

(2011) Julian N. Trollor et al.   AGE

Sustained Activation of mTOR Pathway in Embryonic Neural Stem Cells Leads to Development of Tuberous Sclerosis Complex-Associated Lesions

(2011) Laura Magri et al.   Cell Stem Cell

IRS-2 Deficiency Impairs NMDA Receptor-Dependent Long-term Potentiation

(2011) Eduardo D. Martín et al.   CEREBRAL CORTEX

Insulin sensitivity of the human brain

(2011) Caroline Ketterer et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb

(2011) Tomoko Kuwabara et al.   EMBO Molecular Medicine

Vascular Changes in Rat Hippocampus following a High Saturated Fat and Cholesterol Diet

(2011) Linnea R Freeman et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Insulin receptor substrate 2 is a negative regulator of memory formation

(2011) E. E. Irvine et al.   LEARNING & MEMORY

Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila

(2011) Rita Sousa-Nunes et al.   NATURE

Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway

(2011) Hyunkyung Jeong et al.   NATURE MEDICINE

CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

(2011) Judith Y. Altarejos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways

(2011) Cheng-Che Lee et al.   NEUROPHARMACOLOGY

Insulin Promotes Glycogen Storage and Cell Proliferation in Primary Human Astrocytes

(2011) Martin Heni et al.   PLoS One

A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction

(2011) S. Fusco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage

(2011) Loredana Stoica et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

When is adult hippocampal neurogenesis necessary for learning? Evidence from animal research

(2011) Estela Castilla-Ortega et al.   REVIEWS IN THE NEUROSCIENCES

Vascular Contributions to Cognitive Impairment and Dementia

(2011) Philip B. Gorelick et al.   STROKE

Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes

(2010) Laura D. Baker et al.   ARCHIVES OF NEUROLOGY

Nutrition-Responsive Glia Control Exit of Neural Stem Cells from Quiescence

(2010) James M. Chell et al.   CELL

Different patterns of memory impairments accompany short- and longer-term maintenance on a high-energy diet.

(2010) Scott E. Kanoski et al.   JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL LEARNING AND COGNITION

Diabetes-Associated SorCS1 Regulates Alzheimer's Amyloid-  Metabolism: Evidence for Involvement of SorL1 and the Retromer Complex

(2010) R. F. Lane et al.   JOURNAL OF NEUROSCIENCE

Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease

(2010) Dimitrios Kapogiannis et al.   LANCET NEUROLOGY

The hippocampus in major depression: evidence for the convergence of the bench and bedside in psychiatric research?

(2010) G MacQueen et al.   MOLECULAR PSYCHIATRY

Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance

(2010) Ewan C. McNay et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Hippocampal long-term depression is required for the consolidation of spatial memory

(2010) Y. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FoxO3 Regulates Neural Stem Cell Homeostasis

(2009) Valérie M. Renault et al.   Cell Stem Cell

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

(2009) Antonino Belfiore et al.   ENDOCRINE REVIEWS

Deterioration of physical performance and cognitive function in rats with short-term high-fat feeding

(2009) Andrew J. Murray et al.   FASEB JOURNAL

Blockade of insulin-like growth factor-I has complex effects on structural plasticity in the hippocampus

(2009) Erica R. Glasper et al.   HIPPOCAMPUS

Enhanced NMDA Receptor-Mediated Synaptic Transmission, Enhanced Long-Term Potentiation, and Impaired Learning and Memory in Mice Lacking IRSp53

(2009) M.-H. Kim et al.   JOURNAL OF NEUROSCIENCE

Analgesic, learning and memory and anxiolytic effects of insulin in mice

(2008) Moses A. Akanmu et al.   BEHAVIOURAL BRAIN RESEARCH

Cognitive Dysfunction and Diabetes Mellitus

(2008) Christopher T. Kodl et al.   ENDOCRINE REVIEWS

Inhibition of γ-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes

(2008) Robyn A. Sharples et al.   FASEB JOURNAL

Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats

(2008) Alexis M. Stranahan et al.   HIPPOCAMPUS

High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice

(2008) Lakshmi Thirumangalakudi et al.   JOURNAL OF NEUROCHEMISTRY

Sirt1 contributes critically to the redox-dependent fate of neural progenitors

(2008) Timour Prozorovski et al.   NATURE CELL BIOLOGY

Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons

(2008) Alexis M Stranahan et al.   NATURE NEUROSCIENCE

Effects of triglycerides, obesity, and starvation on ghrelin transport across the blood–brain barrier

(2008) William A. Banks et al.   PEPTIDES

Genetic variant in the glucose transporter type 2 is associated with higher intakes of sugars in two distinct populations

(2008) Karen M. Eny et al.   PHYSIOLOGICAL GENOMICS