Nano versus Molecular: Optical Imaging Approaches to Detect and Monitor Tumor Hypoxia

Activatable Molecular Probes for Second Near-Infrared Fluorescence, Chemiluminescence, and Photoacoustic Imaging

(2020) Kanyi Pu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Quantitative Mapping of Liver Hypoxia in Living Mice Using Time‐Resolved Wide‐Field Phosphorescence Lifetime Imaging

(2020) Yawei Liu et al.   Advanced Science

Modulation of Intracellular Oxygen Pressure by Dual-Drug Nanoparticles to Enhance Photodynamic Therapy

(2019) Ya-Tong Fan et al.   ADVANCED FUNCTIONAL MATERIALS

A Noncovalent Fluorescence Turn-on Strategy for Hypoxia Imaging

(2019) Dong-Sheng Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular landmarks of tumor hypoxia across cancer types

(2019) Vinayak Bhandari et al.   NATURE GENETICS

Merger of dynamic two-photon and phosphorescence lifetime microscopy reveals dependence of lymphocyte motility on oxygen in solid and hematological tumors

(2019) Mateusz Rytelewski et al.   Journal for ImmunoTherapy of Cancer

Hypoxia Patterns in Primary and Metastatic Prostate Cancer Environments

(2019) Santosh Kumar Bharti et al.   NEOPLASIA

Hydrogen Sulfide Oxidation: Adaptive Changes in Mitochondria of SW480 Colorectal Cancer Cells upon Exposure to Hypoxia

(2019) Francesca Malagrinò et al.   Oxidative Medicine and Cellular Longevity

Comparison of phosphorescent agents for noninvasive sensing of tumor oxygenation via Cherenkov-excited luminescence imaging

(2019) Jennifer R. Shell et al.   JOURNAL OF BIOMEDICAL OPTICS

Oxyphor 2P: A High-Performance Probe for Deep-Tissue Longitudinal Oxygen Imaging

(2019) Tatiana V. Esipova et al.   Cell Metabolism

Recent Developments in Nanosensors for Imaging Applications in Biological Systems

(2019) Guoxin Rong et al.   Annual Review of Analytical Chemistry

A Semiconducting Polymer Nano-prodrug for Hypoxia-Activated Photodynamic Cancer Therapy

(2019) Dong Cui et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lipid-Based DNA Therapeutics – Hallmarks of Non-Viral Gene Delivery

(2019) Jonas Buck et al.   ACS Nano

Delivery Aspects of CRISPR/Cas for in Vivo Genome Editing

(2019) Danny Wilbie et al.   ACCOUNTS OF CHEMICAL RESEARCH

A Hypoxia‐Responsive Albumin‐Based Nanosystem for Deep Tumor Penetration and Excellent Therapeutic Efficacy

(2019) Guangbao Yang et al.   ADVANCED MATERIALS

Nanophotosensitizer-engineered Salmonella bacteria with hypoxia targeting and photothermal-assisted mutual bioaccumulation for solid tumor therapy

(2019) Fuming Chen et al.   BIOMATERIALS

Volumetric optoacoustic imaging unveils high-resolution patterns of acute and cyclic hypoxia in a murine model of breast cancer

(2019) Avihai Ron et al.   CANCER RESEARCH

Optical-resolution photoacoustic microscopy of oxygen saturation with nonlinear compensation

(2019) Chao Liu et al.   Biomedical Optics Express

Kinetics-Based Measurement of Hypoxia in Living Cells and Animals Using an Acetoxymethyl Ester Chemiluminescent Probe

(2019) Lucas S. Ryan et al.   ACS Sensors

High-throughput, label-free, single-cell photoacoustic microscopy of intratumoral metabolic heterogeneity

(2019) Pengfei Hai et al.   Nature Biomedical Engineering

Gated Mesoporous Silica Nanocarriers for Hypoxia-Responsive Cargo Release

(2019) Qi Yan et al.   ACS Applied Materials & Interfaces

Towards more accurate bioimaging of drug nanocarriers: turning aggregation-caused quenching into a useful tool

(2019) Jianping Qi et al.   ADVANCED DRUG DELIVERY REVIEWS

Naphthalimides in fluorescent imaging of tumor hypoxia – An up-to-date review

(2019) Rashmi Kumari et al.   BIOORGANIC CHEMISTRY

A near-infrared phosphorescent nanoprobe enables quantitative, longitudinal imaging of tumor hypoxia dynamics during radiotherapy

(2019) Xianchuang Zheng et al.   CANCER RESEARCH

Azodyes as markers for tumor hypoxia imaging and therapy: An up-to-date review

(2019) Rashmi Kumari et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Simultaneous photoacoustic imaging of intravascular and tissue oxygenation

(2019) Maomao Chen et al.   OPTICS LETTERS

In vivo imaging of hypoxia generation stimulated by testosterone using a micelle-based near-infrared fluorescent probe

(2019) Yanxia Nan et al.   SENSORS AND ACTUATORS B-CHEMICAL

Photoacoustic-based oxygen saturation assessment of murine femoral bone marrow in a preclinical model of leukemia

(2019) Cayla Wood et al.   Photoacoustics

Gold nanomaterials as key suppliers in biological and chemical sensing, catalysis, and medicine

(2019) Mojtaba Falahati et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Acute vs. Chronic vs. Cyclic Hypoxia: Their Differential Dynamics, Molecular Mechanisms, and Effects on Tumor Progression

(2019) Saxena et al.   Biomolecules

In vivo three-dimensional evaluation of tumour hypoxia in nasopharyngeal carcinomas using FMT-CT and MSOT

(2019) Wenhui Huang et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

The 2019 Nobel Prize honors fundamental discoveries in hypoxia response

(2019) Javid Moslehi et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-Activated PEGylated Conditional Aptamer/Antibody for Cancer Imaging with Improved Specificity

(2019) Fang Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches

(2019) Karen G. de la Cruz-López et al.   Frontiers in Oncology

In Vivo Photoacoustic Lifetime Based Oxygen Imaging with Tumor Targeted G2 Polyacrylamide Nanosonophores

(2019) Janggun Jo et al.   ACS Nano

Nanoaggregate Probe for Breast Cancer Metastasis through Multispectral Optoacoustic Tomography and Aggregation-Induced NIR-I/II Fluorescence Imaging

(2019) Juan Ouyang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Unsymmetrical Squaraine‐Based Activatable Probe for Imaging Lymphatic Metastasis by Responding to Tumor Hypoxia with MSOT and Aggregation‐Enhanced Fluorescent Imaging

(2019) Yi Lin et al.   CHEMISTRY-A EUROPEAN JOURNAL

Phosphorescent Starburst Pt(II) Porphyrins as Bifunctional Therapeutic Agents for Tumor Hypoxia Imaging and Photodynamic Therapy

(2018) Zhuang Lv et al.   ACS Applied Materials & Interfaces

Photophysical Tuning of N-Oxide-Based Probes Enables Ratiometric Photoacoustic Imaging of Tumor Hypoxia

(2018) Hailey J. Knox et al.   ACS Chemical Biology

A Magnetofluorescent Carbon Dot Assembly as an Acidic H2 O2 -Driven Oxygenerator to Regulate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy

(2018) Qingyan Jia et al.   ADVANCED MATERIALS

Two-photon fluorescent probe for detection of nitroreductase and hypoxia-specific microenvironment of cancer stem cell

(2018) Yajing Liu et al.   ANALYTICA CHIMICA ACTA

Azoreductase and Target Simultaneously Activated Fluorescent Monitoring for Cytochrome c Release under Hypoxia

(2018) Jianru Tang et al.   ANALYTICAL CHEMISTRY

Advanced photosensitizer activation strategies for smarter photodynamic therapy beacons

(2018) Benjamin M Luby et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Glucose & oxygen exhausting liposomes for combined cancer starvation and hypoxia-activated therapy

(2018) Rui Zhang et al.   BIOMATERIALS

Long-Lived Emissive Probes for Time-Resolved Photoluminescence Bioimaging and Biosensing

(2018) Kenneth Yin Zhang et al.   CHEMICAL REVIEWS

Challenges and opportunities in clinical translation of biomedical optical spectroscopy and imaging

(2018) Brian C. Wilson et al.   JOURNAL OF BIOMEDICAL OPTICS

Photoacoustic imaging to assess pixel-based sO2 distributions in experimental prostate tumors

(2018) Alina L. Bendinger et al.   JOURNAL OF BIOMEDICAL OPTICS

Dual-Phosphorescent Iridium(III) Complexes Extending Oxygen Sensing from Hypoxia to Hyperoxia

(2018) Kenneth Yin Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ir(iii) complex-based oxygen imaging of living cells and ocular fundus with a gated ICCD camera

(2018) H. Akiyama et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

A platinum-porphine/poly(perfluoroether) film oxygen tension sensor for noninvasive local monitoring of cellular oxygen metabolism using phosphorescence lifetime imaging

(2018) Yihua Zhao et al.   SENSORS AND ACTUATORS B-CHEMICAL

Engineering of a near-infrared fluorescent probe for real-time simultaneous visualization of intracellular hypoxia and induced mitophagy

(2018) Yongchao Liu et al.   Chemical Science

Advances in highly doped upconversion nanoparticles

(2018) Shihui Wen et al.   Nature Communications

Photoacoustic Imaging as an Early Biomarker of Radio Therapeutic Efficacy in Head and Neck Cancer

(2018) Laurie. J. Rich et al.   Theranostics

Construction of a hypoxia responsive upconversion nanosensor for tumor imaging by fluorescence resonance energy transfer from carbon dots to ruthenium complex

(2018) Di Yang et al.   Journal of Materials Chemistry B

Dimeric BODIPY-loaded liposomes for dual hypoxia marker imaging and activatable photodynamic therapy against tumors

(2018) Huachao Chen et al.   Journal of Materials Chemistry B

A hypoxia-specific and mitochondria-targeted anticancer theranostic agent with high selectivity for cancer cells

(2018) Mingxing Hu et al.   Journal of Materials Chemistry B

The hypoxic tumour microenvironment

(2018) Varvara Petrova et al.   Oncogenesis

Metabolic Symbiosis and Immunomodulation: How Tumor Cell-Derived Lactate May Disturb Innate and Adaptive Immune Responses

(2018) Alexandre Morrot et al.   Frontiers in Oncology

Maps of in vivo oxygen pressure with submillimetre resolution and nanomolar sensitivity enabled by Cherenkov-excited luminescence scanned imaging

(2018) Brian W. Pogue et al.   Nature Biomedical Engineering

Carbonic Anhydrase IX-Targeted Near-Infrared Dye for Fluorescence Imaging of Hypoxic Tumors

(2018) Sakkarapalayam M. Mahalingam et al.   BIOCONJUGATE CHEMISTRY

Tumor hypoxia directed multimodal nanotherapy for overcoming drug resistance in renal cell carcinoma and reprogramming macrophages

(2018) Hashem O. Alsaab et al.   BIOMATERIALS

Azo-based small molecular hypoxia responsive theranostic for tumor-specific imaging and therapy

(2018) Ying Zhou et al.   JOURNAL OF CONTROLLED RELEASE

Fluorescence Modulation of CdTe Nanowire by Azobenzene Photochromic switches

(2018) Shomaila Saeed et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY

Self-Assembly of a Monochromophore-Based Polymer Enables Unprecedented Ratiometric Tracing of Hypoxia

(2018) Shuwen Wang et al.   ADVANCED MATERIALS

A Highly Sensitive Chemiluminescent Probe for Detecting Nitroreductase and Imaging in Living Animals

(2018) Jinyu Sun et al.   ANALYTICAL CHEMISTRY

Azoreductase-Responsive Nanoprobe for Hypoxia-Induced Mitophagy Imaging

(2018) Dandan Ma et al.   ANALYTICAL CHEMISTRY

Confinement of Singlet Oxygen Generated from Ruthenium Complex-Based Oxygen Sensor in the Pores of Mesoporous Silica Nanoparticles

(2018) Natsuko Kitajima et al.   BIOCONJUGATE CHEMISTRY

Compact Conjugated Polymer Dots with Covalently Incorporated Metalloporphyrins for Hypoxia Bioimaging

(2018) Xiaofeng Fang et al.   CHEMBIOCHEM

Small Molecule Optoacoustic Contrast Agents: An Unexplored Avenue for Enhancing In Vivo Imaging

(2018) Matt Laramie et al.   MOLECULES

Exosome-like Nanozyme Vesicles for H2O2-Responsive Catalytic Photoacoustic Imaging of Xenograft Nasopharyngeal Carcinoma

(2018) Hui Ding et al.   NANO LETTERS

Real-Time Imaging of Free Radicals for Mitochondria-Targeting Hypoxic Tumor Therapy

(2018) Xiao-Qiang Wang et al.   NANO LETTERS

Exploration of melanoma metastases in mice brains using endogenous contrast photoacoustic imaging

(2017) Jonathan Lavaud et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

H2O2-responsive liposomal nanoprobe for photoacoustic inflammation imaging and tumor theranostics via in vivo chromogenic assay

(2017) Qian Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A universal fluorogenic switch for Fe(ii) ion based on N-oxide chemistry permits the visualization of intracellular redox equilibrium shift towards labile iron in hypoxic tumor cells

(2017) Tasuku Hirayama et al.   Chemical Science

A bioreducible N-oxide-based probe for photoacoustic imaging of hypoxia

(2017) Hailey J. Knox et al.   Nature Communications

Photoacoustic Imaging in Oxygen Detection

(2017) Fei Cao et al.   Applied Sciences-Basel

Hypoxia and hydrogen sulfide differentially affect normal and tumor-derived vascular endothelium

(2017) Serena Bianco et al.   Redox Biology

Successively activatable ultrasensitive probe for imaging tumour acidity and hypoxia

(2017) Xianchuang Zheng et al.   Nature Biomedical Engineering

Revising Intramolecular Photoinduced Electron Transfer (PET) from First-Principles

(2016) Daniel Escudero   ACCOUNTS OF CHEMICAL RESEARCH

Theranostic Liposomes with Hypoxia-Activated Prodrug to Effectively Destruct Hypoxic Tumors Post-Photodynamic Therapy

(2016) Liangzhu Feng et al.   ACS Nano

Digitization of Endocytic pH by Hybrid Ultra-pH-Sensitive Nanoprobes at Single-Organelle Resolution

(2016) Yiguang Wang et al.   ADVANCED MATERIALS

In Vivo Chemiluminescent Imaging Agents for Nitroreductase and Tissue Oxygenation

(2016) Jian Cao et al.   ANALYTICAL CHEMISTRY

Hypoxia-responsive nanocarriers for cancer imaging and therapy: recent approaches and future perspectives

(2016) Thavasyappan Thambi et al.   CHEMICAL COMMUNICATIONS

4-Nitroimidazole-3-hydroxyflavone conjugate as a fluorescent probe for hypoxic cells

(2016) Weipei Feng et al.   DYES AND PIGMENTS

Nanoparticle–liver interactions: Cellular uptake and hepatobiliary elimination

(2016) Yi-Nan Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Two-Photon Absorbing Phosphorescent Metalloporphyrins: Effects of π-Extension and Peripheral Substitution

(2016) Tatiana V. Esipova et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mitochondrial Nitroreductase Activity Enables Selective Imaging and Therapeutic Targeting

(2016) Arnaud Chevalier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bacteria-Mediated Hypoxia-Specific Delivery of Nanoparticles for Tumors Imaging and Therapy

(2016) Cheng-Hung Luo et al.   NANO LETTERS

A practical guide to photoacoustic tomography in the life sciences

(2016) Lihong V Wang et al.   NATURE METHODS

Lifetime-weighted photoacoustic imaging

(2016) A Forbrich et al.   Journal of Optics

Effective Targeted Photothermal Ablation of Multidrug Resistant Bacteria and Their Biofilms with NIR-Absorbing Gold Nanocrosses

(2016) Choon Peng Teng et al.   Advanced Healthcare Materials

Imaging Mass Spectrometry Revealed the Accumulation Characteristics of the 2-Nitroimidazole-Based Agent “Pimonidazole” in Hypoxia

(2016) Yukiko Masaki et al.   PLoS One

A novel injectable BRET-based in vivo imaging probe for detecting the activity of hypoxia-inducible factor regulated by the ubiquitin-proteasome system

(2016) Takahiro Kuchimaru et al.   Scientific Reports

Versatile Conjugated Polymer Nanoparticles for High-Resolution O2 Imaging in Cells and 3D Tissue Models

(2015) Ruslan I. Dmitriev et al.   ACS Nano

Tracking Cancer Metastasis In Vivo by Using an Iridium-Based Hypoxia-Activated Optical Oxygen Nanosensor

(2015) Xianchuang Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Self-Sensing Porphysomes for Fluorescence-Guided Photothermal Therapy

(2015) Kenneth K. Ng et al.   BIOCONJUGATE CHEMISTRY

A Lactate-Induced Response to Hypoxia

(2015) Dong Chul Lee et al.   CELL

A turn-on fluorescent probe for tumor hypoxia imaging in living cells

(2015) Qi Cai et al.   CHEMICAL COMMUNICATIONS

A novel family of fluorescent hypoxia sensors reveal strong heterogeneity in tumor hypoxia at the cellular level

(2015) R. Erapaneedi et al.   EMBO JOURNAL

Micelle-Encapsulated Quantum Dot-Porphyrin Assemblies as in Vivo Two-Photon Oxygen Sensors

(2015) Christopher M. Lemon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evaluation of CAIX and CAXII Expression in Breast Cancer at Varied O2 Levels: CAIX is the Superior Surrogate Imaging Biomarker of Tumor Hypoxia

(2015) Narges K. Tafreshi et al.   MOLECULAR IMAGING AND BIOLOGY

Opportunities and challenges of radiotherapy for treating cancer

(2015) Dörthe Schaue et al.   Nature Reviews Clinical Oncology

Interaction of Hydrogen Sulfide with Oxygen Sensing under Hypoxia

(2015) Bo Wu et al.   Oxidative Medicine and Cellular Longevity

New ways to image and target tumour hypoxia and its molecular responses

(2015) Ludwig J. Dubois et al.   RADIOTHERAPY AND ONCOLOGY

Fluorescent/phosphorescent dual-emissive conjugated polymer dots for hypoxia bioimaging

(2015) Qiang Zhao et al.   Chemical Science

Hypoxia-specific ultrasensitive detection of tumours and cancer cells in vivo

(2015) Xianchuang Zheng et al.   Nature Communications

A Phosphorescent Iridium(III) Complex-Modified Nanoprobe for Hypoxia Bioimaging Via Time-Resolved Luminescence Microscopy

(2015) Wen Lv et al.   Advanced Science

Multifunctional Phosphorescent Conjugated Polymer Dots for Hypoxia Imaging and Photodynamic Therapy of Cancer Cells

(2015) Xiaobo Zhou et al.   Advanced Science

Combining Optical Reporter Proteins with Different Half-lives to Detect Temporal Evolution of Hypoxia and Reoxygenation in Tumors

(2015) Pierre Danhier et al.   NEOPLASIA

Two-Photon Antenna-Core Oxygen Probe with Enhanced Performance

(2014) Emmanuel Roussakis et al.   ANALYTICAL CHEMISTRY

The tumour hypoxia marker pimonidazole reflects a transcriptional programme associated with aggressive prostate cancer

(2014) H B Ragnum et al.   BRITISH JOURNAL OF CANCER

Imaging tumour hypoxia with positron emission tomography

(2014) I N Fleming et al.   BRITISH JOURNAL OF CANCER

Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics

(2014) Guanying Chen et al.   CHEMICAL REVIEWS

Nanoscale optical probes for cellular imaging

(2014) Hui Xu et al.   CHEMICAL SOCIETY REVIEWS

Nanoscopic optical rulers beyond the FRET distance limit: fundamentals and applications

(2014) Paresh Chandra Ray et al.   CHEMICAL SOCIETY REVIEWS

Direct measurement of local oxygen concentration in the bone marrow of live animals

(2014) Joel A. Spencer et al.   NATURE

Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing

(2014) Adam J Shuhendler et al.   NATURE BIOTECHNOLOGY

Azo-Sulforhodamine Dyes: A Novel Class of Broad Spectrum Dark Quenchers

(2014) Arnaud Chevalier et al.   ORGANIC LETTERS

The Relationship among Hypoxia, Proliferation, and Outcome in Patients with De Novo Glioblastoma: A Pilot Study

(2014) Sydney M. Evans et al.   Translational Oncology

Ultra-sensitive optical oxygen sensors for characterization of nearly anoxic systems

(2014) Philipp Lehner et al.   Nature Communications

Brain Tissue Oxygen Monitoring in Neurocritical Care

(2014) Michael A. De Georgia   JOURNAL OF INTENSIVE CARE MEDICINE

Hydrogen peroxide sensing, signaling and regulation of transcription factors

(2014) H. Susana Marinho et al.   Redox Biology

Imaging Tumor Hypoxia to Advance Radiation Oncology

(2013) Chen-Ting Lee et al.   ANTIOXIDANTS & REDOX SIGNALING

In vivophotoacoustic lifetime imaging of tumor hypoxia in small animals

(2013) Qi Shao et al.   JOURNAL OF BIOMEDICAL OPTICS

Fluorescence resonance energy transfer between NaYF4:Yb,Tm upconversion nanoparticles and gold nanorods: Near-infrared responsive biosensor for streptavidin

(2013) Shuang Zhang et al.   JOURNAL OF LUMINESCENCE

In vivo imaging of brain metabolism activity using a phosphorescent oxygen-sensitive probe

(2013) Vassiliy Tsytsarev et al.   JOURNAL OF NEUROSCIENCE METHODS

Universal Dark Quencher Based on “Clicked” Spectrally Distinct Azo Dyes

(2013) Arnaud Chevalier et al.   ORGANIC LETTERS

Catabolism of Exogenous Lactate Reveals It as a Legitimate Metabolic Substrate in Breast Cancer

(2013) Kelly M. Kennedy et al.   PLoS One

Ratiometric Molecular Sensor for Monitoring Oxygen Levels in Living Cells

(2012) Toshitada Yoshihara et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tumour Hypoxia Affects the Responsiveness of Cancer Cells to Chemotherapy and Promotes Cancer Progression

(2012) Jean-Philippe Cosse et al.   Anti-Cancer Agents in Medicinal Chemistry

Carbonic anhydrase IX is a predictive marker of doxorubicin resistance in early-stage breast cancer independent of HER2 and TOP2A amplification

(2012) A S Betof et al.   BRITISH JOURNAL OF CANCER

Bioconjugatable Azo-Based Dark-Quencher Dyes: Synthesis and Application to Protease-Activatable Far-Red Fluorescent Probes

(2012) Arnaud Chevalier et al.   CHEMISTRY-A EUROPEAN JOURNAL

Lifetime-based photoacoustic oxygen sensing in vivo

(2012) Aniruddha Ray et al.   JOURNAL OF BIOMEDICAL OPTICS

Reversible Off–On Fluorescence Probe for Hypoxia and Imaging of Hypoxia–Normoxia Cycles in Live Cells

(2012) Shodai Takahashi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Advanced Fluorescence Microscopy Techniques—FRAP, FLIP, FLAP, FRET and FLIM

(2012) Hellen C. Ishikawa-Ankerhold et al.   MOLECULES

Intracellular O2 Sensing Probe Based on Cell-Penetrating Phosphorescent Nanoparticles

(2011) Andreas Fercher et al.   ACS Nano

In Vivo Profiling of Hypoxic Gene Expression in Gliomas Using the Hypoxia Marker EF5 and Laser-capture Microdissection

(2011) D. Marotta et al.   CANCER RESEARCH

Lactate: A Metabolic Key Player in Cancer

(2011) F. Hirschhaeuser et al.   CANCER RESEARCH

Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis

(2011) Michael P Lisanti et al.   CELL CYCLE

Ratiometric luminescent molecular oxygen sensors based on uni-luminophores of C⁁N Pt(ii)(acac) complexes that show intense visible-light absorption and balanced fluorescence/phosphorescence dual emission

(2011) Yifan Liu et al.   CHEMICAL COMMUNICATIONS

A highly selective space-folded photo-induced electron transfer fluorescent probe for carbonic anhydrase isozymes IX and its applications for biological imaging

(2011) Shenyi Zhang et al.   CHEMICAL COMMUNICATIONS

Photoacoustic tomography: fundamentals, advances and prospects

(2011) Junjie Yao et al.   Contrast Media & Molecular Imaging

Mechanisms of Resistance to Photodynamic Therapy

(2011) A. Casas et al.   CURRENT MEDICINAL CHEMISTRY

Acute Versus Chronic Hypoxia: Why a Simplified Classification is Simply Not Enough

(2011) Christine Bayer et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Label-free oxygen-metabolic photoacoustic microscopy in vivo

(2011) Junjie Yao et al.   JOURNAL OF BIOMEDICAL OPTICS

Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia

(2011) Aude Carreau et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Porphyrin FRET Acceptors for Apoptosis Induction and Monitoring

(2011) Jonathan F. Lovell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Simultaneous two-photon imaging of oxygen and blood flow in deep cerebral vessels

(2011) Jérôme Lecoq et al.   NATURE MEDICINE

In vivo integrated photoacoustic and confocal microscopy of hemoglobin oxygen saturation and oxygen partial pressure

(2011) Yu Wang et al.   OPTICS LETTERS

Target-Cancer-Cell-Specific Activatable Fluorescence Imaging Probes: Rational Design and in Vivo Applications

(2010) Hisataka Kobayashi et al.   ACCOUNTS OF CHEMICAL RESEARCH

Renal clearance in drug discovery and development: molecular descriptors, drug transporters and disease state

(2010) Bo Feng et al.   Expert Opinion on Drug Metabolism & Toxicology

Optical imaging of tumor hypoxia dynamics

(2010) Gregory M. Palmer et al.   JOURNAL OF BIOMEDICAL OPTICS

Hypoxia-Sensitive Fluorescent Probes forin VivoReal-Time Fluorescence Imaging of Acute Ischemia

(2010) Kazuki Kiyose et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Going deeper than microscopy: the optical imaging frontier in biology

(2010) Vasilis Ntziachristos   NATURE METHODS

Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue

(2010) Sava Sakadžić et al.   NATURE METHODS

Significance of nitroimidazole compounds and hypoxia-inducible factor-1 for imaging tumor hypoxia

(2009) Shinae Kizaka-Kondoh et al.   CANCER SCIENCE

Fluorescence Quenching by Photoinduced Electron Transfer: A Reporter for Conformational Dynamics of Macromolecules

(2009) Sören Doose et al.   CHEMPHYSCHEM

Near-infrared fluorescence: application to in vivo molecular imaging

(2009) Scott A Hilderbrand et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Photoinduced electron transfer in panchromatic zinc phthalocyanine–azobenzene dyad

(2009) Yizhu Liu et al.   INORGANIC CHEMISTRY COMMUNICATIONS

Isomerization and fluorescence characteristics of sterically hindered azobenzene derivatives

(2009) Mina Han et al.   JOURNAL OF LUMINESCENCE

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

A dual-emissive-materials design concept enables tumour hypoxia imaging

(2009) Guoqing Zhang et al.   NATURE MATERIALS

Photoacoustic probing of fluorophore excited state lifetime with application to oxygen sensing

(2008) Shai Ashkenazi et al.   JOURNAL OF BIOMEDICAL OPTICS

Immunohistochemical Detection of HIF-1α and CAIX in Advanced Head-and-Neck Cancer

(2008) Matthias Kappler et al.   STRAHLENTHERAPIE UND ONKOLOGIE