Journal
NANO LETTERS
Volume 18, Issue 11, Pages 6804-6811Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.8b02670
Keywords
Free-radical; real-time imaging; mitochondria-targeting; hypoxia; tumor therapy
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Funding
- National Natural Science Foundation of China [51690152, 21721005]
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Free radicals have emerged as new-type and promising candidates for hypoxic tumor treatment, and further study of their therapeutic mechanism by real-time imaging is of great importance to explore their biomedical applications. Herein, we present a smart free-radical generator AuNC-V057-TPP for hypoxic tumor therapy; the AuNC-V057-TPP not only exhibits good therapeutic effect under both hypoxic and normoxic conditions but also can monitor the release of free radicals in real-time both in vitro and in vivo. What is more, with the mitochondria-targeting ability, the AuNC-V057-TPP is demonstrated with improved antitumor efficacy through enhanced free radical level in mitochondria, which leads to mitochondrial membrane damage and ATP production reduction and finally induces cancer cell apoptosis.
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