Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis

Aging: past, present and future

(2016) Mikhail V. Blagosklonny et al.   Aging-US

Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: Similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling"

(2016) Stephanos Pavlides et al.   Aging-US

Oxidative damage DNA: 8-oxoGua and 8-oxodG as molecular markers of cancer

(2013) Krzysztof Roszkowski et al.   MEDICAL SCIENCE MONITOR

FDG-PET for the diagnosis of fever of unknown origin: a Japanese multi-center study

(2011) Kazuo Kubota et al.   ANNALS OF NUCLEAR MEDICINE

Mitochondrial oxidative stress mediates induction of autophagy and hypertrophy in angiotensin-II treated mouse hearts

(2011) Dao-Fu Dai et al.   Autophagy

Mitochondrial targeted catalase suppresses invasive breast cancer in mice

(2011) Jorming Goh et al.   BMC CANCER

Mitochondrial oxidative stress drives tumor progression and metastasis: should we use antioxidants as a key component of cancer treatment and prevention?

(2011) Federica Sotgia et al.   BMC Medicine

Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment

(2011) Casey Trimmer et al.   CANCER BIOLOGY & THERAPY

Mitochondrial Stress Signals Revise an Old Aging Theory

(2011) Dong Kyun Woo et al.   CELL

Towards a new “stromal-based” classification system for human breast cancer prognosis and therapy

(2011) Agnieszka K. Witkiewicz et al.   CELL CYCLE

An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease spread and epithelial Akt activation

(2011) Dolores Di Vizio et al.   CELL CYCLE

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

Increasing healthy lifespan by suppressing aging in our lifetime: Preliminary proposal 

(2011) Mikhail V Blagosklonny   CELL CYCLE

Molecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancers

(2011) Agnieszka K. Witkiewicz et al.   CELL CYCLE

Cytokine production and inflammation drive autophagy in the tumor microenvironment

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Understanding the metabolic basis of drug resistance

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Accelerated aging in the tumor microenvironment

(2011) Michael P Lisanti et al.   CELL CYCLE

Ketones and lactate increase cancer cell “stemness,” driving recurrence, metastasis and poor clinical outcome in breast cancer

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Evidence for a stromal-epithelial “lactate shuttle” in human tumors

(2011) Diana Whitaker-Menezes et al.   CELL CYCLE

Prognostic Utility of Anti-EBV Antibody Testing for Defining NPC Risk among Individuals from High-Risk NPC Families

(2011) K. J. Yu et al.   CLINICAL CANCER RESEARCH

Mitochondrial reactive oxygen species drive proinflammatory cytokine production: Figure 1.

(2011) Edwina Naik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pathogenesis and biomarkers of carcinogenesis in ulcerative colitis

(2011) Sigrun Thorsteinsdottir et al.   Nature Reviews Gastroenterology & Hepatology

Redox biology and gastric carcinogenesis: the role ofHelicobacter pylori

(2011) Osamu Handa et al.   REDOX REPORT

The impact of caveolin protein expression in tumor stroma on prognosis of breast cancer

(2011) Ja Seung Koo et al.   TUMOR BIOLOGY

Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue

(2010) Nicolai Treiber et al.   AGING CELL

Electrochemical biosensor for the detection of H2O2 from living cancer cells based on ZnO nanosheets

(2010) Qi Rui et al.   ANALYTICA CHIMICA ACTA

Is Dysfunction of Caveolin-1 a Link Between Systemic Sclerosis and Breast Cancer, Opening a Window on Both Etiologies?

(2010) Niansong Qian et al.   ARCHIVES OF MEDICAL RESEARCH

Vitamin D: a novel therapeutic approach for keloid, an in vitro analysis

(2010) G.Y. Zhang et al.   BRITISH JOURNAL OF DERMATOLOGY

Pulmonary tuberculosis increases the risk of lung cancer

(2010) Chen-Yi Wu et al.   CANCER

Stromal caveolin-1 levels predict early DCIS progression to invasive breast cancer

(2010) Agnieszka K. Witkiewicz et al.   CANCER BIOLOGY & THERAPY

Mitochondrial ROS and radiation induced transformation in mouse embryonic fibroblasts

(2010) Changbin Du et al.   CANCER BIOLOGY & THERAPY

Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers

(2010) Agnieszka K. Witkiewicz et al.   CANCER BIOLOGY & THERAPY

Understanding the "lethal" drivers of tumor-stroma co-evolution

(2010) Michael P. Lisanti et al.   CANCER BIOLOGY & THERAPY

NADPH oxidase 4 is an oncoprotein localized to mitochondria

(2010) Kelly A. Graham et al.   CANCER BIOLOGY & THERAPY

AACR Centennial Series: The Biology of Cancer Metastasis: Historical Perspective

(2010) J. E. Talmadge et al.   CANCER RESEARCH

The reverse Warburg Effect: Glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts

(2010) Gloria Bonuccelli et al.   CELL CYCLE

The autophagic tumor stroma model of cancer

(2010) Stephanos Pavlides et al.   CELL CYCLE

Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: Evidence for stromal-epithelial metabolic coupling

(2010) Gemma Migneco et al.   CELL CYCLE

Ketones and lactate “fuel” tumor growth and metastasis

(2010) Gloria Bonuccelli et al.   CELL CYCLE

HIF1-alpha functions as a tumor promoter in cancer-associated fibroblasts, and as a tumor suppressor in breast cancer cells

(2010) Barbara Chiavarina et al.   CELL CYCLE

The autophagic tumor stroma model of cancer or “battery-operated tumor growth”

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Autophagy in cancer associated fibroblasts promotes tumor cell survival

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the “reverse Warburg effect”: A transcriptional informatics analysis with validation

(2010) Stephanos Pavlides et al.   CELL CYCLE

Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: Implications for breast cancer and DCIS therapy with autophagy inhibitors

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide

(2010) Jelena Kasapović et al.   CLINICAL BIOCHEMISTRY

Oxidative stress promotes myofibroblast differentiation and tumour spreading

(2010) Aurore Toullec et al.   EMBO Molecular Medicine

FDG-PET/CT in infections: the imaging method of choice?

(2010) Andor W. J. M. Glaudemans et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Pathology and epidemiology of HPV infection in females

(2010) Margaret Stanley   GYNECOLOGIC ONCOLOGY

18F-FDG PET/CT for Detection of Metastatic Infection in Gram-Positive Bacteremia

(2010) F. J. Vos et al.   JOURNAL OF NUCLEAR MEDICINE

Potential of Noninvasive Serial Assessment of Acute Renal Allograft Rejection by 18F-FDG PET to Monitor Treatment Efficiency

(2010) S. Reuter et al.   JOURNAL OF NUCLEAR MEDICINE

The impact of redox and thiol status on the bone marrow: Pharmacological intervention strategies

(2010) Christina L. Grek et al.   PHARMACOLOGY & THERAPEUTICS

In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter

(2010) G. C. Van de Bittner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Live Imaging of Innate Immune Cell Sensing of Transformed Cells in Zebrafish Larvae: Parallels between Tumor Initiation and Wound Inflammation

(2010) Yi Feng et al.   PLOS BIOLOGY

Catalase delivery for inhibiting ROS-mediated tissue injury and tumor metastasis

(2009) Makiya Nishikawa et al.   ADVANCED DRUG DELIVERY REVIEWS

Quis Custodiet Ipsos Custodies

(2009) Cyrus M. Ghajar et al.   AMERICAN JOURNAL OF PATHOLOGY

Stromal Cell Expression of Caveolin-1 Predicts Outcome in Breast Cancer

(2009) Erica K. Sloan et al.   AMERICAN JOURNAL OF PATHOLOGY

An Absence of Stromal Caveolin-1 Expression Predicts Early Tumor Recurrence and Poor Clinical Outcome in Human Breast Cancers

(2009) Agnieszka K. Witkiewicz et al.   AMERICAN JOURNAL OF PATHOLOGY

Glutathione peroxidases in different stages of carcinogenesis

(2009) Regina Brigelius-Flohé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Fibroblast Growth Factors and Epidermal Growth Factor Cooperate with Oocyte-Derived Members of the TGFbeta Superfamily to Regulate Spry2 mRNA Levels in Mouse Cumulus Cells1

(2009) Koji Sugiura et al.   BIOLOGY OF REPRODUCTION

Ras-induced reactive oxygen species promote growth factor-independent proliferation in human CD34+ hematopoietic progenitor cells

(2009) P. S. Hole et al.   BLOOD

Increased H2O2 level in exhaled breath condensate in primary breast cancer patients

(2009) Robert A. Stolarek et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Prevention of pulmonary metastasis from subcutaneous tumors by binary system-based sustained delivery of catalase

(2009) Kenji Hyoudou et al.   JOURNAL OF CONTROLLED RELEASE

18F-FDG PET for Semiquantitative Evaluation of Acute Allograft Rejection and Immunosuppressive Therapy Efficacy in Rat Models of Liver Transplantation

(2009) A. B. Tsuji et al.   JOURNAL OF NUCLEAR MEDICINE

Elevated Levels of Oxidative Stress Markers in Exhaled Breath Condensate

(2009) Hiang Ping Chan et al.   Journal of Thoracic Oncology

Differential apoptosis markers in human keloids and hypertrophic scars fibroblasts

(2009) Bruna De Felice et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

(2009) Philipp Niethammer et al.   NATURE

Non-Invasive Imaging of Acute Renal Allograft Rejection in Rats Using Small Animal 18F-FDG-PET

(2009) Stefan Reuter et al.   PLoS One

Mouse Oocyte Control of Granulosa Cell Development and Function: Paracrine Regulation of Cumulus Cell Metabolism

(2009) You-Qiang Su et al.   SEMINARS IN REPRODUCTIVE MEDICINE

Increased Susceptibility to Oxidant-Mediated Tissue Injury and Peritoneal Fibrosis in Acatalasemic Mice

(2008) Naomi Fukuoka et al.   AMERICAN JOURNAL OF NEPHROLOGY

Genomic and proteomic profiling of oxidative stress response in human diploid fibroblasts

(2008) Lifang Xie et al.   BIOGERONTOLOGY

Reactive oxygen species in tumor metastasis

(2008) Makiya Nishikawa   CANCER LETTERS

Enterococcus faecalis Induces Aneuploidy and Tetraploidy in Colonic Epithelial Cells through a Bystander Effect

(2008) X. Wang et al.   CANCER RESEARCH

Hydrogen peroxide-mediated nuclear factor κB activation in both liver and tumor cells during initial stages of hepatic metastasis

(2008) Yuki Kobayashi et al.   CANCER SCIENCE

Dynamic 18F-fluoride small animal PET to noninvasively assess renal function in rats

(2008) Uta Schnöckel et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Exhaled breath analysis: Novel approach for early detection of lung cancer

(2008) Hiang Ping Chan et al.   LUNG CANCER

Cancer Chemoprevention Through Dietary Antioxidants: Progress and Promise

(2007) Naghma Khan et al.   ANTIOXIDANTS & REDOX SIGNALING

Human Skin Keloid Fibroblasts Display Bioenergetics of Cancer Cells

(2007) Annette S. Vincent et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY