Article
Cell Biology
Katharina M. Eyme, Alessandro Sammarco, Roshani Jha, Hayk Mnatsakanyan, Caline Pechdimaljian, Litia Carvalho, Rudolph Neustadt, Charlotte Moses, Ahmad Alnasser, Daniel F. Tardiff, Baolong Su, Kevin J. Williams, Steven J. Bensinger, Chee Yeun Chung, Christian E. Badr
Summary: Deregulated de novo lipid synthesis (DNLS) is a potential target for therapeutic intervention in glioblastoma (GBM), but the mechanisms underlying susceptibility to DNLS-targeted therapies are unknown and brain-penetrant inhibitors of DNLS are lacking.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Chiami Moyama, Mitsugu Fujita, Shota Ando, Keiko Taniguchi, Hiromi Ii, Seisuke Tanigawa, Naoya Hashimoto, Susumu Nakata
Summary: The study revealed that Stat5b co-localizes with Lgr5 in GBM tissues, and its expression in GSCs is regulated by hypoxia and the Wnt pathway. Inhibition of Stat5b induced apoptosis and blocked entry into S-phase in the cell cycle, suggesting that Stat5b may be a promising therapeutic target for attacking GSCs.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Yongjun Kou, Feng Geng, Deliang Guo
Summary: This review summarizes the recent progress in understanding lipid metabolism regulation in GBM and discusses novel strategies to induce lipotoxicity in tumor cells by disrupting lipid storage. These findings provide new directions for treating GBM.
Article
Biotechnology & Applied Microbiology
Seisuke Tanigawa, Mitsugu Fujita, Chiami Moyama, Shota Ando, Hiromi Ii, Yasushi Kojima, Teruaki Fujishita, Masahiro Aoki, Hayato Takeuchi, Takumi Yamanaka, Yoshinobu Takahashi, Naoya Hashimoto, Susumu Nakata
Summary: Recent research has identified Gli2 as a key player in glioblastoma, affecting the Hedgehog and Wnt pathways and contributing to the maintenance of GSCs, suggesting it as a potential therapeutic target for glioblastoma treatment.
CANCER GENE THERAPY
(2021)
Article
Clinical Neurology
Jack M. Shireman, Fatemeh Atashi, Gina Lee, Eunus S. Ali, Miranda R. Saathoff, Cheol H. Park, Sol Savchuk, Shivani Baisiwala, Jason Miska, Maciej S. Lesniak, C. David James, Roger Stupp, Priya Kumthekar, Craig M. Horbinski, Issam Ben-Sahra, Atique U. Ahmed
Summary: Glioblastoma is a primary brain cancer with a near 100% recurrence rate. A molecular circuit involving the interaction between ARL13B and IMPDH2 has been identified, which affects the efficacy of chemotherapy.
Article
Chemistry, Multidisciplinary
Jianhuan Qi, Fan Mo, Ni A. An, Tingwei Mi, Jiaxin Wang, Jun-Tian Qi, Xiangshang Li, Boya Zhang, Longkuo Xia, Yingfei Lu, Gaoying Sun, Xinyue Wang, Chuan-Yun Li, Baoyang Hu
Summary: The study identified a human-specific de novo gene, SP0535, which is preferentially expressed in the ventricular zone of the human fetal brain and plays an important role in cortical development and function. Knockout of SP0535 in human embryonic stem cell-derived cortical organoids compromises their growth and neurogenesis. In SP0535 transgenic mice, expression of SP0535 induces fetal cortex expansion and formation of sulci and gyri-like structures. SP0535 also promotes unique proliferation and differentiation of progenitors and neurons in the mouse cortex. SP0535 TG adult mice exhibit improved cognitive ability and working memory. Mechanistically, SP0535 interacts with the membrane protein Na+/K+ ATPase subunit alpha-1 (ATP1A1) and releases Src from the ATP1A1-Src complex, promoting cell proliferation.
Article
Oncology
Cecile Alanio, Zev A. Blinder, Renee B. Chang, MacLean P. Nasrallah, Devora Delman, Joey H. Li, Oliver Y. Tang, Logan Y. Zhang, Jiasi Vicky Zhang, E. John Wherry, Donald M. O. Rourke, Gregory L. Beatty
Summary: The study found that T cells in the perivascular regions of recurrent GBM were enriched and activated, and their presence was associated with outcomes, indicating that these T cells may be potential therapeutic targets.
CANCER IMMUNOLOGY RESEARCH
(2022)
Review
Cell Biology
Ainhoa Hernandez, Marta Domenech, Ana M. Munoz-Marmol, Cristina Carrato, Carmen Balana
Summary: This review discusses how genetic alterations and metabolism pathways in Glioblastoma (GBM) influence tumor immune cells and the tumor microenvironment, and provides an overview of the strategies being tested.
Review
Oncology
Akihiro Inoue, Takanori Ohnishi, Masahiro Nishikawa, Yoshihiro Ohtsuka, Kosuke Kusakabe, Hajime Yano, Junya Tanaka, Takeharu Kunieda
Summary: Recurrence in glioblastoma may be caused by surviving glioma stem-like cells expressing high levels of CD44, which promote invasion and proliferation of tumor cells via various signaling pathways. Severe hypoxia activates genes related to cell invasion, whereas moderate hypoxia activates genes related to cell proliferation.
Article
Virology
See-Chi Lee, Nenavath Gopal Naik, Dora Tombacz, Gabor Gulyas, Balazs Kakuk, Zsolt Boldogkoi, Kevin Hall, Bernadett Papp, Steeve Boulant, Zsolt Toth
Summary: This study investigates the impact of different stress conditions on the primary infection of oncogenic Kaposi's sarcoma-associated herpesvirus (KSHV). The results show that hypoxia induces viral lytic gene expression and replication in biologically relevant cell types, which typically establish latency under normoxia. Hypoxia reduces repressive heterochromatin and promotes transcriptionally permissive chromatin formation on the incoming viral DNA, leading to a switch from latency to lytic infection.
JOURNAL OF VIROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Solene Collet, Jean-Sebastien Guillamo, David Hassanein Berro, Ararat Chakhoyan, Jean-Marc Constans, Emmanuele Lechapt-Zalcman, Jean-Michel Derlon, Mathieu Hatt, Dimitris Visvikis, Stephane Guillouet, Cecile Perrio, Myriam Bernaudin, Samuel Valable
Summary: Conventional MRI plays a crucial role in managing high-grade glioma patients, but multiparametric MRI and PET tracers provide additional information to characterize tumor metabolism and heterogeneity. This study focused on evaluating proliferation, hypervascularization, and hypoxia in glioblastoma patients, finding marked differences in tracer uptake and rCBV maps between individuals, with certain tumor regions extending beyond the contrast enhancement volume.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Urology & Nephrology
Avril Lusty, R. Christopher Doiron, Christopher M. Booth, Marlo Whitehead, D. Robert Siemens
Summary: The study aimed to compare the survival outcomes of patients with muscle-invasive bladder cancer, and found that after adjustment, there were no clinically significant differences in survival rates between de novo cases and progressors undergoing radical cystectomy.
JOURNAL OF UROLOGY
(2021)
Article
Oncology
Hye Jin Yun, Min Li, Dong Guo, So Mi Jeon, Su Hwan Park, Je Sun Lim, Su Bin Lee, Rui Liu, Linyong Du, Seok-Ho Kim, Tae Hwan Shin, Seong-il Eyun, Yun-Yong Park, Zhimin Lu, Jong-Ho Lee
Summary: This study reveals that enhanced glucose-derived de novo serine biosynthesis is a critical metabolic feature of GBM cells under metabolic stress, and highlights the potential to target SSP for treating human GBM.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Wei Tan, Pei Jiang, Wanjun Zhang, Zhaohua Hu, Shaofeng Lin, Lulu Chen, Yingge Li, Changmin Peng, Zhuqing Li, Aihua Sun, Yali Chen, Wenge Zhu, Yu Xue, Yi Yao, Xiangpan Li, Qibin Song, Fuchu He, Weijie Qin, Huadong Pei
Summary: This study demonstrates that the posttranslational modification of SRPK2 by O-GlcNAc plays a key role in regulating de novo lipogenesis by controlling pre-mRNA splicing. O-GlcNAcylation of SRPK2 at a nuclear localization signal and subsequent nuclear import through binding to importin a reveals a general mechanism for protein nuclear import in cells. This work highlights the important role of O-GlcNAc in posttranscriptional regulation and suggests importin a as a reader of an O-GlcNAcylated nuclear localization signal.
Article
Multidisciplinary Sciences
Shuting Li, Chia-Wen Lu, Elia C. Diem, Wang Li, Melanie Guderian, Marc Lindenberg, Friederike Kruse, Manuela Buettner, Stefan Floess, Markus R. Winny, Robert Geffers, Hans-Hermann Richnow, Wolf-Rainer Abraham, Guntram A. Grassl, Matthias Lochner
Summary: This study investigates the impact of de novo fatty acid synthesis on intestinal epithelial cells and reveals that inhibiting this process leads to the loss of crypt structures and a decline in intestinal epithelial stem cells. The findings highlight the importance of cellular lipogenesis in sustaining stem cell function and provide insights for colon cancer therapy.
NATURE COMMUNICATIONS
(2022)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Cameron J. Koch, Sydney M. Evans
JOURNAL OF NUCLEAR MEDICINE
(2015)
Review
Radiology, Nuclear Medicine & Medical Imaging
Cameron J. Koch, Sydney M. Evans
SEMINARS IN NUCLEAR MEDICINE
(2015)
Article
Oncology
Sydney M. Evans, Mary Putt, Xiang-Yang Yang, Robert A. Lustig, Maria Martinez-Lage, Dewight Williams, Arati Desai, Ronald Wolf, Steven Brem, Cameron J. Koch
JOURNAL OF NEURO-ONCOLOGY
(2016)
Article
Oncology
Lilie L. Lin, Antti Silvoniemi, James B. Stubbs, Ramesh Rengan, Sami Suilamo, Olof Solin, Chaitanya Divgi, Olli Eskola, Jonathan M. Sorger, Michael G. Stabin, Alexander Kachur, Stephen M. Hahn, Tove J. Gronroos, Sarita Forsback, Sydney M. Evans, Cameron J. Koch, Heikki Minn
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2012)
Article
Oncology
Diane Marotta, Jayashree Karar, W. Timothy Jenkins, Monika Kumanova, Kevin W. Jenkins, John W. Tobias, Donald Baldwin, Artemis Hatzigeorgiou, Panagiotis Alexiou, Sydney M. Evans, Rodolfo Alarcon, Amit Maity, Cameron Koch, Constantinos Koumenis
Article
Radiology, Nuclear Medicine & Medical Imaging
Cameron J. Koch, Joshua S. Scheuermann, Chaitanya Divgi, Kevin D. Judy, Alexander V. Kachur, Richard Freifelder, Janet S. Reddin, Joel Karp, James B. Stubbs, Stephen M. Hahn, Jason Driesbaugh, Deborah Smith, Susan Prendergast, Sydney M. Evans
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2010)
Article
Biology
Cameron J. Koch, Anne L. Shuman, Walter T. Jenkins, Alexander V. Kachur, Joel S. Karp, Richard Freifelder, William R. Dolbier, Sydney M. Evans
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2009)
Letter
Oncology
Sydney M. Evans, Cameron J. Koch
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2011)
Letter
Oncology
Cameron J. Koch, Sydney M. Evans
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2011)
Review
Neurosciences
Nathan J. Ranalli, Sydney M. Evans, Kevin D. Ju
NEUROSURGERY QUARTERLY
(2009)
Article
Multidisciplinary Sciences
George J. Cerniglia, Nabendu Pore, Jeff H. Tsai, Susan Schultz, Rosemarie Mick, Regine Choe, Xiaoman Xing, Turgut Durduran, Arjun G. Yodh, Sydney M. Evans, Cameron J. Koch, Stephen M. Hahn, Harry Quon, Chandra M. Sehgal, William M. F. Lee, Amit Maity
Article
Multidisciplinary Sciences
Zheng Lao, Catherine J. Kelly, Xiang-Yang Yang, W. Timothy Jenkins, Erik Toorens, Tapan Ganguly, Sydney M. Evans, Cameron J. Koch
Article
Oncology
Cameron J. Koch, Robert A. Lustig, Xiang-Yang Yang, Walter T. Jenkins, Ronald L. Wolf, Maria Martinez-Lage, Arati Desai, Dewight Williams, Sydney M. Evans
TRANSLATIONAL ONCOLOGY
(2014)
Letter
Veterinary Sciences
Lili Duda, John R. Lewis, Sarah H. Kagan, Sydney M. Evans
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
(2009)
Article
Oncology
Xiaofan Pu, Chaolei Zhang, Guoping Ding, Hongpeng Gu, Yang Lv, Tao Shen, Tianshu Pang, Liping Cao, Shengnan Jia
Summary: This study demonstrated the potential utility of the sEV-miRNA d-signature in the diagnosis of PDAC via machine learning methods. A novel sEV biomarker, miR-664a-3p, was identified for the diagnosis of PDAC. It can also potentially promote angiogenesis and metastasis, provide insight into PDAC pathogenesis, and reveal novel regulators of this disease.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Jiaping Wang, Zhijuan Xu, Yanli Lai, Yanli Zhang, Ping Zhang, Qitian Mu, Shujun Yang, Yongcheng Sun, Lixia Sheng, Guifang Ouyang
Summary: This study demonstrates the significance of PD-1 in EBV-infected lymphoma cells. Silencing PD-1 enhances the tumor targeting effect of EBV-specific killer T cells on B lymphocytes and attenuates the immune escape effect.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Qiliang Peng, Jialong Tao, Yingjie Xu, Yi Shen, Yong Wang, Yang Jiao, Yiheng Mao, Yaqun Zhu, Yulong Liu, Ye Tian
Summary: This study investigates the potential role of lipid metabolism-associated genes (LMAGs) in neoadjuvant chemoradiotherapy (nCRT) and immunotherapy for rectal cancer. The results suggest that the SREBF2 gene is a highly predictive factor for nCRT in rectal cancer and is associated with favorable prognosis. SREBF2 is also closely associated with immune cell infiltration and immunotherapy-related genes.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Shiquan Li, Nan Zhang, Yongping Yang, Tongjun Liu
Summary: This study investigated the potential molecular mechanism of SPDEF in immune evasion of colorectal cancer (CRC) and found that it suppresses immune evasion by activating CCL28 through the modulation of M2 polarization of macrophages. These findings provide a new research direction and potential therapeutic target for immunotherapy in CRC.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Manas Sehgal, Soundharya Ramu, Joel Markus Vaz, Yogheshwer Raja Ganapathy, Srinath Muralidharan, Sankalpa Venkatraghavan, Mohit Kumar Jolly
Summary: This study investigates the relationship between gene expression patterns and phenotypic plasticity and heterogeneity in colorectal cancer (CRC). The results demonstrate the interconnectedness between different Consensus Molecular Subtypes (CMS) of CRC and specific phenotypes such as epithelial and mesenchymal characteristics. Additionally, the study reveals correlations between metabolic pathways and phenotypic scores, as well as between PD-L1 activity and mesenchymal phenotype. Single-cell RNA sequencing analysis further confirms the heterogeneity of different CMS subtypes. These findings have important implications for understanding CRC heterogeneity and developing targeted therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yutong Zou, Siyao Guo, Yan Liao, Weidong Chen, Ziyun Chen, Junkai Chen, Lili Wen, Xianbiao Xie
Summary: This study found that ceramide metabolism is associated with the progression and clinical outcome of osteosarcoma by analyzing data from osteosarcoma patients. The gene ST3GAL1 plays an important role in osteosarcoma, regulating the tumor immune microenvironment and affecting T cell function. It may become a new target for the treatment of osteosarcoma.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Chuanhui Chen, Mengzhi Wan, Xiong Peng, Qing Zhang, Yu Liu
Summary: This study examines the function and mechanism of the ceRNA network centered around GPR37 in LUAD. The findings show that high expression of GPR37 in LUAD tissue samples is associated with poor prognosis, and it may regulate the expression of downstream target genes by competitively binding to lncRNA DLEU1 and miR-4458.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Junping Li, Hong Hu, Jinping He, Yuling Hu, Manting Liu, Bihui Cao, Dongni Chen, Xiaodie Ye, Jian Zhang, Zhiru Zhang, Wen Long, Hui Lian, Deji Chen, Likun Chen, Lili Yang, Zhenfeng Zhang
Summary: Sequential administration of CDC7 inhibitor XL413 after carboplatin enhances the chemotherapeutic effect of carboplatin on ovarian cancer cells, possibly by inhibiting homologous recombination repair activity and increasing the accumulation of chemotherapy-induced DNA damage.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Madison Catalanotto, Joel Markus Vaz, Camille Abshire, Reneau Youngblood, Min Chu, Herbert Levine, Mohit Kumar Jolly, Ana -Maria Dragoi
Summary: The study demonstrates that loss of FLASH in cancer cells leads to a hybrid E/M phenotype with high epithelial scores, suggesting FLASH acts as a repressor of the epithelial phenotype. Additionally, FLASH expression is inversely correlated with the epithelial score and subsets of mesenchymal markers are distinctly up-regulated in FLASH, NPAT, or SLBP-depleted cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Xiaorui Wang, Na Li, Minying Zheng, Yongjun Yu, Shiwu Zhang
Summary: Adipocytes are derived from pluripotent mesenchymal stem cells and histone modifications play a key role in their differentiation. Recent studies have shown that cancer stem cells can differentiate into adipocytes, reducing the malignancy of cancer cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Hana Q. Sadida, Alanoud Abdulla, Sara Al Marzooqi, Sheema Hashem, Muzafar A. Macha, Ammira S. Al-Shabeeb Akil, Ajaz A. Bhat
Summary: Cancer heterogeneity and drug resistance are major obstacles to effective cancer treatment, and epigenetic modifications play a pivotal role in these processes. This review explores essential epigenetic modifications, including DNA methylation, histone modifications, and chromatin remodeling, and discusses their complex contributions to cancer biology. However, the interplay of epigenetic and genetic changes in cancer cells presents unique challenges that must be addressed to fully exploit the potential of epigenetic modifications.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Pedro De Marchi, Leticia Ferro Leal, Luciane Sussuchi da Silva, Rodrigo de Oliveira Cavagna, Flavio Augusto Ferreira da Silva, Vinicius Duval da Silva, Eduardo C. A. da Silva, Augusto O. Saito, Vladmir C. Cordeiro de Lima, Rui Manuel Reis
Summary: The TIS and IFN-gamma signatures are predictive biomarkers for identifying NSCLC patients who could potentially benefit from immune checkpoint inhibitor therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Giovanni Marchi, Anna Rajavuori, Mai T. N. Nguyen, Kaisa Huhtinen, Sinikka Oksa, Sakari Hietanen, Sampsa Hautaniemi, Johanna Hynninen, Jaana Oikkonen
Summary: The study shows that ctDNA can adequately represent high-grade serous ovarian carcinoma (HGSC), and the mutations observed at relapse suggest personalized therapy options.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yuncang Yuan, Jiawei Fan, Dandan Liang, Shijie Wang, Xu Luo, Yongjie Zhu, Nan Liu, Tingxiu Xiang, Xudong Zhao
Summary: This study demonstrates that csGRP78-directed CAR-T cells can selectively kill pancreatic cancer cells, and the combination with chemotherapy enhances cytotoxicity.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Niyati Piplani, Tanusri Roy, Neha Saxena, Shamik Sen
Summary: The glycocalyx, a protective barrier surrounding cells, has been found to play a role in cancer cell proliferation, survival, and metastasis. However, its function in maintaining DNA/nuclear integrity during migration through dense matrices has not been explored. This study shows that the bulkiness of the glycocalyx is inversely associated with nuclear stresses, and highlights its mechanical role in shielding migration-associated stresses.
TRANSLATIONAL ONCOLOGY
(2024)