Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 132, Issue 45, Pages 15846-15848Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja105937q
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [22000006, 20689001, 21659204]
- New Energy and Industrial Technology Development Organization (NEDO) of Japan
- Sankyo Foundation of Life Science
- JST, ERATO in Tokyo [160-8582]
- Grants-in-Aid for Scientific Research [20689001, 21659204] Funding Source: KAKEN
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Based on the findings that the azo functional group has excellent properties as the hypoxia-sensor moiety, we developed hypoxia-sensitive near-infrared fluorescent probes in which a large fluorescence increase is triggered by the cleavage of an azo bond. The probes were used for fluorescence imaging of hypoxic cells and real-time monitoring of ischemia in the liver and kidney of live mice.
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