Differentiated Caco-2 cell models in food-intestine interaction study: Current applications and future trends

Therapeutic potential of algal natural products against metabolic syndrome: A review of recent developments

(2020) Ilekuttige Priyan Shanura Fernando et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Importance of digestive mucus and mucins for designing new functional food ingredients

(2020) Mounira Kebouchi et al.   FOOD RESEARCH INTERNATIONAL

Yeasts as probiotics: Mechanisms, outcomes, and future potential

(2020) Swastik Sen et al.   FUNGAL GENETICS AND BIOLOGY

S-layer protein 2 of Lactobacillus crispatus 2029, its structural and immunomodulatory characteristics and roles in protective potential of the whole bacteria against foodborne pathogens

(2020) Vyacheslav M. Abramov et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Lactobacillus fermentum (MTCC-5898) supplementation renders prophylactic action against Escherichia coli impaired intestinal barrier function through tight junction modulation

(2020) Mohd Iqbal Bhat et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Indirectly stimulation of DCs by Ganoderma atrum polysaccharide in intestinal-like Caco-2/DCs co-culture model based on RNA-seq

(2020) Xiaomeng Ding et al.   Journal of Functional Foods

Sources, formulations, advanced delivery and health benefits of probiotics

(2020) Ume Roobab et al.   Current Opinion in Food Science

Establishment and Application of Peristaltic Human Gut-Vessel Microsystem for Studying Host–Microbial Interaction

(2020) Bolin Jing et al.   Frontiers in Bioengineering and Biotechnology

The role of gut microbiota in bone homeostasis

(2020) Jyotirmaya Behera et al.   BONE

Regulatory effects of Ganoderma atrum polysaccharides on LPS-induced inflammatory macrophages model and intestinal-like Caco-2/macrophages co-culture inflammation model

(2020) Xiaoyi Hu et al.   FOOD AND CHEMICAL TOXICOLOGY

In vitro gastrointestinal absorption of red wine anthocyanins – Impact of structural complexity and phase II metabolization

(2020) Fuliang Han et al.   FOOD CHEMISTRY

Flavonoids modulate tight junction barrier functions in hyperglycemic human intestinal Caco-2 cells

(2020) Sapna Sharma et al.   NUTRITION

Effect of sodium caseinate and vitamin A complexation on bioaccessibility and bioavailability of vitamin A in Caco-2 cells

(2019) Seema Rana et al.   FOOD RESEARCH INTERNATIONAL

Modulation of Intestinal Epithelial Permeability and Mucin mRNA (MUC2, MUC5AC, and MUC5B) Expression and Protein Secretion in Caco-2/HT29-MTX Co-cultures Exposed to Aflatoxin M1, Ochratoxin A, and Zearalenone Individually or Collectively

(2019) ChenQing Wu et al.   TOXICOLOGY LETTERS

Probiotic Bacillus subtilis CW14 reduces disruption of the epithelial barrier and toxicity of ochratoxin A to Caco-2 cells

(2019) Mengxue Peng et al.   FOOD AND CHEMICAL TOXICOLOGY

SEDDS for intestinal absorption of insulin: Application of Caco-2 and Caco-2/HT29 co-culture monolayers and intra-jejunal instillation in rats

(2019) Jingying Liu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Bioavailability of bioactive peptides derived from food proteins across the intestinal epithelial membrane: A review

(2019) Qingbiao Xu et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Soluble eggshell membrane protein-loaded chitosan/fucoidan nanoparticles for treatment of defective intestinal epithelial cells

(2019) Meng-Chen Lee et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Intestinal epithelial barrier functions in ageing

(2019) Jacopo J.V. Branca et al.   AGEING RESEARCH REVIEWS

In vitro assessment of CeO2 nanoparticles effects on intestinal microvilli morphology

(2019) Joan Cabellos et al.   TOXICOLOGY IN VITRO

Biocontrol strategies of antibiotic-resistant, highly pathogenic bacteria and fungi with potential bioterrorism risks: Bacteriophage in focus

(2019) Munirah Fahad Aldayel   JOURNAL OF KING SAUD UNIVERSITY SCIENCE

Dendrobium huoshanense polysaccharide regulates intestinal lamina propria immune response by stimulation of intestinal epithelial cells via toll-like receptor 4

(2019) Song-Zi Xie et al.   CARBOHYDRATE POLYMERS

Gut Homeostasis: Active Migration of Intestinal Epithelial Cells in Tissue Renewal

(2019) Aglaja Kopf et al.   CURRENT BIOLOGY

Inhibition of Escherichia coli adhesion to human intestinal Caco-2 cells by probiotic candidate Lactobacillus plantarum strain L15

(2019) Behrooz Alizadeh Behbahani et al.   MICROBIAL PATHOGENESIS

Oral Pharmacokinetics of a Chitosan-Based Nano- Drug Delivery System of Interferon Alpha

(2019) Julieta C. Imperiale et al.   Polymers

High-fat diet-derived free fatty acids impair the intestinal immune system and increase sensitivity to intestinal epithelial damage

(2019) Shohei Tanaka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hydroxytyrosol encapsulated in biocompatible water-in-oil microemulsions: How the structure affects in vitro absorption

(2019) Evgenia Mitsou et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Candida albicans SC5314 inhibits NLRP3/NLRP6 inflammasome expression and dampens human intestinal barrier activity in Caco-2 cell monolayer model

(2019) Xiaqiong Mao et al.   CYTOKINE

Enhancing the oral bioavailability of curcumin using solid lipid nanoparticles

(2019) Choongjin Ban et al.   FOOD CHEMISTRY

Estimation of the iron bioavailability in green vegetables using an in vitro digestion/Caco-2 cell model

(2019) I. Rodriguez-Ramiro et al.   FOOD CHEMISTRY

Pea protein based vitamin D nanoemulsions: Fabrication, stability and in vitro study using Caco-2 cells

(2019) Niharika Walia et al.   FOOD CHEMISTRY

Experimental confounding factors affecting stability, transport and metabolism of flavanols and hydroxycinnamic acids in Caco-2 cells

(2019) M. Gómez-Juaristi et al.   FOOD RESEARCH INTERNATIONAL

Astragaloside IV attenuates sepsis-induced intestinal barrier dysfunction via suppressing RhoA/NLRP3 inflammasome signaling

(2019) Shuhua Xie et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Adhesive mechanism of different Salmonella fimbrial adhesins

(2019) Tayyab Rehman et al.   MICROBIAL PATHOGENESIS

Flavonol glycosides of Rosa multiflora regulates intestinal barrier function through inhibiting claudin expression in differentiated Caco-2 cells

(2019) Satoshi Endo et al.   NUTRITION RESEARCH

Differences between phytosterols with different structures in regulating cholesterol synthesis, transport and metabolism in Caco-2 cells

(2019) Lanlan Yuan et al.   Journal of Functional Foods

Drug metabolizing enzymes and their inhibitors' role in cancer resistance

(2018) Shelly Pathania et al.   BIOMEDICINE & PHARMACOTHERAPY

Food synergies for improving bioavailability of micronutrients from plant foods

(2018) K. Madhavan Nair et al.   FOOD CHEMISTRY

Charge and hydrophobicity of casein peptides influence transepithelial transport and bioavailability

(2018) Bo Wang et al.   FOOD CHEMISTRY

Iron bioavailability from food fortification to precision nutrition. A review

(2018) Ruth Blanco-Rojo et al.   Innovative Food Science & Emerging Technologies

Recent advances in the bioaccessibility and bioavailability of carotenoids and effects of other dietary lipophiles

(2018) Rachel E. Kopec et al.   JOURNAL OF FOOD COMPOSITION AND ANALYSIS

The Intestinal Epithelium: Central Coordinator of Mucosal Immunity

(2018) Joannie M. Allaire et al.   TRENDS IN IMMUNOLOGY

Oat globulin peptides regulate antidiabetic drug targets and glucose transporters in Caco-2 cells

(2018) Feng Wang et al.   Journal of Functional Foods

Soluble dietary fiber from Qing Ke (highland barley) brewers spent grain could alter the intestinal cholesterol efflux in Caco-2 cells

(2018) Huijuan Zhang et al.   Journal of Functional Foods

In vitro anti-inflammatory activity among probiotic Lactobacillus species isolated from fermented foods

(2018) Sundru Manjulata Devi et al.   Journal of Functional Foods

Probiotics in IBD: Combining in vitro and in vivo models for selecting strains with both anti-inflammatory potential as well as a capacity to restore the gut epithelial barrier

(2018) Mazen Zaylaa et al.   Journal of Functional Foods

In vitro bioavailability of chlorophyll pigments from edible seaweeds

(2018) Kewei Chen et al.   Journal of Functional Foods

Comparison of the in vitro gastrointestinal bioavailability of acylated and non-acylated anthocyanins: Purple-Fleshed Sweet Potato vs Red Wine

(2018) Hélder Oliveira et al.   FOOD CHEMISTRY

Micro-patterned endogenous stroma equivalent induces polarized crypt-villus architecture of human small intestinal epithelium

(2018) Vincenza De Gregorio et al.   Acta Biomaterialia

Improved stability, epithelial permeability and cellular antioxidant activity of β-carotene via encapsulation by self-assembled α-lactalbumin micelles

(2018) Yizheng Du et al.   FOOD CHEMISTRY

Intestinal Saturated Long-Chain Fatty Acid, Glucose and Fructose Transporters and Their Inhibition by Natural Plant Extracts in Caco-2 Cells

(2018) Katharina Schreck et al.   MOLECULES

Butyrate interacts with benzo[a]pyrene to alter expression and activities of xenobiotic metabolizing enzymes involved in metabolism of carcinogens within colon epithelial cell models

(2018) Ondřej Zapletal et al.   TOXICOLOGY

Bioaccessibility and intestinal uptake of minerals from different types of home-cooked and ready-to-eat beans

(2018) Miguel A. Faria et al.   Journal of Functional Foods

The Claudins: From Tight Junctions to Biological Systems

(2018) Sachiko Tsukita et al.   TRENDS IN BIOCHEMICAL SCIENCES

Method of preservation and type of protective agent strongly influence probiotic properties of Lactococcus lactis: A complete process of probiotic preparation manufacture and use

(2018) Marta Archacka et al.   FOOD CHEMISTRY

Elucidation of the impact of cell culture conditions of Caco-2 cell monolayer on barrier integrity and intestinal permeability

(2017) Anna Lechanteur et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Astilbin from Engelhardtia chrysolepis enhances intestinal barrier functions in Caco-2 cell monolayers

(2017) Tatsuo Nakahara et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effect of molecular weight on the transepithelial transport and peptidase degradation of casein-derived peptides by using Caco-2 cell model

(2017) Bo Wang et al.   FOOD CHEMISTRY

Surface layer protein from Lactobacillus acidophilus NCFM inhibit intestinal pathogen-induced apoptosis in HT-29 cells

(2017) Jun Meng et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Mucosal immune system of the gastrointestinal tract: maintaining balance between the good and the bad

(2017) Bani Ahluwalia et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

The role of barrier function, autophagy, and cytokines in maintaining intestinal homeostasis

(2017) Dana Elshaer et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Biochemical Mechanisms of Pathogen Restriction by Intestinal Bacteria

(2017) Kavita J. Rangan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Effect of luteolin on the expression of intestinal cholesterol transporters

(2017) Mana Ogawa et al.   Journal of Functional Foods

Anti-inflammatory activity of di-peptides derived from ovotransferrin by simulated peptide-cut in TNF-α-induced Caco-2 cells

(2017) Xiong Wang et al.   Journal of Functional Foods

Recent advances in the applications and biotechnological production of mannitol

(2017) Yiwei Dai et al.   Journal of Functional Foods

Adhesion and invasion of Listeria monocytogenes and interaction with Lactobacillus rhamnosus GG after habituation on fresh-cut pear

(2017) M.B. Iglesias et al.   Journal of Functional Foods

Bovine colostrum demonstrates anti-inflammatory and antibacterial activity in in vitro models of intestinal inflammation and infection

(2017) Anna Chae et al.   Journal of Functional Foods

Effect of dietary polyphenols on fructose uptake by human intestinal epithelial (Caco-2) cells

(2017) Nelson Andrade et al.   Journal of Functional Foods

Intestinal immunostimulatory activity of neutral polysaccharide isolated from traditionally fermented Korean brown rice vinegar

(2016) Hoon Kim et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

An experimental platform using human intestinal epithelial cell lines to differentiate between hazardous and non-hazardous proteins

(2016) Bryan P. Hurley et al.   FOOD AND CHEMICAL TOXICOLOGY

A novel in vitro co-culture model comprised of Caco-2/RBL-2H3 cells to evaluate anti-allergic effects of food factors through the intestine

(2016) Sae Yamashita et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity

(2016) Jenni Küblbeck et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Bifidobacteria—Insight into clinical outcomes and mechanisms of its probiotic action

(2016) Amrita Sarkar et al.   MICROBIOLOGICAL RESEARCH

Induction of cytokines via NF-κB and p38 MAP kinase signalling pathways associated with the immunomodulation by Lactobacillus plantarum NDC 75017 in vitro and in vivo

(2016) Yujun Jiang et al.   Journal of Functional Foods

Comparison of the inhibition on cellular 22-NBD-cholesterol accumulation and transportation of monomeric catechins and their corresponding A-type dimers in Caco-2 cell monolayers

(2016) Zhenzhen Ge et al.   Journal of Functional Foods

Antioxidant peptides released from gastrointestinal digestion of “Stracchino” soft cheese: Characterization, in vitro intestinal protection and bioavailability

(2016) Giacomo Pepe et al.   Journal of Functional Foods

Novel probiotic evidence of lactobacilli on immunomodulation and regulation of satiety hormones release in intestinal cells

(2016) Yanath Belguesmia et al.   Journal of Functional Foods

Application of Caco-2 Cell Line in Herb-Drug Interaction Studies: Current Approaches and Challenges

(2016) Charles Awortwe et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease

(2015) Aaron Lerner et al.   AUTOIMMUNITY REVIEWS

Transport and uptake of clausenamide enantiomers in CYP3A4-transfected Caco-2 cells: An insight into the efflux-metabolism alliance

(2015) Fang Hua et al.   BIOCHEMICAL PHARMACOLOGY

MK571 inhibits phase-2 conjugation of flavonols by Caco-2/TC7 cells, but does not specifically inhibit their apical efflux

(2015) Robert D. Barrington et al.   BIOCHEMICAL PHARMACOLOGY

Dissecting stromal-epithelial interactions in a 3D in vitro cellularized intestinal model for permeability studies

(2015) Carla Pereira et al.   BIOMATERIALS

Tea and soybean extracts in combination with milk fermentation inhibit growth and enterocyte adherence of selected foodborne pathogens

(2015) Danyue Zhao et al.   FOOD CHEMISTRY

Resistant starches differentially stimulate Toll-like receptors and attenuate proinflammatory cytokines in dendritic cells by modulation of intestinal epithelial cells

(2015) Miriam Bermudez-Brito et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The impact of dietary fibers on dendritic cell responses in vitro is dependent on the differential effects of the fibers on intestinal epithelial cells

(2015) Miriam Bermudez-Brito et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Anti-inflammatory effects of gastrointestinal digested Sambucus nigra L. fruit extract analysed in co-cultured intestinal epithelial cells and lipopolysaccharide-stimulated macrophages

(2015) Anna Olejnik et al.   Journal of Functional Foods

Antioxidant peptides from “Mozzarella di Bufala Campana DOP” after simulated gastrointestinal digestion: In vitro intestinal protection, bioavailability, and anti-haemolytic capacity

(2015) Gian Carlo Tenore et al.   Journal of Functional Foods

Biochanin A and prunetin improve epithelial barrier function in intestinal CaCo-2 cells via downregulation of ERK, NF-κB, and tyrosine phosphorylation

(2014) Stefanie Piegholdt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Characterisation of bifidobacteria with immunomodulatory properties isolated from human breast milk

(2014) Yi-Heng Chiu et al.   Journal of Functional Foods

In vitro studies of modulation of pathogenic and probiotic bacterial proliferation and adhesion to intestinal cells by blackcurrant juices

(2014) Shanthi G. Parkar et al.   Journal of Functional Foods

Development, validation, and application of a novel 7-day Caco-2 cell culture system

(2014) Yike Cai et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Extracellular metabolism-dependent uptake of lysolipids through cultured monolayer of differentiated Caco-2 cells

(2013) Maiko Inaba et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Intestinal epithelial cells as mediators of the commensal-host immune crosstalk

(2013) Yoshiyuki Goto et al.   IMMUNOLOGY AND CELL BIOLOGY

Permeation of Insulin, Calcitonin and Exenatide across Caco-2 Monolayers: Measurement Using a Rapid, 3-Day System

(2013) Vivek Gupta et al.   PLoS One

Caco-2 monolayers in experimental and theoretical predictions of drug transport

(2012) Per Artursson et al.   ADVANCED DRUG DELIVERY REVIEWS

Microbial metabolites, but not other phenolics derived from grape seed phenolic extract, are transported through differentiated Caco-2 cell monolayers

(2012) Dongjie Wang et al.   FOOD CHEMISTRY

Theaflavins, dimeric catechins, inhibit peptide transport across Caco-2 cell monolayers via down-regulation of AMP-activated protein kinase-mediated peptide transporter PEPT1

(2012) Junko Takeda et al.   FOOD CHEMISTRY

Constitutive expression of an antioxidant enzyme, glutathione S-transferase P1, during differentiation of human intestinal Caco-2 cells

(2012) Yuri Kusano et al.   FREE RADICAL BIOLOGY AND MEDICINE

Recent developments in microfluidic devices for in vitro cell culture for cell-biology research

(2012) Dan Gao et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Evaluation of Pediococcus pentosaceus strains isolated from Idly batter for probiotic properties in vitro

(2012) Venkatasubramanian Vidhyasagar et al.   Journal of Functional Foods

The physiological performance of a three-dimensional model that mimics the microenvironment of the small intestine

(2011) Jacqueline Pusch et al.   BIOMATERIALS

Nutrition and human health from a sex–gender perspective

(2011) Maria Marino et al.   MOLECULAR ASPECTS OF MEDICINE

Proteins involved in uptake, intracellular transport and basolateral secretion of fat-soluble vitamins and carotenoids by mammalian enterocytes

(2011) Emmanuelle Reboul et al.   PROGRESS IN LIPID RESEARCH

A protocol for in situ enzyme assays to assess the differentiation of human intestinal Caco-2 cells

(2011) Simonetta Ferruzza et al.   TOXICOLOGY IN VITRO

Novel and established intestinal cell line models – An indispensable tool in food science and nutrition

(2011) Tomaz Langerholc et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Intestinal permeability enhancement of levothyroxine sodium by straight chain fatty acids studied in MDCK epithelial cell line

(2010) Dimple Pabla et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Acetylation of hydroxytyrosol enhances its transport across differentiated Caco-2 cell monolayers

(2010) R. Mateos et al.   FOOD CHEMISTRY

Digestion stability and evaluation of the metabolism and transport of olive oil phenols in the human small-intestinal epithelial Caco-2/TC7 cell line

(2009) Aranzazu Soler et al.   FOOD CHEMISTRY

Intestinal barrier function: Molecular regulation and disease pathogenesis

(2009) Katherine R. Groschwitz et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A modified fast (4 day) 96-well plate Caco-2 permeability assay

(2008) Masashi Uchida et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Crosstalk of tight junction components with signaling pathways

(2007) Lorenza González-Mariscal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES