T3D-959: A Multi-Faceted Disease Remedial Drug Candidate for the Treatment of Alzheimer’s Disease

Mechanisms of Nitrosamine-Mediated Neurodegeneration: Potential Relevance to Sporadic Alzheimer's Disease

(2017) Suzanne M. de la Monte et al.   JOURNAL OF ALZHEIMERS DISEASE

Higher glucose levels associated with lower memory and reduced hippocampal microstructure

(2013) L. Kerti et al.   NEUROLOGY

Phosphorylation of tau protein at sites Ser396-404is one of the earliest events in Alzheimer's disease and Down syndrome

(2013) S. Mondragón-Rodríguez et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Brain Insulin Resistance and Deficiency as Therapeutic Targets in Alzheimers Disease

(2012) Suzanne M. de la Monte   Current Alzheimer Research

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Cholinergic Dysfunctions and Enhanced Oxidative Stress in the Neurobehavioral Toxicity of Lambda-Cyhalothrin in Developing Rats

(2012) Reyaz W. Ansari et al.   NEUROTOXICITY RESEARCH

Monocrotophos induced oxidative damage associates with severe acetylcholinesterase inhibition in rat brain

(2012) Amajad Iqbal Kazi et al.   NEUROTOXICOLOGY

Insulin-resistant brain state: The culprit in sporadic Alzheimer's disease?

(2011) Sónia C. Correia et al.   AGEING RESEARCH REVIEWS

Insulin-activated Akt rescues Aβ oxidative stress-induced cell death by orchestrating molecular trafficking

(2011) Pasquale Picone et al.   AGING CELL

Insulin resistance and Alzheimer's disease

(2011) Suzanne M. De La Monte   BMB Reports

Association of Metabolic Dysregulation With Volumetric Brain Magnetic Resonance Imaging and Cognitive Markers of Subclinical Brain Aging in Middle-Aged Adults

(2011) Zaldy S. Tan et al.   DIABETES CARE

Insulin resistance and pathological brain ageing

(2011) B. Cholerton et al.   DIABETIC MEDICINE

The peroxisome proliferator-activated receptor (PPAR) β/δ agonist GW501516 inhibits IL-6-induced signal transducer and activator of transcription 3 (STAT3) activation and insulin resistance in human liver cells

(2011) L. Serrano-Marco et al.   DIABETOLOGIA

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

(2011) Ying Liu et al.   JOURNAL OF PATHOLOGY

Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer’s-like changes

(2011) Amit Gupta et al.   NEUROPHARMACOLOGY

Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes

(2010) Laura D. Baker et al.   ARCHIVES OF NEUROLOGY

Rosiglitazone reversal of Tg2576 cognitive deficits is independent of peripheral gluco-regulatory status

(2010) Jennifer Rodriguez-Rivera et al.   BEHAVIOURAL BRAIN RESEARCH

How does diabetes accelerate Alzheimer disease pathology?

(2010) Catrina Sims-Robinson et al.   Nature Reviews Neurology

Insulin resistance is associated with the pathology of Alzheimer disease: The Hisayama Study

(2010) T. Matsuzaki et al.   NEUROLOGY

Fullerene antioxidants decrease organophosphate-induced acetylcholinesterase inhibition in vitro

(2010) Marion Ehrich et al.   TOXICOLOGY IN VITRO

A PPARdelta Agonist Reduces Amyloid Burden and Brain Inflammation in a Transgenic Mouse Model of Alzheimers Disease

(2009) Sergey Kalinin et al.   Current Alzheimer Research

Effects of pioglitazone and rosiglitazone combined with metformin on body weight in people with diabetes

(2009) G. Derosa et al.   DIABETES OBESITY & METABOLISM

Insulin Receptor Dysfunction Impairs Cellular Clearance of Neurotoxic Oligomeric Aβ

(2009) Wei-Qin Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

(2009) Q.-L. Ma et al.   JOURNAL OF NEUROSCIENCE

Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease

(2008) Wei-Qin Zhao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Insulin Resistance and Alzheimers Disease: Molecular Links & Clinical Implications

(2008) Karen Neumann et al.   Current Alzheimer Research

Insulin-like Growth Factor System Regulates Oligodendroglial Cell Behavior: Therapeutic Potential in CNS

(2008) Daniel Chesik et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

In vivo insulin deficiency as a potential etiology for demyelinating disease

(2008) Xiaoming Gong et al.   MEDICAL HYPOTHESES

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

(2008) Aileen M. Moloney et al.   NEUROBIOLOGY OF AGING

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL