Intranasal insulin therapy for cognitive impairment and neurodegeneration: current state of the art

Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults

(2017) Mark A. Reger et al.   JOURNAL OF ALZHEIMERS DISEASE

Limited Alzheimer-Type Neurodegeneration in Experimental Obesity and Type 2 Diabetes Mellitus

(2017) Natalie Moroz et al.   JOURNAL OF ALZHEIMERS DISEASE

Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

(2013) Jessica Freiherr et al.   CNS DRUGS

Brain Insulin and Leptin Signaling in Metabolic Control

(2013) Thomas Scherer et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Glucose Levels and Risk of Dementia

(2013) Paul K. Crane et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glucose Intolerance, Insulin Resistance, and Pathological Features of Alzheimer Disease in the Baltimore Longitudinal Study of Aging

(2013) Madhav Thambisetty et al.   JAMA Neurology

Central Nervous System Mechanisms Linking the Consumption of Palatable High-Fat Diets to the Defense of Greater Adiposity

(2012) Karen K. Ryan et al.   Cell Metabolism

Brain Insulin Resistance and Deficiency as Therapeutic Targets in Alzheimers Disease

(2012) Suzanne M. de la Monte   Current Alzheimer Research

Insulin: An Emerging Treatment for Alzheimer’s Disease Dementia?

(2012) Jill K. Morris et al.   Current Neurology and Neuroscience Reports

Intranasal Insulin Suppresses Food Intake via Enhancement of Brain Energy Levels in Humans

(2012) K. Jauch-Chara et al.   DIABETES

Type 2 diabetes and/or its treatment leads to less cognitive impairment in Alzheimer's disease patients

(2012) Raúl O. Domínguez et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Nasal insulin changes peripheral insulin sensitivity simultaneously with altered activity in homeostatic and reward-related human brain regions

(2012) M. Heni et al.   DIABETOLOGIA

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Strategies for non-invasive delivery of biologics

(2012) Seung Woo Chung et al.   JOURNAL OF DRUG TARGETING

Metformin, Other Antidiabetic Drugs, and Risk of Alzheimer's Disease: A Population-Based Case-Control Study

(2012) Patrick Imfeld et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Intranasal Insulin Modulates Intrinsic Reward and Prefrontal Circuitry of the Human Brain in Lean Women

(2012) Stephanie Kullmann et al.   NEUROENDOCRINOLOGY

Intranasal Treatment of Central Nervous System Dysfunction in Humans

(2012) Colin D. Chapman et al.   PHARMACEUTICAL RESEARCH

Rosiglitazone and Pioglitazone for the Treatment of Alzheimer's Disease

(2011) Benjamin W Miller et al.   ANNALS OF PHARMACOTHERAPY

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

Insulin resistance and Alzheimer's disease

(2011) Suzanne M. De La Monte   BMB Reports

Rosiglitazone Does Not Improve Cognition or Global Function when Used as Adjunctive Therapy to AChE Inhibitors in Mild-to-Moderate Alzheimers Disease: Two Phase 3 Studies

(2011) C. Harrington et al.   Current Alzheimer Research

Intranasal administration of insulin to the brain impacts cognitive function and peripheral metabolism

(2011) V. Ott et al.   DIABETES OBESITY & METABOLISM

Insulin sensitivity of the human brain

(2011) Caroline Ketterer et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Contributions of Brain Insulin Resistance and Deficiency in Amyloid-Related Neurodegeneration in Alzheimerʼs Disease

(2011) Suzanne M. de la Monte   DRUGS

Effect of Intranasal Insulin on Cognitive Function: A Systematic Review

(2011) Elad Shemesh et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Brain Insulin Signaling and Alzheimer's Disease: Current Evidence and Future Directions

(2011) Helgi B. Schiöth et al.   MOLECULAR NEUROBIOLOGY

The Insulin-Mediated Modulation of Visually Evoked Magnetic Fields Is Reduced in Obese Subjects

(2011) Martina Guthoff et al.   PLoS One

si-RNA inhibition of brain insulin or insulin-like growth factor receptors causes developmental cerebellar abnormalities: relevance to fetal alcohol spectrum disorder

(2011) Suzanne M de la Monte et al.   Molecular Brain

Insulin and the brain

(2011) Zvi Laron   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Insulin to treat Alzheimer’s disease: just follow your nose?

(2011) Helgi B Schiöth et al.   Expert Review of Clinical Pharmacology

Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes

(2010) Laura D. Baker et al.   ARCHIVES OF NEUROLOGY

Rosiglitazone Monotherapy in Mild-to-Moderate Alzheimer’s Disease: Results from a Randomized, Double-Blind, Placebo-Controlled Phase III Study

(2010) Michael Gold et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

New strategies to improve the intranasal absorption of insulin

(2010) Xiaopin Duan et al.   DRUG DISCOVERY TODAY

Intranasal insulin as a therapeutic option in the treatment of cognitive impairments

(2010) Christian Benedict et al.   EXPERIMENTAL GERONTOLOGY

Comparable Sensitivity of Postmenopausal and Young Women to the Effects of Intranasal Insulin on Food Intake and Working Memory

(2010) Rosemarie Krug et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Oligoarginine-linked polymers as a new class of penetration enhancers

(2010) Shinji Sakuma et al.   JOURNAL OF CONTROLLED RELEASE

Rosiglitazone Rescues Memory Impairment in Alzheimer's Transgenic Mice: Mechanisms Involving a Reduced Amyloid and Tau Pathology

(2010) Luis Escribano et al.   NEUROPSYCHOPHARMACOLOGY

Central nervous insulin resistance: a promising target in the treatment of metabolic and cognitive disorders?

(2009) M. Hallschmid et al.   DIABETOLOGIA

Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: A link between diabetes and Alzheimer's disease

(2009) Paula L. McClean et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Intranasal administration of IGF-1 attenuates hypoxic-ischemic brain injury in neonatal rats

(2009) Shuying Lin et al.   EXPERIMENTAL NEUROLOGY

Insulin Modulates Food-Related Activity in the Central Nervous System

(2009) Martina Guthoff et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Insulin/PI3K signaling protects dentate neurons from oxygen–glucose deprivation in organotypic slice cultures

(2009) Xiaolu Sun et al.   JOURNAL OF NEUROCHEMISTRY

Reestablishment of the nasal permeability barrier to several peptides following exposure to the absorption enhancer tetradecyl-β-D-maltoside

(2009) John J. Arnold et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Inhaled insulin—Intrapulmonary, intranasal, and other routes of administration: Mechanisms of action

(2009) R.I. Henkin   NUTRITION

Intranasal insulin: From nose to brain

(2009) R.I. Henkin   NUTRITION

Insulin-Like Growth Factor I

(2009) Ron Kooijman et al.   STROKE

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

(2008) Kelly A. Posey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Rosiglitazone reverses memory decline and hippocampal glucocorticoid receptor down-regulation in an Alzheimer’s disease mouse model

(2008) Luis Escribano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

(Pre)diabetes, brain aging, and cognition

(2008) Jarbas S. Roriz-Filho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

New Generation of Hybrid Poly/Oligosaccharide Nanoparticles as Carriers for the Nasal Delivery of Macromolecules

(2008) Desirée Teijeiro-Osorio et al.   BIOMACROMOLECULES

Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease

(2008) Leah R Hanson et al.   BMC NEUROSCIENCE

RETRACTED: Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy

(2008)   BRAIN

Getting into the Brain

(2008) Mayur M Patel et al.   CNS DRUGS

Insulin Resistance and Alzheimers Disease: Molecular Links & Clinical Implications

(2008) Karen Neumann et al.   Current Alzheimer Research

Mucosal Insulin Vaccination for Type 1 Diabetes Prevention

(2008) E. Bonifacio et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Differential Sensitivity of Men and Women to Anorexigenic and Memory-Improving Effects of Intranasal Insulin

(2008) Christian Benedict et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial

(2008) Kirsti Näntö-Salonen et al.   LANCET

Intranasal insulin attenuates the hypothalamic–pituitary–adrenal axis response to psychosocial stress

(2008) Andreas Bohringer et al.   PSYCHONEUROENDOCRINOLOGY

Towards the therapeutic use of intranasal neuropeptide administration in metabolic and cognitive disorders

(2008) Manfred Hallschmid et al.   REGULATORY PEPTIDES