Activation of the nuclear receptor PPARδ is neuroprotective in a transgenic mouse model of Alzheimer’s disease through inhibition of inflammation

Lipophilic adamantyl- or deferasirox-based conjugates of desferrioxamine B have enhanced neuroprotective capacity: implications for Parkinson disease

(2013) Jeffrey R. Liddell et al.   FREE RADICAL BIOLOGY AND MEDICINE

Blockage of CR1 prevents activation of rodent microglia

(2013) Helen Crehan et al.   NEUROBIOLOGY OF DISEASE

Increased misfolding and truncation of tau in APP/PS1/tau transgenic mice compared to mutant tau mice

(2013) Céline Héraud et al.   NEUROBIOLOGY OF DISEASE

A peroxisome proliferator-activated receptor-δ agonist provides neuroprotection in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson’s disease

(2013) H.L. Martin et al.   NEUROSCIENCE

Neuroinflammation: The role and consequences

(2013) Monty Lyman et al.   NEUROSCIENCE RESEARCH

Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aβ by microglia

(2012) Hongjun Fu et al.   GLIA

PPAR /RXR -Induced and CD36-Mediated Microglial Amyloid-  Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice

(2012) M. Yamanaka et al.   JOURNAL OF NEUROSCIENCE

Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease

(2012) S. Mandrekar-Colucci et al.   JOURNAL OF NEUROSCIENCE

Activation of peroxisome proliferator-activated receptor-δ attenuates glutamate-induced neurotoxicity in HT22 mouse hippocampal cells

(2012) Hana Jin et al.   JOURNAL OF NEUROSCIENCE RESEARCH

CCL2 Is Associated with a Faster Rate of Cognitive Decline during Early Stages of Alzheimer's Disease

(2012) Karin Westin et al.   PLoS One

Modelling Neuroinflammation In Vitro: A Tool to Test the Potential Neuroprotective Effect of Anti-Inflammatory Agents

(2012) Núria Gresa-Arribas et al.   PLoS One

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Human Atherosclerotic Plaque Alternative Macrophages Display Low Cholesterol Handling but High Phagocytosis Because of Distinct Activities of the PPARγ and LXRα Pathways

(2011) Giulia Chinetti-Gbaguidi et al.   CIRCULATION RESEARCH

Apolipoprotein E Promotes β-Amyloid Trafficking and Degradation by Modulating Microglial Cholesterol Levels

(2011) C. Y. Daniel Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical Role of Astroglial Apolipoprotein E and Liver X Receptor-  Expression for Microglial A  Phagocytosis

(2011) D. Terwel et al.   JOURNAL OF NEUROSCIENCE

CX3CR1 Deficiency Alters Microglial Activation and Reduces Beta-Amyloid Deposition in Two Alzheimer's Disease Mouse Models

(2010) Sungho Lee et al.   AMERICAN JOURNAL OF PATHOLOGY

Control of Macrophage Activation and Function by PPARs

(2010) Ajay Chawla   CIRCULATION RESEARCH

Depletion of CXCR2 inhibits γ-secretase activity and amyloid-β production in a murine model of Alzheimer’s disease

(2010) Pancham Bakshi et al.   CYTOKINE

Peroxisome Proliferator-Activated Receptor   Regulation of miR-15a in Ischemia-Induced Cerebral Vascular Endothelial Injury

(2010) K. J. Yin et al.   JOURNAL OF NEUROSCIENCE

Evidence for the Role of Peroxisome Proliferator-Activated Receptor- /  in the Development of Spinal Cord Injury

(2010) I. Paterniti et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phospho-eIF2α Level Is Important for Determining Abilities of BACE1 Reduction to Rescue Cholinergic Neurodegeneration and Memory Defects in 5XFAD Mice

(2010) Latha Devi et al.   PLoS One

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

On the mechanism for PPAR agonists to enhance ABCA1 gene expression

(2009) Masaki Ogata et al.   ATHEROSCLEROSIS

A PPARdelta Agonist Reduces Amyloid Burden and Brain Inflammation in a Transgenic Mouse Model of Alzheimers Disease

(2009) Sergey Kalinin et al.   Current Alzheimer Research

C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine production

(2009) Deborah A. Fraser et al.   JOURNAL OF NEUROCHEMISTRY

AAV1/2-mediated CNS Gene Delivery of Dominant-negative CCL2 Mutant Suppresses Gliosis, β-amyloidosis, and Learning Impairment of APP/PS1 Mice

(2009) Tomomi Kiyota et al.   MOLECULAR THERAPY

Oral apolipoprotein A-I mimetic peptide improves cognitive function and reduces amyloid burden in a mouse model of Alzheimer's disease

(2009) Shaila P. Handattu et al.   NEUROBIOLOGY OF DISEASE

NeuN is not a reliable marker of dopamine neurons in rat substantia nigra

(2009) Jason R. Cannon et al.   NEUROSCIENCE LETTERS

Emerging roles of peroxisome proliferator-activated receptor-β/δ in inflammation

(2009) David Bishop-Bailey et al.   PHARMACOLOGY & THERAPEUTICS

Monocyte Chemoattractant Protein-1 Plays a Dominant Role in the Chronic Inflammation Observed in Alzheimer's Disease

(2008) Anna Sokolova et al.   BRAIN PATHOLOGY

Complement C3 Deficiency Leads to Accelerated Amyloid   Plaque Deposition and Neurodegeneration and Modulation of the Microglia/Macrophage Phenotype in Amyloid Precursor Protein Transgenic Mice

(2008) M. Maier et al.   JOURNAL OF NEUROSCIENCE

C1q, the recognition subcomponent of the classical pathway of complement, drives microglial activation

(2008) Katrin Färber et al.   JOURNAL OF NEUROSCIENCE RESEARCH