Neuroinflammation impairs adaptive structural plasticity of dendritic spines in a preclinical model of Alzheimer’s disease

Intraneuronal APP and extracellular Aβ independently cause dendritic spine pathology in transgenic mouse models of Alzheimer’s disease

(2015) Chengyu Zou et al.   ACTA NEUROPATHOLOGICA

Effect of pioglitazone medication on the incidence of dementia

(2015) Michael T. Heneka et al.   ANNALS OF NEUROLOGY

Pharmacological Inhibition of BACE1 Impairs Synaptic Plasticity and Cognitive Functions

(2015) Severin Filser et al.   BIOLOGICAL PSYCHIATRY

The interplay between inflammatory cytokines and the endocannabinoid system in the regulation of synaptic transmission

(2015) Silvia Rossi et al.   NEUROPHARMACOLOGY

Anti-Diabetes Drug Pioglitazone Ameliorates Synaptic Defects in AD Transgenic Mice by Inhibiting Cyclin-Dependent Kinase5 Activity

(2015) Jinan Chen et al.   PLoS One

Obesity Elicits Interleukin 1-Mediated Deficits in Hippocampal Synaptic Plasticity

(2014) J. R. Erion et al.   JOURNAL OF NEUROSCIENCE

Valproic Acid Alleviates Memory Deficits and Attenuates Amyloid-β Deposition in Transgenic Mouse Model of Alzheimer’s Disease

(2014) Ai-Guo Xuan et al.   MOLECULAR NEUROBIOLOGY

The Evolution of Preclinical Alzheimer’s Disease: Implications for Prevention Trials

(2014) Reisa Sperling et al.   NEURON

Environment and Brain Plasticity: Towards an Endogenous Pharmacotherapy

(2014) Alessandro Sale et al.   PHYSIOLOGICAL REVIEWS

Amyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer’s disease

(2014) M-S Tan et al.   Cell Death & Disease

Preventing cognitive decline in preclinical Alzheimer's disease

(2013) Wim J Riedel   CURRENT OPINION IN PHARMACOLOGY

Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study

(2013) Stephanie JB Vos et al.   LANCET NEUROLOGY

Genetic mouse models of brain ageing and Alzheimer's disease

(2013) Andras Bilkei-Gorzo   PHARMACOLOGY & THERAPEUTICS

Nonsteroidal anti-inflammatory drug use and the risk of cognitive impairment and Alzheimer’s disease

(2012) Sharlène Côté et al.   Alzheimers & Dementia

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Structural Dynamics of Dendritic Spines are Influenced by an Environmental Enrichment: An In Vivo Imaging Study

(2012) Christian K.E. Jung et al.   CEREBRAL CORTEX

Covarying alterations in Aβ deposition, glucose metabolism, and gray matter volume in cognitively normal elderly

(2012) Hwamee Oh et al.   HUMAN BRAIN MAPPING

Brain-Derived Neurotrophic Factor-Dependent Synaptic Plasticity Is Suppressed by Interleukin-1  via p38 Mitogen-Activated Protein Kinase

(2012) L. Tong et al.   JOURNAL OF NEUROSCIENCE

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

Effects of collagen-induced rheumatoid arthritis on amyloidosis and microvascular pathology in APP/PS1 mice

(2011) Sun Park et al.   BMC NEUROSCIENCE

Testing the Right Target and Right Drug at the Right Stage

(2011) R. A. Sperling et al.   Science Translational Medicine

Experience-dependent structural plasticity in the cortex

(2011) Min Fu et al.   TRENDS IN NEUROSCIENCES

Anti-inflammatory effect by lentiviral-mediated overexpression of IL-10 or IL-1 receptor antagonist in rat glial cells and macrophages

(2010) M E van Strien et al.   GENE THERAPY

Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging

(2010) Christopher C. Rowe et al.   NEUROBIOLOGY OF AGING

Probing the Biology of Alzheimer's Disease in Mice

(2010) Karen H. Ashe et al.   NEURON

Amyloid Plaques Disrupt Resting State Default Mode Network Connectivity in Cognitively Normal Elderly

(2009) Yvette I. Sheline et al.   BIOLOGICAL PSYCHIATRY

Disruption of Functional Connectivity in Clinically Normal Older Adults Harboring Amyloid Burden

(2009) T. Hedden et al.   JOURNAL OF NEUROSCIENCE

Rapid formation and selective stabilization of synapses for enduring motor memories

(2009) Tonghui Xu et al.   NATURE

Stably maintained dendritic spines are associated with lifelong memories

(2009) Guang Yang et al.   NATURE

Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window

(2009) Anthony Holtmaat et al.   Nature Protocols

Amyloid Deposition Is Associated with Impaired Default Network Function in Older Persons without Dementia

(2009) Reisa A. Sperling et al.   NEURON

Aspirin in Alzheimer's disease (AD2000): a randomised open-label trial

(2008) AD Collaborative Group   LANCET NEUROLOGY

Experience leaves a lasting structural trace in cortical circuits

(2008) Sonja B. Hofer et al.   NATURE

Episodic memory deficits are not related to altered glutamatergic synaptic transmission and plasticity in the CA1 hippocampus of the APPswe/PS1ΔE9-deleted transgenic mice model of β-amyloidosis

(2008) Arturas Volianskis et al.   NEUROBIOLOGY OF AGING