Article
Biochemistry & Molecular Biology
Zhentao Zhang, Xiao-Guang Li, Zhi-Hao Wang, Mingke Song, Shan Ping Yu, Seong Su Kang, Xia Liu, Zhaohui Zhang, Manling Xie, Gong-Ping Liu, Jian-Zhi Wang, Keqiang Ye
Summary: This study reveals that the fragments generated by delta-secretase cleavage, APP and Tau, act additively to drive AD pathogenesis and cognitive dysfunctions. Tau(1-368) fragment enhances BACE1 expression and A beta generation, and has a more robust effect than full-length Tau, promoting the nuclear translocation of active STAT1 and increasing BACE1 and A beta production. Further mechanism involving A beta-activated kinases phosphorylating STAT1 and its association with Tau(1-368) is also discussed.
MOLECULAR PSYCHIATRY
(2021)
Article
Geriatrics & Gerontology
Yamei Wang, Jianhao Wang, Hongyu Chen, Xiang Li, Ruifeng Xu, Feng Gao, Hang Yu, Fang Li, Dongdong Qin, Jiabei Wang, Yuke Shi, Yiyi Li, Songyan Liu, Xi Zhang, Shuai Ding, Yiqian Hu, Liqin Huang, Xin-Ya Gao, Zuneng Lu, Jin Luo, Zhi-Hao Wang
Summary: This study revealed that mitochondrial dysfunction is associated with depressive-like behaviors and cognitive deficits in hTau mice. Inhibition of AEP, clearance of Tau N368, and activation of PPAR-delta can effectively alleviate chronic stress-induced depressive-like behaviors and cognitive decline.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Cell Biology
Li Li, Haoming Sun, Jionghao Chen, Cong Ding, Xiaojun Yang, Hua Han, Qingzhu Sun
Summary: The therapeutic potential of Orm2, a protein predominantly secreted by hepatocytes, for treating NAFLD and NASH was investigated in this study. The results showed that high Orm2 expression prevented obesity induced by a high-fat diet in mice. The pharmacological administration of recombinant ORM2 protein ameliorated hepatic steatosis, inflammation, hepatocyte injury, and fibrosis in mouse livers afflicted by NAFLD and NASH. Overall, Orm2 plays a critical role in preventing NASH and associated NAFLD in the context of obesity.
Article
Biochemistry & Molecular Biology
Samar O. El-Ganainy, Omar A. Soliman, Aya A. Ghazy, Maram Allam, Aya I. Elbahnasi, Amira M. Mansour, Mennatallah A. Gowayed
Summary: Oxytocin has neuroprotective potential in Alzheimer's disease, restoring cognition and suppressing beta-amyloid, Tau accumulation, and neuronal death. Combined treatment with galantamine and oxytocin shows better biochemical and histopathological profiles.
NEUROCHEMICAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Meijian Zhang, Emma Barroso, Maria Ruart, Lucia Pena, Mona Peyman, David Aguilar-Recarte, Marta Montori-Grau, Patricia Rada, Clara Cugat, Carla Montironi, Mohammad Zarei, Javier Jurado-Aguilar, Antoni Camins, Jesus Balsinde, Angela M. Valverde, Walter Wahli, Xavier Palomer, Manuel Vazquez-Carrera
Summary: Elafibranor has been found to ameliorate steatosis, inflammation, and fibrogenesis in the livers of mice fed a high-fat diet. Unexpectedly, Elafibranor also increases the levels of the EMT-promoting protein S100A4 through PPAR β/δ activation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cell Biology
Mohammad Rafi Khezri, Keyvan Yousefi, Ayda Esmaeili, Morteza Ghasemnejad-Berenji
Summary: This review summarizes the potential roles of ERK1/2 in the pathophysiology of Alzheimer's disease.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Cairong Dong, Shenglan Huang, Liang Sun, Jinping Yao, Jinlong Yan, Xiangbao Yin
Summary: This study investigated the prognostic effect of DLGAP4 on HCC patients using bioinformatics. The results showed that DLGAP4 expression was significantly correlated with clinical characteristics and high expression of DLGAP4 was associated with poor prognosis in HCC. DLGAP4 can serve as a predictive biomarker for HCC.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Barbara Bettegazzi, Laura Sebastian Monasor, Serena Bellani, Franca Codazzi, Lisa Michelle Restelli, Alessio Vittorio Colombo, Nikolaus Deigendesch, Stephan Frank, Takashi Saito, Takaomi C. Saido, Sven Lammich, Sabina Tahirovic, Fabio Grohovaz, Daniele Zacchetti
Summary: The study provides evidence for the role of Casein Kinase 2 in controlling BACE1 expression and demonstrates a mechanism linking neuronal activity with amyloid production and deposition in the brain. The findings offer new perspectives for AD treatment strategies.
CELL DEATH & DISEASE
(2021)
Article
Endocrinology & Metabolism
Zifan Xu, Jiahui Yang, Haohan Zheng, Tianhua Xie, Qian Yang, Jiping Cai, Chao Sun, Yujuan Cao, Meili Wu, Yanqiu Liu, Yuqing Cui, Yong Yao, Xiaolu Wang
Summary: Diabetic retinopathy (DR) is a common complication in patients with diabetes and the mechanisms involved in proliferative DR (PDR) causing blindness are not fully understood. miRNAs and long noncoding RNAs can accurately regulate target gene expression through competing endogenous RNAs. Through deep sequencing of extracellular vesicles (EVs) in the serum, aberrantly low expression of PPT2-EGFL8 and significantly increased level of miR-423-5p were found in individuals with PDR. PPT2-EGFL8 acts as a molecular sponge for miR-423-5p and inhibits hypoxia-induced proliferation of retinal endothelial cells. Egfl8-overexpression treatment reduces diabetes-related complications and pathological neovascularization in mouse models. The findings suggest the identification of potential biomarkers and therapeutic targets.
Review
Biochemistry & Molecular Biology
Tabinda Sidrat, Zia-Ur Rehman, Myeong-Don Joo, Kyeong-Lim Lee, Il-Keun Kong
Summary: The Wnt/beta-catenin signaling pathway is crucial in early embryonic development, regulating cell proliferation and maintaining ESCs in a pluripotent state. Dysregulation of this pathway can lead to hereditary diseases and abnormalities. The interaction of Wnt signaling with other molecules and with PPAR delta is important in embryonic development and gene expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lorena Mazuecos, Cristina Pintado, Blanca Rubio, Eduardo Guisantes-Batan, Antonio Andres, Nilda Gallardo
Summary: The study demonstrates that PPAR beta/delta is involved in the up-regulation of FGF21 expression induced by leptin in visceral adipose tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ruta Dekeryte, Zara Franklin, Claire Hull, Lorenzo Croce, Sarah Kamli-Salino, Oliver Helk, Philip A. Hoffmann, Zhixiang Yang, Gernot Riedel, Mirela Delibegovic, Bettina Platt
Summary: The study demonstrates the role of BACE1 in regulating systemic glucose homeostasis and suggests BACE1 inhibitors for treating T2DM-associated pathologies. LY2886721 treatment improved glucose homeostasis and hepatic insulin sensitivity in PLB4 mice, but did not show improvements in motor coordination.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Chemistry, Organic
Gang Sun, Jing Li, Xin Liu, Yiting Liu, Xiaoan Wen, Hongbin Sun, Qing-Long Xu
Summary: A green method for constructing C-S bonds using sulfonyl chlorides and alcohols/acids via a P-III/P-V=O catalytic system is reported. The organophosphorus-catalyzed umpolung reaction promotes the proposal of a dual-substrate deoxygenation strategy. The method demonstrates the deoxygenation of sulfonyl chlorides and alcohols/acids driven by P-III/P-V=O redox cycling and shows high functional group tolerance, making it applicable for late-stage diversification of drug analogues.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Yingjing Pan, Tianci Lin, Longquan Shao, Yulin Zhang, Qiao Han, Liyuan Sheng, Rui Guo, Ting Sun, Yanli Zhang
Summary: In this study, a puerarin-attached lignin nanoparticle-incorporated hydrogel was found to promote angiogenesis, possibly through puerarin-mediated autophagy activation and increase in PPAR beta/delta. This research is of great significance for the treatment of ischemic diseases.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ioanna Papatheodorou, Eleftheria Galatou, Georgios-Dimitrios Panagiotidis, Tana Ravingerova, Antigone Lazou
Summary: Evidence suggests that PPAR beta/delta activation has cardioprotective effects by enhancing antioxidant defense and preserving mitochondrial function to alleviate myocardial I/R injury, with ALDH2 identified as a crucial downstream target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
David Aguilar-Recarte, Emma Barroso, Meijian Zhang, Patricia Rada, Javier Pizarro -Delgado, Lucia Pena, Xavier Palomer, Angela M. Valverde, Walter Wahli, Manuel Vazquez-Carrera
Summary: This study reveals a novel mechanism by which the activation of AMPK by metformin is dependent on the upregulation of GDF15, independent of the central nervous system. This finding provides insights into the therapeutic effects of metformin in the treatment of type 2 diabetes.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Cell Biology
Rut Fado, Sebastian Zagmutt, Laura Herrero, Helena Muley, Rosalia Rodriguez-Rodriguez, Huichang Bi, Dolors Serra, Nuria Casals
Summary: There is a need for reliable genetic biomarkers in the diagnosis, prognosis, and treatment of different tumor types. One potential biomarker is CPT1C, a neuronal protein involved in cancer cell adaptation to nutrient depletion and hypoxia. However, its molecular role in cancer cells is controversial. This review discusses the evidence on CPT1C in neurons and its potential role in lipid metabolism and cell adaptation to stressors in cancer cells.
CELL DEATH & DISEASE
(2023)
Article
Pharmacology & Pharmacy
Ruth M. Galindo-Camacho, Isabel Haro, Maria J. Gomara, Marta Espina, Joel Fonseca, Carlos Martins-Gomes, Antoni Camins, Amelia M. Silva, Maria L. Garcia, Eliana B. Souto
Summary: The biocompatibility of cell penetrating peptides-functionalized Licochalcone-A-loaded PLGA nanoparticles was evaluated in Caco-2 cell lines, demonstrating non-cytotoxicity, while the anti-inflammatory activity of the nanoparticles was tested in RAW 264.7 cell lines. Freeze-drying with different cryoprotectants was performed to prevent particle aggregation and physical stress. An in-situ forming gel based on poloxamer 407 containing Licochalcone-A-loaded PLGA nanoparticles functionalized with B6 and Tet-1 was developed for ocular administration, providing viscoelasticity, suitable mechanical properties, and mucoadhesive performance.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Geriatrics & Gerontology
Marta Riba, Jaume del Valle, Clara Romera, Raquel Alsina, Laura Molina-Porcel, Carme Pelegri, Jordi Vilaplana
Summary: Brain corpora amylacea (BCA), recently renamed as wasteosomes, are polyglucosan bodies that appear during aging and some neurodegenerative conditions. They collect waste substances and are part of a brain cleaning mechanism. In this work, we analyzed the presence of tau protein in wasteosomes and found that it was dependent on the neuropathological condition, with Alzheimer's disease (AD) patients showing the presence of tau protein, while non-AD patients did not. These findings highlight the different composition of wasteosomes and reinforce their role as waste containers.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Medicine, Research & Experimental
Meijian Zhang, Emma Barroso, Maria Ruart, Lucia Pena, Mona Peyman, David Aguilar-Recarte, Marta Montori-Grau, Patricia Rada, Clara Cugat, Carla Montironi, Mohammad Zarei, Javier Jurado-Aguilar, Antoni Camins, Jesus Balsinde, Angela M. Valverde, Walter Wahli, Xavier Palomer, Manuel Vazquez-Carrera
Summary: Elafibranor has been found to ameliorate steatosis, inflammation, and fibrogenesis in the livers of mice fed a high-fat diet. Unexpectedly, Elafibranor also increases the levels of the EMT-promoting protein S100A4 through PPAR β/δ activation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Neurosciences
Christian Grinan-Ferre, Julia Jarne-Ferrer, Aina Bellver-Sanchis, Sandra Codony, Dolors Puigoriol-Illamola, Coral Sanfeliu, Yumin Oh, Seulki Lee, Santiago Vazquez, Merce Pallas
Summary: This study found that inhibiting soluble epoxide hydrolase (sEH) is helpful in combating neuroinflammation, and it can achieve neuroprotection by modulating the eIF2 alpha/CHOP pathway, which is of potential significance for the treatment of Alzheimer's disease.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biophysics
Gerard Esteruelas, Alba Ortiz, Josefina Prat, Estefania Vega, Montserrat Munoz-Juncosa, Maria Luisa Garcia Lopez, Miren Ettcheto, Antoni Camins, Elena Sanchez-Lopez, Montserrat Pujol
Summary: Ocular inflammation is commonly treated using nonsteroidal anti-inflammatory drugs. Encapsulating these drugs into PLGA nanoparticles allows for better bioavailability. This study investigates the interaction of Dexibuprofen (DXI) nanoparticles with corneal membranes and finds differences in interactions between elder and adult corneal tissues.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Biochemistry & Molecular Biology
Jordi Olloquequi, Miren Ettcheto, Amanda Cano, Ana Fortuna, Joana Bicker, Elena Sanchez-Lopez, Cristian Paz, Jesus Urena, Ester Verdaguer, Carme Auladell, Antoni Camins
Summary: Licochalcone A (Lico-A) is a potential neuroprotective agent with various mechanisms of action, including enhancing cognitive activity, inhibiting neuroinflammation, reducing tau phosphorylation, increasing acetylcholine levels, decreasing amyloid plaques, and exerting antioxidant effects. Further research on the underlying mechanisms and targets of Lico-A may provide new insights for the treatment of cognitive disorders and neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Meijian Zhang, Andrea Bagan, Donna Martinez, Emma Barroso, Xavier Palomer, Santiago Vazquez, Carmen Escolano, Manuel Vazquez-Carrera
Summary: A novel series of AMPK activators were designed, synthesized, and evaluated in vitro to upregulate GDF15 levels as a strategy for treating obesity and type 2 diabetes mellitus. Compound 21 showed a higher increase in GDF15 mRNA levels and protein levels compared with metformin and BC1618 in human hepatic cells.
Review
Pharmacology & Pharmacy
Emma Barroso, Marta Montori-Grau, Walter Wahli, Xavier Palomer, Manuel Vazquez-Carrera
Summary: Metformin, the most prescribed drug for T2DM, has both liver and gut as important targets for its glucose-lowering effect through new mechanisms of action. The understanding of metformin's action in these organs and its relevance in patients remains a challenge for current and future research, potentially impacting T2DM drug development.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Andrea Bagan, Sergio Rodriguez-Arevalo, Teresa Taboada-Jara, Christian Grinan-Ferre, Merce Pallas, Iria Brocos-Mosquera, Luis F. Callado, Jose A. Morales-Garcia, Belen Perez, Caridad Diaz, Rosario Fernandez-Godino, Olga Genilloud, Milan Beljkas, Slavica Oljacic, Katarina Nikolic, Carmen Escolano
Summary: This study aims to find molecular entities that modulate imidazoline I-2 receptors (I-2-IRs) as potential therapeutic targets for Alzheimer's disease. The findings demonstrate that the new I-2-IR ligands have beneficial effects in neuroprotection, anti-inflammation, and improvement of cognitive impairment, suggesting their potential as a promising therapeutic strategy for neurodegenerative diseases.
Review
Anatomy & Morphology
Marta Riba, Clara Romera, Raquel Alsina, Gerard Alsina-Scheer, Carme Pelegri, Jordi Vilaplana, Jaume del Valle
Summary: The first report of corpora amylacea (CA) was made by Morgagni in the prostate in the 18th century, and later Virchow described them in the brain. Virchow provided techniques to visualize CA but did not explain their cause, association with aging, or clinical significance. Recent data have shown that CA accumulate waste products and can be found in the cerebrospinal fluid and lymphatic nodes, leading to their renaming as wasteosomes.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Cell Biology
Kevin Ibeas, Christian Grinan-Ferre, Maria del Mar Romero, David Sebastian, Marianela Bastias-Perez, Roberto Gomez, M. Carmen Soler-Vazquez, Sebastian Zagmutt, Merce Pallas, Margarida Castell, Denise D. Belsham, Paula Mera, Laura Herrero, Dolors Serra
Summary: This study found that CPT1A in AgRP neurons plays a key role in regulating overall energy balance and fluid homeostasis, promoting health and protecting against aging. Lacking Cpt1a in AgRP neurons enhances endurance and cognitive capacity, delaying the aging process. Additionally, Cpt1a KO mice showed reduced inflammation and oxidative stress.
Article
Medicine, Research & Experimental
Mona Peyman, Emma Barroso, Andreea L. Turcu, Francesc Estrany Jr, Daire Smith, Javier Jurado-Aguilar, Patricia Rada, Christophe Morisseau, Bruce D. Hammock, Angela M. Valverde, Xavier Palomer, Carles Galdeano, Santiago Vazquez, Manuel Vazquez-Carrera
Summary: This study demonstrates that targeting sEH with degraders can degrade the protein, regulate AMPK activation, and reduce ER stress and inflammation in mice.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
M. T. Ciubuc-Batcu, N. J. C. Stapelberg, J. P. Headrick, G. M. C. Renshaw
Summary: The nervous system relies on mitochondria, and impaired mitochondrial function is associated with major depressive disorder. Modulating mitochondrial function may be a therapeutic target for treating MDD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Correction
Biochemistry & Molecular Biology
Saowaluk Saisomboon, Ryusho Kariya, Piyanard Boonnate, Kanlayanee Sawanyawisuth, Ubon Cha'on, Vor Luvira, Yaovalux Chamgramol, Chawalit Pairojkul, Wunchana Seubwai, Atit Silsirivanit, Sopit Wongkham, Seiji Okada, Sarawut Jitrapakdee, Kulthida Vaeteewoottacharn
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Pavan Thapak, Zhe Ying, Victoria Palafox-Sanchez, Guanglin Zhang, Xia Yang, Fernando Gomez-Pinilla
Summary: Traumatic brain injury (TBI) impairs cellular energy demand, compromising neuronal function and plasticity. This study demonstrates that the mitochondrial activator humanin (HN) can counteract the reduction in mitochondrial bioenergetics caused by TBI, restore memory function and synaptic protein levels, and suppress inflammation and astrocyte proliferation. HN plays an integral role in normalizing fundamental aspects of TBI pathology.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Paul Murphy, Valeria A. Buzinova, Carrie E. Johnson
Summary: Progress has been made in the treatment of Alzheimer's disease through the development of anti-A beta therapeutics, which have shown modest efficacy in slowing the progression of the disease. However, the puzzling issue remains as to why completely removing A beta does not fully stop the disease.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Mengxin Li, Xuanzhong Wang, Xuyang Chen, Jinghui Hong, Ye Du, Dong Song
Summary: Pancreatic adenocarcinoma (PAAD) is a common digestive malignant tumor with limited treatment options. This study demonstrates that TGM2 may serve as a marker for treatment and prognosis in pancreatic cancer patients. Co-treatment of low dose cisplatin (DDP) and the TGM2 inhibitor GK921 effectively inhibits PAAD cell viability and proliferation in vitro and in vivo, by inhibiting epithelial-to-mesenchymal transition (EMT) induced by TGM2 and enhancing cell cycle arrest and apoptosis caused by DDP. These findings suggest that the combination of GK921 and DDP holds promise as a treatment for PAAD patients.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Liaoran Niu, Qi Wang, Fan Feng, Wanli Yang, Zhenyu Xie, Gaozan Zheng, Wei Zhou, Lili Duan, Kunli Du, Yiding Li, Ye Tian, Junfeng Chen, Qibin Xie, Aqiang Fan, Hanjun Dan, Jinqiang Liu, Daiming Fan, Liu Hong, Jian Zhang, Jianyong Zheng
Summary: This review provides a comprehensive summary of the interaction between cancer cells and macrophages in the tumor microenvironment, and discusses the role of small extracellular vesicles (sEVs) in this process. It also explores the various effects of macrophage-secreted sEVs on tumor malignant transformation, and addresses the therapeutic advancements and challenges associated with these vesicles.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Neha Sawant, Sudhir Kshirsagar, P. Hemachandra Reddy, Arubala P. Reddy
Summary: Depression is a common neuropsychiatric comorbidity in Alzheimer's disease (AD) and other Tauopathies. Selective serotonin reuptake inhibitor (SSRI) treatment, such as Citalopram, not only has anti-depressive and anxiolytic effects, but also helps improve neurogenesis, reduce amyloid burden & Tau pathologies, and neuroinflammation in AD. In this study, Citalopram was found to reduce pathologically pTau level, increase synaptic gene expression and cytoskeletal structure, as well as improve cell survival, mitochondrial respiration, and mitochondrial morphology in cells expressing mutant APP and Tau. These findings suggest that Citalopram could be a promising therapeutic drug for treating depression and AD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Yueqi Chen, Jiulin Tan, Chuan Yang, Zhiguo Ling, Jianzhong Xu, Dong Sun, Fei Luo
Summary: Bone is a self-healing organ that undergoes continuous regeneration through the cooperation of osteoclasts and osteoblasts. This study used ATAC-seq and RNA-Seq techniques to investigate the chromatin accessibility and transcriptomic landscape of osteoblast differentiation and mineralization. The results showed that global chromatin accessibility was extensively improved during osteoblastogenesis. Additionally, several transcription factors including MEF2A, PRRX1, Shox2, and HOXB13 were found to modulate the promoter accessibility of target genes during osteoblast differentiation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Zi-Ran Kang, Shanshan Jiang, Ji-Xuan Han, Yaqi Gao, Yile Xie, Jinxian Chen, Qiang Liu, Jun Yu, Xin Zhao, Jie Hong, Haoyan Chen, Ying-Xuan Chen, Huimin Chen, Jing-Yuan Fang
Summary: The study demonstrates that BCAA metabolism is involved in the development of colorectal cancer (CRC). BCAT2 deficiency promotes CRC progression by inhibiting BCAA metabolism and chronically activating the mTORC1 pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Chao Zheng, Lingling Liu, Caiyun Liu, Fengna Chu, Yue Lang, Shan Liu, Yan Mi, Jie Zhu, Tao Jin
Summary: Inducing tolerogenic dendritic cells (tDCs) with low RelB expression could effectively alleviate symptoms and reduce immune cell infiltration and demyelination in experimental autoimmune encephalomyelitis (EAE) mouse model.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Hang Lam Li, Simei Go, Jung-Chin Chang, Arthur Verhoeven, Ronald Oude Elferink
Summary: This review highlights the distinct characteristics and crucial role of soluble adenylyl cyclase (sAC) in cellular processes, as well as recent significant advancements in the field of sAC research.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Seco-Cervera, D. Ortiz-Masia, D. C. Macias-Ceja, S. Coll, L. Gisbert-Ferrandiz, J. Cosin-Roger, C. Bauset, M. Ortega, B. Heras-Moran, F. Navarro-Vicente, M. Millan, J. V. Esplugues, S. Calatayud, M. D. Barrachina
Summary: The study revealed the presence of resistance to apoptosis in complicated ileal Crohn's disease, with PDGFB inducing an ETS1-mediated resistance to apoptosis associated with an inflammatory and fibrogenic pattern of expression in intestinal fibroblasts. Potential targets against ileal fibrosis include PDGFRB, IL1R1, or MCL1.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yunmeng Wang, Ping Cheng
Summary: Oncolytic viruses (OVs) are emerging as therapeutically relevant anticancer agents, especially when combined with genetically modified bispecific T cell engagers (BiTEs). This combination strategy can overcome the limitations of BiTEs alone and provide targeted cytotoxicity to solid tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Stephanie Tannous, Hassan Y. Naim
Summary: Congenital sucrase-isomaltase deficiency (CSID) is an autosomal recessive disorder caused by variants in the SI gene. A frameshift mutation called c.273_274delAG (p.Gly92Leufs*8) has been identified in CSID patients in Greenlandic population, which leads to loss of digestive function of SI. Surprisingly, the truncated mutant can still be located on the cell surface and interacts with wild type SI, negatively affecting its enzymatic function. Furthermore, heterozygote carriers of this mutation may also exhibit CSID symptoms.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)