Gut–Liver Axis and Inflammasome Activation in Cholangiocyte Pathophysiology

Intestinal dysbiosis augments liver disease progression via NLRP3 in a murine model of primary sclerosing cholangitis

(2019) Lijun Liao et al.   GUT

Targeting NLRP3 Inflammasome in Inflammatory Bowel Disease: Putting out the Fire of Inflammation

(2019) Bo-Zong Shao et al.   INFLAMMATION

The selective NLRP3 inflammasome inhibitor MCC950 alleviates cholestatic liver injury and fibrosis in mice

(2019) Junwen Qu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Canonical and noncanonical inflammasomes in intestinal epithelial cells

(2019) Nathaniel Winsor et al.   CELLULAR MICROBIOLOGY

Effects of Antibiotic Therapy in Primary Sclerosing Cholangitis with and without Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

(2019) Ayesha Shah et al.   SEMINARS IN LIVER DISEASE

Gal-3 Deficiency Suppresses Novosphyngobium aromaticivorans Inflammasome Activation and IL-17 Driven Autoimmune Cholangitis in Mice

(2019) Aleksandar Arsenijevic et al.   Frontiers in Immunology

High occurrence of small intestinal bacterial overgrowth in primary biliary cholangitis

(2019) Jeremy Liu Chen Kiow et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Bile acids in glucose metabolism and insulin signalling — mechanisms and research needs

(2019) Tiara R. Ahmad et al.   Nature Reviews Endocrinology

Methane-Rich Saline Counteracts Cholestasis-Induced Liver Damage via Regulating the TLR4/NF-κB/NLRP3 Inflammasome Pathway

(2019) Zeyu Li et al.   Oxidative Medicine and Cellular Longevity

Diversification of host bile acids by members of the gut microbiota

(2019) Jenessa A. Winston et al.   Gut Microbes

The microbiome and autoimmunity: a paradigm from the gut–liver axis

(2018) Bo Li et al.   Cellular & Molecular Immunology

Anti-Inflammatory Effects of Vardenafil Against Cholestatic Liver Damage in Mice: a Mechanistic Study

(2018) Dina S. El-Agamy et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Liver disease in patients with cystic fibrosis

(2018) Natasha Kamal et al.   CURRENT OPINION IN GASTROENTEROLOGY

Regulation of Epithelial Injury and Bile Duct Obstruction by NLRP3 and IL-1R1 in Experimental Biliary Atresia

(2018) Li Yang et al.   JOURNAL OF HEPATOLOGY

Methane Medicine: A Rising Star Gas with Powerful Anti-Inflammation, Antioxidant, and Antiapoptosis Properties

(2018) Yifan Jia et al.   Oxidative Medicine and Cellular Longevity

Sequence determinants of specific pattern-recognition of bacterial ligands by the NAIP–NLRC4 inflammasome

(2018) Jingyi Yang et al.   Cell Discovery

Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis

(2018) Amandeep K Dhillon et al.   LIVER INTERNATIONAL

Inflammation and the Gut-Liver Axis in the Pathophysiology of Cholangiopathies

(2018) Debora Giordano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy

(2017) Ruqi Tang et al.   GUT

Knockout of the primary sclerosing cholangitis-risk gene Fut2 causes liver disease in mice

(2017) Luca Maroni et al.   HEPATOLOGY

The gut microbiota contributes to a mouse model of spontaneous bile duct inflammation

(2017) Elisabeth Schrumpf et al.   JOURNAL OF HEPATOLOGY

Gut barrier failure biomarkers are associated with poor disease outcome in patients with primary sclerosing cholangitis

(2017) Tamas Tornai et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Relevance of the NLRP3 Inflammasome in the Pathogenesis of Chronic Liver Disease

(2017) Xiaoqin Wu et al.   Frontiers in Immunology

Modulation of liver tolerance by conventional and nonconventional antigen-presenting cells and regulatory immune cells

(2016) Andrea Kristina Horst et al.   Cellular & Molecular Immunology

Galectin-3 regulates inflammasome activation in cholestatic liver injury

(2016) Jijing Tian et al.   FASEB JOURNAL

Primary sclerosing cholangitis is characterised by intestinal dysbiosis independent from IBD

(2016) João Sabino et al.   GUT

The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls

(2016) Martin Kummen et al.   GUT

Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome

(2016) Chuansheng Guo et al.   IMMUNITY

The Human Intestinal Microbiome in Health and Disease

(2016) Susan V. Lynch et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Chenodeoxycholic acid activates NLRP3 inflammasome and contributes to cholestatic liver fibrosis

(2016) Zizhen Gong et al.   Oncotarget

Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis

(2015) James H. Tabibian et al.   HEPATOLOGY

Initiation and perpetuation of NLRP3 inflammasome activation and assembly

(2015) Eric I. Elliott et al.   IMMUNOLOGICAL REVIEWS

TLR4, TLR9, and NLRP3 in biliary epithelial cells of primary sclerosing cholangitis: Relationship with clinical characteristics

(2015) Hiroshi Matsushita et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

The Cholangiopathies

(2015) Konstantinos N. Lazaridis et al.   MAYO CLINIC PROCEEDINGS

Distinctive inflammatory bowel disease phenotype in primary sclerosing cholangitis

(2015) A Boudewijn de Vries   WORLD JOURNAL OF GASTROENTEROLOGY

Fucosyltransferase 2: A Genetic Risk Factor for Primary Sclerosing Cholangitis and Crohn's Disease—A Comprehensive Review

(2014) Luca Maroni et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

NLRP3 inflammasome activation is required for fibrosis development in NAFLD

(2014) Alexander Wree et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Adipocyte cell size, free fatty acids and apolipoproteins are associated with non-alcoholic liver injury progression in severely obese patients

(2014) Alexander Wree et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Inflammasomes

(2014) M. R. de Zoete et al.   Cold Spring Harbor Perspectives in Biology

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

Role of the Microbiota and Antibiotics in Primary Sclerosing Cholangitis

(2013) James H. Tabibian et al.   Biomed Research International

Interactions between Nod-Like Receptors and Intestinal Bacteria

(2013) Marcel R. de Zoete et al.   Frontiers in Immunology

Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease

(2012) Derrick E. Fouts et al.   JOURNAL OF HEPATOLOGY

Inflammasomes in liver diseases

(2012) Gyongyi Szabo et al.   JOURNAL OF HEPATOLOGY

Loss of CFTR Affects Biliary Epithelium Innate Immunity and Causes TLR4–NF-κB—Mediated Inflammatory Response in Mice

(2011) Romina Fiorotto et al.   GASTROENTEROLOGY

Altered biliary epithelial cell and monocyte responses to lipopolysaccharide as a TLR ligand in patients with primary biliary cirrhosis

(2011) Jingmin Zhao et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Long-term bacterial exposure can trigger nonsuppurative destructive cholangitis associated with multifocal epithelial inflammation

(2010) Ikuko Haruta et al.   LABORATORY INVESTIGATION

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Bile acids: regulation of synthesis

(2009) John Y. L. Chiang   JOURNAL OF LIPID RESEARCH

A re-evaluation of the risk factors for the recurrence of primary sclerosing cholangitis in liver allografts

(2009) Edward Alabraba et al.   LIVER TRANSPLANTATION

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

The immunobiology of cholangiocytes

(2008) Xian-Ming Chen et al.   IMMUNOLOGY AND CELL BIOLOGY

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The Nod-Like Receptor (NLR) Family: A Tale of Similarities and Differences

(2008) Martina Proell et al.   PLoS One