Article
Cell Biology
Peng Ye, Wei Li, Xin Huang, Sheng Zhao, Wu Chen, Yuqi Xia, Weimin Yu, Ting Rao, Jinzhuo Ning, Xiangjun Zhou, Yuan Ruan, Fan Cheng
Summary: This study aimed to investigate the role and mechanism of BMAL1 in renal ischemia-reperfusion injury (IRI). The results showed that BMAL1 mediates mitochondrial homeostasis in renal IRI through the SIRT1/PGC-1 alpha axis, providing a new direction for targeted therapy for renal IRI.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Weili Li, Jing Cao, Xiaoping Wang, Yawen Zhang, Qianbin Sun, Yanyan Jiang, Junkai Yao, Chun Li, Yong Wang, Wei Wang
Summary: The study demonstrated that Ferruginol (FGL) exerts cardioprotective effects by enhancing mitochondrial biogenesis and fatty acid oxidation through stimulating the SIRT1-PGC-1 alpha axis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ying Jiang, Da Li, Zhiqiang Du, Jie Li, Rongrong Lu, Qin Zhou, Qi Wang, Haohao Zhu
Summary: The study investigated the protective effects of Perampanel on mitochondrial biogenesis and bioenergetics in human neuronal cells. Results showed that Perampanel stimulated mitochondrial biogenesis and improved mitochondrial bioenergetics.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Neurosciences
Yu Chen, Yuhui Jiang, Yinuo Yang, Xinzhong Huang, Cheng Sun
Summary: The study revealed that SIRT1 has neuroprotective effects on dopaminergic neurons by promoting cell survival, maintaining mitochondrial function, and reducing cell apoptosis. These effects are dependent on SIRT1-mediated mitochondrial biogenesis via PGC-1α, suggesting great therapeutic potential of SIRT1 for disorders associated with dopaminergic neuron loss such as PD.
NEUROTOXICITY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yi Li, Yu-Fan Feng, Xiao-Tian Liu, Yu-Chen Li, Hui-Min Zhu, Meng-Ru Sun, Ping Li, Baolin Liu, Hua Yang
Summary: Songorine protects cardiac contractive function against endotoxin insult by activating Nrf2, suppressing mitochondrial reactive oxygen species production, and promoting mitochondrial biogenesis, ultimately enhancing cardioprotection.
Article
Neurosciences
Mastura Akter, Haiying Ma, Mahadi Hasan, Anwarul Karim, Xiaowei Zhu, Liang Zhang, Ying Li
Summary: L-lactate plays a critical role in learning and memory. Studies in rats showed that exogenous L-lactate administration can improve decision-making and enhance long-term memory formation. The molecular mechanisms underlying these beneficial effects are still under investigation. Recent studies have found that L-lactate supplementation results in a reactive oxygen species burst and induction of pro-survival pathways. In this study, rats were injected with L-lactate or artificial CSF, and mass spectrometry analysis revealed increased levels of key regulators of mitochondrial biogenesis and antioxidant defense in the L-lactate treated rats' hippocampus.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Environmental Sciences
Huan Liu, Siyu Zhu, Wenna Han, Yueqi Cai, Chunhong Liu
Summary: DMEP induces mitochondrial damage and cellular oxidative stress in HepG2 cells, impacting the Nrf2 pathway and mitochondrial biogenesis, leading to autophagy and apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Medicine, Research & Experimental
Yuqiang Liu, Han Yang, Nanbo Luo, Yifei Fu, Fang Qiu, Zhenglong Pan, Xiongjuan Li, Wenling Jian, Xinping Yang, Qingsheng Xue, Yan Luo, Buwei Yu, Zhiheng Liu
Summary: This study investigated the protective effects of an Fgr kinase inhibitor in sepsis-associated encephalopathy (SAE) and the underlying mechanisms. The results showed that the Fgr inhibitor can attenuate neuroinflammation, oxidative stress, and mitochondrial dysfunction, and exert neuroprotective effects by activating the SIRT1/PGC-1a pathway. This study provides a promising therapeutic target for SAE.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Jara Tabitha Hees, Angelika Bettina Harbauer
Summary: Mitochondria play a critical role in neuronal function by providing ATP and buffering Ca2+. The regulation of mitochondrial biogenesis at the transcriptional and translational level is necessary for neurons to adapt to local differences in mitochondrial demand. Defects in the localization of mRNAs encoding mitochondrial proteins and contact site formation between mitochondria and endolysosomes can lead to mitochondrial dysfunction in various neurological disorders.
Article
Environmental Sciences
Hui Shan, Xiaohong Li, Chuan Ouyang, Hongyang Ke, Xiaoli Yu, Jinfeng Tan, Junhao Chen, Chunping Wang, Liping Zhang, Yunfeng Tang, Li Yu, Wanwei Li
Summary: This study investigated the protective effect of Salidroside (Sal) on PM2.5-induced bronchial injury and the underlying mechanisms. The results demonstrated that Sal effectively inhibited PM2.5-induced cell apoptosis and oxidative stress by regulating mitochondrial function and the SIRT1/PGC-1α signaling pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Chemistry, Multidisciplinary
Qing Zheng, Hanghang Liu, Hao Zhang, Yaobao Han, Jiaxin Yuan, Tingting Wang, Yifan Gao, Zhen Li
Summary: This study reports the use of Cu2-xSe-based nanoparticles functionalized with curcumin and wrapped with DSPE-PEG(2000)-TPP-modified macrophage membrane (CSCCT NPs) to promote mitochondrial biogenesis and ameliorate mitochondrial dysfunction for the treatment of Parkinson's disease.
Article
Cell Biology
Ruzhou Zhao, Yixin Xu, Xiaobo Wang, Xiang Zhou, Yanqi Liu, Shuai Jiang, Lin Zhang, Zhibin Yu
Summary: In extremely hypoxic environments, WA can protect cells by affecting the mitophagy and mitochondrial biogenesis pathways to reduce myocardial damage, maintain cardiac function, and improve survival. Enhanced mitophagy eliminates damaged mitochondria and prevents apoptosis induction, while enhanced mitochondrial biogenesis can supplement functional mitochondria and maintain mitochondrial respiration to ensure mitochondrial ATP production under acute extreme hypoxia.
Article
Chemistry, Medicinal
Jiayu Song, Luyao Ren, Zhenzhu Ren, Xing Ren, Yang Qi, Yuxi Qin, Xiaohui Zhang, Yuan Ren, Yunlan Li
Summary: The mitochondria are key targets in nonalcoholic fatty liver disease (NAFLD), and this study identified several mitochondrial biogenesis-related proteins as therapeutic targets for NAFLD. By synthesizing a series of compounds, it was found that hydroxyl and ketone groups influence mitochondrial biogenesis activity, with the o-hydroxyl group on the benzene ring exhibiting stronger activity. In vitro and in vivo experiments confirmed that these compounds could improve mitochondrial dysfunction and NAFLD by activating the PGC1a signaling pathway in a SIRT1-dependent manner.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Mariantonietta Capristo, Valentina Del Dotto, Concetta Valentina Tropeano, Claudio Fiorini, Leonardo Caporali, Chiara La Morgia, Maria Lucia Valentino, Monica Montopoli, Valerio Carelli, Alessandra Maresca
Summary: The study suggests that rapamycin-based therapy may be a promising treatment option for MERRF. The first therapeutic strategy was ineffective in high-mutation load cell lines, while the second strategy showed significant improvement in fibroblasts with intermediate-mutation load, rescuing the bioenergetics defect completely.
MOLECULAR MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Qingxia Huang, Hang Su, Bin Qi, Ying Wang, Kaili Yan, Xinglin Wang, Xiangyan Li, Daqing Zhao
Summary: The study confirms that ginsenoside Rc promotes the activity of SIRT1, leading to improved mitochondrial function and energy metabolism, thus enhancing cardio- and neuroprotective functions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Medicine, General & Internal
Jyun-Bin Huang, Nai-Ching Chen, Chien-Liang Chen, Mu-Hui Fu, Hsiu-Yung Pan, Chung-Yao Hsu, Shang-Der Chen, Yao-Chung Chuang
Summary: Neuroinflammation plays a crucial role in cell damage and death after acute ischemic stroke, with sTREM-1, TNF alpha, IL-6, and S100B levels correlating with stroke volume and NIHSS scores. Targeting the TREM-1 pathway may offer a new therapeutic strategy for acute ischemic stroke.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Wei-Chih Yeh, Chiou-Lian Lai, Meng-Ni Wu, Hsun-Chang Lin, Kuo-Wei Lee, Ying-Sheng Li, Chung-Yao Hsu
Summary: Patients with refractory epilepsy exhibited more disrupted REM sleep compared to those with medically controlled epilepsy. There were no significant differences in other sleep parameters and the prevalence of OSA between the two groups. This study suggests that patients with refractory epilepsy may be less susceptible to OSA.
Article
Environmental Sciences
Chih-Chuan Pan, Che-Sheng Chu, Chien-Liang Chen, Yao-Chung Chuang, Nai-Ching Chen
Summary: The study showed that a prolonged use of AChEIs for more than 22 months could reduce the risk of rapid cognitive decline in patients with AD. Patients aged over 85 or between 75-85 had a lower risk of rapid cognitive decline compared to those aged 65-75. Patients with mild and moderate AD were also more likely to experience rapid cognitive decline.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Kuo-Jung Ho, Tzu-Hua Chen, Chen-Cheng Yang, Yao-Chung Chuang, Hung-Yi Chuang
Summary: Smoking and lead exposure can increase oxidative stress in the human body. The study examined the relationship between oxidative stress markers and gene polymorphisms in lead workers, finding that smokers had higher levels of oxidative stress markers compared to non-smokers. The findings suggest that smoking cessation is important in lead-exposed working environments.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Medicine, General & Internal
Chi-Ren Huang, Hung-Yi Chuang, Nai-Ching Chen, Shu-Fang Chen, Chung-Yao Hsu, Yao-Chung Chuang
Summary: The study evaluated the efficacy of the antiepileptic drug zonisamide (ZNS) in reducing obesity, preventing vascular diseases, and fatty liver. Results showed that ZNS treatment for 12 and 24 weeks significantly decreased patients' body weight, BMI, HbA1c, triglycerides, hs-CRP, and HSI index.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Ya-Ting Yang, Han-Yun Chang, Chung-Yao Hsu, Jamie M. Zeitzer
Summary: The study aimed to translate and validate a Chinese version of the Cleveland Adolescent Sleepiness Questionnaire (C-CASQ) using data from 458 adolescents in Taiwan. The C-CASQ showed acceptable to good internal consistency, with initial criterion validity established and higher sleepiness observed in evening-types.
NATURE AND SCIENCE OF SLEEP
(2021)
Article
Environmental Sciences
Chung-Yao Hsu, Yao-Chung Chuang, Fang-Chia Chang, Hung-Yi Chuang, Terry Ting-Yu Chiou, Chien-Te Lee
Summary: Chronic lead exposure disrupts the sleep-wake cycle in rats, particularly disrupting sleep homeostasis. This disturbance is associated with toxic effects on clock gene expression in the hypothalamus.
Review
Medicine, General & Internal
Cheng-Fang Hsieh, Ping-Tao Tseng, Tien-Yu Chen, Pao-Yen Lin, Yen-Wen Chen, Bo-Lin Ho, Chung-Yao Hsu, Ching-Kuan Liu
Summary: Our meta-analysis found that after treatment with donepezil, the percentage of REM sleep significantly increased in patients, while the percentage of stage 2 sleep, sleep efficiency, and total sleep time decreased. Larger sample size studies are needed to further validate these findings.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Environmental Sciences
Ting-Hao Chen, Chen-Cheng Yang, Kuei-Hau Luo, Chia-Yen Dai, Yao-Chung Chuang, Hung-Yi Chuang
Summary: This study utilized whole genomic genotypes from the Taiwan Biobank to explore the association between Al concentrations in plasma and renal function, identifying a link between DPP6 SNPs, plasma Al concentrations, and eGFR. Further longitudinal studies and research on mechanism are needed to validate these findings. This analysis represents the first study to investigate the impact of DPP6, SNPs, and Al in plasma on eGFR.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Biochemistry & Molecular Biology
Kai-Jung Lin, Tzu-Jou Wang, Shang-Der Chen, Kai-Lieh Lin, Chia-Wei Liou, Min-Yu Lan, Yao-Chung Chuang, Jiin-Haur Chuang, Pei-Wen Wang, Jong-Jer Lee, Feng-Sheng Wang, Hung-Yu Lin, Tsu-Kung Lin
Summary: Parkinson's disease is a common neurodegenerative disease with unknown etiology and no disease-modifying treatment available. Research has shown a link between type-2 diabetes and Parkinson's disease risk and severity, with antidiabetic drugs potentially providing neuroprotective effects for patients.
Review
Medicine, Research & Experimental
Kuan-Ying Li, Chung-Yao Hsu, Yuan-Han Yang
Summary: Anti-seizure medications may have cognitive or behavioral adverse reactions, so it is important to consider this when choosing the right medication. Brivaracetam, a newer type of medication, is expected to have fewer neuropsychiatric adverse effects due to its mechanism of action. A review of studies showed that Brivaracetam has minimal impact on cognition and behavior compared to other anti-seizure medications.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2023)
Review
Cell Biology
Kai-Jung Lin, Shang-Der Chen, Kai-Lieh Lin, Chia-Wei Liou, Min-Yu Lan, Yao-Chung Chuang, Pei-Wen Wang, Jong-Jer Lee, Feng-Sheng Wang, Hung-Yu Lin, Tsu-Kung Lin
Summary: Parkinson's disease is the second most common neurodegenerative disease and is associated with iron accumulation and iron-dependent phospholipid peroxidation, which leads to a novel cell death pathway called ferroptosis. Recent research has focused on targeting ferroptosis as a potential intervention for PD.
Article
Clinical Neurology
Wei-Chih Yeh, Ying-Sheng Li, Chung-Yao Hsu
Summary: This study evaluated the differences in REM microstructure between patients with refractory and medically controlled epilepsy. The results showed that patients with refractory epilepsy had significantly decreased REM sleep, especially in the first and second sleep cycles. Additionally, the REM microstructure of patients with refractory epilepsy was also significantly affected.
Review
Clinical Neurology
Ying-Sheng Li, Wei-Chih Yeh, Chung-Yao Hsu
Summary: This meta-analysis found an association between iron deficiency and augmentation of restless legs syndrome (RLS), suggesting that iron supplementation can not only relieve symptoms but also lower the risk of augmentation in iron-deficient RLS patients. Furthermore, non-dopaminergic agents should be considered as the first-line treatment for patients with persistent low serum ferritin levels or moderate to severe RLS to prevent augmentation.
Review
Clinical Neurology
Yi-On Fong, Poyin Huang, Chung Yao Hsu, Yuan-Han Yang
Summary: This review summarizes the effects of the antiseizure agent perampanel (PER) on cognition, behavior, and psychological status of patients. The results show that PER is effective in reducing seizure frequency and has satisfactory responder and retention rates. It does not have negative effects on cognitive function, but may have an impact on aggressive behavior compared to other antiseizure medications. Patients with previous psychiatric comorbidities may have a higher risk of psychiatric side effects under PER treatment.
JOURNAL OF CLINICAL NEUROLOGY
(2022)