Mitochondrial dynamics, mitophagy and biogenesis in neonatal hypoxic-ischaemic brain injury

3′-Daidzein sulfonate sodium inhibits neuronal apoptosis induced by cerebral ischemia-reperfusion

(2017) Ruizhen Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Production of superoxide and hydrogen peroxide from specific mitochondrial sites under different bioenergetic conditions

(2017) Hoi-Shan Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of mitochondrial homeostasis by endocytic regulatory proteins

(2017) Trey Farmer et al.   JOURNAL OF CELL SCIENCE

Systemic activation of Toll-like receptor 2 suppresses mitochondrial respiration and exacerbates hypoxic–ischemic injury in the developing brain

(2017) Amin Mottahedin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mitochondria as Molecular Platforms Integrating Multiple Innate Immune Signalings

(2017) Marie Monlun et al.   JOURNAL OF MOLECULAR BIOLOGY

3′-Daidzein sulfonate sodium improves mitochondrial functions after cerebral ischemia/reperfusion injury

(2017) Jing Zeng et al.   Neural Regeneration Research

Mdivi-1 Alleviates Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats, Possibly via Inhibition of Drp1-Activated Mitochondrial Fission and Oxidative Stress

(2017) Pei Wu et al.   NEUROCHEMICAL RESEARCH

Downregulation of Iduna is associated with AIF nuclear translocation in neonatal brain after hypoxia–ischemia

(2017) Xiaoxia Yang et al.   NEUROSCIENCE

Coenzyme Q10 ameliorates cerebral ischemia reperfusion injury in hyperglycemic rats

(2017) Cui-Jie Lu et al.   PATHOLOGY RESEARCH AND PRACTICE

Mitochondrial function in hypoxic ischemic injury and influence of aging

(2017) P. Benson Ham et al.   PROGRESS IN NEUROBIOLOGY

Mitochondria, Bioenergetics and Excitotoxicity: New Therapeutic Targets in Perinatal Brain Injury

(2017) Bryan Leaw et al.   Frontiers in Cellular Neuroscience

Haploinsufficiency in the mitochondrial protein CHCHD4 reduces brain injury in a mouse model of neonatal hypoxia-ischemia

(2017) Yanyan Sun et al.   Cell Death & Disease

MIEF1/2 function as adaptors to recruit Drp1 to mitochondria and regulate the association of Drp1 with Mff

(2017) Rong Yu et al.   Scientific Reports

Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury

(2016) Cuicui Xie et al.   Autophagy

How do reactive oxygen species and calcium trigger mitochondrial membrane permeabilisation?

(2016) Nicolas Tajeddine   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mitochondrial division inhibitor 1 (Mdivi-1) offers neuroprotection through diminishing cell death and improving functional outcome in a mouse model of traumatic brain injury

(2016) Qiong Wu et al.   BRAIN RESEARCH

Neuroprotective Effectiveness of Intravenous Ubiquinone in Rat Model of Irreversible Cerebral Ischemia

(2016) M. A. Belousova et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Suppressors of Superoxide-H 2 O 2 Production at Site I Q of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury

(2016) Martin D. Brand et al.   Cell Metabolism

Metformin Attenuates Cognitive Impairments in Hypoxia–Ischemia Neonatal Rats via Improving Remyelination

(2016) Boxiang Qi et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Melatonin: A Mitochondrial Targeting Molecule Involving Mitochondrial Protection and Dynamics

(2016) Dun-Xian Tan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intravenous Treatment With Coenzyme Q10 Improves Neurological Outcome and Reduces Infarct Volume After Transient Focal Brain Ischemia in Rats

(2016) Margarita Belousova et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Potential biomarkers to follow the progression and treatment response of Huntington’s disease

(2016) Marie-Hélène Disatnik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autophagy activation involved in hypoxic-ischemic brain injury induces cognitive and memory impairment in neonatal rats

(2016) Ying Xu et al.   JOURNAL OF NEUROCHEMISTRY

Sex-dependent mitophagy and neuronal death following rat neonatal hypoxia–ischemia

(2016) T.G. Demarest et al.   NEUROSCIENCE

Post-ischemia mdivi-1 treatment protects against ischemia/reperfusion-induced brain injury in a rat model

(2016) Xuesong Ma et al.   NEUROSCIENCE LETTERS

Mitochondria in mesenchymal stem cell biology and cell therapy: From cellular differentiation to mitochondrial transfer

(2016) Yi-Chao Hsu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mitochondrial Dynamics and Metabolic Regulation

(2016) Timothy Wai et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death

(2016) Laura E Sanman et al.   eLife

Mitochondrial control through nutritionally regulated global histone H3 lysine-4 demethylation

(2016) Maria Soloveychik et al.   Scientific Reports

Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses

(2015) Francesc Baixauli et al.   Cell Metabolism

Calcineurin Links Mitochondrial Elongation with Energy Metabolism

(2015) Paul T. Pfluger et al.   Cell Metabolism

Molecular Mechanisms of Mitochondrial Autophagy/Mitophagy in the Heart

(2015) T. Saito et al.   CIRCULATION RESEARCH

Mitochondrial Optic Atrophy (OPA) 1 Processing Is Altered in Response to Neonatal Hypoxic-Ischemic Brain Injury

(2015) Ana Baburamani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Restoration of Opa1-long isoform inhibits retinal injury-induced neurodegeneration

(2015) Yue Sun et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Neuroprotective Effects of Mitochondria-Targeted Plastoquinone and Thymoquinone in a Rat Model of Brain Ischemia/Reperfusion Injury

(2015) Denis Silachev et al.   MOLECULES

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Suppressors of superoxide production from mitochondrial complex III

(2015) Adam L Orr et al.   Nature Chemical Biology

The role of inflammation in perinatal brain injury

(2015) Henrik Hagberg et al.   Nature Reviews Neurology

Neuroprotective effects of daidzein on focal cerebral ischemia injury in rats

(2015) AdemBozkurt Aras et al.   Neural Regeneration Research

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Neuronal hypoxia disrupts mitochondrial fusion

(2015) T.H. Sanderson et al.   NEUROSCIENCE

Mitofusin 2 ablation increases endoplasmic reticulum–mitochondria coupling

(2015) Riccardo Filadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Animal studies of neonatal hypothermic neuroprotection have translated well in to practice

(2015) Alistair J. Gunn et al.   RESUSCITATION

Autophagy in neonatal hypoxia ischemic brain is associated with oxidative stress

(2015) Qing Lu et al.   Redox Biology

The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy

(2014) Hao Wu et al.   Autophagy

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

(2014) Agne Kazlauskaite et al.   BIOCHEMICAL JOURNAL

Sex differences in mitochondrial biogenesis determine neuronal death and survival in response to oxygen glucose deprivation and reoxygenation

(2014) Jaswinder Sharma et al.   BMC NEUROSCIENCE

BNIP3 Interacting with LC3 Triggers Excessive Mitophagy in Delayed Neuronal Death in Stroke

(2014) Ruo-Yang Shi et al.   CNS Neuroscience & Therapeutics

Amelioration of Ischemic Mitochondrial Injury and Bax-Dependent Outer Membrane Permeabilization by Mdivi-1

(2014) Yan-Xin Zhao et al.   CNS Neuroscience & Therapeutics

Drp1 in Ischemic Neuronal Death: An Unusual Suspect

(2014) H. Pradeep et al.   CURRENT MEDICINAL CHEMISTRY

Keeping the immune system in check: a role for mitophagy

(2014) Michael Lazarou   IMMUNOLOGY AND CELL BIOLOGY

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

Mdivi-1 Prevents Apoptosis Induced by Ischemia–Reperfusion Injury in Primary Hippocampal Cells via Inhibition of Reactive Oxygen Species–Activated Mitochondrial Pathway

(2014) Jinying Wang et al.   Journal of Stroke & Cerebrovascular Diseases

Mitochondria: hub of injury responses in the developing brain

(2014) Henrik Hagberg et al.   LANCET NEUROLOGY

Mitochondrial transcription factor A (Tfam) is a pro-inflammatory extracellular signaling molecule recognized by brain microglia

(2014) Jonathan P. Little et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

A Regulatory Signaling Loop Comprising the PGAM5 Phosphatase and CK2 Controls Receptor-Mediated Mitophagy

(2014) Guo Chen et al.   MOLECULAR CELL

Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

(2014) Bryce W. Carey et al.   NATURE

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

Disturbed mitochondrial dynamics and neurodegenerative disorders

(2014) Florence Burté et al.   Nature Reviews Neurology

Mitochondria autophagy is induced after hypoxic/ischemic stress in a Drp1 dependent manner: The role of inhibition of Drp1 in ischemic brain damage

(2014) Wei Zuo et al.   NEUROPHARMACOLOGY

Effects of Hypothermia for Perinatal Asphyxia on Childhood Outcomes

(2014) Denis Azzopardi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis

(2014) X. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy

(2014) J. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subcutaneous daidzein administration enhances recovery of skilled ladder rung walking performance following stroke in rats

(2013) Jessica M. Stout et al.   BEHAVIOURAL BRAIN RESEARCH

Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency

(2013) Sara Cogliati et al.   CELL

Inhibition of mitochondrial fragmentation diminishes Huntington’s disease–associated neurodegeneration

(2013) Xing Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission

(2013) Oliver C. Losón et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy in the brain of neonates following hypoxia–ischemia shows sex- and region-specific effects

(2013) S.N. Weis et al.   NEUROSCIENCE

Mitochondrial Dynamics Associated with Oxygen-Glucose Deprivation in Rat Primary Neuronal Cultures

(2013) Edina A. Wappler et al.   PLoS One

Acute Inhibition of Excessive Mitochondrial Fission After Myocardial Infarction Prevents Long‐term Cardiac Dysfunction

(2013) Marie‐Hélène Disatnik et al.   Journal of the American Heart Association

Neonatal encephalopathy: An inadequate term for hypoxic-ischemic encephalopathy

(2012) Joseph J. Volpe   ANNALS OF NEUROLOGY

Antemortem cranial MRI compared with postmortem histopathologic examination of the brain in term infants with neonatal encephalopathy following perinatal asphyxia

(2012) Thomas Alderliesten et al.   Archives of Disease in Childhood-Fetal and Neonatal Edition

Inhibition of Drp1 provides neuroprotection in vitro and in vivo

(2012) J Grohm et al.   CELL DEATH AND DIFFERENTIATION

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

PAMPs and DAMPs: signal 0s that spur autophagy and immunity

(2012) Daolin Tang et al.   IMMUNOLOGICAL REVIEWS

A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity

(2012) X. Qi et al.   JOURNAL OF CELL SCIENCE

Tertiary mechanisms of brain damage: a new hope for treatment of cerebral palsy?

(2012) Bobbi Fleiss et al.   LANCET NEUROLOGY

Role of melatonin in the regulation of autophagy and mitophagy: A review

(2012) Ana Coto-Montes et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Seven- to eight-year follow-up of the CoolCap trial of head cooling for neonatal encephalopathy

(2012) Ronnie Guillet et al.   PEDIATRIC RESEARCH

Combined effect of hypothermia and caspase-2 gene deficiency on neonatal hypoxic–ischemic brain injury

(2012) Ylva Carlsson et al.   PEDIATRIC RESEARCH

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Umbilical Cord Blood Therapy Potentiated with Erythropoietin for Children with Cerebral Palsy: A Double-blind, Randomized, Placebo-Controlled Trial

(2012) Kyunghoon Min et al.   STEM CELLS

Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines

(2012) Aiwu Cheng et al.   Nature Communications

Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes

(2011) Youngil Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Neuronal cell death in neonatal hypoxia-ischemia

(2011) Frances J. Northington et al.   ANNALS OF NEUROLOGY

Genetic inhibition of caspase-2 reduces hypoxic-ischemic and excitotoxic neonatal brain injury

(2011) Ylva Carlsson et al.   ANNALS OF NEUROLOGY

Targeting the p53 pathway to protect the neonatal ischemic brain

(2011) Cora H. Nijboer et al.   ANNALS OF NEUROLOGY

Mitochondria-Targeted Small Molecule Therapeutics and Probes

(2011) Robin A.J. Smith et al.   ANTIOXIDANTS & REDOX SIGNALING

Effect of Coenzyme Q10 on ischemia and neuronal damage in an experimental traumatic brain-injury model in rats

(2011) Murat Kalayci et al.   BMC NEUROSCIENCE

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

(2011) Ariel C. Bulua et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PKA/AKAP1 and PP2A/B 2 Regulate Neuronal Morphogenesis via Drp1 Phosphorylation and Mitochondrial Bioenergetics

(2011) A. S. Dickey et al.   JOURNAL OF NEUROSCIENCE

Functionalized nanosystems for targeted mitochondrial delivery

(2011) Shelley A. Durazo et al.   MITOCHONDRION

Fine-Tuning of Drp1/Fis1 Availability by AKAP121/Siah2 Regulates Mitochondrial Adaptation to Hypoxia

(2011) Hyungsoo Kim et al.   MOLECULAR CELL

Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death

(2011) Shaida A Andrabi et al.   NATURE MEDICINE

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

Targeting neonatal ischemic brain injury with a pentapeptide-based irreversible caspase inhibitor

(2011) D Chauvier et al.   Cell Death & Disease

Mechanism of Neuroprotective Mitochondrial Remodeling by PKA/AKAP1

(2011) Ronald A. Merrill et al.   PLOS BIOLOGY

Setting Research Priorities to Reduce Almost One Million Deaths from Birth Asphyxia by 2015

(2011) Joy E. Lawn et al.   PLOS MEDICINE

Erythropoietin Activates Mitochondrial Biogenesis and Couples Red Cell Mass to Mitochondrial Mass in the Heart

(2010) Martha S. Carraway et al.   CIRCULATION RESEARCH

The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms

(2010) Thomas Landes et al.   EMBO REPORTS

Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells

(2010) Hidenori Otera et al.   JOURNAL OF CELL BIOLOGY

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An optimised tract-based spatial statistics protocol for neonates: Applications to prematurity and chronic lung disease

(2010) Gareth Ball et al.   NEUROIMAGE

Human Recombinant Erythropoietin in Asphyxia Neonatorum: Pilot Trial

(2010) H. Elmahdy et al.   PEDIATRICS

Neuroprotective Effect of Bax-Inhibiting Peptide on Neonatal Brain Injury

(2010) Xiaoyang Wang et al.   STROKE

Inhibition of the JNK/AP-1 pathway reduces neuronal death and improves behavioral outcome after neonatal hypoxic–ischemic brain injury

(2009) Cora H. Nijboer et al.   BRAIN BEHAVIOR AND IMMUNITY

Regulation of OPA1 processing and mitochondrial fusion bym-AAA protease isoenzymes and OMA1

(2009) Sarah Ehses et al.   JOURNAL OF CELL BIOLOGY

Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells

(2009) Brian Head et al.   JOURNAL OF CELL BIOLOGY

Apoptotic Mechanisms in the Immature Brain: Involvement of Mitochondria

(2009) Henrik Hagberg et al.   JOURNAL OF CHILD NEUROLOGY

Developmental Shift of Cyclophilin D Contribution to Hypoxic-Ischemic Brain Injury

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic–ischaemic encephalopathy: a nested substudy of a randomised controlled trial

(2009) Mary Rutherford et al.   LANCET NEUROLOGY

Moderate Hypothermia to Treat Perinatal Asphyxial Encephalopathy

(2009) Denis V. Azzopardi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Supra- and sub-baseline phosphocreatine recovery in developing brain after transient hypoxia-ischaemia: relation to baseline energetics, insult severity and outcome

(2008) Osuke Iwata et al.   BRAIN

The mitochondrial outer membrane protein hFis1 regulates mitochondrial morphology and fission through self-interaction

(2008) Madhavika N. Serasinghe et al.   EXPERIMENTAL CELL RESEARCH

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Opa1-Mediated Cristae Opening Is Bax/Bak and BH3 Dependent, Required for Apoptosis, and Independent of Bak Oligomerization

(2008) Ryuji Yamaguchi et al.   MOLECULAR CELL

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE

Neonatal rat hypoxia-ischemia: Effect of the anti-oxidant mitoquinol, and S-PBN

(2008) Catherine E. Hobbs et al.   PEDIATRICS INTERNATIONAL

Strong Neuroprotection by Inhibition of NF-κB After Neonatal Hypoxia-Ischemia Involves Apoptotic Mechanisms but Is Independent of Cytokines

(2008) Cora H.A. Nijboer et al.   STROKE

Rapidly Increased Neuronal Mitochondrial Biogenesis After Hypoxic-Ischemic Brain Injury

(2008) Wei Yin et al.   STROKE

Postnatal developmental regulation of Bcl-2 family proteins in brain mitochondria

(2007) Lucian Soane et al.   JOURNAL OF NEUROSCIENCE RESEARCH