Therapeutic Strategies for Regulating Mitochondrial Oxidative Stress

The Use of a Microfluidic Device to Encapsulate a Poorly Water-Soluble Drug CoQ10 in Lipid Nanoparticles and an Attempt to Regulate Intracellular Trafficking to Reach Mitochondria

(2019) Mitsue Hibino et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Therapeutic potential of coenzyme Q10 in mitochondrial dysfunction during tacrolimus-induced beta cell injury

(2019) Kang Luo et al.   Scientific Reports

A pH-Activatable nanoparticle for dual-stage precisely mitochondria-targeted photodynamic anticancer therapy

(2019) Tong Qi et al.   BIOMATERIALS

Liver-targeted Nano-MitoPBN normalizes glucose metabolism by improving mitochondrial redox balance

(2019) Meiling Wu et al.   BIOMATERIALS

Precisely Striking Tumors without Adjacent Normal Tissue Damage via Mitochondria-Templated Accumulation

(2018) Zhaoyu Ma et al.   ACS Nano

Mitochondrial specific photodynamic therapy by rare-earth nanoparticles mediated near-infrared graphene quantum dots

(2018) Dandan Zhang et al.   BIOMATERIALS

Tuning the Hydrophobicity of a Mitochondria-Targeted NO Photodonor

(2018) Federica Sodano et al.   ChemMedChem

Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis

(2018) Anja Jelinek et al.   FREE RADICAL BIOLOGY AND MEDICINE

Triphenylphosphonium and D-α-tocopheryl polyethylene glycol 1000 succinate-modified, tanshinone IIA-loaded lipid-polymeric nanocarriers for the targeted therapy of myocardial infarction

(2018) Shouwen Zhang et al.   International Journal of Nanomedicine

Cardiac progenitor cells activated by mitochondrial delivery of resveratrol enhance the survival of a doxorubicin-induced cardiomyopathy mouse model via the mitochondrial activation of a damaged myocardium

(2018) Jiro Abe et al.   JOURNAL OF CONTROLLED RELEASE

Mitochondrial transgene expression via an artificial mitochondrial DNA vector in cells from a patient with a mitochondrial disease

(2018) Takuya Ishikawa et al.   JOURNAL OF CONTROLLED RELEASE

Advances in highly doped upconversion nanoparticles

(2018) Shihui Wen et al.   Nature Communications

The use of cardiac progenitor cells for transplantation in congenital heart disease and an innovative strategy for activating mitochondrial function in such cells

(2018) Jiro Abe et al.   Journal of Thoracic Disease

Neuroprotective Effects of Mitochondria-Targeted Plastoquinone in a Rat Model of Neonatal Hypoxic–Ischemic Brain Injury

(2018) Denis Silachev et al.   MOLECULES

Targeted Mitochondrial COQ10 Delivery Attenuates Antiretroviral-Drug-Induced Senescence of Neural Progenitor Cells

(2018) Martina Velichkovska et al.   MOLECULAR PHARMACEUTICS

Nitric Oxide Donor-Based Cancer Therapy: Advances and Prospects

(2017) Zhangjian Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mitochondrial Delivery of Doxorubicin Using MITO-Porter Kills Drug-Resistant Renal Cancer Cells via Mitochondrial Toxicity

(2017) Yuma Yamada et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A Mitochondria-Targeted Cryptocyanine-Based Photothermogenic Photosensitizer

(2017) Hyo Sung Jung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The pathophysiological role of mitochondrial oxidative stress in lung diseases

(2017) Xiaojing Liu et al.   Journal of Translational Medicine

Neuronal protection against oxidative insult by polyanhydride nanoparticle-based mitochondria-targeted antioxidant therapy

(2017) Timothy M. Brenza et al.   Nanomedicine-Nanotechnology Biology and Medicine

Photoinduced electron transfer reaction in mitochondria for spatiotemporal selective photo-oxidation of lipids by donor/acceptor linked molecules

(2017) Yuta Takano et al.   Nanoscale

Optical control of mitochondrial reductive reactions in living cells using an electron donor–acceptor linked molecule

(2017) Yuta Takano et al.   Nanoscale

Cancer-mitochondria-targeted photodynamic therapy with supramolecular assembly of HA and a water soluble NIR cyanine dye

(2017) Ajesh P. Thomas et al.   Chemical Science

Inhibition of cancer growth in vitro and in vivo by a novel ROS-modulating agent with ability to eliminate stem-like cancer cells

(2017) Jiankang Wang et al.   Cell Death & Disease

A Mitochondria-Targeted Photosensitizer Showing Improved Photodynamic Therapy Effects Under Hypoxia

(2016) Wen Lv et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity

(2016) Kuo Du et al.   ARCHIVES OF TOXICOLOGY

Multimodal Upconversion Nanoplatform with a Mitochondria-Targeted Property for Improved Photodynamic Therapy of Cancer Cells

(2016) Xiaoman Zhang et al.   INORGANIC CHEMISTRY

Validation of a Strategy for Cancer Therapy: Delivering Aminoglycoside Drugs to Mitochondria in HeLa Cells

(2016) Jiro Abe et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Photodynamic Therapy Induced Enhancement of Tumor Vasculature Permeability Using an Upconversion Nanoconstruct for Improved Intratumoral Nanoparticle Delivery in Deep Tissues

(2016) Weidong Gao et al.   Theranostics

Apoptosis-Resistant Cardiac Progenitor Cells Modified With Apurinic/Apyrimidinic Endonuclease/Redox Factor 1 Gene Overexpression Regulate Cardiac Repair After Myocardial Infarction

(2016) Tatsuya Aonuma et al.   Stem Cells Translational Medicine

Antioxidant Activity during Tumor Progression: A Necessity for the Survival of Cancer Cells?

(2016) Mark Hawk et al.   Cancers

Dual-Targeting Nanosystem for Enhancing Photodynamic Therapy Efficiency

(2015) Jiangsheng Xu et al.   ACS Applied Materials & Interfaces

A Near-Infrared Triggered Nanophotosensitizer Inducing Domino Effect on Mitochondrial Reactive Oxygen Species Burst for Cancer Therapy

(2015) Zhengze Yu et al.   ACS Nano

Tumor mitochondria-targeted photodynamic therapy with a translocator protein (TSPO)-specific photosensitizer

(2015) Shaojuan Zhang et al.   Acta Biomaterialia

Dual-Stage-Light-Guided Tumor Inhibition by Mitochondria-Targeted Photodynamic Therapy

(2015) Kai Han et al.   ADVANCED FUNCTIONAL MATERIALS

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

(2015) Isaac S. Harris et al.   CANCER CELL

Nanoparticles in Photodynamic Therapy

(2015) Sasidharan Swarnalatha Lucky et al.   CHEMICAL REVIEWS

A mitochondria-targeted derivative of ascorbate: MitoC

(2015) Peter G. Finichiu et al.   FREE RADICAL BIOLOGY AND MEDICINE

A mitochondrial superoxide theory for oxidative stress diseases and aging

(2015) Hiroko P. Indo et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Mitochondrial delivery of Coenzyme Q 10 via systemic administration using a MITO-Porter prevents ischemia/reperfusion injury in the mouse liver

(2015) Yuma Yamada et al.   JOURNAL OF CONTROLLED RELEASE

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Antioxidants can increase melanoma metastasis in mice

(2015) Kristell Le Gal et al.   Science Translational Medicine

The energy blocker inside the power house: mitochondria targeted delivery of 3-bromopyruvate

(2015) Sean Marrache et al.   Chemical Science

High resolution imaging of intracellular oxygen concentration by phosphorescence lifetime

(2015) Hiromi Kurokawa et al.   Scientific Reports

Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation

(2014) Yoshihiko Ichikawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of pre-irradiation with different doses, wavelengths, and application intervals of low-level laser therapy on cytochrome c oxidase activity in intact skeletal muscle of rats

(2014) Gianna Móes Albuquerque-Pontes et al.   LASERS IN MEDICAL SCIENCE

Nanoparticles for photothermal therapies

(2014) D. Jaque et al.   Nanoscale

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Antioxidants Accelerate Lung Cancer Progression in Mice

(2014) V. I. Sayin et al.   Science Translational Medicine

A Prototypical Small-Molecule Modulator Uncouples Mitochondria in Response to Endogenous Hydrogen Peroxide Production

(2013) Stephen J. McQuaker et al.   CHEMBIOCHEM

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

3-bromopyruvate (3BP) a fast acting, promising, powerful, specific, and effective “small molecule” anti-cancer agent taken from labside to bedside: introduction to a special issue

(2012) Peter L. Pedersen   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Application of Near-Infrared Dyes for Tumor Imaging, Photothermal, and Photodynamic Therapies

(2012) Ahu Yuan et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Cardioprotection: chances and challenges of its translation to the clinic

(2012) Gerd Heusch   LANCET

Identification of the molecular basis of doxorubicin-induced cardiotoxicity

(2012) Sui Zhang et al.   NATURE MEDICINE

In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers

(2012) Niagara Muhammad Idris et al.   NATURE MEDICINE

The Nuts and Bolts of Low-level Laser (Light) Therapy

(2011) Hoon Chung et al.   ANNALS OF BIOMEDICAL ENGINEERING

Photoinduced Nitric Oxide Release from a Nitrobenzene Derivative in Mitochondria

(2011) Taeko Horinouchi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly Selective Mitochondria-Targeting Amphiphilic Silicon(IV) Phthalocyanines with Axially Ligated Rhodamine B for Photodynamic Therapy

(2011) Zhixin Zhao et al.   INORGANIC CHEMISTRY

Selective Uncoupling of Individual Mitochondria within a Cell Using a Mitochondria-Targeted Photoactivated Protonophore

(2011) Susan Chalmers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cancer cell–selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules

(2011) Makoto Mitsunaga et al.   NATURE MEDICINE

Mitochondria-Targeting Single-Walled Carbon Nanotubes for Cancer Photothermal Therapy

(2011) Feifan Zhou et al.   Small

New Insights of Transmembranal Mechanism and Subcellular Localization of Noncovalently Modified Single-Walled Carbon Nanotubes

(2010) Feifan Zhou et al.   NANO LETTERS

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of mitochondria-associated hexokinase II in cancer cell death induced by 3-bromopyruvate

(2009) Zhao Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Anthracycline Cardiomyopathy Is Mediated by Depletion of the Cardiac Stem Cell Pool and Is Rescued by Restoration of Progenitor Cell Function

(2009) Antonella De Angelis et al.   CIRCULATION

Cardioprotection by metabolic shut-down and gradual wake-up

(2009) Lindsay S. Burwell et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitochondrial drug delivery systems for macromolecule and their therapeutic application to mitochondrial diseases☆

(2008) Yuma Yamada et al.   ADVANCED DRUG DELIVERY REVIEWS

Targeting lipophilic cations to mitochondria

(2008) Michael P. Murphy   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Controlled Delivery of Basic Fibroblast Growth Factor Promotes Human Cardiosphere-Derived Cell Engraftment to Enhance Cardiac Repair for Chronic Myocardial Infarction

(2008) Naofumi Takehara et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mechanisms Underlying Acute Protection From Cardiac Ischemia-Reperfusion Injury

(2008) Elizabeth Murphy et al.   PHYSIOLOGICAL REVIEWS

MITO-Porter: A liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion

(2007) Yuma Yamada et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES