Mechanisms and therapeutic implications of cellular senescence in osteoarthritis

A proteomic atlas of senescence-associated secretomes for aging biomarker development

(2020) Nathan Basisty et al.   PLOS BIOLOGY

Positive effects of the young systemic environment and high GDF‐11 levels on chondrocyte proliferation and cartilage matrix synthesis in old mice

(2020) Lu Li et al.   Arthritis & Rheumatology

Deletion of c‐Jun N‐terminal Kinase Enhances Senescence in Joint Tissues and Increases the Severity of Age‐Related Osteoarthritis in Mice

(2020) Richard F. Loeser et al.   Arthritis & Rheumatology

Autophagy regulates the localization and degradation of p16 INK4a

(2020) Philip R. Coryell et al.   AGING CELL

Effects of Interleukin-1β Inhibition on Incident Hip and Knee Replacement

(2020) Matthias Schieker et al.   ANNALS OF INTERNAL MEDICINE

Serum NT/CT SIRT1 ratio reflects early osteoarthritis and chondrosenescence

(2020) George Batshon et al.   ANNALS OF THE RHEUMATIC DISEASES

Senolytic CAR T cells reverse senescence-associated pathologies

(2020) Corina Amor et al.   NATURE

A Phase 2 Trial of Lutikizumab, an Anti-Interleukin 1α/β Dual Variable Domain Immunoglobulin, in Knee Osteoarthritis Patients With Synovitis

(2019) Roy M. Fleischmann et al.   Arthritis & Rheumatology

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

(2019) Jamie N. Justice et al.   EBioMedicine

Expansion and Cell-Cycle Arrest: Common Denominators of Cellular Senescence

(2019) Mikolaj Ogrodnik et al.   TRENDS IN BIOCHEMICAL SCIENCES

Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy

(2019) Uxía Nogueira-Recalde et al.   EBioMedicine

Controlled induction and targeted elimination of p16INK4a-expressing chondrocytes in cartilage explant culture

(2019) Garrett A. Sessions et al.   FASEB JOURNAL

Replicative senescence is distinguishable from DNA damage-induced senescence by increased methylation of promoter of rDNA and reduced expression of rRNA

(2019) Reiko Sanokawa-Akakura et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

(2019) LaTonya J. Hickson et al.   EBioMedicine

Senescent synovial fibroblasts accumulate prematurely in rheumatoid arthritis tissues and display an enhanced inflammatory phenotype

(2019) Manuel J. Del Rey et al.   Immunity & Ageing

Expression of p16INK 4a is a biomarker of chondrocyte aging but does not cause osteoarthritis

(2018) Brian O. Diekman et al.   AGING CELL

The Role of Peroxiredoxins in the Transduction of H2O2 Signals

(2018) Sue Goo Rhee et al.   ANTIOXIDANTS & REDOX SIGNALING

Cellular senescence in tissue repair: every cloud has a silver lining

(2018) Maximina H. Yun   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Senescent cells and osteoarthritis: a painful connection

(2018) Ok Hee Jeon et al.   JOURNAL OF CLINICAL INVESTIGATION

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

H2O2 oxidation of cysteine residues in c-Jun N-terminal kinase 2 (JNK2) contributes to redox regulation in human articular chondrocytes

(2018) Kimberly J Nelson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Embryonic Stem Cell–Derived mmu-miR-291a-3p Inhibits Cellular Senescence in Human Dermal Fibroblasts Through the TGF-β Receptor 2 Pathway

(2018) Yun-Ui Bae et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Fisetin is a senotherapeutic that extends health and lifespan

(2018) Matthew J. Yousefzadeh et al.   EBioMedicine

Etanercept in patients with inflammatory hand osteoarthritis (EHOA): a multicentre, randomised, double-blind, placebo-controlled trial

(2018) Margreet Kloppenburg et al.   ANNALS OF THE RHEUMATIC DISEASES

Fisetin inhibits IL-1β-induced inflammatory response in human osteoarthritis chondrocytes through activating SIRT1 and attenuates the progression of osteoarthritis in mice

(2017) Wenhao Zheng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Chemical screening identifies ATM as a target for alleviating senescence

(2017) Hyun Tae Kang et al.   Nature Chemical Biology

Targeting cellular senescence prevents age-related bone loss in mice

(2017) Joshua N Farr et al.   NATURE MEDICINE

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Senescent cells: an emerging target for diseases of ageing

(2017) Bennett G. Childs et al.   NATURE REVIEWS DRUG DISCOVERY

Oncogenic senescence: a multi-functional perspective

(2017) Darren J. Baker et al.   Oncotarget

A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1−/ − mice is correlated to increased cellular senescence

(2017) Yiqiang Zhang et al.   Redox Biology

Age-Related Changes in Plasma Extracellular Vesicle Characteristics and Internalization by Leukocytes

(2017) Erez Eitan et al.   Scientific Reports

The impact of autophagy on the development of senescence in primary tubular epithelial cells

(2016) Arpita Baisantry et al.   CELL CYCLE

Autophagy in osteoarthritis

(2016) Hyelin Jeon et al.   CONNECTIVE TISSUE RESEARCH

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue

(2016) Marissa J. Schafer et al.   DIABETES

Antisenescence effect of mouse embryonic stem cell conditioned medium through a PDGF/FGF pathway

(2016) Yun-Ui Bae et al.   FASEB JOURNAL

Oxidative Stress Promotes Peroxiredoxin Hyperoxidation and Attenuates Pro-survival Signaling in Aging Chondrocytes

(2016) John A. Collins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Senescent Cells in the Bone Microenvironment

(2016) Joshua N Farr et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Interruption of progerin–lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotype

(2016) Su-Jin Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Induced superficial chondrocyte death reduces catabolic cartilage damage in murine posttraumatic osteoarthritis

(2016) Minjie Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Ageing and the pathogenesis of osteoarthritis

(2016) Richard F. Loeser et al.   Nature Reviews Rheumatology

Alternative Methods for Defining Osteoarthritis and the Impact on Estimating Prevalence in a US Population-Based Survey

(2016) Miriam G. Cisternas et al.   ARTHRITIS CARE & RESEARCH

A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood

(2016) Justin Rebo et al.   Nature Communications

Is senescence-associated β-galactosidase a marker of neuronal senescence?

(2016) Malgorzata Piechota et al.   Oncotarget

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

(2015) Nicolás Herranz et al.   NATURE CELL BIOLOGY

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

(2015) Ming Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lifetime Medical Costs of Knee Osteoarthritis Management in the United States: Impact of Extending Indications for Total Knee Arthroplasty

(2015) Elena Losina et al.   ARTHRITIS CARE & RESEARCH

Interleukin-1 Acts via the JNK-2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes

(2015) Heba M. Ismail et al.   Arthritis & Rheumatology

Redox theory of aging

(2015) Dean P. Jones   Redox Biology

Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage

(2014) Wang Hui et al.   ANNALS OF THE RHEUMATIC DISEASES

The epidemiology of osteoarthritis

(2014) Victoria L. Johnson et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Reactive oxygen species promotes cellular senescence in normal human epidermal keratinocytes through epigenetic regulation of p16INK4a

(2014) Mina Sasaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Senescence-associated release of transmembrane proteins involves proteolytic processing by ADAM17 and microvesicle shedding

(2014) Timo Effenberger et al.   FASEB JOURNAL

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

In Vivo and In Vitro Analysis of Age-Associated Changes and Somatic Cellular Senescence in Renal Epithelial Cells

(2014) Birgit Berkenkamp et al.   PLoS One

Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice

(2013) Tokio Matsuzaki et al.   ANNALS OF THE RHEUMATIC DISEASES

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

Oxidative Stress in Aging-Matters of the Heart and Mind

(2013) Krishnan Venkataraman et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular senescence mediated by p16INK4A-coupled miRNA pathways

(2013) Marita G. Overhoff et al.   NUCLEIC ACIDS RESEARCH

Macrophages are required for adult salamander limb regeneration

(2013) James W. Godwin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MMP13 is a critical target gene during the progression of osteoarthritis

(2013) Meina Wang et al.   ARTHRITIS RESEARCH & THERAPY

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

(2012) Diana Jurk et al.   AGING CELL

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

NF-κB inhibition delays DNA damage–induced senescence and aging in mice

(2012) Jeremy S. Tilstra et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy activation by rapamycin reduces severity of experimental osteoarthritis

(2011) Beatriz Caramés et al.   ANNALS OF THE RHEUMATIC DISEASES

Tumor Suppressor and Aging Biomarker p16INK4aInduces Cellular Senescence without the Associated Inflammatory Secretory Phenotype

(2011) Jean-Philippe Coppé et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease

(2010) J. L. Scott et al.   ANNALS OF THE RHEUMATIC DISEASES

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Cartilage cell clusters

(2010) Martin K. Lotz et al.   ARTHRITIS AND RHEUMATISM

Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

(2010) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

Cellular senescence: putting the paradoxes in perspective

(2010) Judith Campisi   CURRENT OPINION IN GENETICS & DEVELOPMENT

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

Matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs in non-neoplastic diseases

(2010) Takayuki Shiomi et al.   PATHOLOGY INTERNATIONAL

MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses

(2009) Shigeru Miyaki et al.   ARTHRITIS AND RHEUMATISM

Dasatinib

(2009) Susan J Keam   BIODRUGS

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix

(2009) R.F. Loeser   OSTEOARTHRITIS AND CARTILAGE

Senescence-Associated Exosome Release from Human Prostate Cancer Cells

(2008) B. D. Lehmann et al.   CANCER RESEARCH

Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial

(2008) Josef S Smolen et al.   LANCET