The impact of autophagy on the development of senescence in primary tubular epithelial cells

Biomarkers to identify and isolate senescent cells

(2016) Mantas Matjusaitis et al.   AGEING RESEARCH REVIEWS

Autophagy in acute kidney injury

(2016) Gur P. Kaushal et al.   KIDNEY INTERNATIONAL

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Autophagy-independent senescence and genome instability driven by targeted telomere dysfunction

(2015) Florie A Mar et al.   Autophagy

Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis

(2015) Mandy OJ Grootaert et al.   Autophagy

Autophagy-mediated degradation of nuclear envelope proteins during oncogene-induced senescence

(2015) Christelle Lenain et al.   CARCINOGENESIS

Essential role for autophagy in life span extension

(2015) Frank Madeo et al.   JOURNAL OF CLINICAL INVESTIGATION

Telomerase deficiency delays renal recovery in mice after ischemia–reperfusion injury by impairing autophagy

(2015) Huifang Cheng et al.   KIDNEY INTERNATIONAL

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradation

(2015) G Grassi et al.   Cell Death & Disease

High Glucose Induces Bone Marrow-Derived Mesenchymal Stem Cell Senescence by Upregulating Autophagy

(2015) Tzu-Ching Chang et al.   PLoS One

Autophagy suppresses melanoma tumorigenesis by inducing senescence

(2014) He Liu et al.   Autophagy

Autophagy functions on EMT in gastrulation of avian embryo

(2014) Wen-Hui Lu et al.   CELL CYCLE

Suppression of autophagy during liver regeneration impairs energy charge and hepatocyte senescence in mice

(2014) Takeo Toshima et al.   HEPATOLOGY

In Vivo and In Vitro Analysis of Age-Associated Changes and Somatic Cellular Senescence in Renal Epithelial Cells

(2014) Birgit Berkenkamp et al.   PLoS One

Autophagy and senescence

(2013) David A. Gewirtz   Autophagy

Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial–mesenchymal transition

(2013) Jun Li et al.   CARCINOGENESIS

Rapamycin induces pluripotent genes associated with avoidance of replicative senescence

(2013) Tatyana V. Pospelova et al.   CELL CYCLE

p16INK4a reporter mice reveal age-promoting effects of environmental toxicants

(2013) Jessica A. Sorrentino et al.   JOURNAL OF CLINICAL INVESTIGATION

Nrf2 signalling promotes ex vivo tubular epithelial cell survival and regeneration via murine double minute (MDM)-2

(2013) Jan H. Hagemann et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Pre-Transplant CDKN2A Expression in Kidney Biopsies Predicts Renal Function and Is a Future Component of Donor Scoring Criteria

(2013) Marc Gingell-Littlejohn et al.   PLoS One

Expression of the senescence marker p16INK4a in skin biopsies of acute lymphoblastic leukemia survivors: a pilot study

(2013) Sophie Marcoux et al.   Radiation Oncology

Autophagy Guards Against Cisplatin-Induced Acute Kidney Injury

(2012) Atsushi Takahashi et al.   AMERICAN JOURNAL OF PATHOLOGY

New Insights on Molecular Mechanisms of Renal Aging

(2012) R. Schmitt et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Cellular Senescence Limits Regenerative Capacity and Allograft Survival

(2012) H. Braun et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Autophagy in proximal tubules protects against acute kidney injury

(2012) Man Jiang et al.   KIDNEY INTERNATIONAL

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease

(2012) Satoko Fujii et al.   OncoImmunology

Autophagy May Precede Cellular Senescence of Bile Ductular Cells in Ductular Reaction in Primary Biliary Cirrhosis

(2011) Motoko Sasaki et al.   DIGESTIVE DISEASES AND SCIENCES

Identification of Small Molecule Inhibitors of Phosphatidylinositol 3-Kinase and Autophagy

(2011) Thomas Farkas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy Protects the Proximal Tubule from Degeneration and Acute Ischemic Injury

(2011) T. Kimura et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Autophagy mediates the process of cellular senescence characterizing bile duct damages in primary biliary cirrhosis

(2010) Motoko Sasaki et al.   LABORATORY INVESTIGATION

Autophagy mediates the mitotic senescence transition

(2009) A. R.J. Young et al.   GENES & DEVELOPMENT

Telomere Shortening Reduces Regenerative Capacity after Acute Kidney Injury

(2009) J. H. Westhoff et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The cell cycle and acute kidney injury

(2009) Peter M. Price et al.   KIDNEY INTERNATIONAL

Markers of cellular senescence in zero hour biopsies predict outcome in renal transplantation

(2008) Christian Koppelstaetter et al.   AGING CELL

Zag Expression during Aging Suppresses Proliferation after Kidney Injury

(2008) R. Schmitt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY