Identification of Senescent Cells in the Bone Microenvironment

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Transcriptional Profiling of Laser Capture Microdissected Subpopulations of the Osteoblast Lineage Provides Insight Into the Early Response to Sclerostin Antibody in Rats

(2015) Paul Nioi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

Effects of Age and Estrogen on Skeletal Gene Expression in Humans as Assessed by RNA Sequencing

(2015) Joshua N. Farr et al.   PLoS One

Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging

(2014) Dorian V. Ziegler et al.   AGING CELL

Leptin-Receptor-Expressing Mesenchymal Stromal Cells Represent the Main Source of Bone Formed by Adult Bone Marrow

(2014) Bo O. Zhou et al.   Cell Stem Cell

Bone Cell Senescence: Mechanisms and Perspectives

(2014) Pierre J Marie   JOURNAL OF BONE AND MINERAL RESEARCH

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

(2014) Diana Jurk et al.   Nature Communications

Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model

(2013) Christin E. Burd et al.   CELL

The Osteocyte: An Endocrine Cell … and More

(2013) Sarah L. Dallas et al.   ENDOCRINE REVIEWS

Substantial Health And Economic Returns From Delayed Aging May Warrant A New Focus For Medical Research

(2013) Dana P. Goldman et al.   HEALTH AFFAIRS

Suppression of Autophagy in Osteocytes Mimics Skeletal Aging

(2013) Melda Onal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence

(2013) Eric C. Swanson et al.   JOURNAL OF CELL BIOLOGY

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Isolation and characterization of human osteoblasts from needle biopsies without in vitro culture

(2013) K. Fujita et al.   OSTEOPOROSIS INTERNATIONAL

p21 Both Attenuates and Drives Senescence and Aging in BubR1 Progeroid Mice

(2013) Darren J. Baker et al.   Cell Reports

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

The number of p16INK4a positive cells in human skin reflects biological age

(2012) Mariëtte E.C. Waaijer et al.   AGING CELL

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

(2012) Diana Jurk et al.   AGING CELL

Demonstration of osteocytic perilacunar/canalicular remodeling in mice during lactation

(2012) Hai Qing et al.   JOURNAL OF BONE AND MINERAL RESEARCH

DNA damage drives accelerated bone aging via an NF-κB-dependent mechanism

(2012) Qian Chen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Senescence-associated intrinsic mechanisms of osteoblast dysfunctions

(2011) Moustapha Kassem et al.   AGING CELL

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)

(2011) Antero Salminen et al.   CELLULAR SIGNALLING

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Matrix-embedded cells control osteoclast formation

(2011) Jinhu Xiong et al.   NATURE MEDICINE

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Effects of chronic estrogen treatment on modulating age-related bone loss in female mice

(2010) Farhan A Syed et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Identification of differentially expressed genes between osteoblasts and osteocytes

(2009) Frane Paic et al.   BONE

A novel purification method for multipotential skeletal stem cells

(2009) Shousaku Itoh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A crucial role for adipose tissue p53 in the regulation of insulin resistance

(2009) Tohru Minamino et al.   NATURE MEDICINE

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY