Serum NT/CT SIRT1 ratio reflects early osteoarthritis and chondrosenescence

The invasin D protein fromYersinia pseudotuberculosisselectively binds the Fab region of host antibodies and affects colonization of the intestine

(2018) Pooja Sadana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A predicted unstructured C-terminal loop domain in SIRT1 is required for cathepsin B cleavage

(2018) Ashok Kumar et al.   JOURNAL OF CELL SCIENCE

LEF1-mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes

(2017) Jinan Elayyan et al.   FASEB JOURNAL

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Chondrocyte secretome: a source of novel insights and exploratory biomarkers of osteoarthritis

(2017) C. Sanchez et al.   OSTEOARTHRITIS AND CARTILAGE

Acetylation reduces SOX9 nuclear entryand ACANgene transactivation in human chondrocytes

(2016) Michal Bar Oz et al.   AGING CELL

SOX9 and the many facets of its regulation in the chondrocyte lineage

(2016) Véronique Lefebvre et al.   CONNECTIVE TISSUE RESEARCH

The Senescence-Associated Secretory Phenotype: Critical Effector in Skin Cancer and Aging

(2016) Kanad Ghosh et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cysteine cathepsins control hepatic NF-κB-dependent inflammation via sirtuin-1 regulation

(2016) Álvaro de Mingo et al.   Cell Death & Disease

Anti-TNF-α treatment modulates SASP and SASP-related microRNAs in endothelial cells and in circulating angiogenic cells

(2016) Francesco Prattichizzo et al.   Oncotarget

The Need for Predictive, Prognostic, Objective and Complementary Blood-Based Biomarkers in Osteoarthritis (OA)

(2016) Anne-C. Bay-Jensen et al.   EBioMedicine

TNFα Regulates SIRT1 Cleavage during Ocular Autoimmune Disease

(2015) Peter J. Gardner et al.   AMERICAN JOURNAL OF PATHOLOGY

Chondrosenescence: Definition, hallmarks and potential role in the pathogenesis of osteoarthritis

(2015) Ali Mobasheri et al.   MATURITAS

Circulating SIRT1 Increases After Intragastric Balloon Fat Loss in Obese Patients

(2015) Stefania Mariani et al.   OBESITY SURGERY

Identification of serum sirtuins as novel noninvasive protein markers for frailty

(2014) Rahul Kumar et al.   AGING CELL

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice

(2013) Tokio Matsuzaki et al.   ANNALS OF THE RHEUMATIC DISEASES

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Frailty in elderly people

(2013) Andrew Clegg et al.   LANCET

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Sirtuin1: A Promising Serum Protein Marker for Early Detection of Alzheimer’s Disease

(2013) Rahul Kumar et al.   PLoS One

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

Cathepsin Cleavage of Sirtuin 1 in Endothelial Progenitor Cells Mediates Stress-Induced Premature Senescence

(2012) Jun Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction

(2012) Angeliki Chalkiadaki et al.   Cell Metabolism

Sox9 Directs Hypertrophic Maturation and Blocks Osteoblast Differentiation of Growth Plate Chondrocytes

(2012) Peter Dy et al.   DEVELOPMENTAL CELL

Seven sirtuins for seven deadly diseases ofaging

(2012) Brian J. Morris   FREE RADICAL BIOLOGY AND MEDICINE

Tumor necrosis factor α-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes

(2011) Mona Dvir-Ginzberg et al.   ARTHRITIS AND RHEUMATISM

75-kd sirtuin 1 blocks tumor necrosis factor α-mediated apoptosis in human osteoarthritic chondrocytes

(2011) Hanna Oppenheimer et al.   ARTHRITIS AND RHEUMATISM

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)

(2011) Antero Salminen et al.   CELLULAR SIGNALLING

Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging

(2011) O. Albayram et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE

Sirtuin 1 Reduction Parallels the Accumulation of Tau in Alzheimer Disease

(2008) Carl Julien et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Sirt1 protects against high-fat diet-induced metabolic damage

(2008) P. T. Pfluger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA