Reverse engineering Lewy bodies: how far have we come and how far can we go?

Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophy

(2020) Mohammad Shahnawaz et al.   NATURE

The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

(2020) Anne-Laure Mahul-Mellier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure

(2020) David R. Boyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein-Protein Interactions in Alpha-Synuclein Biogenesis: New Potential Targets in Parkinson’s Disease

(2020) Sarah M. Hernandez et al.   Frontiers in Aging Neuroscience

Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in nonhuman primates

(2020) M. Bourdenx et al.   Science Advances

α-Synuclein aggregation nucleates through liquid–liquid phase separation

(2020) Soumik Ray et al.   Nature Chemistry

Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease

(2020) Simon Dujardin et al.   NATURE MEDICINE

Do Lewy bodies contain alpha-synuclein fibrils? and Does it matter? A brief history and critical analysis of recent reports

(2020) Hilal A. Lashuel   NEUROBIOLOGY OF DISEASE

Pronounced α-synuclein pathology in a seeding-based mouse model is not sufficient to induce mitochondrial respiration deficits in the striatum and amygdala

(2020) Johannes Burtscher et al.   eNeuro

Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network

(2019) Simona Gribaudo et al.   Stem Cell Reports

Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson’s iPSC-derived dopamine neurons

(2019) Federico Zambon et al.   HUMAN MOLECULAR GENETICS

Wide distribution of alpha-synuclein oligomers in multiple system atrophy brain detected by proximity ligation

(2019) Hiroaki Sekiya et al.   ACTA NEUROPATHOLOGICA

Alpha-synuclein (αSyn) preformed fibrils induce endogenous αSyn aggregation, compromise synaptic activity and enhance synapse loss in cultured excitatory hippocampal neurons

(2019) Qihui Wu et al.   JOURNAL OF NEUROSCIENCE

Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson’s disease model

(2019) Michal Wegrzynowicz et al.   ACTA NEUROPATHOLOGICA

Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes

(2019) Sarah H. Shahmoradian et al.   NATURE NEUROSCIENCE

Understanding the pathogenesis of multiple system atrophy: state of the art and future perspectives

(2019) Giacomo Monzio Compagnoni et al.   Acta Neuropathologica Communications

Parkinson’s disease is a type of amyloidosis featuring accumulation of amyloid fibrils of α-synuclein

(2019) Katsuya Araki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipids as Trans-Acting Effectors for α-Synuclein in the Pathogenesis of Parkinson’s Disease

(2019) Kensuke Ikenaka et al.   Frontiers in Neuroscience

Lewy body pathology is more prevalent in older individuals with mitochondrial disease than controls

(2019) Daniel Erskine et al.   ACTA NEUROPATHOLOGICA

Intrastriatal alpha-synuclein fibrils in monkeys: spreading, imaging and neuropathological changes

(2019) Yaping Chu et al.   BRAIN

Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts

(2019) Timo Strohäker et al.   Nature Communications

Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach

(2018) Erika Bereczki et al.   BRAIN

The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases

(2018) Nolwen L. Rey et al.   NEUROBIOLOGY OF DISEASE

α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton

(2018) Dalila G. Ordonez et al.   NEURON

Cryo-EM structure of alpha-synuclein fibrils

(2018) Ricardo Guerrero-Ferreira et al.   eLife

Modeling Parkinson’s disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain

(2017) Poonam Thakur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defective synaptic connectivity and axonal neuropathology in a human iPSC-based model of familial Parkinson’s disease

(2017) Georgia Kouroupi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Propagation of pathological α-synuclein in marmoset brain

(2017) Aki Shimozawa et al.   Acta Neuropathologica Communications

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease

(2016) Emma Deas et al.   ANTIOXIDANTS & REDOX SIGNALING

Alpha-Synuclein as a Biomarker for Parkinson's Disease

(2016) Anzari Atik et al.   BRAIN PATHOLOGY

The Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation

(2016) Airi Tarutani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson’s disease

(2016) Nolwen L. Rey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson’s disease

(2016) Mohamed-Bilal Fares et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity

(2016) Kelvin C. Luk et al.   Cell Reports

Molecular Features Underlying Neurodegeneration Identified through In Vitro Modeling of Genetically Diverse Parkinson’s Disease Patients

(2016) Lin Lin et al.   Cell Reports

Structural and functional properties of prefibrillar α-synuclein oligomers

(2016) Laura Pieri et al.   Scientific Reports

Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson’s disease brain

(2015) Rosalind F. Roberts et al.   BRAIN

Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death

(2015) A-L Mahul-Mellier et al.   CELL DEATH AND DIFFERENTIATION

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

(2015) W. Peelaerts et al.   NATURE

Synchrotron FTIR micro-spectroscopy for structural analysis of Lewy bodies in the brain of Parkinson’s disease patients

(2015) Katsuya Araki et al.   Scientific Reports

Formaldehyde-fixed brain tissue from spontaneously ill α-synuclein transgenic mice induces fatal α-synucleinopathy in transgenic hosts

(2014) Manuel Schweighauser et al.   ACTA NEUROPATHOLOGICA

The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of  -synuclein, and enhances its secretion and nuclear localization in cells

(2014) M.-B. Fares et al.   HUMAN MOLECULAR GENETICS

The H50Q Mutation Enhances α-Synuclein Aggregation, Secretion, and Toxicity

(2014) Ossama Khalaf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Divergent effects of the H50Q and G51DSNCAmutations on the aggregation of α-synuclein

(2014) Nicola J. Rutherford et al.   JOURNAL OF NEUROCHEMISTRY

Brain Injection of  -Synuclein Induces Multiple Proteinopathies, Gliosis, and a Neuronal Injury Marker

(2014) A. N. Sacino et al.   JOURNAL OF NEUROSCIENCE

Formation of α-synuclein Lewy neurite–like aggregates in axons impedes the transport of distinct endosomes

(2014) Laura A. Volpicelli-Daley et al.   MOLECULAR BIOLOGY OF THE CELL

Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases

(2014) Jing L Guo et al.   NATURE MEDICINE

Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates

(2014) Laura A Volpicelli-Daley et al.   Nature Protocols

Extracellular α-synuclein—a novel and crucial factor in Lewy body diseases

(2014) He-Jin Lee et al.   Nature Reviews Neurology

A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology

(2014) Petra Pasanen et al.   NEUROBIOLOGY OF AGING

Higher Vulnerability and Stress Sensitivity of Neuronal Precursor Cells Carrying an Alpha-Synuclein Gene Triplication

(2014) Adrian Flierl et al.   PLoS One

Proteomic analysis of human substantia nigra identifies novel candidates involved in Parkinson's disease pathogenesis

(2014) Virginie Licker et al.   PROTEOMICS

α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration

(2014) Hien T. Tran et al.   Cell Reports

Models of α-synuclein aggregation in Parkinson’s disease

(2014) Rosa María Giráldez-Pérez et al.   Acta Neuropathologica Communications

Pathological alpha-synuclein propagates through neural networks

(2014) Masami Masuda-Suzukake et al.   Acta Neuropathologica Communications

α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson’s disease and multiple system atrophy?

(2013) Aoife P. Kiely et al.   ACTA NEUROPATHOLOGICA

G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome

(2013) Suzanne Lesage et al.   ANNALS OF NEUROLOGY

Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys

(2013) Ariadna Recasens et al.   ANNALS OF NEUROLOGY

The Parkinson’s Disease-Associated H50Q Mutation Accelerates α-Synuclein Aggregation in Vitro

(2013) Dhiman Ghosh et al.   BIOCHEMISTRY

Prion-like spreading of pathological α-synuclein in brain

(2013) Masami Masuda-Suzukake et al.   BRAIN

A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats

(2013) Silke Nuber et al.   BRAIN

Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

(2013) Jing L. Guo et al.   CELL

Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription

(2013) Scott D. Ryan et al.   CELL

α-Synuclein Senses Lipid Packing Defects and Induces Lateral Expansion of Lipids Leading to Membrane Remodeling

(2013) Myriam M. Ouberai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration

(2013) Marusela Oliveras-Salvá et al.   Molecular Neurodegeneration

Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease

(2013) Silke Appel-Cresswell et al.   MOVEMENT DISORDERS

Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies

(2013) David J. Irwin et al.   NATURE REVIEWS NEUROSCIENCE

Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases

(2013) Adamantios Mamais et al.   NEUROBIOLOGY OF DISEASE

A novel  -synuclein missense mutation in Parkinson disease

(2013) C. Proukakis et al.   NEUROLOGY

Novel A18T and pA29S substitutions in α-synuclein may be associated with sporadic Parkinson's disease

(2013) Dorota Hoffman-Zacharska et al.   PARKINSONISM & RELATED DISORDERS

Membrane Lipid Co-Aggregation with α-Synuclein Fibrils

(2013) Erik Hellstrand et al.   PLoS One

Transmission of multiple system atrophy prions to transgenic mice

(2013) J. C. Watts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and Rescue of  -Synuclein Toxicity in Parkinson Patient-Derived Neurons

(2013) C. Y. Chung et al.   SCIENCE

Structural and functional characterization of two alpha-synuclein strains

(2013) Luc Bousset et al.   Nature Communications

Genetics of Parkinson's Disease

(2013) C. Klein et al.   Cold Spring Harbor Perspectives in Medicine

Can we clinically diagnose dementia with Lewy bodies yet?

(2013) Yue Huang et al.   Translational Neurodegeneration

Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein

(2013) Amanda N Sacino et al.   Acta Neuropathologica Communications

Expression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment

(2012) Jason R. Cannon et al.   EXPERIMENTAL NEUROLOGY

Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation

(2012) Igor F. Tsigelny et al.   FEBS Journal

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

(2012) Kelvin C. Luk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alpha-Synuclein Posttranslational Modification and Alternative Splicing as a Trigger for Neurodegeneration

(2012) Katrin Beyer et al.   MOLECULAR NEUROBIOLOGY

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

Animal models of Parkinson's disease: Limits and relevance to neuroprotection studies

(2012) Erwan Bezard et al.   MOVEMENT DISORDERS

100 years of Lewy pathology

(2012) Michel Goedert et al.   Nature Reviews Neurology

Impaired neurotransmission caused by overexpression of  -synuclein in nigral dopamine neurons

(2012) M. Lundblad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Alpha-synuclein: from secretion to dysfunction and death

(2012) O Marques et al.   Cell Death & Disease

Gelsolin co-occurs with Lewy bodies in vivo and accelerates α-synuclein aggregation in vitro

(2011) Hedvig Welander et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Proteome of the Locus Ceruleus in Parkinson's Disease: Relevance to Pathogenesis

(2011) Karin D. van Dijk et al.   BRAIN PATHOLOGY

Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations

(2011) Frank Soldner et al.   CELL

Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers

(2011) He-Jin Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

E46K Human α-Synuclein Transgenic Mice Develop Lewy-like and Tau Pathology Associated with Age-dependent, Detrimental Motor Impairment

(2011) Kristel L. Emmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein and ALPS motifs are membrane curvature sensors whose contrasting chemistry mediates selective vesicle binding

(2011) Iwona M. Pranke et al.   JOURNAL OF CELL BIOLOGY

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

(2011) Christian Hansen et al.   JOURNAL OF CLINICAL INVESTIGATION

Induction of Intracellular Tau Aggregation Is Promoted by  -Synuclein Seeds and Provides Novel Insights into the Hyperphosphorylation of Tau

(2011) E. A. Waxman et al.   JOURNAL OF NEUROSCIENCE

α-Synuclein-Induced Tubule Formation in Lipid Bilayers

(2011) Anjan P. Pandey et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Mechanism of Membrane Interaction and Disruption by α-Synuclein

(2011) Nicholas P. Reynolds et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Milestones in Parkinson's disease-Clinical and pathologic features

(2011) Glenda Halliday et al.   MOVEMENT DISORDERS

Prion-like acceleration of a synucleinopathy in a transgenic mouse model

(2011) Anne-Laure Mougenot et al.   NEUROBIOLOGY OF AGING

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission

(2011) Lydia Alvarez-Erviti et al.   NEUROBIOLOGY OF DISEASE

Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons

(2011) M. Decressac et al.   NEUROBIOLOGY OF DISEASE

Identification of Novel α-Synuclein Isoforms in Human Brain Tissue by using an Online NanoLC-ESI-FTICR-MS Method

(2011) Annika Öhrfelt et al.   NEUROCHEMICAL RESEARCH

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

SNCA Triplication Parkinson's Patient's iPSC-derived DA Neurons Accumulate α-Synuclein and Are Susceptible to Oxidative Stress

(2011) Blake Byers et al.   PLoS One

Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus

(2011) Michael J. Devine et al.   Nature Communications

Non-invasive evaluation of nigrostriatal neuropathology in a proteasome inhibitor rodent model of Parkinson's disease

(2010) Anthony C Vernon et al.   BMC NEUROSCIENCE

A New Hypothesis of Pathogenesis Based on the Divorce between Mitochondria and their Host Cells: Possible Relevance for Alzheimers Disease

(2010) L.F. Agnati et al.   Current Alzheimer Research

Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated α-synuclein gene mutations precede central nervous system changes

(2010) Yien-Ming Kuo et al.   HUMAN MOLECULAR GENETICS

Seeded Aggregation and Toxicity of α-Synuclein and Tau

(2010) Takashi Nonaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Curvature Induction and Tubulation Are Common Features of Synucleins and Apolipoproteins

(2010) Jobin Varkey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aggregation of α-Synuclein in S. cerevisiae is Associated with Defects in Endosomal Trafficking and Phospholipid Biosynthesis

(2010) James H. Soper et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation at S87 Is Enhanced in Synucleinopathies, Inhibits  -Synuclein Oligomerization, and Influences Synuclein-Membrane Interactions

(2010) K. E. Paleologou et al.   JOURNAL OF NEUROSCIENCE

Fcγ receptors are required for NF-κB signaling, microglial activation and dopaminergic neurodegeneration in an AAV-synuclein mouse model of Parkinson's disease

(2010) Shuwen Cao et al.   Molecular Neurodegeneration

Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease

(2010) Jia-Yi Li et al.   MOVEMENT DISORDERS

Evidence in favor of Braak staging of Parkinson's disease

(2010) Dennis W. Dickson et al.   MOVEMENT DISORDERS

Synphilin-1 Enhances α-Synuclein Aggregation in Yeast and Contributes to Cellular Stress and Cell Death in a Sir2-Dependent Manner

(2010) Sabrina Büttner et al.   PLoS One

Lewy body pathology in fetal grafts

(2009) Yaping Chu et al.   Annals of the New York Academy of Sciences

Detection of elevated levels of soluble  -synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies

(2009) K. E. Paleologou et al.   BRAIN

Interaction with synphilin-1 promotes inclusion formation of α-synuclein: mechanistic insights and pathological implication

(2009) Yuan-Yuan Xie et al.   FASEB JOURNAL

Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents

(2009) Songcang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Differences between subacute and chronic MPTP mice models: investigation of dopaminergic neuronal degeneration and α-synuclein inclusions

(2009) Claire Gibrat et al.   JOURNAL OF NEUROCHEMISTRY

Pathologic Modifications of α-Synuclein in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)-Treated Squirrel Monkeys

(2009) Alison L. McCormack et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Rab11a and HSP90 Regulate Recycling of Extracellular  -Synuclein

(2009) J. Liu et al.   JOURNAL OF NEUROSCIENCE

No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism

(2009) Glenda Halliday et al.   MOVEMENT DISORDERS

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

(2009) Wataru Satake et al.   NATURE GENETICS

Genome-wide association study reveals genetic risk underlying Parkinson's disease

(2009) Javier Simón-Sánchez et al.   NATURE GENETICS

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

(2009) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exogenous  -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

(2009) K. C. Luk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-Layered Structure Shared Between Lewy Bodies and Lewy Neurites—Three-Dimensional Reconstruction of Triple-Labeled Sections

(2008) Toshiro Kanazawa et al.   BRAIN PATHOLOGY

Modelling Parkinson-like neurodegeneration via osmotic minipump delivery of MPTP and probenecid

(2008) Daniel Alvarez-Fischer et al.   JOURNAL OF NEUROCHEMISTRY

Depletion of 26S Proteasomes in Mouse Brain Neurons Causes Neurodegeneration and Lewy-Like Inclusions Resembling Human Pale Bodies

(2008) L. Bedford et al.   JOURNAL OF NEUROSCIENCE

Transplanted dopaminergic neurons develop PD pathologic changes: A second case report

(2008) Jeffrey H. Kordower et al.   MOVEMENT DISORDERS

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

(2008) Jeffrey H Kordower et al.   NATURE MEDICINE

A stable proportion of Lewy body bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death

(2008) Sandrine Greffard et al.   NEUROBIOLOGY OF AGING

Elevated α-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease

(2008) Jan Gründemann et al.   NUCLEIC ACIDS RESEARCH

Modeling PD pathogenesis in mice: Advantages of a chronic MPTP protocol

(2008) Gloria E. Meredith et al.   PARKINSONISM & RELATED DISORDERS

Proteome analysis of human substantia nigra in Parkinson's disease

(2008) Cornelius J Werner et al.   Proteome Science

Identification of proteins in human substantia nigra

(2008) Efstathia Kitsou et al.   Proteomics Clinical Applications

C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging

(2008) Tjakko J. van Ham et al.   PLoS Genetics

Selective loss of nigral dopamine neurons induced by overexpression of truncated human α-synuclein in mice

(2006) Masaki Wakamatsu et al.   NEUROBIOLOGY OF AGING