Alpha-Synuclein Posttranslational Modification and Alternative Splicing as a Trigger for Neurodegeneration

Mitochondrial Dysfunction in Parkinson's Disease

(2017) Jianhui Zhu et al.   JOURNAL OF ALZHEIMERS DISEASE

Changes in the solubility and phosphorylation of α-synuclein over the course of Parkinson’s disease

(2011) Jinxia Zhou et al.   ACTA NEUROPATHOLOGICA

Role of Matrix Metalloproteinase 3-mediated α-Synuclein Cleavage in Dopaminergic Cell Death

(2011) Dong-Hee Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of Ser-129 Phosphorylation on Interaction of α-Synuclein with Synaptic and Cellular Membranes

(2011) Naomi P. Visanji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conserved C-Terminal Charge Exerts a Profound Influence on the Aggregation Rate of α-Synuclein

(2011) Katerina Levitan et al.   JOURNAL OF MOLECULAR BIOLOGY

C-terminal part of α-synuclein mediates its activity in promoting proliferation of dopaminergic cells

(2011) Juanjuan Yin et al.   JOURNAL OF NEURAL TRANSMISSION

Etiology and pathogenesis of Parkinson's disease

(2011) Anthony H. Schapira et al.   MOVEMENT DISORDERS

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Familial Parkinson disease mutations influence α-synuclein assembly

(2011) Kenjiro Ono et al.   NEUROBIOLOGY OF DISEASE

Over-expression of α-synuclein 98 triggers intracellular oxidative stress and enhances susceptibility to rotenone

(2011) Kai-Li Ma et al.   NEUROSCIENCE LETTERS

Ubiquitinylation of α-Synuclein by Carboxyl Terminus Hsp70-Interacting Protein (CHIP) Is Regulated by Bcl-2-Associated Athanogene 5 (BAG5)

(2011) Lorraine V. Kalia et al.   PLoS One

A soluble  -synuclein construct forms a dynamic tetramer

(2011) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel molecular mechanism for nitrated α-synuclein-induced cell death

(2011) Yanying Liu et al.   Journal of Molecular Cell Biology

Proteinase K-resistant α-synuclein is deposited in presynapses in human Lewy body disease and A53T α-synuclein transgenic mice

(2010) Kunikazu Tanji et al.   ACTA NEUROPATHOLOGICA

The synaptic pathology of α-synuclein aggregation in dementia with Lewy bodies, Parkinson’s disease and Parkinson’s disease dementia

(2010) Walter J. Schulz-Schaeffer   ACTA NEUROPATHOLOGICA

DJ-1 Cleavage by Matrix Metalloproteinase 3 Mediates Oxidative Stress-Induced Dopaminergic Cell Death

(2010) Dong-Hee Choi et al.   ANTIOXIDANTS & REDOX SIGNALING

The decrease of β-synuclein in cortical brain areas defines a molecular subgroup of dementia with Lewy bodies

(2010) Katrin Beyer et al.   BRAIN

Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology

(2010) Ayse Ulusoy et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Parkinson's disease: insights from pathways

(2010) M. R. Cookson et al.   HUMAN MOLECULAR GENETICS

Accelerated formation of α-synuclein oligomers by concerted action of the 20S proteasome and familial Parkinson mutations

(2010) Karen A. Lewis et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Phosphorylation at S87 Is Enhanced in Synucleinopathies, Inhibits  -Synuclein Oligomerization, and Influences Synuclein-Membrane Interactions

(2010) K. E. Paleologou et al.   JOURNAL OF NEUROSCIENCE

Characterization of kinases involved in the phosphorylation of aggregated α-synuclein

(2010) Elisa A. Waxman et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The effect of SNCA 3′ region on the levels of SNCA-112 splicing variant

(2010) Jeanette J. McCarthy et al.   NEUROGENETICS

Nitrated α-Synuclein Induces the Loss of Dopaminergic Neurons in the Substantia Nigra of Rats

(2010) Zhongwang Yu et al.   PLoS One

Mechanisms of mono- and poly-ubiquitination: Ubiquitination specificity depends on compatibility between the E2 catalytic core and amino acid residues proximal to the lysine

(2010) Martin Sadowski et al.   Cell Division

Preferentially Increased Nitration of α-Synuclein at Tyrosine-39 in a Cellular Oxidative Model of Parkinson’s Disease

(2009) Steven R. Danielson et al.   ANALYTICAL CHEMISTRY

Differential Phospholipid Binding of α-Synuclein Variants Implicated in Parkinson’s Disease Revealed by Solution NMR Spectroscopy

(2009) Christina R. Bodner et al.   BIOCHEMISTRY

Methionine oxidation stabilizes non-toxic oligomers of α-synuclein through strengthening the auto-inhibitory intra-molecular long-range interactions

(2009) Wenbo Zhou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Formation of dopamine-mediated α-synuclein-soluble oligomers requires methionine oxidation

(2009) Su Ling Leong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidants induce alternative splicing of α-synuclein: Implications for Parkinson's disease

(2009) Shasi V. Kalivendi et al.   FREE RADICAL BIOLOGY AND MEDICINE

The mitochondrial kinase PINK1, stress response and Parkinson’s disease

(2009) Marina Jendrach et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Phosphorylation of Synucleins by Members of the Polo-like Kinase Family

(2009) Martial K. Mbefo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents

(2009) Songcang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Charge neutralization and collapse of the C-terminal tail of alpha-synuclein at low pH

(2009) Sebastian McClendon et al.   PROTEIN SCIENCE

Structural characterization of α-synuclein in an aggregation prone state

(2009) Min-Kyu Cho et al.   PROTEIN SCIENCE

A critical reappraisal of current staging of Lewy-related pathology in human brain

(2008) Kurt A. Jellinger   ACTA NEUROPATHOLOGICA

Cathepsin D Is the Main Lysosomal Enzyme Involved in the Degradation of α-Synuclein and Generation of Its Carboxy-Terminally Truncated Species†

(2008) Daniel Sevlever et al.   BIOCHEMISTRY

A critical evaluation of current staging of α-synuclein pathology in Lewy body disorders

(2008) Kurt A. Jellinger   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

CHIP Targets Toxic α-Synuclein Oligomers for Degradation

(2008) Julie E. Tetzlaff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System

(2008) Kelly J. Inglis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel intracellular role of matrix metalloproteinase-3 during apoptosis of dopaminergic cells

(2008) Dong Hee Choi et al.   JOURNAL OF NEUROCHEMISTRY

Neuroinflammation and Oxidation/Nitration of  -Synuclein Linked to Dopaminergic Neurodegeneration

(2008) H.-M. Gao et al.   JOURNAL OF NEUROSCIENCE

Differential expression of alpha-synuclein, parkin, and synphilin-1 isoforms in Lewy body disease

(2008) Katrin Beyer et al.   NEUROGENETICS

Cleavage of normal and pathological forms of α-synuclein by neurosin in vitro

(2008) Takashi Kasai et al.   NEUROSCIENCE LETTERS

Nitrated α–Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons

(2008) Eric J. Benner et al.   PLoS One

Inhibition of α-Synuclein Fibrillization by Dopamine Is Mediated by Interactions with Five C-Terminal Residues and with E83 in the NAC Region

(2008) Fernando E. Herrera et al.   PLoS One

Localization of CKII β subunits in Lewy bodies of Parkinson's disease

(2007) Myung Yi Ryu et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The solubility of α-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease

(2003) Bruce C. V. Campbell et al.   JOURNAL OF NEUROCHEMISTRY