标题
Reverse engineering Lewy bodies: how far have we come and how far can we go?
作者
关键词
-
出版物
NATURE REVIEWS NEUROSCIENCE
Volume 22, Issue 2, Pages 111-131
出版商
Springer Science and Business Media LLC
发表日期
2021-01-11
DOI
10.1038/s41583-020-00416-6
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophy
- (2020) Mohammad Shahnawaz et al. NATURE
- The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration
- (2020) Anne-Laure Mahul-Mellier et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure
- (2020) David R. Boyer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Protein-Protein Interactions in Alpha-Synuclein Biogenesis: New Potential Targets in Parkinson’s Disease
- (2020) Sarah M. Hernandez et al. Frontiers in Aging Neuroscience
- Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in nonhuman primates
- (2020) M. Bourdenx et al. Science Advances
- α-Synuclein aggregation nucleates through liquid–liquid phase separation
- (2020) Soumik Ray et al. Nature Chemistry
- Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease
- (2020) Simon Dujardin et al. NATURE MEDICINE
- Do Lewy bodies contain alpha-synuclein fibrils? and Does it matter? A brief history and critical analysis of recent reports
- (2020) Hilal A. Lashuel NEUROBIOLOGY OF DISEASE
- Pronounced α-synuclein pathology in a seeding-based mouse model is not sufficient to induce mitochondrial respiration deficits in the striatum and amygdala
- (2020) Johannes Burtscher et al. eNeuro
- Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network
- (2019) Simona Gribaudo et al. Stem Cell Reports
- Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson’s iPSC-derived dopamine neurons
- (2019) Federico Zambon et al. HUMAN MOLECULAR GENETICS
- Wide distribution of alpha-synuclein oligomers in multiple system atrophy brain detected by proximity ligation
- (2019) Hiroaki Sekiya et al. ACTA NEUROPATHOLOGICA
- Alpha-synuclein (αSyn) preformed fibrils induce endogenous αSyn aggregation, compromise synaptic activity and enhance synapse loss in cultured excitatory hippocampal neurons
- (2019) Qihui Wu et al. JOURNAL OF NEUROSCIENCE
- Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson’s disease model
- (2019) Michal Wegrzynowicz et al. ACTA NEUROPATHOLOGICA
- Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes
- (2019) Sarah H. Shahmoradian et al. NATURE NEUROSCIENCE
- Understanding the pathogenesis of multiple system atrophy: state of the art and future perspectives
- (2019) Giacomo Monzio Compagnoni et al. Acta Neuropathologica Communications
- Parkinson’s disease is a type of amyloidosis featuring accumulation of amyloid fibrils of α-synuclein
- (2019) Katsuya Araki et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lipids as Trans-Acting Effectors for α-Synuclein in the Pathogenesis of Parkinson’s Disease
- (2019) Kensuke Ikenaka et al. Frontiers in Neuroscience
- Lewy body pathology is more prevalent in older individuals with mitochondrial disease than controls
- (2019) Daniel Erskine et al. ACTA NEUROPATHOLOGICA
- Intrastriatal alpha-synuclein fibrils in monkeys: spreading, imaging and neuropathological changes
- (2019) Yaping Chu et al. BRAIN
- Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts
- (2019) Timo Strohäker et al. Nature Communications
- Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach
- (2018) Erika Bereczki et al. BRAIN
- The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases
- (2018) Nolwen L. Rey et al. NEUROBIOLOGY OF DISEASE
- α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton
- (2018) Dalila G. Ordonez et al. NEURON
- Cryo-EM structure of alpha-synuclein fibrils
- (2018) Ricardo Guerrero-Ferreira et al. eLife
- Modeling Parkinson’s disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain
- (2017) Poonam Thakur et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Defective synaptic connectivity and axonal neuropathology in a human iPSC-based model of familial Parkinson’s disease
- (2017) Georgia Kouroupi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Propagation of pathological α-synuclein in marmoset brain
- (2017) Aki Shimozawa et al. Acta Neuropathologica Communications
- Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease
- (2016) Emma Deas et al. ANTIOXIDANTS & REDOX SIGNALING
- Alpha-Synuclein as a Biomarker for Parkinson's Disease
- (2016) Anzari Atik et al. BRAIN PATHOLOGY
- The Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation
- (2016) Airi Tarutani et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson’s disease
- (2016) Nolwen L. Rey et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson’s disease
- (2016) Mohamed-Bilal Fares et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity
- (2016) Kelvin C. Luk et al. Cell Reports
- Molecular Features Underlying Neurodegeneration Identified through In Vitro Modeling of Genetically Diverse Parkinson’s Disease Patients
- (2016) Lin Lin et al. Cell Reports
- Structural and functional properties of prefibrillar α-synuclein oligomers
- (2016) Laura Pieri et al. Scientific Reports
- Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson’s disease brain
- (2015) Rosalind F. Roberts et al. BRAIN
- Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death
- (2015) A-L Mahul-Mellier et al. CELL DEATH AND DIFFERENTIATION
- α-Synuclein strains cause distinct synucleinopathies after local and systemic administration
- (2015) W. Peelaerts et al. NATURE
- Synchrotron FTIR micro-spectroscopy for structural analysis of Lewy bodies in the brain of Parkinson’s disease patients
- (2015) Katsuya Araki et al. Scientific Reports
- Formaldehyde-fixed brain tissue from spontaneously ill α-synuclein transgenic mice induces fatal α-synucleinopathy in transgenic hosts
- (2014) Manuel Schweighauser et al. ACTA NEUROPATHOLOGICA
- The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of -synuclein, and enhances its secretion and nuclear localization in cells
- (2014) M.-B. Fares et al. HUMAN MOLECULAR GENETICS
- The H50Q Mutation Enhances α-Synuclein Aggregation, Secretion, and Toxicity
- (2014) Ossama Khalaf et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Divergent effects of the H50Q and G51DSNCAmutations on the aggregation of α-synuclein
- (2014) Nicola J. Rutherford et al. JOURNAL OF NEUROCHEMISTRY
- Brain Injection of -Synuclein Induces Multiple Proteinopathies, Gliosis, and a Neuronal Injury Marker
- (2014) A. N. Sacino et al. JOURNAL OF NEUROSCIENCE
- Formation of α-synuclein Lewy neurite–like aggregates in axons impedes the transport of distinct endosomes
- (2014) Laura A. Volpicelli-Daley et al. MOLECULAR BIOLOGY OF THE CELL
- Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases
- (2014) Jing L Guo et al. NATURE MEDICINE
- Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates
- (2014) Laura A Volpicelli-Daley et al. Nature Protocols
- Extracellular α-synuclein—a novel and crucial factor in Lewy body diseases
- (2014) He-Jin Lee et al. Nature Reviews Neurology
- A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology
- (2014) Petra Pasanen et al. NEUROBIOLOGY OF AGING
- Higher Vulnerability and Stress Sensitivity of Neuronal Precursor Cells Carrying an Alpha-Synuclein Gene Triplication
- (2014) Adrian Flierl et al. PLoS One
- Proteomic analysis of human substantia nigra identifies novel candidates involved in Parkinson's disease pathogenesis
- (2014) Virginie Licker et al. PROTEOMICS
- α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration
- (2014) Hien T. Tran et al. Cell Reports
- Models of α-synuclein aggregation in Parkinson’s disease
- (2014) Rosa María Giráldez-Pérez et al. Acta Neuropathologica Communications
- Pathological alpha-synuclein propagates through neural networks
- (2014) Masami Masuda-Suzukake et al. Acta Neuropathologica Communications
- α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson’s disease and multiple system atrophy?
- (2013) Aoife P. Kiely et al. ACTA NEUROPATHOLOGICA
- G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome
- (2013) Suzanne Lesage et al. ANNALS OF NEUROLOGY
- Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys
- (2013) Ariadna Recasens et al. ANNALS OF NEUROLOGY
- The Parkinson’s Disease-Associated H50Q Mutation Accelerates α-Synuclein Aggregation in Vitro
- (2013) Dhiman Ghosh et al. BIOCHEMISTRY
- Prion-like spreading of pathological α-synuclein in brain
- (2013) Masami Masuda-Suzukake et al. BRAIN
- A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats
- (2013) Silke Nuber et al. BRAIN
- Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons
- (2013) Jing L. Guo et al. CELL
- Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription
- (2013) Scott D. Ryan et al. CELL
- α-Synuclein Senses Lipid Packing Defects and Induces Lateral Expansion of Lipids Leading to Membrane Remodeling
- (2013) Myriam M. Ouberai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration
- (2013) Marusela Oliveras-Salvá et al. Molecular Neurodegeneration
- Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease
- (2013) Silke Appel-Cresswell et al. MOVEMENT DISORDERS
- Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies
- (2013) David J. Irwin et al. NATURE REVIEWS NEUROSCIENCE
- Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases
- (2013) Adamantios Mamais et al. NEUROBIOLOGY OF DISEASE
- A novel -synuclein missense mutation in Parkinson disease
- (2013) C. Proukakis et al. NEUROLOGY
- Novel A18T and pA29S substitutions in α-synuclein may be associated with sporadic Parkinson's disease
- (2013) Dorota Hoffman-Zacharska et al. PARKINSONISM & RELATED DISORDERS
- Membrane Lipid Co-Aggregation with α-Synuclein Fibrils
- (2013) Erik Hellstrand et al. PLoS One
- Transmission of multiple system atrophy prions to transgenic mice
- (2013) J. C. Watts et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds
- (2013) B. B. Holmes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification and Rescue of -Synuclein Toxicity in Parkinson Patient-Derived Neurons
- (2013) C. Y. Chung et al. SCIENCE
- Structural and functional characterization of two alpha-synuclein strains
- (2013) Luc Bousset et al. Nature Communications
- Genetics of Parkinson's Disease
- (2013) C. Klein et al. Cold Spring Harbor Perspectives in Medicine
- Can we clinically diagnose dementia with Lewy bodies yet?
- (2013) Yue Huang et al. Translational Neurodegeneration
- Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein
- (2013) Amanda N Sacino et al. Acta Neuropathologica Communications
- Expression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment
- (2012) Jason R. Cannon et al. EXPERIMENTAL NEUROLOGY
- Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation
- (2012) Igor F. Tsigelny et al. FEBS Journal
- Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
- (2012) Kelvin C. Luk et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Alpha-Synuclein Posttranslational Modification and Alternative Splicing as a Trigger for Neurodegeneration
- (2012) Katrin Beyer et al. MOLECULAR NEUROBIOLOGY
- Exosomal cell-to-cell transmission of alpha synuclein oligomers
- (2012) Karin M Danzer et al. Molecular Neurodegeneration
- Animal models of Parkinson's disease: Limits and relevance to neuroprotection studies
- (2012) Erwan Bezard et al. MOVEMENT DISORDERS
- 100 years of Lewy pathology
- (2012) Michel Goedert et al. Nature Reviews Neurology
- Impaired neurotransmission caused by overexpression of -synuclein in nigral dopamine neurons
- (2012) M. Lundblad et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pathological -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
- (2012) K. C. Luk et al. SCIENCE
- Alpha-synuclein: from secretion to dysfunction and death
- (2012) O Marques et al. Cell Death & Disease
- Gelsolin co-occurs with Lewy bodies in vivo and accelerates α-synuclein aggregation in vitro
- (2011) Hedvig Welander et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The Proteome of the Locus Ceruleus in Parkinson's Disease: Relevance to Pathogenesis
- (2011) Karin D. van Dijk et al. BRAIN PATHOLOGY
- Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations
- (2011) Frank Soldner et al. CELL
- Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers
- (2011) He-Jin Lee et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- E46K Human α-Synuclein Transgenic Mice Develop Lewy-like and Tau Pathology Associated with Age-dependent, Detrimental Motor Impairment
- (2011) Kristel L. Emmer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- α-Synuclein and ALPS motifs are membrane curvature sensors whose contrasting chemistry mediates selective vesicle binding
- (2011) Iwona M. Pranke et al. JOURNAL OF CELL BIOLOGY
- α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
- (2011) Christian Hansen et al. JOURNAL OF CLINICAL INVESTIGATION
- Induction of Intracellular Tau Aggregation Is Promoted by -Synuclein Seeds and Provides Novel Insights into the Hyperphosphorylation of Tau
- (2011) E. A. Waxman et al. JOURNAL OF NEUROSCIENCE
- α-Synuclein-Induced Tubule Formation in Lipid Bilayers
- (2011) Anjan P. Pandey et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Mechanism of Membrane Interaction and Disruption by α-Synuclein
- (2011) Nicholas P. Reynolds et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Milestones in Parkinson's disease-Clinical and pathologic features
- (2011) Glenda Halliday et al. MOVEMENT DISORDERS
- Prion-like acceleration of a synucleinopathy in a transgenic mouse model
- (2011) Anne-Laure Mougenot et al. NEUROBIOLOGY OF AGING
- Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission
- (2011) Lydia Alvarez-Erviti et al. NEUROBIOLOGY OF DISEASE
- Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons
- (2011) M. Decressac et al. NEUROBIOLOGY OF DISEASE
- Identification of Novel α-Synuclein Isoforms in Human Brain Tissue by using an Online NanoLC-ESI-FTICR-MS Method
- (2011) Annika Öhrfelt et al. NEUROCHEMICAL RESEARCH
- Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
- (2011) Laura A. Volpicelli-Daley et al. NEURON
- SNCA Triplication Parkinson's Patient's iPSC-derived DA Neurons Accumulate α-Synuclein and Are Susceptible to Oxidative Stress
- (2011) Blake Byers et al. PLoS One
- Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
- (2011) Michael J. Devine et al. Nature Communications
- Non-invasive evaluation of nigrostriatal neuropathology in a proteasome inhibitor rodent model of Parkinson's disease
- (2010) Anthony C Vernon et al. BMC NEUROSCIENCE
- A New Hypothesis of Pathogenesis Based on the Divorce between Mitochondria and their Host Cells: Possible Relevance for Alzheimers Disease
- (2010) L.F. Agnati et al. Current Alzheimer Research
- Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated α-synuclein gene mutations precede central nervous system changes
- (2010) Yien-Ming Kuo et al. HUMAN MOLECULAR GENETICS
- Seeded Aggregation and Toxicity of α-Synuclein and Tau
- (2010) Takashi Nonaka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Membrane Curvature Induction and Tubulation Are Common Features of Synucleins and Apolipoproteins
- (2010) Jobin Varkey et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Aggregation of α-Synuclein in S. cerevisiae is Associated with Defects in Endosomal Trafficking and Phospholipid Biosynthesis
- (2010) James H. Soper et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Cell-Produced -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival
- (2010) E. Emmanouilidou et al. JOURNAL OF NEUROSCIENCE
- Phosphorylation at S87 Is Enhanced in Synucleinopathies, Inhibits -Synuclein Oligomerization, and Influences Synuclein-Membrane Interactions
- (2010) K. E. Paleologou et al. JOURNAL OF NEUROSCIENCE
- Fcγ receptors are required for NF-κB signaling, microglial activation and dopaminergic neurodegeneration in an AAV-synuclein mouse model of Parkinson's disease
- (2010) Shuwen Cao et al. Molecular Neurodegeneration
- Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease
- (2010) Jia-Yi Li et al. MOVEMENT DISORDERS
- Evidence in favor of Braak staging of Parkinson's disease
- (2010) Dennis W. Dickson et al. MOVEMENT DISORDERS
- Synphilin-1 Enhances α-Synuclein Aggregation in Yeast and Contributes to Cellular Stress and Cell Death in a Sir2-Dependent Manner
- (2010) Sabrina Büttner et al. PLoS One
- Lewy body pathology in fetal grafts
- (2009) Yaping Chu et al. Annals of the New York Academy of Sciences
- Detection of elevated levels of soluble -synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies
- (2009) K. E. Paleologou et al. BRAIN
- Interaction with synphilin-1 promotes inclusion formation of α-synuclein: mechanistic insights and pathological implication
- (2009) Yuan-Yuan Xie et al. FASEB JOURNAL
- Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents
- (2009) Songcang Chen et al. JOURNAL OF CLINICAL INVESTIGATION
- Differences between subacute and chronic MPTP mice models: investigation of dopaminergic neuronal degeneration and α-synuclein inclusions
- (2009) Claire Gibrat et al. JOURNAL OF NEUROCHEMISTRY
- Pathologic Modifications of α-Synuclein in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)-Treated Squirrel Monkeys
- (2009) Alison L. McCormack et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Rab11a and HSP90 Regulate Recycling of Extracellular -Synuclein
- (2009) J. Liu et al. JOURNAL OF NEUROSCIENCE
- No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism
- (2009) Glenda Halliday et al. MOVEMENT DISORDERS
- Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
- (2009) Wataru Satake et al. NATURE GENETICS
- Genome-wide association study reveals genetic risk underlying Parkinson's disease
- (2009) Javier Simón-Sánchez et al. NATURE GENETICS
- Inclusion formation and neuronal cell death through neuron-to-neuron transmission of -synuclein
- (2009) P. Desplats et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Oligomeric amyloid associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques
- (2009) R. M. Koffie et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Exogenous -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
- (2009) K. C. Luk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Three-Layered Structure Shared Between Lewy Bodies and Lewy Neurites—Three-Dimensional Reconstruction of Triple-Labeled Sections
- (2008) Toshiro Kanazawa et al. BRAIN PATHOLOGY
- Modelling Parkinson-like neurodegeneration via osmotic minipump delivery of MPTP and probenecid
- (2008) Daniel Alvarez-Fischer et al. JOURNAL OF NEUROCHEMISTRY
- Depletion of 26S Proteasomes in Mouse Brain Neurons Causes Neurodegeneration and Lewy-Like Inclusions Resembling Human Pale Bodies
- (2008) L. Bedford et al. JOURNAL OF NEUROSCIENCE
- Transplanted dopaminergic neurons develop PD pathologic changes: A second case report
- (2008) Jeffrey H. Kordower et al. MOVEMENT DISORDERS
- Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
- (2008) Jia-Yi Li et al. NATURE MEDICINE
- Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease
- (2008) Jeffrey H Kordower et al. NATURE MEDICINE
- A stable proportion of Lewy body bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death
- (2008) Sandrine Greffard et al. NEUROBIOLOGY OF AGING
- Elevated α-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease
- (2008) Jan Gründemann et al. NUCLEIC ACIDS RESEARCH
- Modeling PD pathogenesis in mice: Advantages of a chronic MPTP protocol
- (2008) Gloria E. Meredith et al. PARKINSONISM & RELATED DISORDERS
- Proteome analysis of human substantia nigra in Parkinson's disease
- (2008) Cornelius J Werner et al. Proteome Science
- Identification of proteins in human substantia nigra
- (2008) Efstathia Kitsou et al. Proteomics Clinical Applications
- C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging
- (2008) Tjakko J. van Ham et al. PLoS Genetics
- Selective loss of nigral dopamine neurons induced by overexpression of truncated human α-synuclein in mice
- (2006) Masaki Wakamatsu et al. NEUROBIOLOGY OF AGING
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started