rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration
Published 2013 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration
Authors
Keywords
Parkinson’s disease, Alpha-synuclein, Mouse, Model, AAV, A53T, Neurodegeneration, Phosphorylation, Aggregation, Behaviour
Journal
Molecular Neurodegeneration
Volume 8, Issue 1, Pages 44
Publisher
Springer Nature
Online
2013-11-25
DOI
10.1186/1750-1326-8-44
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson’s disease and multiple system atrophy?
- (2013) Aoife P. Kiely et al. ACTA NEUROPATHOLOGICA
- A novel -synuclein missense mutation in Parkinson disease
- (2013) C. Proukakis et al. NEUROLOGY
- Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity
- (2012) Meret Nora Gaugler et al. ACTA NEUROPATHOLOGICA
- Biochemical Increase in Phosphorylated Alpha-Synuclein Precedes Histopathology of Lewy-Type Synucleinopathies
- (2012) Lih-Fen Lue et al. BRAIN PATHOLOGY
- Systematic Mutagenesis of -Synuclein Reveals Distinct Sequence Requirements for Physiological and Pathological Activities
- (2012) J. Burre et al. JOURNAL OF NEUROSCIENCE
- Dysregulated dopamine storage increases the vulnerability to α-synuclein in nigral neurons
- (2012) Ayse Ulusoy et al. NEUROBIOLOGY OF DISEASE
- Efficient and stable transduction of dopaminergic neurons in rat substantia nigra by rAAV 2/1, 2/2, 2/5, 2/6.2, 2/7, 2/8 and 2/9
- (2011) A Van der Perren et al. GENE THERAPY
- Modelling of Parkinson's disease in mice
- (2011) Marie-Françoise Chesselet et al. LANCET NEUROLOGY
- Use of viral vectors to create animal models for Parkinson's disease
- (2011) Karin Löw et al. NEUROBIOLOGY OF DISEASE
- Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons
- (2011) M. Decressac et al. NEUROBIOLOGY OF DISEASE
- Progressive Neurodegeneration or Endogenous Compensation in an Animal Model of Parkinson's Disease Produced by Decreasing Doses of Alpha-Synuclein
- (2011) James B. Koprich et al. PLoS One
- Rapid, Simple, and Versatile Manufacturing of Recombinant Adeno-Associated Viral Vectors at Scale
- (2010) Martin Lock et al. HUMAN GENE THERAPY
- α-Synuclein Transgenic Mice Reveal Compensatory Increases in Parkinson's Disease-Associated Proteins DJ-1 and Parkin and Have Enhanced α-Synuclein and PINK1 Levels After Rotenone Treatment
- (2010) Sonia George et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Inhibition of FK506 Binding Proteins Reduces -Synuclein Aggregation and Parkinson's Disease-Like Pathology
- (2010) M. Gerard et al. JOURNAL OF NEUROSCIENCE
- Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model the pathology of Parkinson's disease
- (2010) James B Koprich et al. Molecular Neurodegeneration
- Fcγ receptors are required for NF-κB signaling, microglial activation and dopaminergic neurodegeneration in an AAV-synuclein mouse model of Parkinson's disease
- (2010) Shuwen Cao et al. Molecular Neurodegeneration
- Microglia Acquire Distinct Activation Profiles Depending on the Degree of α-Synuclein Neuropathology in a rAAV Based Model of Parkinson's Disease
- (2010) Vanesa Sanchez-Guajardo et al. PLoS One
- α-Synuclein S129 Phosphorylation Mutants Do Not Alter Nigrostriatal Toxicity in a Rat Model of Parkinson Disease
- (2009) Nikolaus R. McFarland et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Comparative Transduction Efficiency of AAV Vector Serotypes 1–6 in the Substantia Nigra and Striatum of the Primate Brain
- (2009) Eleni A Markakis et al. MOLECULAR THERAPY
- Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
- (2009) Wataru Satake et al. NATURE GENETICS
- Genome-wide association study reveals genetic risk underlying Parkinson's disease
- (2009) Javier Simón-Sánchez et al. NATURE GENETICS
- Transgenic overexpression of the alpha-synuclein interacting protein synphilin-1 leads to behavioral and neuropathological alterations in mice
- (2009) Silke Nuber et al. NEUROGENETICS
- Effects of UCH-L1 on α-synuclein over-expression mouse model of Parkinson’s disease
- (2008) Toru Yasuda et al. JOURNAL OF NEUROCHEMISTRY
- Targeted Overexpression of Human α-Synuclein Triggers Microglial Activation and an Adaptive Immune Response in a Mouse Model of Parkinson Disease
- (2008) Shaji Theodore et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started