Engineering of highly potent and selective HNTX-III mutant against hNav1.7 sodium channel for treatment of pain
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Title
Engineering of highly potent and selective HNTX-III mutant against hNav1.7 sodium channel for treatment of pain
Authors
Keywords
hNa, v, 1.7, HNTX-III, peptide, analgesia, structure activity relationship
Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume -, Issue -, Pages 100326
Publisher
Elsevier BV
Online
2021-01-23
DOI
10.1016/j.jbc.2021.100326
References
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Note: Only part of the references are listed.- Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin
- (2019) Hui Xu et al. CELL
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- (2019) Huaizong Shen et al. SCIENCE
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- (2019) Yoshiyuki Kawamoto et al. BIOCHEMICAL PHARMACOLOGY
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- (2019) Steven J. McKerrall et al. JOURNAL OF MEDICINAL CHEMISTRY
- Challenges and Opportunities for Therapeutics Targeting the Voltage-Gated Sodium Channel Isoform NaV1.7
- (2019) John V. Mulcahy et al. JOURNAL OF MEDICINAL CHEMISTRY
- Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V
- (2018) Bryan D. Moyer et al. PLoS One
- Treatment with Sulforaphane Produces Antinociception and Improves Morphine Effects during Inflammatory Pain in Mice
- (2017) Alejandro Redondo et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel Na V 1.7
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- Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a
- (2017) Jennifer R. Deuis et al. Scientific Reports
- Electrophysiological and Pharmacological Analyses of Nav1.9 Voltage-Gated Sodium Channel by Establishing a Heterologous Expression System
- (2017) Xi Zhou et al. Frontiers in Pharmacology
- The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant
- (2017) Sassan Rahnama et al. PLoS One
- Histamine H4receptor agonist-induced relief from painful peripheral neuropathy is mediated by inhibition of spinal neuroinflammation and oxidative stress
- (2016) Maria Domenica Sanna et al. BRITISH JOURNAL OF PHARMACOLOGY
- Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain
- (2016) Anatoly Shcherbatko et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx-1
- (2016) Justin K. Murray et al. JOURNAL OF MEDICINAL CHEMISTRY
- Nav1.7-A1632G Mutation from a Family with Inherited Erythromelalgia: Enhanced Firing of Dorsal Root Ganglia Neurons Evoked by Thermal Stimuli
- (2016) Y. Yang et al. JOURNAL OF NEUROSCIENCE
- A Gain-of-Function Mutation in Nav1.6 in a Case of Trigeminal Neuralgia
- (2016) Brian S Tanaka et al. MOLECULAR MEDICINE
- Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
- (2016) Jeremiah D. Osteen et al. NATURE
- Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release
- (2016) Aristos J. Alexandrou et al. PLoS One
- p.L1612P, a Novel Voltage-gated Sodium Channel Nav1.7 Mutation Inducing a Cold Sensitive Paroxysmal Extreme Pain Disorder
- (2015) Marc R. Suter et al. ANESTHESIOLOGY
- Sustained inhibition of the Na V 1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1
- (2015) Justin K. Murray et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Seven novel modulators of the analgesic target NaV1.7 uncovered using a high-throughput venom-based discovery approach
- (2015) Julie K Klint et al. BRITISH JOURNAL OF PHARMACOLOGY
- De novo gain-of-function and loss-of-function mutations ofSCN8Ain patients with intellectual disabilities and epilepsy
- (2015) Maxime G Blanchard et al. JOURNAL OF MEDICAL GENETICS
- Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the NaV1.7 Sodium Channel
- (2015) Justin K. Murray et al. JOURNAL OF MEDICINAL CHEMISTRY
- Local knockdown of the NaV1.6 sodium channel reduces pain behaviors, sensory neuron excitability, and sympathetic sprouting in rat models of neuropathic pain
- (2015) W. Xie et al. NEUROSCIENCE
- Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist
- (2015) S. Ahuja et al. SCIENCE
- Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula
- (2015) Chun Chow et al. Toxins
- Recent progress in sodium channel modulators for pain
- (2014) Sharan K. Bagal et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- A novel de novo mutation of SCN8A (Nav1.6) with enhanced channel activation in a child with epileptic encephalopathy
- (2014) Mark Estacion et al. NEUROBIOLOGY OF DISEASE
- Paroxysmal itch caused by gain-of-function Nav1.7 mutation
- (2014) Grazia Devigili et al. PAIN
- Global Nav1.7 Knockout Mice Recapitulate the Phenotype of Human Congenital Indifference to Pain
- (2014) Jacinthe Gingras et al. PLoS One
- Synthesis and Analgesic Effects of μ-TRTX-Hhn1b on Models of Inflammatory and Neuropathic Pain
- (2014) Yu Liu et al. Toxins
- Novel analgesic peptides from the tree frog of Hyla japonica
- (2013) Yuqin Zhu et al. BIOCHIMIE
- Structure and Function of Hainantoxin-III, a Selective Antagonist of Neuronal Tetrodotoxin-sensitive Voltage-gated Sodium Channels Isolated from the Chinese Bird SpiderOrnithoctonus hainana
- (2013) Zhonghua Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Knockdown of sodium channel NaV1.6 blocks mechanical pain and abnormal bursting activity of afferent neurons in inflamed sensory ganglia
- (2013) Wenrui Xie et al. PAIN
- Potency optimization of Huwentoxin-IV on hNav1.7: A neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena
- (2013) Jefferson D. Revell et al. PEPTIDES
- Novel action of metformin in the prevention of haloperidol-induced catalepsy in mice: Potential in the treatment of Parkinson's disease?
- (2013) Halimah A. Adedeji et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- De Novo Pathogenic SCN8A Mutation Identified by Whole-Genome Sequencing of a Family Quartet Affected by Infantile Epileptic Encephalopathy and SUDEP
- (2012) Krishna R. Veeramah et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Spider-venom peptides that target voltage-gated sodium channels: Pharmacological tools and potential therapeutic leads
- (2012) Julie K. Klint et al. TOXICON
- Pain as a global public health priority
- (2011) Daniel S Goldberg et al. BMC PUBLIC HEALTH
- Venoms as a platform for human drugs: translating toxins into therapeutics
- (2011) Glenn F King EXPERT OPINION ON BIOLOGICAL THERAPY
- The Roles of Sodium Channels in Nociception: Implications for Mechanisms of Neuropathic Pain
- (2011) Min Liu et al. PAIN MEDICINE
- Sodium Channels in Normal and Pathological Pain
- (2010) Sulayman D. Dib-Hajj et al. Annual Review of Neuroscience
- Targeting voltage sensors in sodium channels with spider toxins
- (2010) Frank Bosmans et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Biological diversity and therapeutic potential of natural and engineered cystine knot miniproteins
- (2009) Harald Kolmar CURRENT OPINION IN PHARMACOLOGY
- Voltage-Gated Sodium Channels: Therapeutic Targets for Pain
- (2009) Sulayman D. Dib-Hajj et al. PAIN MEDICINE
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