Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula

Seven novel modulators of the analgesic target NaV1.7 uncovered using a high-throughput venom-based discovery approach

(2015) Julie K Klint et al.   BRITISH JOURNAL OF PHARMACOLOGY

From Foe to Friend: Using Animal Toxins to Investigate Ion Channel Function

(2015) Jeet Kalia et al.   JOURNAL OF MOLECULAR BIOLOGY

No Gain, No Pain: NaV1.7 as an Analgesic Target

(2014) Glenn F. King et al.   ACS Chemical Neuroscience

Chemical Synthesis, 3D Structure, and ASIC Binding Site of the Toxin Mambalgin-2

(2013) Christina I. Schroeder et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models

(2013) S. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spider-Venom Peptides: Structure, Pharmacology, and Potential for Control of Insect Pests

(2012) Glenn F. King et al.   Annual Review of Entomology

Spider-venom peptides that target voltage-gated sodium channels: Pharmacological tools and potential therapeutic leads

(2012) Julie K. Klint et al.   TOXICON

Deletion mutation of sodium channel NaV1.7 in inherited erythromelalgia: enhanced slow inactivation modulates dorsal root ganglion neuron hyperexcitability

(2011) X. Cheng et al.   BRAIN

Venoms as a platform for human drugs: translating toxins into therapeutics

(2011) Glenn F King   EXPERT OPINION ON BIOLOGICAL THERAPY

Recent Developments Regarding Voltage-Gated Sodium Channel Blockers for the Treatment of Inherited and Acquired Neuropathic Pain Syndromes

(2011) Jonathan W. Theile et al.   Frontiers in Pharmacology

Sodium Channels in Normal and Pathological Pain

(2010) Sulayman D. Dib-Hajj et al.   Annual Review of Neuroscience

Peptide toxins that selectively target insect NaVand CaVchannels

(2010) Glenn F. King et al.   Channels

ArachnoServer 2.0, an updated online resource for spider toxin sequences and structures

(2010) V. Herzig et al.   NUCLEIC ACIDS RESEARCH

Targeting voltage sensors in sodium channels with spider toxins

(2010) Frank Bosmans et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Spider-Venom Peptides as Therapeutics

(2010) Natalie J. Saez et al.   Toxins

ArachnoServer: a database of protein toxins from spiders

(2009) David LA Wood et al.   BMC GENOMICS

Subtype-selective targeting of voltage-gated sodium channels

(2009) Steve England et al.   BRITISH JOURNAL OF PHARMACOLOGY

Molecular diversity and evolution of cystine knot toxins of the tarantula Chilobrachys jingzhao

(2008) J. Chen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

NaV1.7 Gain-of-Function Mutations as a Continuum: A1632E Displays Physiological Changes Associated with Erythromelalgia and Paroxysmal Extreme Pain Disorder Mutations and Produces Symptoms of Both Disorders

(2008) M. Estacion et al.   JOURNAL OF NEUROSCIENCE

ProTx-II, a Selective Inhibitor of NaV1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors

(2008) W. A. Schmalhofer et al.   MOLECULAR PHARMACOLOGY

Deconstructing voltage sensor function and pharmacology in sodium channels

(2008) Frank Bosmans et al.   NATURE

A rational nomenclature for naming peptide toxins from spiders and other venomous animals

(2008) Glenn F. King et al.   TOXICON