Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain

Seven novel modulators of the analgesic target NaV1.7 uncovered using a high-throughput venom-based discovery approach

(2015) Julie K Klint et al.   BRITISH JOURNAL OF PHARMACOLOGY

Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the NaV1.7 Sodium Channel

(2015) Justin K. Murray et al.   JOURNAL OF MEDICINAL CHEMISTRY

Methods for the directed evolution of proteins

(2015) Michael S. Packer et al.   NATURE REVIEWS GENETICS

Mapping the interaction site for the tarantula toxin hainantoxin-IV (β-TRTX-Hn2a) in the voltage sensor module of domain II of voltage-gated sodium channels

(2015) Tianfu Cai et al.   PEPTIDES

Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7

(2015) Michael S. Minett et al.   Nature Communications

Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula

(2015) Chun Chow et al.   Toxins

No Gain, No Pain: NaV1.7 as an Analgesic Target

(2014) Glenn F. King et al.   ACS Chemical Neuroscience

A Monoclonal Antibody that Targets a NaV1.7 Channel Voltage Sensor for Pain and Itch Relief

(2014) Jun-Ho Lee et al.   CELL

Residue specific contributions to stability and activity inferred from saturation mutagenesis and deep sequencing

(2014) Arti Tripathi et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Spider venomics: implications for drug discovery

(2014) Sandy S Pineda et al.   Future Medicinal Chemistry

Studies Examining the Relationship between the Chemical Structure of Protoxin II and Its Activity on Voltage Gated Sodium Channels

(2014) Jae H. Park et al.   JOURNAL OF MEDICINAL CHEMISTRY

Toxins and drug discovery

(2014) Alan L. Harvey   TOXICON

Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV (μ-TRTX-Hh2a)

(2013) Natali A. Minassian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potency optimization of Huwentoxin-IV on hNav1.7: A neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena

(2013) Jefferson D. Revell et al.   PEPTIDES

Native Pyroglutamation of Huwentoxin-IV: A Post-Translational Modification that Increases the Trapping Ability to the Sodium Channel

(2013) Mingqiang Rong et al.   PLoS One

Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models

(2013) S. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Future of Peptide-based Drugs

(2012) David J. Craik et al.   Chemical Biology & Drug Design

Biologics: the next generation of analgesic drugs?

(2012) Iain P. Chessell et al.   DRUG DISCOVERY TODAY

Spider-venom peptides that target voltage-gated sodium channels: Pharmacological tools and potential therapeutic leads

(2012) Julie K. Klint et al.   TOXICON

Gain of function NaV1.7 mutations in idiopathic small fiber neuropathy

(2011) Catharina G. Faber et al.   ANNALS OF NEUROLOGY

Microscale to manufacturing scale-up of cell-free cytokine production-a new approach for shortening protein production development timelines

(2011) James F. Zawada et al.   BIOTECHNOLOGY AND BIOENGINEERING

Pain as a global public health priority

(2011) Daniel S Goldberg et al.   BMC PUBLIC HEALTH

Intra- and Interfamily Phenotypic Diversity in Pain Syndromes Associated with a Gain-of-Function Variant of NaV1.7

(2011) Mark Estación et al.   Molecular Pain

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Targeting voltage sensors in sodium channels with spider toxins

(2010) Frank Bosmans et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Spider-Venom Peptides as Therapeutics

(2010) Natalie J. Saez et al.   Toxins

ArachnoServer: a database of protein toxins from spiders

(2009) David LA Wood et al.   BMC GENOMICS

Animal Peptides Targeting Voltage-Activated Sodium Channels

(2008) Bert Billen et al.   CURRENT PHARMACEUTICAL DESIGN

Tarantula Huwentoxin-IV Inhibits Neuronal Sodium Channels by Binding to Receptor Site 4 and Trapping the Domain II Voltage Sensor in the Closed Configuration

(2008) Yucheng Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY