Venoms as a platform for human drugs: translating toxins into therapeutics

Bioactive cystine knot proteins

(2011) Norelle L Daly et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Chemical Re-engineering of Chlorotoxin Improves Bioconjugation Properties for Tumor Imaging and Targeted Therapy

(2011) Muharrem Akcan et al.   JOURNAL OF MEDICINAL CHEMISTRY

The productivity crisis in pharmaceutical R&D

(2011) Fabio Pammolli et al.   NATURE REVIEWS DRUG DISCOVERY

Unique scorpion toxin with a putative ancestral fold provides insight into evolution of the inhibitor cystine knot motif

(2011) J. J. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A case of zootherapy with the tarantula Brachypelma vagans Ausserer, 1875 in traditional medicine of the Chol Mayan ethnic group in Mexico

(2011) Salima Machkour-M'Rabet et al.   Journal of Ethnobiology and Ethnomedicine

Venomics: a new paradigm for natural products-based drug discovery

(2010) Irina Vetter et al.   AMINO ACIDS

The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain

(2010) Richard J. Clark et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-Specific Effects of Diselenide Bridges on the Oxidative Folding of a Cystine Knot Peptide, ω-Selenoconotoxin GVIA

(2010) Konkallu Hanumae Gowd et al.   BIOCHEMISTRY

Molecular diversity of spider venom

(2010) A. A. Vassilevski et al.   BIOCHEMISTRY-MOSCOW

Peptide toxins that selectively target insect NaVand CaVchannels

(2010) Glenn F. King et al.   Channels

µ-Conotoxins as Leads in the Development of New Analgesics

(2010) Raymond S. Norton   MOLECULES

Vicrostatin – An Anti-Invasive Multi-Integrin Targeting Chimeric Disintegrin with Tumor Anti-Angiogenic and Pro-Apoptotic Activities

(2010) Radu O. Minea et al.   PLoS One

Spider-Venom Peptides as Therapeutics

(2010) Natalie J. Saez et al.   Toxins

Positron emission tomography imaging of prostate cancer

(2009) Hao Hong et al.   AMINO ACIDS

Direct Visualization of Disulfide Bonds through Diselenide Proxies Using77Se NMR Spectroscopy

(2009) Mehdi Mobli et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Toxicogenomic Multiverse: Convergent Recruitment of Proteins Into Animal Venoms

(2009) Bryan G. Fry et al.   Annual Review of Genomics and Human Genetics

Pilot study of huachansu in patients with hepatocellular carcinoma, nonsmall-cell lung cancer, or pancreatic cancer

(2009) Zhiqiang Meng et al.   CANCER

Batroxobin Mobilizes Circulating Endothelial Progenitor Cells in Patients With Deep Vein Thrombosis

(2009) Lei Zhang et al.   CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS

Synthetic therapeutic peptides: science and market

(2009) Patrick Vlieghe et al.   DRUG DISCOVERY TODAY

Exenatide once weekly for the treatment of type 2 diabetes

(2009) James Malone et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Venomics as a drug discovery platform

(2009) Pierre Escoubas et al.   Expert Review of Proteomics

Annexin A2 Is a Molecular Target for TM601, a Peptide with Tumor-targeting and Anti-angiogenic Effects

(2009) Kamala Kesavan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacodynamics Pharmacodynamics of a Novel Designer Natriuretic Peptide, CD-NP, in a First-in-Human Clinical Trial in Healthy Subjects

(2009) Candace Y. W. Lee et al.   JOURNAL OF CLINICAL PHARMACOLOGY

χ-Conopeptide Pharmacophore Development: Toward a Novel Class of Norepinephrine Transporter Inhibitor (Xen2174) for Pain⊥

(2009) Andreas Brust et al.   JOURNAL OF MEDICINAL CHEMISTRY

Engineering a Stable and Selective Peptide Blocker of the Kv1.3 Channel in T Lymphocytes

(2009) M. W. Pennington et al.   MOLECULAR PHARMACOLOGY

Pharmaceutical R&D: the road to positive returns

(2009) Eric David et al.   NATURE REVIEWS DRUG DISCOVERY

Lessons from 60 years of pharmaceutical innovation

(2009) Bernard Munos   NATURE REVIEWS DRUG DISCOVERY

CNSB004 (Leconotide) Causes Antihyperalgesia Without Side Effects When Given Intravenously: A Comparison with Ziconotide in a Rat Model of Diabetic Neuropathic Pain

(2009) Anton Kolosov et al.   PAIN MEDICINE

Remarkable inter- and intra-species complexity of conotoxins revealed by LC/MS

(2009) Jasmine Davis et al.   PEPTIDES

Ancrod in Acute Ischemic Stroke

(2009) David E. Levy et al.   STROKE

Therapeutic application of peptides and proteins: parenteral forever?

(2009) Zuzana Antosova et al.   TRENDS IN BIOTECHNOLOGY

Conus Venoms - A Rich Source of Peptide-Based Therapeutics

(2008) Tiffany Han et al.   CURRENT PHARMACEUTICAL DESIGN

ASIC3, a sensor of acidic and primary inflammatory pain

(2008) Emmanuel Deval et al.   EMBO JOURNAL

Proteome and peptidome profiling of spider venoms

(2008) Songping Liang   Expert Review of Proteomics

Venomics: unravelling the complexity of animal venoms with mass spectrometry

(2008) P. Escoubas et al.   JOURNAL OF MASS SPECTROMETRY

Selenopeptide chemistry

(2008) Markus Muttenthaler et al.   JOURNAL OF PEPTIDE SCIENCE

Breaching the barrier

(2008) Alan Dove   NATURE BIOTECHNOLOGY

Maurocalcine as a Non Toxic Drug Carrier Overcomes Doxorubicin Resistance in the Cancer Cell Line MDA-MB 231

(2008) Sonia Aroui et al.   PHARMACEUTICAL RESEARCH

NMR-spectroscopic screening of spider venom reveals sulfated nucleosides as major components for the brown recluse and related species

(2008) F. C. Schroeder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A rational nomenclature for naming peptide toxins from spiders and other venomous animals

(2008) Glenn F. King et al.   TOXICON