Engineering of highly potent and selective HNTX-III mutant against hNav1.7 sodium channel for treatment of pain

Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin

(2019) Hui Xu et al.   CELL

Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins

(2019) Huaizong Shen et al.   SCIENCE

Inhibition of mast cell degranulation by melanin

(2019) Yoshiyuki Kawamoto et al.   BIOCHEMICAL PHARMACOLOGY

Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain

(2019) Steven J. McKerrall et al.   JOURNAL OF MEDICINAL CHEMISTRY

Challenges and Opportunities for Therapeutics Targeting the Voltage-Gated Sodium Channel Isoform NaV1.7

(2019) John V. Mulcahy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V

(2018) Bryan D. Moyer et al.   PLoS One

Treatment with Sulforaphane Produces Antinociception and Improves Morphine Effects during Inflammatory Pain in Mice

(2017) Alejandro Redondo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel Na V 1.7

(2017) Thomas J. Kornecook et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a

(2017) Jennifer R. Deuis et al.   Scientific Reports

Electrophysiological and Pharmacological Analyses of Nav1.9 Voltage-Gated Sodium Channel by Establishing a Heterologous Expression System

(2017) Xi Zhou et al.   Frontiers in Pharmacology

The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant

(2017) Sassan Rahnama et al.   PLoS One

Histamine H4receptor agonist-induced relief from painful peripheral neuropathy is mediated by inhibition of spinal neuroinflammation and oxidative stress

(2016) Maria Domenica Sanna et al.   BRITISH JOURNAL OF PHARMACOLOGY

Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain

(2016) Anatoly Shcherbatko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx-1

(2016) Justin K. Murray et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nav1.7-A1632G Mutation from a Family with Inherited Erythromelalgia: Enhanced Firing of Dorsal Root Ganglia Neurons Evoked by Thermal Stimuli

(2016) Y. Yang et al.   JOURNAL OF NEUROSCIENCE

A Gain-of-Function Mutation in Nav1.6 in a Case of Trigeminal Neuralgia

(2016) Brian S Tanaka et al.   MOLECULAR MEDICINE

Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain

(2016) Jeremiah D. Osteen et al.   NATURE

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release

(2016) Aristos J. Alexandrou et al.   PLoS One

p.L1612P, a Novel Voltage-gated Sodium Channel Nav1.7 Mutation Inducing a Cold Sensitive Paroxysmal Extreme Pain Disorder

(2015) Marc R. Suter et al.   ANESTHESIOLOGY

Sustained inhibition of the Na V 1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1

(2015) Justin K. Murray et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Seven novel modulators of the analgesic target NaV1.7 uncovered using a high-throughput venom-based discovery approach

(2015) Julie K Klint et al.   BRITISH JOURNAL OF PHARMACOLOGY

De novo gain-of-function and loss-of-function mutations ofSCN8Ain patients with intellectual disabilities and epilepsy

(2015) Maxime G Blanchard et al.   JOURNAL OF MEDICAL GENETICS

Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the NaV1.7 Sodium Channel

(2015) Justin K. Murray et al.   JOURNAL OF MEDICINAL CHEMISTRY

Local knockdown of the NaV1.6 sodium channel reduces pain behaviors, sensory neuron excitability, and sympathetic sprouting in rat models of neuropathic pain

(2015) W. Xie et al.   NEUROSCIENCE

Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist

(2015) S. Ahuja et al.   SCIENCE

Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula

(2015) Chun Chow et al.   Toxins

Recent progress in sodium channel modulators for pain

(2014) Sharan K. Bagal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A novel de novo mutation of SCN8A (Nav1.6) with enhanced channel activation in a child with epileptic encephalopathy

(2014) Mark Estacion et al.   NEUROBIOLOGY OF DISEASE

Paroxysmal itch caused by gain-of-function Nav1.7 mutation

(2014) Grazia Devigili et al.   PAIN

Global Nav1.7 Knockout Mice Recapitulate the Phenotype of Human Congenital Indifference to Pain

(2014) Jacinthe Gingras et al.   PLoS One

Synthesis and Analgesic Effects of μ-TRTX-Hhn1b on Models of Inflammatory and Neuropathic Pain

(2014) Yu Liu et al.   Toxins

Novel analgesic peptides from the tree frog of Hyla japonica

(2013) Yuqin Zhu et al.   BIOCHIMIE

Structure and Function of Hainantoxin-III, a Selective Antagonist of Neuronal Tetrodotoxin-sensitive Voltage-gated Sodium Channels Isolated from the Chinese Bird SpiderOrnithoctonus hainana

(2013) Zhonghua Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Knockdown of sodium channel NaV1.6 blocks mechanical pain and abnormal bursting activity of afferent neurons in inflamed sensory ganglia

(2013) Wenrui Xie et al.   PAIN

Potency optimization of Huwentoxin-IV on hNav1.7: A neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena

(2013) Jefferson D. Revell et al.   PEPTIDES

Novel action of metformin in the prevention of haloperidol-induced catalepsy in mice: Potential in the treatment of Parkinson's disease?

(2013) Halimah A. Adedeji et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

De Novo Pathogenic SCN8A Mutation Identified by Whole-Genome Sequencing of a Family Quartet Affected by Infantile Epileptic Encephalopathy and SUDEP

(2012) Krishna R. Veeramah et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Spider-venom peptides that target voltage-gated sodium channels: Pharmacological tools and potential therapeutic leads

(2012) Julie K. Klint et al.   TOXICON

Pain as a global public health priority

(2011) Daniel S Goldberg et al.   BMC PUBLIC HEALTH

Venoms as a platform for human drugs: translating toxins into therapeutics

(2011) Glenn F King   EXPERT OPINION ON BIOLOGICAL THERAPY

The Roles of Sodium Channels in Nociception: Implications for Mechanisms of Neuropathic Pain

(2011) Min Liu et al.   PAIN MEDICINE

Sodium Channels in Normal and Pathological Pain

(2010) Sulayman D. Dib-Hajj et al.   Annual Review of Neuroscience

Targeting voltage sensors in sodium channels with spider toxins

(2010) Frank Bosmans et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Biological diversity and therapeutic potential of natural and engineered cystine knot miniproteins

(2009) Harald Kolmar   CURRENT OPINION IN PHARMACOLOGY

Voltage-Gated Sodium Channels: Therapeutic Targets for Pain

(2009) Sulayman D. Dib-Hajj et al.   PAIN MEDICINE