USP33 deubiquitinates PRKN/parkin and antagonizes its role in mitophagy

Mechanism of parkin activation by PINK1

(2018) Christina Gladkova et al.   NATURE

PICK1 inhibits the E3 ubiquitin ligase activity of Parkin and reduces its neuronal protective effect

(2018) Jing He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Study of the degradation of a multidrug transporter using a non-radioactive pulse chase method

(2016) Qian Chai et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

PKA Regulates PINK1 Stability and Parkin Recruitment to Damaged Mitochondria through Phosphorylation of MIC60

(2016) Shiori Akabane et al.   MOLECULAR CELL

Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance

(2016) K. Ito et al.   SCIENCE

The three ‘P’s of mitophagy: PARKIN, PINK1, and post-translational modifications

(2015) Thomas M. Durcan et al.   GENES & DEVELOPMENT

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Development of a novel method for quantification of autophagic protein degradation by AHA labeling

(2014) Jianbin Zhang et al.   Autophagy

USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin

(2014) T. M. Durcan et al.   EMBO JOURNAL

The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy

(2014) Tom Cornelissen et al.   HUMAN MOLECULAR GENETICS

USP33 mediates Slit-Robo signaling in inhibiting colorectal cancer cell migration

(2014) Zhaohui Huang et al.   INTERNATIONAL JOURNAL OF CANCER

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

(2014) Baris Bingol et al.   NATURE

USP33, a new player in lung cancer, mediates Slit-Robo signaling

(2014) Pushuai Wen et al.   Protein & Cell

The Novel Tetramethylpyrazine Bis-nitrone (TN-2) Protects Against MPTP/MPP+-Induced Neurotoxicity via Inhibition of Mitochondrial-Dependent Apoptosis

(2013) Daping Xu et al.   Journal of Neuroimmune Pharmacology

USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110

(2013) Ji Li et al.   NATURE

The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response

(2013) Michal Simicek et al.   NATURE CELL BIOLOGY

Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation

(2013) J.-F. Trempe et al.   SCIENCE

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

PINK1-parkin-dependent mitophagy involves ubiquitination of mitofusins 1 and 2: Implications for Parkinson disease pathogenesis

(2011) Matthew E. Gegg et al.   Autophagy

Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy

(2011) Nickie C. Chan et al.   HUMAN MOLECULAR GENETICS

Isoform-Specific Localization of the Deubiquitinase USP33 to the Golgi Apparatus

(2011) Christopher Thorne et al.   TRAFFIC

Midline crossing and Slit responsiveness of commissural axons require USP33

(2009) Junichi Yuasa-Kawada et al.   NATURE NEUROSCIENCE

 -Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2

(2009) S. K. Shenoy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA