Functions of N6-methyladenosine and its role in cancer

N6-methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO-PGC-1α signalling axis

(2019) Changshui Zhuang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A dynamic reversible RNA N6 -methyladenosine modification: current status and perspectives

(2019) Zhen Bi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network

(2019) Maosheng Cheng et al.   ONCOGENE

LPLUNC1 stabilises PHB1 by counteracting TRIM21-mediated ubiquitination to inhibit NF-κB activity in nasopharyngeal carcinoma

(2019) Heran Wang et al.   ONCOGENE

Dynamic m6A mRNA methylation reveals the role of METTL3-m6A-CDCP1 signaling axis in chemical carcinogenesis

(2019) Fan Yang et al.   ONCOGENE

Author Correction: Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells

(2019) Dali Han et al.   NATURE

Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally

(2019) Huilin Huang et al.   NATURE

Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex

(2019) Ok Hyun Park et al.   MOLECULAR CELL

RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3

(2019) Yi Niu et al.   Molecular Cancer

Functions of RNA N6-methyladenosine modification in cancer progression

(2019) Bing Chen et al.   MOLECULAR BIOLOGY REPORTS

m6A RNA modification and its writer/reader VIRMA/YTHDF3 in testicular germ cell tumors: a role in seminoma phenotype maintenance

(2019) João Lobo et al.   Journal of Translational Medicine

The Critical Role of RNA m6A Methylation in Cancer

(2019) Qing Lan et al.   CANCER RESEARCH

Genome-wide screening and functional analysis identifies tumor suppressor long non-coding RNAs epigenetically silenced in hepatocellular carcinoma

(2019) Feiyue Xu et al.   CANCER RESEARCH

METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes

(2019) Huiwen Song et al.   Autophagy

Three hypomethylated genes were associated with poor overall survival in pancreatic cancer patients

(2019) Huiming Chen et al.   Aging-US

METTL3 mediated m6A modification plays an oncogenic role in cutaneous squamous cell carcinoma by regulating ΔNp63

(2019) Renpeng Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia

(2019) Yue Huang et al.   CANCER CELL

ALKBH5 inhibited autophagy of epithelial ovarian cancer through miR-7 and BCL-2

(2019) Hongtao Zhu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

m6A-induced lncRNA RP11 triggers the dissemination of colorectal cancer cells via upregulation of Zeb1

(2019) Yingmin Wu et al.   Molecular Cancer

The role of m6A RNA methylation in human cancer

(2019) Xiao-Yu Chen et al.   Molecular Cancer

Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers

(2019) Hailing Shi et al.   MOLECULAR CELL

Stage-specific requirement for Mettl3-dependent m6A mRNA methylation during haematopoietic stem cell differentiation

(2019) Heather Lee et al.   NATURE CELL BIOLOGY

KIAA1429 regulates the migration and invasion of hepatocellular carcinoma by altering m6A modification of ID2 mRNA

(2019) Xiaoyu Cheng et al.   OncoTargets and Therapy

Excessive miR-25-3p maturation via N6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression

(2019) Jialiang Zhang et al.   Nature Communications

mRNA methylation in cell senescence

(2019) Gabriel Casella et al.   Wiley Interdisciplinary Reviews-RNA

Expression profiles and prognostic significance of RNA N6-methyladenosine-related genes in patients with hepatocellular carcinoma: evidence from independent datasets

(2019) Yu Zhou et al.   Cancer Management and Research

m6A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2

(2019) Junchen Chen et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma

(2019) Yang Bai et al.   Frontiers in Oncology

Long non-coding RNA FAM225A promotes nasopharyngeal carcinoma tumorigenesis and metastasis by acting as ceRNA to sponge miR-590-3p/miR-1275 and upregulate ITGB3

(2019) Zi-Qi Zheng et al.   CANCER RESEARCH

HDAC6 inhibition synergizes with anti-PD-L1 therapy in ARID1A-inactivated ovarian cancer.

(2019) Takeshi Fukumoto et al.   CANCER RESEARCH

Enhancement of LIN28B-induced hematopoietic reprogramming by IGF2BP3

(2019) Saifeng Wang et al.   GENES & DEVELOPMENT

METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner

(2019) Jie Han et al.   Molecular Cancer

METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma

(2019) Ting Li et al.   Molecular Cancer

Elevated N‐methyltransferase expression induced by hepatic stellate cells contributes to the metastasis of hepatocellular carcinoma via regulation of the CD44v3 isoform

(2019) Jie Li et al.   Molecular Oncology

RNAmod: an integrated system for the annotation of mRNA modifications

(2019) Qi Liu et al.   NUCLEIC ACIDS RESEARCH

MTHFD2 links RNA methylation to metabolic reprogramming in renal cell carcinoma

(2019) Nathanael H. Green et al.   ONCOGENE

Regulation of Gene Expression by N-methyladenosine in Cancer

(2019) Jun Liu et al.   TRENDS IN CELL BIOLOGY

m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade

(2019) Seungwon Yang et al.   Nature Communications

RNA m6A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail

(2019) Xinyao Lin et al.   Nature Communications

EBV epitranscriptome reprogramming by METTL14 is critical for viral-associated tumorigenesis

(2019) Fengchao Lang et al.   PLoS Pathogens

N6-methyladenosine Modulates Nonsense-mediated mRNA Decay in Human Glioblastoma

(2019) Fuxi Li et al.   CANCER RESEARCH

Correction to: Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA

(2019) Min Wang et al.   CELL DEATH AND DIFFERENTIATION

Exposure to environmental toxicants reduces global N6-methyladenosine RNA methylation and alters expression of RNA methylation modulator genes

(2019) Akin Cayir et al.   ENVIRONMENTAL RESEARCH

Molecular characterization and clinical relevance of m6A regulators across 33 cancer types

(2019) Yongsheng Li et al.   Molecular Cancer

WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1

(2019) Yunhao Chen et al.   Molecular Cancer

Reading, writing and erasing mRNA methylation

(2019) Sara Zaccara et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

m6A promotes R-loop formation to facilitate transcription termination

(2019) Xin Yang et al.   CELL RESEARCH

METTL3-mediated m6A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance

(2019) Qiang Wang et al.   GUT

METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer

(2019) Ben Yue et al.   Molecular Cancer

Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m6A reader YTHDF3

(2019) Wen Ni et al.   Molecular Cancer

N6-Methyladenosine Modification Controls Circular RNA Immunity

(2019) Y. Grace Chen et al.   MOLECULAR CELL

N6-methyladenosine mRNA marking promotes selective translation of regulons required for human erythropoiesis

(2019) Daniel A. Kuppers et al.   Nature Communications

ALKBH overexpression in head and neck cancer: potential target for novel anticancer therapy

(2019) Tomaš Pilžys et al.   Scientific Reports

m 6 A demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expression

(2018) Jiqin Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g

(2018) Xiaoli Cai et al.   CANCER LETTERS

DDX3 activates CBC-eIF3-mediated translation of uORF-containing oncogenic mRNAs to promote metastasis in HNSCC

(2018) Hung-Hsi Chen et al.   CANCER RESEARCH

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m 6 A/MYC/CEBPA Signaling

(2018) Rui Su et al.   CELL

RNA N6-methyladenosine modification in cancers: current status and perspectives

(2018) Xiaolan Deng et al.   CELL RESEARCH

Mettl3–Mettl14 methyltransferase complex regulates the quiescence of adult hematopoietic stem cells

(2018) Qi Jason Yao et al.   CELL RESEARCH

METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m 6 A Modification

(2018) Hengyou Weng et al.   Cell Stem Cell

ALKBH5 Inhibits Pancreatic Cancer Motility by Decreasing Long Non-Coding RNA KCNK15-AS1 Methylation

(2018) Yuan He et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Methylation of RNA N 6 -methyladenosine in modulation of cytokine responses and tumorigenesis

(2018) Guoqiang Chang et al.   CYTOKINE

Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d

(2018) Philip Knuckles et al.   GENES & DEVELOPMENT

RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2

(2018) Mengnuo Chen et al.   HEPATOLOGY

Post-transcriptional regulation DPC4 gene by miR-190 in colorectal cancer cells

(2018) Desheng Xiao et al.   Journal of Cancer Research and Therapeutics

Circular RNAs function as ceRNAs to regulate and control human cancer progression

(2018) Yaxian Zhong et al.   Molecular Cancer

Novel insights on m6A RNA methylation in tumorigenesis: a double-edged sword

(2018) Shaoyun Wang et al.   Molecular Cancer

FTO regulates the chemo-radiotherapy resistance of cervical squamous cell carcinoma (CSCC) by targeting β-catenin through mRNA demethylation

(2018) Shun Zhou et al.   MOLECULAR CARCINOGENESIS

Zc3h13 Regulates Nuclear RNA m 6 A Methylation and Mouse Embryonic Stem Cell Self-Renewal

(2018) Jing Wen et al.   MOLECULAR CELL

Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

(2018) Huilin Huang et al.   NATURE CELL BIOLOGY

IGF2BP1 enhances an aggressive tumor cell phenotype by impairing miRNA-directed downregulation of oncogenic factors

(2018) Simon Müller et al.   NUCLEIC ACIDS RESEARCH

SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function

(2018) Yuzhang Du et al.   NUCLEIC ACIDS RESEARCH

Mechanism of N 6 -methyladenosine Modification and Its Emerging Role in Cancer

(2018) Sicong Zhang   PHARMACOLOGY & THERAPEUTICS

N6-methyladenosine links RNA metabolism to cancer progression

(2018) Dongjun Dai et al.   Cell Death & Disease

Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development

(2018) Seth D. Kasowitz et al.   PLoS Genetics

ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2

(2018) Devanshi Jain et al.   eLife

VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

(2018) Yanan Yue et al.   Cell Discovery

Loss of YTHDF2-mediated m6A-dependent mRNA clearance facilitates hematopoietic stem cell regeneration

(2018) Hu Wang et al.   CELL RESEARCH

Mettl14 is required for mouse postimplantation development by facilitating epiblast maturation

(2018) Tie-Gang Meng et al.   FASEB JOURNAL

METTL3 promotes ovarian carcinoma growth and invasion through the regulation of AXL translation and epithelial to mesenchymal transition

(2018) Wenfeng Hua et al.   GYNECOLOGIC ONCOLOGY

Aberrant Regulation of mRNA m6A Modification in Cancer Development

(2018) Junyun Luo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The dual role of N6-methyladenosine modification of RNAs is involved in human cancers

(2018) Liujia He et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor

(2018) Katelyn A. Doxtader et al.   MOLECULAR CELL

Methylation of Structured RNA by the m6A Writer METTL16 Is Essential for Mouse Embryonic Development

(2018) Mateusz Mendel et al.   MOLECULAR CELL

mRNA circularization by METTL3–eIF3h enhances translation and promotes oncogenesis

(2018) Junho Choe et al.   NATURE

m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer

(2018) Jun Liu et al.   NATURE CELL BIOLOGY

Premature polyadenylation of MAGI3 is associated with diminished N6-methyladenosine in its large internal exon

(2018) Thomas K. Ni et al.   Scientific Reports

A designed cell-penetrating human SOCS2 protein suppresses GH-dependent cancer cell proliferation

(2018) Azusa Miyamoto et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors

(2018) Panagiotis Karras et al.   CANCER CELL

A dynamic N6-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors

(2018) Fei Yan et al.   CELL RESEARCH

IGF2BP1 promotes SRF-dependent transcription in cancer in a m6A- and miRNA-dependent manner

(2018) Simon Müller et al.   NUCLEIC ACIDS RESEARCH

N 6-methyladenosine modification and METTL3 modulate enterovirus 71 replication

(2018) Haojie Hao et al.   NUCLEIC ACIDS RESEARCH

Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation

(2018) Xiang Zhong et al.   Cell Reports

Cross-talk among writers, readers, and erasers of m6A regulates cancer growth and progression

(2018) Subbarayalu Panneerdoss et al.   Science Advances

YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA in hepatocellular carcinoma

(2018) Li Zhong et al.   CANCER LETTERS

MicroRNA-145 ModulatesN6-Methyladenosine Levels by Targeting the 3′-Untranslated mRNA Region of theN6-Methyladenosine Binding YTH Domain Family 2 Protein

(2017) Zhe Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of m 6 A Transcripts by the 3ʹ→5ʹ RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline

(2017) Magdalena Natalia Wojtas et al.   MOLECULAR CELL

Corrigendum: Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex

(2017) Xiang Wang et al.   NATURE

Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control

(2017) Isaia Barbieri et al.   NATURE

The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells

(2017) Ly P Vu et al.   NATURE MEDICINE

N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein

(2017) Nian Liu et al.   NUCLEIC ACIDS RESEARCH

Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance

(2017) A Visvanathan et al.   ONCOGENE

ALKBH5-dependent m6A demethylation controls splicing and stability of long 3′-UTR mRNAs in male germ cells

(2017) Chong Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

S -Adenosylmethionine Synthesis Is Regulated by Selective N 6 -Adenosine Methylation and mRNA Degradation Involving METTL16 and YTHDC1

(2017) Hiroki Shima et al.   Cell Reports

m 6 A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells

(2017) Qi Cui et al.   Cell Reports

The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline

(2017) Alexis S Bailey et al.   eLife

YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs

(2017) Ian A Roundtree et al.   eLife

The RNA Modification N 6 -methyladenosine and Its Implications in Human Disease

(2017) Pedro J. Batista   GENOMICS PROTEOMICS & BIOINFORMATICS

METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulatingN6-methyladenosine-dependent primary MicroRNA processing

(2016) Jin-zhao Ma et al.   HEPATOLOGY

Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases

(2016) Ping Wang et al.   MOLECULAR CELL

The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells

(2016) Shuibin Lin et al.   MOLECULAR CELL

eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation

(2016) Amy S. Y. Lee et al.   NATURE

m6A RNA methylation promotes XIST-mediated transcriptional repression

(2016) Deepak P. Patil et al.   NATURE

The oncogenic triangle of HMGA2, LIN28B and IGF2BP1 antagonizes tumor-suppressive actions of the let-7 family

(2016) Bianca Busch et al.   NUCLEIC ACIDS RESEARCH

Methyltransferase-like protein 16 binds the 3′-terminal triple helix of MALAT1 long noncoding RNA

(2016) Jessica A. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA

(2016) Chuanzhao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The GAS6-AXL signaling network is a mesenchymal (Mes) molecular subtype-specific therapeutic target for ovarian cancer

(2016) J. Antony et al.   Science Signaling

YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex

(2016) Hao Du et al.   Nature Communications

Multi-phenotypic Role of Serum Response Factor in the Gastrointestinal System

(2016) Seungil Ro   Journal of Neurogastroenterology and Motility

The GAS6-AXL signaling network is a mesenchymal (Mes) molecular subtype-specific therapeutic target for ovarian cancer

(2016) J. Antony et al.   Science Signaling

5′ UTR m6A Promotes Cap-Independent Translation

(2015) Kate D. Meyer et al.   CELL

HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events

(2015) Claudio R. Alarcón et al.   CELL

N6-methyladenosine Modulates Messenger RNA Translation Efficiency

(2015) Xiao Wang et al.   CELL

Carbonic anhydrase IVinhibits colon cancer development by inhibiting the Wnt signalling pathway through targeting the WTAP–WT1–TBL1 axis

(2015) Jingwan Zhang et al.   GUT

The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond

(2015) Bogdan I. Fedeles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions

(2015) Nian Liu et al.   NATURE

Widespread occurrence ofN6-methyladenosine in bacterial mRNA

(2015) Xin Deng et al.   NUCLEIC ACIDS RESEARCH

FTO influences adipogenesis by regulating mitotic clonal expansion

(2015) Myrte Merkestein et al.   Nature Communications

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

(2014) Xu Zhao et al.   CELL RESEARCH

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

(2014) Xiao-Li Ping et al.   CELL RESEARCH

Structural and Mechanistic Insights into Poly(uridine) Tract Recognition by the hnRNP C RNA Recognition Motif

(2014) Zuzana Cieniková et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain

(2014) Chao Xu et al.   Nature Chemical Biology

Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5

(2014) Yue Huang et al.   NUCLEIC ACIDS RESEARCH

Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites

(2014) Schraga Schwartz et al.   Cell Reports

Direct Competition between hnRNP C and U2AF65 Protects the Transcriptome from the Exonization of Alu Elements

(2013) Kathi Zarnack et al.   CELL

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

(2013) Jianzhao Liu et al.   Nature Chemical Biology

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

hnRNP C Tetramer Measures RNA Length to Classify RNA Polymerase II Transcripts for Export

(2012) A. McCloskey et al.   SCIENCE

iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution

(2010) Julian König et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis

(2009) Souhila Medjkane et al.   NATURE CELL BIOLOGY