BRD4 amplification facilitates an oncogenic gene expression program in high-grade serous ovarian cancer and confers sensitivity to BET inhibitors

AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies

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Histo-genomic stratification reveals the frequent amplification/overexpression ofCCNE1andBRD4genes in non-BRCAness high grade ovarian carcinoma

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Hematogenous Metastasis of Ovarian Cancer: Rethinking Mode of Spread

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Disrupting the Interaction of BRD4 with Diacetylated Twist Suppresses Tumorigenesis in Basal-like Breast Cancer

(2014) Jian Shi et al.   CANCER CELL

The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition

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Brd4 activates P-TEFb for RNA polymerase II CTD phosphorylation

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An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma

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Transcriptome meta-analysis of lung cancer reveals recurrent aberrations in NRG1 and Hippo pathway genes

(2014) Saravana M. Dhanasekaran et al.   Nature Communications

CD74-NRG1 Fusions in Lung Adenocarcinoma

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Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation

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A distinctive ovarian cancer molecular subgroup characterized by poor prognosis and somatic focal copy number amplifications at chromosome 19

(2013) Chang Ohk Sung et al.   GYNECOLOGIC ONCOLOGY

Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA

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BRD4 Short Isoform Interacts with RRP1B, SIPA1 and Components of the LINC Complex at the Inner Face of the Nuclear Membrane

(2013) Jude Alsarraj et al.   PLoS One

BRD4 associates with p53 in DNMT3A-mutated leukemia cells and is implicated in apoptosis by the bromodomain inhibitor JQ1

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Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

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Systematic identification of genomic markers of drug sensitivity in cancer cells

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BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

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Integrated genomic analyses of ovarian carcinoma

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An Activated ErbB3/NRG1 Autocrine Loop Supports In Vivo Proliferation in Ovarian Cancer Cells

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Somatic Mutations in BRCA1 and BRCA2 Could Expand the Number of Patients That Benefit From Poly (ADP Ribose) Polymerase Inhibitors in Ovarian Cancer

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Suppression of inflammation by a synthetic histone mimic

(2010) Edwige Nicodeme et al.   NATURE

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

ARID1AMutations in Endometriosis-Associated Ovarian Carcinomas

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Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma

(2010) Siân Jones et al.   SCIENCE

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Phase II Evaluation of Pemetrexed in the Treatment of Recurrent or Persistent Platinum-Resistant Ovarian or Primary Peritoneal Carcinoma: A Study of the Gynecologic Oncology Group

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Cooperative binding of two acetylation marks on a histone tail by a single bromodomain

(2009) Jeanne Morinière et al.   NATURE

Neuregulin 1 in neural development, synaptic plasticity and schizophrenia

(2008) Lin Mei et al.   NATURE REVIEWS NEUROSCIENCE