Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation

CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer

(2014) Edmond Chipumuro et al.   CELL

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

(2014) Nicholas Kwiatkowski et al.   NATURE

Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch

(2014) Alaji Bah et al.   NATURE

Transition-metal-substituted polyoxometalate derivatives as functional anti-amyloid agents for Alzheimer’s disease

(2014) Nan Gao et al.   Nature Communications

Human TFIID Binds to Core Promoter DNA in a Reorganized Structural State

(2013) Michael A. Cianfrocco et al.   CELL

A decade and a half of protein intrinsic disorder: Biology still waits for physics

(2013) Vladimir N. Uversky   PROTEIN SCIENCE

Transcription initiation by human RNA polymerase II visualized at single-molecule resolution

(2012) A. Revyakin et al.   GENES & DEVELOPMENT

Identification of a Polyoxometalate Inhibitor of the DNA Binding Activity of Sox2

(2011) Kamesh Narasimhan et al.   ACS Chemical Biology

Polyoxometalates as Inhibitors of the Aggregation of Amyloid β Peptides Associated with Alzheimer’s Disease

(2011) Jie Geng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Intrinsically disordered proteins: regulation and disease

(2011) M Madan Babu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

XPB, a subunit of TFIIH, is a target of the natural product triptolide

(2011) Denis V Titov et al.   Nature Chemical Biology

HIV-1 protease inhibition potential of functionalized polyoxometalates

(2010) Andreas Flütsch et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Intrinsically disordered proteins are potential drug targets

(2010) Steven J Metallo   CURRENT OPINION IN CHEMICAL BIOLOGY

Developmental regulation of transcription initiation: more than just changing the actors

(2010) Ferenc Müller et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

RNA Polymerase II and TAFs Undergo a Slow Isomerization after the Polymerase Is Recruited to Promoter-Bound TFIID

(2010) Petro Yakovchuk et al.   JOURNAL OF MOLECULAR BIOLOGY

Unexpected roles for core promoter recognition factors in cell-type-specific transcription and gene regulation

(2010) James A. Goodrich et al.   NATURE REVIEWS GENETICS

Crystal Structure of an Archaeal Rad51 Homologue in Complex with a Metatungstate Inhibitor

(2009) Yang Li et al.   BIOCHEMISTRY

Recent advances in understanding the structure and function of general transcription factor TFIID

(2009) Emilie Cler et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regulation of gene expression via the core promoter and the basal transcriptional machinery

(2009) Tamar Juven-Gershon et al.   DEVELOPMENTAL BIOLOGY

Structures of three distinct activator-TFIID complexes

(2009) W.-L. Liu et al.   GENES & DEVELOPMENT

Caudal, a key developmental regulator, is a DPE-specific transcriptional factor

(2008) T. Juven-Gershon et al.   GENES & DEVELOPMENT

Dominant and Redundant Functions of TFIID Involved in the Regulation of Hepatic Genes

(2008) Antonis Tatarakis et al.   MOLECULAR CELL