- Home
- Publications
- Publication Search
- Publication Details
Title
Targeting cancer metabolism: a therapeutic window opens
Authors
Keywords
-
Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 10, Issue 9, Pages 671-684
Publisher
Springer Nature
Online
2011-08-31
DOI
10.1038/nrd3504
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
- (2011) Wei Xu et al. CANCER CELL
- NAMPT in Regulated NAD Biosynthesis and its Pivotal Role in Human Metabolism
- (2011) E S. Burgos CURRENT MEDICINAL CHEMISTRY
- The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
- (2011) Rasheduzzaman Chowdhury et al. EMBO REPORTS
- Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress
- (2011) K. Zaugg et al. GENES & DEVELOPMENT
- Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme
- (2011) Amparo Wolf et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Pyruvate carboxylase is required for glutamine-independent growth of tumor cells
- (2011) T. Cheng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Exploring the Genomes of Cancer Cells: Progress and Promise
- (2011) M. R. Stratton SCIENCE
- Genome-Scale Metabolic Modeling Elucidates the Role of Proliferative Adaptation in Causing the Warburg Effect
- (2011) Tomer Shlomi et al. PLoS Computational Biology
- The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein
- (2010) Matthew J. Ovens et al. BIOCHEMICAL JOURNAL
- Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase
- (2010) Jian-kang Jiang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- A randomised phase II study of pegylated arginine deiminase (ADI-PEG 20) in Asian advanced hepatocellular carcinoma patients
- (2010) T-S Yang et al. BRITISH JOURNAL OF CANCER
- The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate
- (2010) Patrick S. Ward et al. CANCER CELL
- Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
- (2010) Maria E. Figueroa et al. CANCER CELL
- Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation
- (2010) Jian-Bin Wang et al. CANCER CELL
- Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1
- (2010) Roel G.W. Verhaak et al. CANCER CELL
- Metformin Prevents Tobacco Carcinogen-Induced Lung Tumorigenesis
- (2010) R. M. Memmott et al. Cancer Prevention Research
- Metformin and Other Biguanides in Oncology: Advancing the Research Agenda
- (2010) M. Pollak Cancer Prevention Research
- Metformin Suppresses Colorectal Aberrant Crypt Foci in a Short-term Clinical Trial
- (2010) K. Hosono et al. Cancer Prevention Research
- Inhibition of Glutaminase Preferentially Slows Growth of Glioma Cells with Mutant IDH1
- (2010) M. J. Seltzer et al. CANCER RESEARCH
- Glutaminolysis: Supplying carbon or nitrogen or both for cancer cells?
- (2010) Chi V. Dang CELL CYCLE
- Fatty acid synthase as a potential therapeutic target in cancer
- (2010) Richard Flavin et al. Future Oncology
- Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells
- (2010) Sybille Mazurek INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Inhibition of Nicotinamide Phosphoribosyltransferase
- (2010) Maria Pittelli et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- IDH1andIDH2Gene Mutations Identify Novel Molecular Subsets Within De Novo Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study
- (2010) Guido Marcucci et al. JOURNAL OF CLINICAL ONCOLOGY
- Small Is Beautiful: Insulin-Like Growth Factors and Their Role in Growth, Development, and Cancer
- (2010) Robert G. Maki JOURNAL OF CLINICAL ONCOLOGY
- Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
- (2010) Stefan Gross et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Sunitinib Malate and Figitumumab in Solitary Fibrous Tumor: Patterns and Molecular Bases of Tumor Response
- (2010) S. Stacchiotti et al. MOLECULAR CANCER THERAPEUTICS
- Cellular Metabolic Stress: Considering How Cells Respond to Nutrient Excess
- (2010) Kathryn E. Wellen et al. MOLECULAR CELL
- Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
- (2010) Katrin Düvel et al. MOLECULAR CELL
- Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
- (2010) Myunggon Ko et al. NATURE
- mTOR: from growth signal integration to cancer, diabetes and ageing
- (2010) Roberto Zoncu et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Sugar-free approaches to cancer cell killing
- (2010) N El Mjiyad et al. ONCOGENE
- Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo
- (2010) C Algire et al. ONCOGENE
- Alternative fuel--another role for p53 in the regulation of metabolism
- (2010) K. H. Vousden PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
- (2010) W. Hu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
- (2010) A. Le et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells
- (2010) M. G. Vander Heiden et al. SCIENCE
- Metabolic Modulation of Glioblastoma with Dichloroacetate
- (2010) E. D. Michelakis et al. Science Translational Medicine
- Identification of small molecule inhibitors of pyruvate kinase M2
- (2009) Matthew G. Vander Heiden et al. BIOCHEMICAL PHARMACOLOGY
- Glioblastoma Cells Require Glutamate Dehydrogenase to Survive Impairments of Glucose Metabolism or Akt Signaling
- (2009) C. Yang et al. CANCER RESEARCH
- Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission
- (2009) H. A. Hirsch et al. CANCER RESEARCH
- Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
- (2009) Ji Luo et al. CELL
- Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis
- (2009) Daniel K. Nomura et al. CELL
- Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer
- (2009) Abdullah Yalcin et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- Targeting glucose metabolism with 2-deoxy-D-glucose for improving cancer therapy
- (2009) BS Dwarakanath et al. Future Oncology
- Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation
- (2009) Kelly M Kennedy et al. Future Oncology
- Tumor suppressors and cell metabolism: a recipe for cancer growth
- (2009) R. G. Jones et al. GENES & DEVELOPMENT
- Metformin and Pathologic Complete Responses to Neoadjuvant Chemotherapy in Diabetic Patients With Breast Cancer
- (2009) Sao Jiralerspong et al. JOURNAL OF CLINICAL ONCOLOGY
- Evaluation of SubstitutedN,N′-Diarylsulfonamides as Activators of the Tumor Cell Specific M2 Isoform of Pyruvate Kinase
- (2009) Matthew B. Boxer et al. JOURNAL OF MEDICINAL CHEMISTRY
- 18F-FDG PET and PET/CT in the Evaluation of Cancer Treatment Response
- (2009) S. Ben-Haim et al. JOURNAL OF NUCLEAR MEDICINE
- Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
- (2009) Lenny Dang et al. NATURE
- Tumours with PI3K activation are resistant to dietary restriction
- (2009) Nada Y. Kalaany et al. NATURE
- c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
- (2009) Ping Gao et al. NATURE
- Cancer's insatiable appetite
- (2009) Jason W Locasale et al. NATURE BIOTECHNOLOGY
- Somatic EGFR mutations and efficacy of tyrosine kinase inhibitors in NSCLC
- (2009) Helena Linardou et al. Nature Reviews Clinical Oncology
- Implications for KRAS status and EGFR-targeted therapies in metastatic CRC
- (2009) Nicola Normanno et al. Nature Reviews Clinical Oncology
- Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome
- (2009) Elaine R. Mardis et al. NEW ENGLAND JOURNAL OF MEDICINE
- IDH1andIDH2Mutations in Gliomas
- (2009) Hai Yan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
- (2009) G L Semenza ONCOGENE
- Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death
- (2009) D A Tennant et al. ONCOGENE
- Catastrophic NAD+ Depletion in Activated T Lymphocytes through Nampt Inhibition Reduces Demyelination and Disability in EAE
- (2009) Santina Bruzzone et al. PLoS One
- Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis
- (2009) K. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells
- (2009) J. Yun et al. SCIENCE
- Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
- (2009) M. Tahiliani et al. SCIENCE
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate1
- (2008) Ana Paula Pereira Da Silva et al. BIOCHEMICAL JOURNAL
- Arginine deiminase, a potential anti-tumor drug
- (2008) Ye Ni et al. CANCER LETTERS
- The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
- (2008) Ralph J. DeBerardinis et al. Cell Metabolism
- Isotype-specific inhibitors of the glycolytic key regulator pyruvate kinase subtype M2 moderately decelerate tumor cell proliferation
- (2008) Gilles A. Spoden et al. INTERNATIONAL JOURNAL OF CANCER
- Current and Potential Applications of Clinical 13C MR Spectroscopy
- (2008) J. Kurhanewicz et al. JOURNAL OF NUCLEAR MEDICINE
- Evaluation of lactate and alanine as metabolic biomarkers of prostate cancer using1H HR-MAS spectroscopy of biopsy tissues
- (2008) May-Britt Tessem et al. MAGNETIC RESONANCE IN MEDICINE
- Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth
- (2008) B. Clem et al. MOLECULAR CANCER THERAPEUTICS
- Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
- (2008) William G. Kaelin et al. MOLECULAR CELL
- Pyruvate kinase M2 is a phosphotyrosine-binding protein
- (2008) Heather R. Christofk et al. NATURE
- The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
- (2008) Heather R. Christofk et al. NATURE
- Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
- (2008) Jeffrey A Engelman et al. NATURE MEDICINE
- Disruption of the hexokinase–VDAC complex for tumor therapy
- (2008) L Galluzzi et al. ONCOGENE
- Drug discovery approaches targeting the PI3K/Akt pathway in cancer
- (2008) C Garcia-Echeverria et al. ONCOGENE
- Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
- (2008) D. R. Wise et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An Integrated Genomic Analysis of Human Glioblastoma Multiforme
- (2008) D. W. Parsons et al. SCIENCE
- Hexokinase-2 bound to mitochondria: Cancer's stygian link to the “Warburg effect” and a pivotal target for effective therapy
- (2008) Saroj P. Mathupala et al. SEMINARS IN CANCER BIOLOGY
- Nampt: linking NAD biology, metabolism and cancer
- (2008) Antje Garten et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started