The E3 ubiquitin ligase MARCHF6 as a metabolic integrator in cholesterol synthesis and beyond

The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6

(2020) Nicola A. Scott et al.   BIOCHEMICAL JOURNAL

Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery

(2020) George M. Burslem et al.   CELL

Twin enzymes, divergent control: The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally

(2020) Isabelle M. Capell-Hattam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hrd1 forms the retrotranslocation pore regulated by auto-ubiquitination and binding of misfolded proteins

(2020) Vedran Vasic et al.   NATURE CELL BIOLOGY

Ubiquitin-mediated regulation of sterol homeostasis

(2020) Dick J.H. van den Boomen et al.   CURRENT OPINION IN CELL BIOLOGY

Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex

(2020) Michael L. van de Weijer et al.   MOLECULAR CELL

Squalene monooxygenase: a journey to the heart of cholesterol synthesis

(2020) Ngee Kiat Chua et al.   PROGRESS IN LIPID RESEARCH

The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting

(2020) Josephine Mathilde Elisabeth Tan et al.   Cell Reports

Doa10 is a membrane protein retrotranslocase in ER-associated protein degradation

(2020) Claudia C Schmidt et al.   eLife

Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling

(2020) Emma J Fenech et al.   eLife

Post-translational control of the long and winding road to cholesterol

(2020) Laura J. Sharpe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Breaking the chains: deubiquitylating enzyme specificity begets function

(2019) Michael J. Clague et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase

(2019) Ngee Kiat Chua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Membrane-Associated MARCH E3 Ligase Family: Emerging Roles in Immune Regulation

(2019) Heng Lin et al.   Frontiers in Immunology

Consulting prostate cancer cohort data uncovers transcriptional control: Regulation of the MARCH6 gene

(2019) Hudson W. Coates et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Unstable TTTTA/TTTCA expansions in MARCH6 are associated with Familial Adult Myoclonic Epilepsy type 3

(2019) Rahel T. Florian et al.   Nature Communications

Cycles of autoubiquitination and deubiquitination regulate the ERAD ubiquitin ligase Hrd1

(2019) Brian G Peterson et al.   eLife

Mechanisms and regulation of cholesterol homeostasis

(2019) Jie Luo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MARCH6 and TRC8 facilitate the quality control of cytosolic and tail‐anchored proteins

(2018) Sandra Stefanovic‐Barrett et al.   EMBO REPORTS

Perilipin-2 Deletion Promotes Carbohydrate-Mediated Browning of White Adipose Tissue at Ambient Temperature

(2018) Andrew E. Libby et al.   JOURNAL OF LIPID RESEARCH

Consensus clinical management guidelines for Niemann-Pick disease type C

(2018) Tarekegn Geberhiwot et al.   Orphanet Journal of Rare Diseases

Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD

(2018) Mark L. Schultz et al.   Nature Communications

N-terminal acetylation and the N-end rule pathway control degradation of the lipid droplet protein PLIN2

(2018) Kha The Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol increases protein levels of the E3 ligase MARCH6, and thereby stimulates protein degradation

(2018) Laura J. Sharpe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin-dependent protein degradation at the endoplasmic reticulum and nuclear envelope

(2018) Adrian B. Mehrtash et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1

(2018) Sam A Menzies et al.   eLife

A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis

(2017) Ngee Kiat Chua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overview of the membrane-associated RING-CH (MARCH) E3 ligase family

(2017) Johannes Bauer et al.   New Biotechnology

Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP

(2017) Li Zhang et al.   eLife

The BRCA1 Ubiquitin ligase function sets a new trend for remodelling in DNA repair

(2017) Ruth M. Densham et al.   Nucleus

The BRCA1 Ubiquitin ligase function sets a new trend for remodelling in DNA repair

(2017) Ruth M. Densham et al.   Nucleus

Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene

(2017) Emma C. L. Cook et al.   PLoS One

Cholesterol-mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis

(2016) Anika V. Prabhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Conserved C-terminal Element in the Yeast Doa10 and Human MARCH6 Ubiquitin Ligases Required for Selective Substrate Degradation

(2016) Dimitrios Zattas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acute accumulation of free cholesterol induces the degradation of perilipin 2 and Rab18-dependent fusion of ER and lipid droplets in cultured human hepatocytes

(2016) Asami Makino et al.   MOLECULAR BIOLOGY OF THE CELL

Sequential Poly-ubiquitylation by Specialized Conjugating Enzymes Expands the Versatility of a Quality Control Ubiquitin Ligase

(2016) Annika Weber et al.   MOLECULAR CELL

Unravelling biological macromolecules with cryo-electron microscopy

(2016) Rafael Fernandez-Leiro et al.   NATURE

Perilipin2 plays a positive role in adipocytes during lipolysis by escaping proteasomal degradation

(2016) Yu Takahashi et al.   Scientific Reports

5p deletions: Current knowledge and future directions

(2015) Joanne M. Nguyen et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

The BioPlex Network: A Systematic Exploration of the Human Interactome

(2015) Edward L. Huttlin et al.   CELL

The Regulatory Domain of Squalene Monooxygenase Contains a Re-entrant Loop and Senses Cholesterol via a Conformational Change

(2015) Vicky Howe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of mammalian G protein signaling by N-terminal acetylation and the N-end rule pathway

(2015) S.-E. Park et al.   SCIENCE

Ubiquitin-dependent protein degradation at the yeast endoplasmic reticulum and nuclear envelope

(2014) Dimitrios Zattas et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Ubiquitin-specific protease 19 regulates the stability of the E3 ubiquitin ligase MARCH6

(2014) Nobuhiro Nakamura et al.   EXPERIMENTAL CELL RESEARCH

The E3 Ubiquitin Ligase MARCH6 Degrades Squalene Monooxygenase and Affects 3-Hydroxy-3-Methyl-Glutaryl Coenzyme A Reductase and the Cholesterol Synthesis Pathway

(2014) N. Zelcer et al.   MOLECULAR AND CELLULAR BIOLOGY

SCF ubiquitin ligase-targeted therapies

(2014) Jeffrey R. Skaar et al.   NATURE REVIEWS DRUG DISCOVERY

Thyroid Hormone Regulation of Metabolism

(2014) Rashmi Mullur et al.   PHYSIOLOGICAL REVIEWS

Ube2W conjugates ubiquitin to α-amino groups of protein N-termini

(2013) Michael H. Tatham et al.   BIOCHEMICAL JOURNAL

The Ubiquitin-conjugating Enzyme (E2) Ube2w Ubiquitinates the N Terminus of Substrates

(2013) Kenneth Matthew Scaglione et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis

(2013) Winnie Luu et al.   JOURNAL OF LIPID RESEARCH

Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells

(2013) Jonathan J Hulce et al.   NATURE METHODS

A novel locus for body mass index on 5p15.2: A meta-analysis of two genome-wide association studies

(2012) Ke-Sheng Wang et al.   GENE

Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms

(2011) P de Bie et al.   CELL DEATH AND DIFFERENTIATION

Cholesterol-Dependent Degradation of Squalene Monooxygenase, a Control Point in Cholesterol Synthesis beyond HMG-CoA Reductase

(2011) Saloni Gill et al.   Cell Metabolism

An Unusual Transmembrane Helix in the Endoplasmic Reticulum Ubiquitin Ligase Doa10 Modulates Degradation of Its Cognate E2 Enzyme

(2011) Stefan G. Kreft et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulators of G-Protein Signaling and Their G  Substrates: Promises and Challenges in Their Use as Drug Discovery Targets

(2011) A. J. Kimple et al.   PHARMACOLOGICAL REVIEWS

Regulation of HMG-CoA reductase in mammals and yeast

(2011) John S. Burg et al.   PROGRESS IN LIPID RESEARCH

Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase

(2010) Youngah Jo et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The TRC8 Ubiquitin Ligase Is Sterol Regulated and Interacts with Lipid and Protein Biosynthetic Pathways

(2010) J. P. Lee et al.   MOLECULAR CANCER RESEARCH

N-Terminal Acetylation of Cellular Proteins Creates Specific Degradation Signals

(2010) C.-S. Hwang et al.   SCIENCE

Role of the bile salt export pump, BSEP, in acquired forms of cholestasis

(2009) Bruno Stieger   DRUG METABOLISM REVIEWS

The Sterol-sensing Endoplasmic Reticulum (ER) Membrane Protein TRC8 Hampers ER to Golgi Transport of Sterol Regulatory Element-binding Protein-2 (SREBP-2)/SREBP Cleavage-activated Protein and Reduces SREBP-2 Cleavage

(2009) Masato Irisawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ube2j2 ubiquitinates hydroxylated amino acids on ER-associated degradation substrates

(2009) Xiaoli Wang et al.   JOURNAL OF CELL BIOLOGY

The E3 Ubiquitin Ligase TEB4 Mediates Degradation of Type 2 Iodothyronine Deiodinase

(2009) A. M. Zavacki et al.   MOLECULAR AND CELLULAR BIOLOGY

LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor

(2009) Noam Zelcer et al.   SCIENCE

Degradation of the bile salt export pump at endoplasmic reticulum in progressive familial intrahepatic cholestasis type II

(2008) Lin Wang et al.   HEPATOLOGY

Niemann-Pick Type C1 I1061T Mutant Encodes a Functional Protein That Is Selected for Endoplasmic Reticulum-associated Degradation Due to Protein Misfolding

(2008) Mark E. Gelsthorpe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RGS2 C1114G polymorphism and body weight gain in hypertensive patients

(2008) Michelangelo Sartori et al.   METABOLISM-CLINICAL AND EXPERIMENTAL