Cholesterol-mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis

The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally

(2015) Winnie Luu et al.   JOURNAL OF LIPID RESEARCH

Rapid suppression of 7-dehydrocholesterol reductase activity in keratinocytes by vitamin D

(2015) Ling Zou et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Should vitamin D supplements be recommended to prevent chronic diseases?

(2015) H. E. Meyer et al.   BMJ-British Medical Journal

Should vitamin D supplements be recommended to prevent chronic diseases?

(2015) H. E. Meyer et al.   BMJ-British Medical Journal

Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways

(2015) Matthew A Mitsche et al.   eLife

The sterol-based transcriptional control of human 7-dehydrocholesterol reductase (DHCR7): Evidence of a cooperative regulatory program in cholesterol synthesis

(2014) Anika V. Prabhu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Determination of the allelic frequency in Smith-Lemli-Opitz syndrome by analysis of massively parallel sequencing data sets

(2014) J.L. Cross et al.   CLINICAL GENETICS

Genotype-based databases for variants causing rare diseases

(2014) Barbara Lanthaler et al.   GENE

The E3 Ubiquitin Ligase MARCH6 Degrades Squalene Monooxygenase and Affects 3-Hydroxy-3-Methyl-Glutaryl Coenzyme A Reductase and the Cholesterol Synthesis Pathway

(2014) N. Zelcer et al.   MOLECULAR AND CELLULAR BIOLOGY

Structure of an integral membrane sterol reductase from Methylomicrobium alcaliphilum

(2014) Xiaochun Li et al.   NATURE

Genetically low vitamin D concentrations and increased mortality: mendelian randomisation analysis in three large cohorts

(2014) S. Afzal et al.   BMJ-British Medical Journal

Vitamin D concentration, obesity, and risk of diabetes: a mendelian randomisation study

(2014) Shoaib Afzal et al.   Lancet Diabetes & Endocrinology

DHCR7 mutations linked to higher vitamin D status allowed early human migration to Northern latitudes

(2013) Valerie Kuan et al.   BMC EVOLUTIONARY BIOLOGY

Controlling Cholesterol Synthesis beyond 3-Hydroxy-3-methylglutaryl-CoA Reductase (HMGCR)

(2013) Laura J. Sharpe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis

(2013) Winnie Luu et al.   JOURNAL OF LIPID RESEARCH

Lipid-regulated degradation of HMG-CoA reductase and Insig-1 through distinct mechanisms in insect cells

(2013) Rebecca A. Faulkner et al.   JOURNAL OF LIPID RESEARCH

Vitamin D for Health: A Global Perspective

(2013) Arash Hossein-nezhad et al.   MAYO CLINIC PROCEEDINGS

Mutational spectrum of Smith-Lemli-Opitz syndrome

(2012) Hans R. Waterham et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma

(2012) Jeffrey G. McDonald et al.   JOURNAL OF LIPID RESEARCH

The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1)

(2011) Eser J. Zerenturk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cholesterol-Dependent Degradation of Squalene Monooxygenase, a Control Point in Cholesterol Synthesis beyond HMG-CoA Reductase

(2011) Saloni Gill et al.   Cell Metabolism

Conversion of 7-Dehydrocholesterol to 7-Ketocholesterol Is Catalyzed by Human Cytochrome P450 7A1 and Occurs by Direct Oxidation without an Epoxide Intermediate

(2011) Raku Shinkyo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide association study of circulating vitamin D levels

(2010) Jiyoung Ahn et al.   HUMAN MOLECULAR GENETICS

Common genetic determinants of vitamin D insufficiency: a genome-wide association study

(2010) Thomas J Wang et al.   LANCET

Analysis of short-term behavioral effects of dietary cholesterol supplementation in Smith-Lemli-Opitz syndrome

(2009) Elaine Tierney et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Rate Constants for Peroxidation of Polyunsaturated Fatty Acids and Sterols in Solution and in Liposomes

(2009) Libin Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Two Distinct Pathways for Cyclooxygenase-2 Protein Degradation

(2008) Uri R. Mbonye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolution of our understanding of vitamin D

(2008) Hector F DeLuca   NUTRITION REVIEWS