Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis

Thyroid hormone receptor and liver X receptor competitively up-regulate human selective Alzheimer’s disease indicator-1 gene expression at the transcriptional levels

(2013) Emi Ishida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protein kinase C pharmacology: refining the toolbox

(2013) Alyssa X. Wu-zhang et al.   BIOCHEMICAL JOURNAL

The role of signalling in cellular cholesterol homeostasis

(2013) Winnie Luu et al.   IUBMB LIFE

Controlling Cholesterol Synthesis beyond 3-Hydroxy-3-methylglutaryl-CoA Reductase (HMGCR)

(2013) Laura J. Sharpe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bacterial Colonization of Host Cells in the Absence of Cholesterol

(2013) Stacey D. Gilk et al.   PLoS Pathogens

Sterols regulate 3β-hydroxysterol Δ24-reductase (DHCR24) via dual sterol regulatory elements: Cooperative induction of key enzymes in lipid synthesis by Sterol Regulatory Element Binding Proteins

(2012) Eser J. Zerenturk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses

(2012) Nathanael J. Spann et al.   CELL

High-Density Lipoproteins Inhibit Vascular Endothelial Inflammation by Increasing 3β-Hydroxysteroid-Δ24 Reductase Expression and Inducing Heme Oxygenase-1

(2012) Ben J. Wu et al.   CIRCULATION RESEARCH

What dictates the accumulation of desmosterol in the developing brain?

(2012) Maurice Jansen et al.   FASEB JOURNAL

WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression

(2012) M. A. Bogoyevitch et al.   JOURNAL OF CELL SCIENCE

Lipid Metabolite Profiling Identifies Desmosterol Metabolism as a New Antiviral Target for Hepatitis C Virus

(2012) Mary A. Rodgers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proteomic Analyses Reveal Divergent Ubiquitylation Site Patterns in Murine Tissues

(2012) Sebastian A. Wagner et al.   MOLECULAR & CELLULAR PROTEOMICS

Ensembl 2013

(2012) Paul Flicek et al.   NUCLEIC ACIDS RESEARCH

Desmosterolosis-phenotypic and molecular characterization of a third case and review of the literature

(2011) Christian P. Schaaf et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1)

(2011) Eser J. Zerenturk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Akt acutely activates the cholesterogenic transcription factor SREBP-2

(2011) Winnie Luu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cholesterol-Dependent Degradation of Squalene Monooxygenase, a Control Point in Cholesterol Synthesis beyond HMG-CoA Reductase

(2011) Saloni Gill et al.   Cell Metabolism

Defects in cholesterol synthesis genes in mouse and in humans: lessons for drug development and safer treatments

(2011) Simon Horvat et al.   DRUG METABOLISM REVIEWS

The desmosterolosis phenotype: spasticity, microcephaly and micrognathia with agenesis of corpus callosum and loss of white matter

(2011) Jenny Zolotushko et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles

(2011) Sebastian A. Wagner et al.   MOLECULAR & CELLULAR PROTEOMICS

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse

(2011) P. V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

System-Wide Temporal Characterization of the Proteome and Phosphoproteome of Human Embryonic Stem Cell Differentiation

(2011) K. T. G. Rigbolt et al.   Science Signaling

Constitutive androstane receptor transactivates the hepatic expression of mouse Dhcr24 and human DHCR24 encoding a cholesterogenic enzyme 24-dehydrocholesterol reductase

(2011) Kouichi Yoshinari et al.   TOXICOLOGY LETTERS

Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes

(2010) Takashi Takano et al.   JOURNAL OF HEPATOLOGY

Mass Spectrometric Analysis of Lysine Ubiquitylation Reveals Promiscuity at Site Level

(2010) Jannie M. R. Danielsen et al.   MOLECULAR & CELLULAR PROTEOMICS

Identification and analysis of the promoter region of the human DHCR24 gene: involvement of DNA methylation and histone acetylation

(2010) Joanna Drzewinska et al.   MOLECULAR BIOLOGY REPORTS

Improved Phos-tag SDS-PAGE under neutral pH conditions for advanced protein phosphorylation profiling

(2010) Eiji Kinoshita et al.   PROTEOMICS

Akt Phosphorylates Sec24: New Clues into the Regulation of ER-to-Golgi Trafficking

(2010) Laura J. Sharpe et al.   TRAFFIC

Role of 3β-Hydroxysteroid-Δ24 Reductase in Mediating Antiinflammatory Effects of High-Density Lipoproteins in Endothelial Cells

(2009) K.C.Y. McGrath et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

24-Dehydrocholesterol Reductase/Seladin-1: A Key Protein Differentially Involved in Adrenocorticotropin Effects Observed in Human and Rat Adrenal Cortex

(2009) Marie-Claude Battista et al.   ENDOCRINOLOGY

Down-regulation of Seladin-1 Increases BACE1 Levels and Activity through Enhanced GGA3 Depletion during Apoptosis

(2009) Timo Sarajärvi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Pfam protein families database

(2009) Robert D. Finn et al.   NUCLEIC ACIDS RESEARCH

Seladin-1 Is a Fundamental Mediator of the Neuroprotective Effects of Estrogen in Human Neuroblast Long-Term Cell Cultures

(2008) Paola Luciani et al.   ENDOCRINOLOGY

Cholesterol Substitution Increases the Structural Heterogeneity of Caveolae

(2008) Maurice Jansen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Androgen receptor regulation of the seladin-1/DHCR24 gene: altered expression in prostate cancer

(2008) Lorella Bonaccorsi et al.   LABORATORY INVESTIGATION

Homology modelling of human DHCR24 (seladin-1) and analysis of its binding properties through molecular docking and dynamics simulations

(2008) Alessandro Pedretti et al.   STEROIDS

A novel megaprimed and ligase-free, PCR-based, site-directed mutagenesis method

(2007) Wen-Chi Tseng et al.   ANALYTICAL BIOCHEMISTRY